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    PACKAGING METHODS FOR FABRICATION OF ANALYTICAL DEVICE PACKAGES AND ANALYTICAL DEVICE PACKAGES MADE THEREOF
    4.
    发明申请
    PACKAGING METHODS FOR FABRICATION OF ANALYTICAL DEVICE PACKAGES AND ANALYTICAL DEVICE PACKAGES MADE THEREOF 审中-公开
    用于制造分析装置包装的包装方法和由其制造的分析装置包装

    公开(公告)号：WO2017087662A1

    公开(公告)日：2017-05-26

    申请号：PCT/US2016/062516

    申请日：2016-11-17

    申请人： PACIFIC BIOSCIENCES OF CALIFORNIA, INC.

    发明人： SAXENA, Ravi ,  LOGAN, Elizabeth ,  ORIMOTO, Takashi

    IPC分类号： G01N27/416 ,  H01L23/48

    CPC分类号： H01L21/78 ,  G01D11/245 ,  H01L23/3171 ,  H01L2224/48091 ,  H01L2224/97 ,  H01L2924/00014

    摘要： Disclosed are packaging methods for the fabrication of analytical device packages and fabricated analytical device packages. The methods include providing a sensor wafer and mounting individual plates or a plate wafer on the sensor wafer. The sensor wafer includes sensor chips with aperture regions and is treated with selective depositions, either prior to or during the fabrication of the analytical device packages, to produce different surface characteristics at different portions of the aperture regions. Before dicing the sensor wafer, openings of the individual plates or the plate wafer are covered by a protective layer to protect surface characteristics at different portions of the aperture regions. A fabricated analytical device package includes a sensor chip with different surface characteristics, a plate, a packaging substrate and an optional cover.

    摘要翻译： 公开了用于制造分析装置封装和制造的分析装置封装的封装方法。 该方法包括提供传感器晶片和在传感器晶片上安装单个板或板晶片。 传感器晶片包括具有开口区域的传感器芯片，并且在制造分析装置封装之前或期间用选择性沉积来处理，以在开口区域的不同部分产生不同的表面特性。 在切割传感器晶片之前，各个板或板晶片的开口被保护层覆盖以保护开口区域的不同部分处的表面特性。 制造的分析设备包装包括具有不同表面特性的传感器芯片，平板，封装基板和可选封盖。

    NUCLEIC ACID SEQUENCING CARTRIDGES, PACKAGED DEVICES, AND SYSTEMS
    5.
    发明申请
    NUCLEIC ACID SEQUENCING CARTRIDGES, PACKAGED DEVICES, AND SYSTEMS 审中-公开

    公开(公告)号：WO2021146443A1

    公开(公告)日：2021-07-22

    申请号：PCT/US2021/013465

    申请日：2021-01-14

    申请人： PACIFIC BIOSCIENCES OF CALIFORNIA, INC.

    发明人： BERMAN, Russell ,  BENITEZ-MARZAN, Jaime Juan ,  POPOVICH, Natasha ,  RULISON, Aaron ,  SAXENA, Ravi

    IPC分类号： G01N21/03 ,  G01N21/64 ,  G01N21/77 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2201/0873

    摘要： Provided herein are cartridges, packaged devices, and systems for improved nucleic acid sequencing. The cartridges, devices, and systems include a highly multiplexed optical chip comprising a plurality of nanoscale reaction regions that is configured to perform and report nucleic acid sequencing reactions. The chips are, in some embodiments, packaged for use in analytical nucleic acid sequencing reactions. The chips may be attached to a printed circuit board, may be surrounded by a protective enclosure, may include a flow cell, and may include optical features to minimize or block photobleaching of the sequencing reagents and background fluorescent signals. Also provided are analytical systems for nucleic acid sequencing that comprise the disclosed cartridges and packaged devices. The systems comprise an analytical instrument with electronic, optical, mechanical, fluidic, and/or thermal connectors designed to interact with the corresponding connectors on an associated cartridge or packaged device in a highly precise but reversible manner.