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    BIOLOGICAL SAMPLE PROCESSING
    1.
    发明申请
    BIOLOGICAL SAMPLE PROCESSING 审中-公开

    公开(公告)号：WO2014160903A3

    公开(公告)日：2014-10-02

    申请号：PCT/US2014/032092

    申请日：2014-03-27

    申请人： THERANOS, INC.

    发明人： HOLMES, Elizabeth, A. ,  LATH, Adrit

    IPC分类号： G01N1/28 ,  G01N35/02

    摘要： Systems and methods are provided for processing a biological sample. In one embodiment, the method comprises receiving a sample vessel containing the sample; retrieving information from an information storage unit associated with the sample; using said information for selecting at least one cartridge from at least two or more different cartridges, each configured for use with a sample processing device; loading at least one or more reagents onto the cartridge, wherein the one or more reagents to be added are selected based at least in part on the information or instructions derived from the information; and placing the sample vessel in the cartridge.

    RAPID MEASUREMENT OF FORMED BLOOD COMPONENT SEDIMENTATION RATE FROM SMALL SAMPLE VOLUMES
    3.
    发明申请
    RAPID MEASUREMENT OF FORMED BLOOD COMPONENT SEDIMENTATION RATE FROM SMALL SAMPLE VOLUMES 审中-公开
    从小样本量快速测量血液成分的成分速率

    公开(公告)号：WO2014015177A1

    公开(公告)日：2014-01-23

    申请号：PCT/US2013/051143

    申请日：2013-07-18

    申请人： THERANOS, INC.

    发明人： DAYEL, Mark ,  ANEKAL, Samartha ,  HOLMES, Elizabeth, A.

    IPC分类号： G01N33/49 ,  G01N15/04 ,  B04B5/10 ,  B01D21/32 ,  G06K9/78

    CPC分类号： G01N15/042 ,  G01N15/05 ,  G01N33/491 ,  G01N2015/0069 ,  G01N2015/0073 ,  G01N2015/045 ,  G01N2015/055

    摘要： Devices and methods are described for measuring formed blood component sedimentation rate. Some of the methods may use (1) centrifugal techniques for separating red blood cells from plasma and (2) video and/or still imaging capability. Both may be used alone or in combination to accelerate formed blood component sedimentation and to measure its rate. In one example, the method may advantageously enable rapid measurement of sedimentation rate using small blood sample volumes. Automated image analysis can be used to determine both sedimentation rate and hematocrit. Automated techniques may be used to compensate for effects of hematocrit on uncorrected sedimentation rate data.

    摘要翻译： 描述了用于测量形成的血液成分沉降速率的装置和方法。 一些方法可以使用（1）用于从血浆中分离红细胞的离心技术和（2）视频和/或静止成像能力。 两者可以单独使用或组合使用以加速形成的血液成分沉降并测量其速率。 在一个实例中，该方法可以有利地使得能够使用小的血液样本体积快速测量沉降速率。 自动图像分析可用于确定沉降速率和血细胞比容。 自动化技术可用于补偿血细胞比容对未校正沉降速率数据的影响。

    METHODS, SYSTEMS, AND DEVICES FOR REAL TIME EXECUTION AND OPTIMIZATION OF CONCURRENT TEST PROTOCOLS ON A SINGLE DEVICE
    4.
    发明申请
    METHODS, SYSTEMS, AND DEVICES FOR REAL TIME EXECUTION AND OPTIMIZATION OF CONCURRENT TEST PROTOCOLS ON A SINGLE DEVICE 审中-公开
    实时执行方法，系统和设备，并优化单个设备上的同步测试协议

    公开(公告)号：WO2014127269A1

    公开(公告)日：2014-08-21

    申请号：PCT/US2014/016548

    申请日：2014-02-14

    申请人： THERANOS, INC.

    发明人： HOLMES, Elizabeth, A. ,  YOUNG, Daniel

    IPC分类号： G01N35/00 ,  G06F9/50 ,  G06F15/16 ,  G06Q10/06

    CPC分类号： G01N35/0092 ,  G01N2035/00326

    摘要： Provided herein are medical testing devices, systems, and methods that integrate multiplex, multi-technology, multi-configuration, multisample, or multi-threading capabilities. These capabilities are achieved using one or more of a level operations and communications architecture, a protocol exection engine, and a machine vision and processing system, method, or device in order to make testing of biologic or other samples more efficient in terms of cost, time, energy, or by prioritizing at least one other objective.

    摘要翻译： 这里提供集成多路复用，多技术，多配置，多采样或多线程功能的医疗测试设备，系统和方法。 这些功能使用一个或多个一级操作和通信架构，协议排除引擎以及机器视觉和处理系统，方法或设备来实现，以便使生物或其他样本的测试在成本方面更有效率， 时间，精力或者至少排列一个其他目标。

    INFORMATION MANAGEMENT SYSTEMS AND METHODS USING A BIOLOGICAL SIGNATURE
    5.
    发明申请
    INFORMATION MANAGEMENT SYSTEMS AND METHODS USING A BIOLOGICAL SIGNATURE 审中-公开
    信息管理系统和使用生物学签名的方法

    公开(公告)号：WO2014042986A1

    公开(公告)日：2014-03-20

    申请号：PCT/US2013/058450

    申请日：2013-09-06

    申请人： THERANOS, INC. ,  HOLMES, Elizabeth, A.

    发明人： HOLMES, Elizabeth, A.

