公开(公告)号：WO2015100373A3

公开(公告)日：2015-08-13

申请号：PCT/US2014072256

申请日：2014-12-23

Applicant: ILLUMINA INC

Inventor： BOWEN M SHANE ,  VENKATESAN BALA MURALI ,  HAN HUI ,  PARK SANG RYUL

IPC: C12N15/09

CPC classification number: C12Q1/6834 ,  B82Y30/00 ,  C12N15/09 ,  C12N15/1093 ,  C12Q2563/107 ,  C12Q2565/628

Abstract: Structured substrate including (a) a plurality of nanoparticles distributed on a solid support, (b) a gel material forming a layer in association with the plurality of nanoparticles, and (c) a library of target nucleic acids in the gel material.

Abstract translation: （a）分布在固体支持物上的多个纳米颗粒，（b）形成与所述多个纳米颗粒结合的层的凝胶材料，和（c）凝胶材料中的靶核酸文库。

公开(公告)号：WO2013063382A3

公开(公告)日：2013-10-10

申请号：PCT/US2012062105

申请日：2012-10-26

Applicant: ILLUMINA INC ,  BOWEN M SHANE ,  GUNDERSON KEVIN L ,  LIN SHENGRONG ,  BACIGALUPO MARIA CANDELARIA ROGERT ,  VIJAYAN KANDASWAMY ,  WU YIR-SHYUAN ,  VENKATESAN BALA MURALI ,  TSAY JAMES ,  BEIERLE JOHN M ,  BERTI LORENZO ,  PARK SANG RYUL

Inventor： BOWEN M SHANE ,  GUNDERSON KEVIN L ,  LIN SHENGRONG ,  BACIGALUPO MARIA CANDELARIA ROGERT ,  VIJAYAN KANDASWAMY ,  WU YIR-SHYUAN ,  VENKATESAN BALA MURALI ,  TSAY JAMES ,  BEIERLE JOHN M ,  BERTI LORENZO ,  PARK SANG RYUL

IPC: B01J19/00 ,  C12Q1/68 ,  G01N33/543

CPC classification number: C12Q1/6844 ,  B01J19/0046 ,  B01J2219/00529 ,  B01J2219/00608 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00644 ,  B01J2219/00648 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00662 ,  B01J2219/00722 ,  B01J2219/00788 ,  C12Q1/686 ,  C40B50/18 ,  C12Q2527/125 ,  C12Q2535/122 ,  C12Q2565/543

Abstract: A microarray is designed capture one or more molecules of interest at each of a plurality of sites on a substrate. The sites comprise base pads, such as polymer base pads, that promote the attachment of the molecules at the sites. The microarray may be made by one or more patterning techniques to create a layout of base pads in a desired pattern. Further, the microarrays may include features to encourage clonality at the sites.

Abstract translation: 微阵列被设计为在基底上的多个位点中的每一个处捕获一个或多个感兴趣的分子。 这些位点包含基垫，例如聚合物基垫，其促进分子在该位点处的附着。 微阵列可以通过一种或多种图案化技术制成，以便以期望的图案形成基垫的布局。 此外，微阵列可以包括鼓励在该位点克隆的特征。

公开(公告)号：WO2015187868A8

公开(公告)日：2017-01-05

申请号：PCT/US2015034053

申请日：2015-06-03

Applicant: ILLUMINA INC

Inventor： BOHM SEBASTIAN ,  ARAVANIS ALEX ,  HSIAO ALEXANDER ,  JAVANMARDI BEHNAM ,  KHURANA TARUN ,  TRAN HAI QUANG ,  AGHABABAZADEH MAJID ,  BOWEN M SHANE ,  BOYANOV BOYAN ,  BUERMANN DALE

IPC: B01L3/00

CPC classification number: B01L3/502738 ,  B01L3/502715 ,  B01L3/50273 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/0644 ,  B01L2400/0655 ,  C12Q1/6869 ,  F16K99/0013 ,  F16K99/0015 ,  F16K99/0028 ,  F16K2099/0084

Abstract: Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.

