公开(公告)号：WO2015187868A3

公开(公告)日：2016-01-28

申请号：PCT/US2015034053

申请日：2015-06-03

Applicant: ILLUMINA INC

Inventor： BOHM SEBASTIAN ,  ARAVANIS ALEX ,  HSIAO ALEXANDER ,  JAVANMARDI BEHNAM ,  KHURANA TARUN ,  TRAN HAI QUANG ,  AGHABABAZADEH MAJID ,  BOWEN M SHANE ,  BOYANOV BOYAN ,  BUERMANN DALE

IPC: B01L3/00

CPC classification number: B01L3/502738 ,  B01L3/502715 ,  B01L3/50273 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/0644 ,  B01L2400/0655 ,  C12Q1/6869 ,  F16K99/0013 ,  F16K99/0015 ,  F16K99/0028 ,  F16K2099/0084

Abstract: Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.

Abstract translation: 用于进行指定反应的系统和方法，其包括具有样品通道的流体网络，反应室和储存器。 样品通道与样品端口流通。 该系统还包括具有流动通道并被配置为在第一和第二阀位置之间旋转的旋转阀。 当旋转阀处于第一阀位置时，流动通道流体耦合反应室和样品通道，并且当旋转阀处于第二阀位置时，流体流动地联接储存器和反应室。 当旋转阀处于第一阀位置时，泵组件将生物样品流向反应室，当旋转阀处于第二阀位置时，泵组件将反应组分从储存器流向反应室。

公开(公告)号：WO2015187868A8

公开(公告)日：2017-01-05

申请号：PCT/US2015034053

申请日：2015-06-03

Applicant: ILLUMINA INC

Inventor： BOHM SEBASTIAN ,  ARAVANIS ALEX ,  HSIAO ALEXANDER ,  JAVANMARDI BEHNAM ,  KHURANA TARUN ,  TRAN HAI QUANG ,  AGHABABAZADEH MAJID ,  BOWEN M SHANE ,  BOYANOV BOYAN ,  BUERMANN DALE

IPC: B01L3/00

CPC classification number: B01L3/502738 ,  B01L3/502715 ,  B01L3/50273 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/0644 ,  B01L2400/0655 ,  C12Q1/6869 ,  F16K99/0013 ,  F16K99/0015 ,  F16K99/0028 ,  F16K2099/0084

Abstract: Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.

Abstract translation: 用于进行指定反应的系统和方法，其包括具有样品通道的流体网络，反应室和储存器。 样品通道与样品端口流通。 该系统还包括具有流动通道并被配置为在第一和第二阀位置之间旋转的旋转阀。 当旋转阀处于第一阀位置时，流动通道流体耦合反应室和样品通道，并且当旋转阀处于第二阀位置时，流体流动地联接储存器和反应室。 当旋转阀处于第一阀位置时，泵组件将生物样品流向反应室，当旋转阀处于第二阀位置时，泵组件将反应组分从储存器流向反应室。

公开(公告)号：WO2009102688A2

公开(公告)日：2009-08-20

申请号：PCT/US2009033637

申请日：2009-02-10

Applicant: ILLUMINA INC

Inventor： LEBL MICHAL ,  BUERMANN DALE ,  REED MARK T ,  HEINER DAVID L ,  TRIENER ALEXANDER

IPC: G01N1/14 ,  B01L3/02 ,  F04B37/10

CPC classification number: F04B19/006 ,  B01L3/502715 ,  B01L3/50273 ,  B01L7/00 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2400/0418 ,  G01N35/00613 ,  G01N35/1095 ,  Y10T436/2575

Abstract: A flow cell for use in a microfluidic detection system is provided. The flow cell includes a flow cell body having a channel that is configured to convey a solution through the flow cell body. The flow cell also includes a bottom surface and a top surface. The bottom surface is configured to be removably held by the detection system, and the top surface is transparent and permits light to pass therethrough. The flow cell body also includes fluidic inlet and outlet ports that are in fluid communication with the channel. A pump cavity is also provided in the flow cell body. The pump cavity fluidly communicates with, and is interposed between, an end of the channel and one of the fluidic inlet and outlet ports. An electroosmotic (EO) pump is held in the pump cavity. The EO pump induces flow of the solution through the EO pump and channel between the fluidic inlet and outlet ports.

Abstract translation: 提供了一种用于微流体检测系统的流通池。 流动池包括具有通道的流动池主体，该通道被配置为将溶液输送通过流动池主体。 流动池还包括底面和顶面。 底表面被构造成由检测系统可移除地保持，并且顶表面是透明的并且允许光通过。 流动池主体还包括与通道流体连通的流体入口和出口。 在流动池主体中还设有泵腔。 泵腔与通道的端部和流体入口和出口之一流体连通并且介于其间。 电渗（EO）泵保持在泵腔中。 EO泵通过EO泵和流体入口和出口之间的通道引起溶液的流动。