公开(公告)号：WO2014012078A2

公开(公告)日：2014-01-16

申请号：PCT/US2013050402

申请日：2013-07-12

Applicant: HARVARD COLLEGE

Inventor： AIZENBERG JOANNA ,  WONG TAK SING ,  HATTON BENJAMIN

IPC: A61F13/47

CPC classification number: A61F13/537 ,  A61F13/15617 ,  A61F13/15699 ,  A61F2013/8455 ,  A61L15/42 ,  A61L15/50 ,  A61L29/06 ,  B05D1/36 ,  B05D3/0218 ,  B05D3/104 ,  B05D3/107 ,  B05D3/12 ,  B05D5/08 ,  B08B17/065 ,  B32B3/26 ,  B32B3/263 ,  B32B5/16 ,  B32B7/12 ,  B32B27/08 ,  B32B27/283 ,  B32B27/322 ,  B32B37/0038 ,  B32B37/1284 ,  B32B37/24 ,  B32B38/0004 ,  B32B38/0012 ,  B32B38/06 ,  B32B2037/1246 ,  B32B2037/243 ,  B32B2038/0016 ,  B32B2038/002 ,  B32B2255/10 ,  B32B2264/102 ,  B32B2307/746 ,  B32B2307/754 ,  B32B2405/00 ,  B32B2419/00 ,  B32B2419/04 ,  B32B2419/06 ,  B32B2457/12 ,  B32B2535/00 ,  B32B2551/00 ,  B32B2556/00 ,  B32B2590/00 ,  C09D5/1681 ,  C09D5/1693 ,  C09D171/00 ,  C10M107/38 ,  C10M177/00 ,  C10M2213/0623 ,  C10M2229/0415 ,  C10N2230/06 ,  C10N2250/18 ,  Y10T156/10 ,  Y10T428/24322 ,  Y10T428/24355 ,  Y10T428/24364

Abstract: Methods and compositions disclosed herein relate to liquid repellant surfaces having selective wetting and transport properties.

Abstract translation: 本文公开的方法和组合物涉及具有选择性润湿和输送性质的液体排斥表面。

公开(公告)号：WO2013115868A3

公开(公告)日：2013-10-24

申请号：PCT/US2012063609

申请日：2012-11-05

Applicant: HARVARD COLLEGE

Inventor： AIZENBERG JOANNA ,  HATTON BENJAMIN ,  YAO XI ,  AIZENBERG MICHAEL ,  WANG WENDONG

IPC: A61L27/50 ,  A61L15/50

CPC classification number: C10M171/001 ,  A61F2/28 ,  A61F2240/001 ,  A61L15/425 ,  A61L15/50 ,  A61L27/50 ,  A61L27/56 ,  A61L29/14 ,  A61L29/146 ,  A61L2400/10 ,  A61L2400/16 ,  A61L2400/18 ,  A61M31/00 ,  B05D3/007 ,  B05D3/0254 ,  B05D3/06 ,  B05D3/12 ,  B05D3/14 ,  B05D3/207 ,  F17D1/08 ,  Y10T137/0324 ,  Y10T428/139 ,  Y10T428/24355

Abstract: The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces (SLIPS) that can be modified as desired. Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of objects, referred to herein as Object A (Solid A or Liquid A). Use of an external stimuli or degradation of the Liquid B can be utilized to change the characteristics of SLIPS structures reversibly or irreversibly that may be desired in a number of different applications. Numerous characteristics, such as adhesion, optical, mechanical, and the like, can be dynamically changed.

公开(公告)号：WO2013115868A9

公开(公告)日：2013-12-12

申请号：PCT/US2012063609

申请日：2012-11-05

Applicant: HARVARD COLLEGE

Inventor： AIZENBERG JOANNA ,  HATTON BENJAMIN ,  YAO XI ,  AIZENBERG MICHAEL ,  WANG WENDONG

IPC: A61L27/50 ,  A61L15/50

CPC classification number: C10M171/001 ,  A61F2/28 ,  A61F2240/001 ,  A61L15/425 ,  A61L15/50 ,  A61L27/50 ,  A61L27/56 ,  A61L29/14 ,  A61L29/146 ,  A61L2400/10 ,  A61L2400/16 ,  A61L2400/18 ,  A61M31/00 ,  B05D3/007 ,  B05D3/0254 ,  B05D3/06 ,  B05D3/12 ,  B05D3/14 ,  B05D3/207 ,  F17D1/08 ,  Y10T137/0324 ,  Y10T428/139 ,  Y10T428/24355

Abstract: The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces (SLIPS) that can be modified as desired. Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of objects, referred to herein as Object A (Solid A or Liquid A). Use of an external stimuli or degradation of the Liquid B can be utilized to change the characteristics of SLIPS structures reversibly or irreversibly that may be desired in a number of different applications. Numerous characteristics, such as adhesion, optical, mechanical, and the like, can be dynamically changed.

