公开(公告)号：WO2011132083A3

公开(公告)日：2012-01-05

申请号：PCT/IB2011001289

申请日：2011-04-19

Applicant: ACTAVIS GROUP PTC EHF ,  KHILE ANIL SHAHAJI ,  PATEL JAYESH ,  TRIVEDI NIKHIL ,  PRADHAN NITIN SHARADCHANDRA

Inventor： KHILE ANIL SHAHAJI ,  PATEL JAYESH ,  TRIVEDI NIKHIL ,  PRADHAN NITIN SHARADCHANDRA

IPC: C07C45/46 ,  C07C49/233 ,  C07C201/10 ,  C07C201/12 ,  C07C205/10 ,  C07C205/16 ,  C07C205/45 ,  C07C209/34

CPC classification number: C07C209/34 ,  C07C45/46 ,  C07C201/10 ,  C07C201/12 ,  C07C205/05 ,  C07C205/10 ,  C07C205/16 ,  C07C205/26 ,  C07C205/45 ,  C07C211/40 ,  C07C2601/02 ,  C07C49/233

Abstract: Provided herein is a novel process for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.

Abstract translation: 本文提供了一种制备苯基环丙基胺衍生物的新方法，其是三唑并[4,5-d]嘧啶化合物的制备中的有用中间体。 本文特别地提供了一种用于制备基本上纯粹的泰格列洛中间体，反 - （1R，2S）-2-（3,4-二氟苯基） - 环丙胺的新颖的，商业上可行的和工业上有利的方法。 中间体可用于以高产率和纯度制备替卡格雷或其药学上可接受的盐。

公开(公告)号：WO2011132083A2

公开(公告)日：2011-10-27

申请号：PCT/IB2011/001289

申请日：2011-04-19

Applicant: ACTAVIS GROUP PTC EHF ,  KHILE, Anil, Shahaji ,  PATEL, Jayesh ,  TRIVEDI, Nikhil ,  PRADHAN, Nitin, Sharadchandra

Inventor： KHILE, Anil, Shahaji ,  PATEL, Jayesh ,  TRIVEDI, Nikhil ,  PRADHAN, Nitin, Sharadchandra

IPC: C07C45/46

CPC classification number: C07C209/34 ,  C07C45/46 ,  C07C201/10 ,  C07C201/12 ,  C07C205/05 ,  C07C205/10 ,  C07C205/16 ,  C07C205/26 ,  C07C205/45 ,  C07C211/40 ,  C07C2601/02 ,  C07C49/233

Abstract: Provided herein is a novel process for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.

Abstract translation: 本文提供了一种制备苯基环丙基胺衍生物的新方法，其是三唑并[4,5-d]嘧啶化合物的制备中的有用中间体。 本文特别地提供了一种用于制备基本上纯粹的泰格列洛中间体，反 - （1R，2S）-2-（3,4-二氟苯基） - 环丙胺的新颖的，商业上可行的和工业上有利的方法。 中间体可用于以高产率和纯度制备替卡格雷或其药学上可接受的盐。

公开(公告)号：WO2011042376A2

公开(公告)日：2011-04-14

申请号：PCT/EP2010064700

申请日：2010-10-04

Applicant: BAYER CROPSCIENCE AG ,  ANTONS STEFAN ,  LUI NORBERT ,  GERLACH ARNE

Inventor： ANTONS STEFAN ,  LUI NORBERT ,  GERLACH ARNE

IPC: C07C209/34

CPC classification number: C07C209/34 ,  C07C211/15

Abstract: The invention relates to a method for producing 2,2-difluoroethylamine, characterised in that 1,1-difluoro-2-nitroethane is subjected to catalytic hydrogenation.

Abstract translation: 一种制备2,2-二氟乙胺，其特征在于，1,1-二氟-2-硝基乙烷过程经受催化氢化。

公开(公告)号：WO1997003946A1

公开(公告)日：1997-02-06

申请号：PCT/EP1996002928

申请日：1996-07-04

Applicant: BASF AKTIENGESELLSCHAFT ,  KROPP, Rudolf ,  SIEGEL, Wolfgang ,  BREITSCHEIDEL, Boris ,  HARDER, Wolfgang ,  SCHWAHN, Harald ,  REIF, Wolfgang