Abstract translation: 用于进行指定反应的系统和方法，其包括具有样品通道的流体网络，反应室和储存器。 样品通道与样品端口流通。 该系统还包括具有流动通道并被配置为在第一和第二阀位置之间旋转的旋转阀。 当旋转阀处于第一阀位置时，流动通道流体耦合反应室和样品通道，并且当旋转阀处于第二阀位置时，流体流动地联接储存器和反应室。 当旋转阀处于第一阀位置时，泵组件将生物样品流向反应室，当旋转阀处于第二阀位置时，泵组件将反应组分从储存器流向反应室。

公开(公告)号：WO2015187868A3

公开(公告)日：2016-01-28

申请号：PCT/US2015034053

申请日：2015-06-03

Applicant: ILLUMINA INC

Inventor： BOHM SEBASTIAN ,  ARAVANIS ALEX ,  HSIAO ALEXANDER ,  JAVANMARDI BEHNAM ,  KHURANA TARUN ,  TRAN HAI QUANG ,  AGHABABAZADEH MAJID ,  BOWEN M SHANE ,  BOYANOV BOYAN ,  BUERMANN DALE

IPC: B01L3/00

CPC classification number: B01L3/502738 ,  B01L3/502715 ,  B01L3/50273 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/0644 ,  B01L2400/0655 ,  C12Q1/6869 ,  F16K99/0013 ,  F16K99/0015 ,  F16K99/0028 ,  F16K2099/0084

Abstract: Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.

Abstract translation: 用于进行指定反应的系统和方法，其包括具有样品通道的流体网络，反应室和储存器。 样品通道与样品端口流通。 该系统还包括具有流动通道并被配置为在第一和第二阀位置之间旋转的旋转阀。 当旋转阀处于第一阀位置时，流动通道流体耦合反应室和样品通道，并且当旋转阀处于第二阀位置时，流体流动地联接储存器和反应室。 当旋转阀处于第一阀位置时，泵组件将生物样品流向反应室，当旋转阀处于第二阀位置时，泵组件将反应组分从储存器流向反应室。

公开(公告)号：WO2011053845A3

公开(公告)日：2011-09-22

申请号：PCT/US2010054829

申请日：2010-10-29

Applicant: ILLUMINA INC ,  MOON JOHN A ,  BOWEN M SHANE ,  SMITH RYAN C ,  PERBOST MICHEL ,  LEBL MICHAL ,  MODIANO STEVEN H

Inventor： MOON JOHN A ,  BOWEN M SHANE ,  SMITH RYAN C ,  PERBOST MICHEL ,  LEBL MICHAL ,  MODIANO STEVEN H

IPC: G01N33/50 ,  C12Q1/68 ,  G01N21/84 ,  G01N33/52

CPC classification number: G01N33/50 ,  B01J19/0046 ,  B01J2219/00306 ,  B01J2219/00511 ,  B01J2219/0052 ,  B01J2219/00524 ,  B01J2219/00545 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00673 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01L3/502761 ,  B01L3/5082 ,  B01L3/50857 ,  B01L3/5088 ,  B01L3/545 ,  C40B20/04 ,  G01N21/01 ,  G01N21/253 ,  G01N21/6452 ,  G01N35/00732

Abstract: A method of reading a plurality of encoded microvessels used in an assay for biological or chemical analysis The method can include providing a plurality of encoded microvessels The microvessels can include a respective microbody and a reservoir core configured to hold a substance in the reservoir core The microbody can include a material that surrounds the reservoir core and facilitates detection of a characteristic of the substance within the reservoir core Optionally, the material can be transparent so as to facilitate detection of an optical characteristic of a substance within the reservoir core The microbody can include an identifiable code associated with the substance The method can also include determining the corresponding codes of the microvessels.

Abstract translation: 读取用于生物或化学分析的测定中使用的多个编码的微血管的方法该方法可以包括提供多个编码的微血管。微血管可以包括相应的微体和构造成将物质保持在储存器核心中的储存器芯。微体 可以包括围绕贮存器芯体的材料并且便于检测贮存器芯体内的物质的特性。可选地，该材料可以是透明的，以便于检测贮存器芯体内的物质的光学特性。微体可以包括 与物质相关的可识别代码该方法还可以包括确定微血管的相应代码。