Abstract translation: 本公开描述了一种制造可根据需要进行修改的自修复光滑液体注入多孔表面（SLIPS）的策略。 粗糙的（例如，多孔的）表面可以用来锁定润滑液，这里称为液体B以排斥各种各样的物体，这里称为物体A（固体A或液体A）。 可以利用外部刺激或液体B的降解来可逆地或不可逆地改变SLIPS结构的特性，这在许多不同的应用中可能是期望的。 可以动态地改变诸如粘附，光学，机械等的许多特征。

公开(公告)号：WO2011031964A3

公开(公告)日：2011-08-11

申请号：PCT/US2010048422

申请日：2010-09-10

Applicant: HARVARD COLLEGE ,  LOPEZ DANIEL ,  HATTON BENJAMIN ,  KOLTER ROBERTO

Inventor： LOPEZ DANIEL ,  HATTON BENJAMIN ,  KOLTER ROBERTO

IPC: A61L27/54 ,  A01N63/00 ,  A01P1/00 ,  A61L27/28 ,  A61L27/34

CPC classification number: A61L15/44 ,  A01N43/16 ,  A01N43/72 ,  A01N43/80 ,  A01N43/90 ,  A01N57/22 ,  A61K31/355 ,  A61K31/66 ,  A61L15/26 ,  A61L15/46 ,  A61L24/0015 ,  A61L24/046 ,  A61L27/18 ,  A61L27/34 ,  A61L27/54 ,  A61L29/06 ,  A61L29/085 ,  A61L29/16 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/434 ,  C08L63/00

Abstract: Disclosed herein is a composition for inhibiting bacterial biofilm formation comprising carrier and an effective amount of an inhibitor of squalene/phytoene synthesis. Inhibitors may inhibit, for example, HMG-CoA Reductase, squalene synthase, 1-deoxy-D-xylulose 5-phosphate synthase. Examples of such inhibitors are a phosphonosulfonate (e.g., BPH-652, BPH-689, BPH-700), a statin (e.g., mevastatin, lovastatin, atorvastatin, cerivastatin, fluvastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin), zaragozic acid, clomazone, and lapaquistat acetate or a functional derivative thereof. Also disclosed are substrates comprising the inhibitor of squalene/phytoene synthesis, and methods of inhibiting bacterial biofilm formation.

Abstract translation: 本文公开了用于抑制细菌生物膜形成的组合物，其包含载体和有效量的角鲨烯/八氢番茄红素合成抑制剂。 抑制剂可以抑制例如HMG-CoA还原酶，角鲨烯合酶，1-脱氧-D-木酮糖-5-磷酸合酶。 这些抑制剂的实例是膦酰基磺酸盐（例如BPH-652，BPH-689，BPH-700），他汀（例如，美伐他汀，洛伐他汀，阿托伐他汀，西立伐他汀，氟伐他汀，匹伐他汀，普伐他汀，罗苏伐他汀和辛伐他汀），萨拉戈酸 ，异恶草酮和醋酸拉帕喹酯或其功能性衍生物。 还公开了包含角鲨烯/八氢番茄红素合成抑制剂的底物以及抑制细菌生物膜形成的方法。

公开(公告)号：WO2012078351A3

公开(公告)日：2012-08-16

申请号：PCT/US2011061710

申请日：2011-11-21

Applicant: HARVARD COLLEGE ,  BURGESS IAN B ,  MISHCHENKO LIDIYA ,  HATTON BENJAMIN ,  AIZENBERG JOANNA ,  LONCAR MARCO

Inventor： BURGESS IAN B ,  MISHCHENKO LIDIYA ,  HATTON BENJAMIN ,  AIZENBERG JOANNA ,  LONCAR MARCO

IPC: G01N21/77

CPC classification number: G01N21/78 ,  B82Y20/00 ,  C08G59/502 ,  C08L63/00 ,  G01N21/774