Inventor： BASF AKTIENGESELLSCHAFT

IPC: C07C209/34

CPC classification number: C10L1/231 ,  C07B43/00 ,  C07C201/12 ,  C07C205/02 ,  C07C205/15 ,  C07C209/325 ,  C07C209/34 ,  C07C211/03 ,  C07C211/09 ,  C07C249/10 ,  C07C251/08 ,  C07C251/38 ,  C10L1/238 ,  C10L10/06 ,  C10L10/08

Abstract: The invention relates to the production of organic nitrogen compounds, especially aminoalkanes, alkyloximes, alkylnitrons or mixtures thereof having only one nitrogen-functional grouping and no alcoholic hydroxyl groups in the molecule, from nitro group-containing reaction products of polymers of C2 to C6 olefines with a mean degree of polymerisation P = 5 to 100 with nitrogen oxides, mixtures of nitrogen oxides and oxygen by the hydration of said reaction products. The invention also relates to certain mixtures of such aminoalkanes, alkyloximes and/or alkylnitrons and such individual compounds themselves. The products specified are suitable as fuel and lubricant additives.

Abstract translation: 本发明涉及的有机氮化合物的制备，尤其是氨基烷烃，alkyloximes，alkylnitrones或它们的混合物，其仅支持一个氮官能团和分子中不含醇羟基，从硝基，1至C 6烯烃具有的平均聚合度C2的聚合物的反应产物的含 P =与氮氧化物或氮的氧化物和氧气的混合物通过这些反应产物的氢化5至100。 本发明进一步提供了这样的氨基烷烃，alkyloximes和/或alkylnitrones和这种单独化合物本身的某些混合物。所描述的产品适合作为燃料和润滑油添加剂。

公开(公告)号：WO2015189235A1

公开(公告)日：2015-12-17

申请号：PCT/EP2015/062879

申请日：2015-06-10

Applicant: COVESTRO DEUTSCHLAND AG ,  BAYER MATERIALSCIENCE LLC

Inventor： PENNEMANN, Bernd ,  WESTPHAL, Ulrich ,  FÖRTSCH, Dieter ,  MILLER, Spotswood

IPC: C07C209/34

CPC classification number: B01D53/56 ,  B01D53/77 ,  C07C201/08 ,  C07C209/32 ,  C07C209/36 ,  C07C209/76 ,  C07C209/34 ,  C07C211/49 ,  C07C211/47 ,  C07C205/06 ,  C07C211/46

Abstract: Method for reducing the concentration of nitrogen oxides in waste gases released during the production of organic amino compounds, wherein an organic compound is first reacted with NO x and/or nitric acid to form an organic nitro compound with the formation of an NO x -containing waste gas stream and the organic nitro compound is converted to the organic amino compound by means of a hydrogen-containing reaction gas, the reaction of the organic nitro compound with the hydrogen-containing reduction gas taking place with the formation of a hydrogen-containing waste gas stream, the method being characterised in that the NO x -containing waste gas stream (1) is combined with the hydrogen-containing waste gas stream and/or an externally supplied hydrogen stream (3) and is reacted at a temperature of 800 to 1700°C for the at least partial reduction of the NO x concentration. An apparatus for carrying out the method is also described.

Abstract translation: 减少在生产有机氨基化合物期间释放的废气中的氮氧化物浓度的方法，其中有机化合物首先与NO x和/或硝酸反应形成有机硝基化合物，形成含NO x的废气 流，有机硝基化合物通过含氢反应气体转化为有机氨基化合物，有机硝基化合物与含氢还原气体的反应发生，形成含氢废气流 该方法的特征在于含有NO x的废气流（1）与含氢废气流和/或外部供应的氢气流（3）组合，并在800至1700℃的温度下反应 用于至少部分地降低NOx浓度。 还描述了用于执行该方法的装置。

公开(公告)号：WO2014100591A1

公开(公告)日：2014-06-26

申请号：PCT/US2013/076930

申请日：2013-12-20

Applicant: DOW GLOBAL TECHNOLOGIES LLC ,  ANGUS CHEMICAL COMPANY ,  MOORE, David, Wayne ,  BUGAJSKY, Douglas, John

Inventor： MOORE, David, Wayne ,  BUGAJSKY, Douglas, John

IPC: C07C209/34 ,  C07C213/02 ,  C07C217/08 ,  C07C211/12

CPC classification number: C07C209/34 ,  C07C213/02 ,  C07C217/08 ,  C07C211/12

Abstract: This disclosure relates to methods for limiting the undesired reverse Mannich reaction during the hydrogenation reduction of one or more nitro functional groups (-NO 2 ) to their corresponding amines (-NH 2 ).