    IPC分类号： C12Q1/68

    CPC分类号： G06F21/32 ,  G06F19/00 ,  G06F21/6245 ,  G16H10/60

    摘要： Systems and methods are provided for generating a biological signature such as a genetic signature and using such signature of an individual. The biological signature may be used to verify the identity of the individual. A verified individual may be granted access to a secured location, item, and/or service. Biological signatures may also be used to search or aggregate records for an individual.

    摘要翻译： 提供了用于生成诸如遗传签名的生物特征和使用个体的这种签名的系统和方法。 生物特征可用于验证个体的身份。 被授权的个人可以被授权访问安全的位置，项目和/或服务。 生物签名也可用于搜索或汇总个人的记录。

    DEVICES, SYSTEMS AND METHODS FOR SAMPLE PREPARATION
    7.
    发明申请
    DEVICES, SYSTEMS AND METHODS FOR SAMPLE PREPARATION 审中-公开
    装置，系统和样品制备方法

    公开(公告)号：WO2014150290A1

    公开(公告)日：2014-09-25

    申请号：PCT/US2014/022847

    申请日：2014-03-10

    申请人： THERANOS, INC.

    发明人： LOO, Alexander ,  HOLMES, Elizabeth, A.

    IPC分类号： G01N33/48 ,  G01N29/02 ,  G01N1/28

    CPC分类号： G01N35/00 ,  B01F11/0266 ,  C12Q1/04 ,  G01N1/28 ,  G01N1/286 ,  G01N1/38 ,  G01N33/487 ,  G01N35/00871 ,  G01N35/1009 ,  G01N2001/4094 ,  G01N2035/00524 ,  G01N2035/00554

    摘要： Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.

    摘要翻译： 提供了包括用于样品制备的超声波发生器的装置，系统和方法。 超声波仪可用于混合，重悬，雾化，分散，分解或除气。 超声波仪器可用于破坏细胞，如样品中的病原体细胞。 样品制备可以包括通过超声处理暴露病原体识别材料以检测，鉴定或测量病原体。 超声波发生器可通过将其尖端接触到含有样品的容器的外壁将超声能量转移到样品溶液。 包括超声波发生器的多用途装置还包括用于附加动作和测定的其它组件。 设备和包括这种设备的系统可以与用于样品测定和分析的系统中的实验室或其他设备通信。 提供了利用这种装置和系统的方法。 改进的样品制备装置，系统和方法可用于分析样品，例如 用于诊断病原体感染的患者。

    INTEGRATED HEALTH DATA CAPTURE AND ANALYSIS SYSTEM
    8.
    发明申请
    INTEGRATED HEALTH DATA CAPTURE AND ANALYSIS SYSTEM 审中-公开
    综合健康数据收集与分析系统

    公开(公告)号：WO2011049886A1

    公开(公告)日：2011-04-28

    申请号：PCT/US2010/053088

    申请日：2010-10-18

    申请人： THERANOS, INC. ,  HOLMES, Elizabeth, A.

    发明人： HOLMES, Elizabeth, A.

    IPC分类号： G06F17/00 ,  G06Q50/00

    CPC分类号： G06F19/3437 ,  G06F19/00 ,  G06F19/3443 ,  G06F19/345 ,  G06F19/3493 ,  G16H50/20 ,  G16H50/50 ,  G16H50/70 ,  G16H50/80 ,  Y02A90/22 ,  Y02A90/24 ,  Y02A90/26

    摘要： The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.

    摘要翻译： 本发明提供了综合的医疗保健监控和监测系统，其提供实时采样，建模，分析和推荐的干预措施。 该系统可用于监测感染性和慢性疾病。 当面对流行性感冒病毒等传染病发病时，系统可以通过在高风险地点（如学校或拥挤的商业区）进行主动抽样来识别活动病例。 当检测到事件时，系统可以通知适当的实体，例如地方，区域和国家政府，从而允许主动管理可能的爆发。 该系统还预测部署稀缺资源的最佳反应。

    SYSTEMS, DEVICES, AND METHODS FOR BODILY FLUID SAMPLE COLLECTION AND TRANSPORT
    10.
    发明申请
    SYSTEMS, DEVICES, AND METHODS FOR BODILY FLUID SAMPLE COLLECTION AND TRANSPORT 审中-公开
    体液样品收集和运输的系统，装置和方法

    公开(公告)号：WO2014088606A2

    公开(公告)日：2014-06-12

    申请号：PCT/US2013/000268

    申请日：2013-12-05

    申请人： THERANOS, INC.

    发明人： HOLMES, Elizabeth, A. ,  LUI, Clarissa ,  CHEN, Michael ,  YOUNG, Daniel

    CPC分类号： A61B5/154 ,  A61B5/150022 ,  A61B5/15003 ,  A61B5/150099 ,  A61B5/150251 ,  A61B5/150305 ,  A61B5/150755 ,  A61B5/150984 ,  A61B5/150992 ,  A61B5/157 ,  A61B90/90 ,  A61B90/94 ,  A61B90/98 ,  G01N33/491

    摘要： Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample vessel for receiving the bodily fluid sample collected in the sample collection channel, the sample vessel operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the vessel and/or another source provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the vessel.

    摘要翻译： 提供了体液样品收集系统，装置和方法。 该装置可以包括第一部分，该第一部分至少包括样品收集通道，该样品收集通道经配置以经由第一类型的动力将流体样品吸入样品收集通道。 样品收集装置可以包括第二部分，其包括用于接收收集在样品收集通道中的体液样品的样品容器，该样品容器可操作地可接合地与收集通道流体连通，于是当建立流体连通时，容器 和/或另一个源提供不同于第一动力的第二动力，以将大部分体液样品从通道移动到容器中。