Abstract: A three-dimensional porous photonic structure, whose internal pore surfaces can be provided with desired surface properties in a spatially selective manner with arbitrary patterns, and methods for making the same are described. When exposed to a fluid (e.g., via immersion or wicking), the fluid can selectively penetrate the regions of the structure with compatible surface properties. Broad applications, for example in security, encryption and document authentication, as well as in areas such as simple microfluidics and diagnostics, are anticipated.

Abstract translation: 描述了一种三维多孔光子结构，其内孔表面可以以任意图案以空间选择的方式提供所需的表面性质，以及制造其的方法。 当暴露于流体（例如通过浸渍或芯吸）时，流体可以选择地渗透具有相容表面性质的结构区域。 预计广泛的应用，例如安全，加密和文档认证以及简单微流体和诊断等领域。

公开(公告)号：WO2012100100A2

公开(公告)日：2012-07-26

申请号：PCT/US2012021929

申请日：2012-01-19

Applicant: HARVARD COLLEGE ,  AIZENBERG JOANNA ,  HATTON BENJAMIN ,  INGBER DONALD ELLIOTT ,  SUPER MICHAEL ,  WONG TAK SING

Inventor： AIZENBERG JOANNA ,  HATTON BENJAMIN ,  INGBER DONALD ELLIOTT ,  SUPER MICHAEL ,  WONG TAK SING

IPC: C09D5/16

CPC classification number: C09D5/1693 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  A61L33/0094 ,  A61L33/064 ,  A61L2400/12 ,  B05D5/083 ,  C09D5/1656 ,  C09D5/1681 ,  F15D1/02 ,  F15D1/10 ,  C08L27/12

Abstract: A self-healing, scratch resistant slippery surface that is manufactured by wicking a chemically-inert, high-density liquid coating over a roughened solid surface featuring micro and nanoscale topographies is described. Such a slippery surface shows anti-wetting properties, as well as exhibits significant reduction of adhesion of a broad range of biological materials, including particles in suspension or solution. Specifically, the slippery surfaces can be applied to medical devices and equipment to effectively repel biological materials such as blood, and prevent, reduce, or delay coagulation and surface-mediated clot formation. Moreover, the slippery surfaces can be used to prevent fouling by microorganisms such as bacteria.

Abstract translation: 描述了一种自我修复，抗划伤的光滑表面，该表面是通过芯吸化学惰性，高密度液体涂层在具有微米和纳米级形貌的粗糙的固体表面上制造的。 这种光滑表面显示出抗湿性，并且显示出广泛范围的生物材料（包括悬浮液或溶液中的颗粒）的粘附性的显着降低。 具体而言，光滑表面可以应用于医疗设备和设备以有效排斥生物材料如血液，并且防止，减少或延迟凝结和表面介导的血块形成。 而且，光滑的表面可用于防止微生物如细菌污染。

公开(公告)号：WO2011156484A3

公开(公告)日：2012-01-26

申请号：PCT/US2011039625

申请日：2011-06-08

Applicant: HARVARD COLLEGE ,  AIZENBERG JOANNA ,  HATTON BENJAMIN

Inventor： AIZENBERG JOANNA ,  HATTON BENJAMIN

IPC: C23C16/40 ,  C23C16/455 ,  C23C16/54

CPC classification number: C23C16/402 ,  B05D3/10 ,  B05D3/105 ,  B05D3/107 ,  C23C16/45525 ,  C23C16/45534 ,  C23C16/45551 ,  C23C16/45595 ,  C23C16/545

Abstract: An ambient pressure Atomic Layer Deposition (ALD) technique to grow uniform silica layers onto organic substrates at low temperatures, including room temperature, is described. For example, tetramethoxysilane vapor is used alternately with ammonia vapor as a catalyst in an ambient environment.

Abstract translation: 描述了一种环境压力原子层沉积（ALD）技术，用于在包括室温在内的低温下在均匀的二氧化硅层上生长到有机基底上。 例如，四甲氧基硅烷蒸气与氨蒸汽交替地作为周围环境中的催化剂。