Abstract translation: 本公开涉及在一个或多个硝基官能团（-NO 2）氢化还原成其相应的胺（-NH 2）期间限制不期望的反向曼尼期反应的方法。

公开(公告)号：WO2011113369A1

公开(公告)日：2011-09-22

申请号：PCT/CN2011/071928

申请日：2011-03-17

Applicant: 苏州泽璟生物制药有限公司 ,  高小勇 ,  冯卫东 ,  代晓俊

Inventor： 高小勇 ,  冯卫东 ,  代晓俊

IPC: C07C209/34 ,  C07B59/00 ,  C07C209/62 ,  C07C211/03

CPC classification number: C07B59/002 ,  C07B59/001 ,  C07B2200/05 ,  C07C209/34 ,  C07C211/04

公开(公告)号：WO2014037444A1

公开(公告)日：2014-03-13

申请号：PCT/EP2013/068371

申请日：2013-09-05

Applicant: UNIVERSITA' DEGLI STUDI DI MILANO

Inventor： BENAGLIA, Maurizio ,  BONSIGNORE, Martina

IPC: C07B43/04 ,  C07C209/34 ,  C07C209/36 ,  C07C213/02 ,  C07C221/00 ,  C07C227/04 ,  C07C231/12

CPC classification number: C07C209/325 ,  C07B43/04 ,  C07C209/34 ,  C07C209/365 ,  C07C213/02 ,  C07C221/00 ,  C07C227/04 ,  C07C231/12 ,  C07C211/03 ,  C07C215/08 ,  C07C229/08 ,  C07C211/52 ,  C07C215/68 ,  C07C217/84 ,  C07C217/86 ,  C07C233/43 ,  C07C225/22 ,  C07C223/06 ,  C07C229/60

Abstract: Disclosed is a novel process for the reduction of nitro groups to amino derivatives, based on the use of trichlorosilane and an organic base, which is efficient from the chemical standpoint and of wide general applicability.

Abstract translation: 公开了一种基于三氯硅烷和有机碱的使用将硝基还原为氨基衍生物的新方法，其从化学观点和广泛的普遍适用性是有效的。

公开(公告)号：WO2012173735A1

公开(公告)日：2012-12-20

申请号：PCT/US2012/038336

申请日：2012-05-17

Applicant: ANGUS CHEMICAL COMPANY ,  MAJOR, Michael, D. ,  MOORE, David, W.

Inventor： MAJOR, Michael, D. ,  MOORE, David, W.

IPC: C07C209/34

CPC classification number: C07C209/34 ,  C07C211/11

Abstract: Provided is a process for preparing alkyl diamine compounds in high purity. The process utilizes an alkyl amine compound during the reduction of a nitroamine, resulting in reduction of the concentration of undesired byproducts.

Abstract translation: 提供了制备高纯度烷基二胺化合物的方法。 该方法在还原硝基胺期间使用烷基胺化合物，导致不期望的副产物的浓度降低。

公开(公告)号：WO2011044472A1

公开(公告)日：2011-04-14

申请号：PCT/US2010/051995

申请日：2010-10-08

Applicant: ANGUS CHEMICAL COMPANY ,  SWEDO, Raymond

Inventor： SWEDO, Raymond

IPC: C07C209/34 ,  C07C211/11 ,  C07C211/10

CPC classification number: C07C209/34 ,  C07C211/10

Abstract: A compound having formula (I) (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 independently are hydrogen, C 1 -C 10 alkyl, C 5 -C 10 cycloalkyl, C 6 -C 10 aryl or C 7 -C 20 aralkyl; X is a difunctional group selected from the group consisting of C 2 -C 20 alkyl, C 5 -C 20 cycloalkyl, C 6 -C 10 aryl, C 8 -C 20 aryl alkyl, C 4 -C 20 heteroalkyl or C 10 -C 20 aryl heteroalkyl.

Abstract translation: 具有式（I）（I）的化合物，其中R 1，R 2，R 3，R 4，R 5和R 6独立地是氢，C 1 -C 10烷基，C 5 -C 10环烷基，C 6 -C 10芳基或C 7 -C 20芳烷基; X是选自C 2 -C 20烷基，C 5 -C 20环烷基，C 6 -C 10芳基，C 8 -C 20芳基烷基，C 4 -C 20杂烷基或C 10 -C 20芳基杂烷基的二官能团。