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    PROCESS FOR THE PREPARATION OF ALOGLIPTIN
    2.
    发明申请
    PROCESS FOR THE PREPARATION OF ALOGLIPTIN 审中-公开
    制备阿德列酮的方法

    公开(公告)号：WO2010109468A1

    公开(公告)日：2010-09-30

    申请号：PCT/IL2010/000260

    申请日：2010-03-25

    Applicant: MAPI PHARMA HK LIMITED ,  MAROM, Ehud ,  MIZHIRITSKII, Michael ,  RUBNOV, Shai

    Inventor： MAROM, Ehud ,  MIZHIRITSKII, Michael ,  RUBNOV, Shai

    IPC: A01N43/54

    CPC classification number: A61K31/513 ,  C07C275/24 ,  C07C275/50 ,  C07D239/545 ,  C07D239/62 ,  C07D403/04

    Abstract: The present invention is based on the discovery of a process for preparing pyrimidin- dione compounds, especially alogliptin and its derivatives, which comprises the reaction of a urea derivative of formula (VIII) with a malonic acid or its derivatives to form intermediates of formulae (VII) or (VII-A), which are subsequently converted to a compound of formula (II) upon introduction of a leaving group X. Compound (II) then reacts with an amine to form compound (I), which is optionally converted to its salts of formula (IV).

    Abstract translation: 本发明基于发现制备嘧啶二酮化合物，特别是奥曲肽及其衍生物的方法，其包括式（VIII）的脲衍生物与丙二酸或其衍生物的反应，形成式 VII）或（VII-A），其随后在引入离去基团X时转化为式（II）化合物。然后化合物（II）与胺反应以形成化合物（I），其可任选地转化为 其式（Ⅳ）的盐。

    ACYL-UREA DERIVATIVES AND USES THEREOF
    3.
    发明申请
    ACYL-UREA DERIVATIVES AND USES THEREOF 审中-公开
    ACYL-UREA衍生物及其用途

    公开(公告)号：WO2009001356A3

    公开(公告)日：2009-03-05

    申请号：PCT/IL2008000870

    申请日：2008-06-25

    Applicant: YISSUM RES DEV CO ,  BIALER MEIR ,  YAGEN BORIS ,  SHIMSHONI JAKOB AVI

    Inventor： BIALER MEIR ,  YAGEN BORIS ,  SHIMSHONI JAKOB AVI

    IPC: C07C275/50 ,  A61K31/17 ,  A61P25/00

    CPC classification number: C07C275/50

    Abstract: Novel acyl-urea containing compounds, processes of preparing same, compositions containing same and uses thereof in the treatment of neurological diseases and disorders such as epilepsy, neuropathic pain, bipolar disorder, status epilepticus, chemically-induced convulsions and/or seizure disorders, febrile convulsions conditions, metabolic disturbances and a sustenance withdrawal conditions, are provided. Also provided are uses of these and other acyl-urea containing compounds in the treatment of neurological diseases and disorders.

    Abstract translation: 新型含酰基脲的化合物，其制备方法，含有该组合物的组合物及其用于治疗神经疾病和病症如癫痫，神经性疼痛，双相性精神障碍，癫痫持续状态，化学诱发性惊厥和/或发作性疾病，发热 提供抽搐状况，代谢紊乱和维持戒断条件。 还提供了这些和其它含酰基脲的化合物在治疗神经疾病和病症中的用途。

    POLYMERIZABLE UREA/UREIDO FUNCTIONAL MONOMERS
    5.
    发明申请
    POLYMERIZABLE UREA/UREIDO FUNCTIONAL MONOMERS 审中-公开
    可聚合尿素/尿素功能单体

    公开(公告)号：WO1997049685A1

    公开(公告)日：1997-12-31

    申请号：PCT/US1997010951

    申请日：1997-06-24

    Applicant: CYTEC TECHNOLOGY CORP.

    Inventor： CYTEC TECHNOLOGY CORP. ,  SINGH, Balwant ,  SIESEL, David, A. ,  DILEONE, Roland, Ralph ,  CHANG, Laurence, W.

    IPC: C07D233/32

    CPC classification number: C07D207/408 ,  C07C275/50 ,  C07C275/52 ,  C07C2601/16 ,  C07C2602/42 ,  C07D207/456 ,  C08F22/38

    Abstract: New classes of urea/ureido functional compounds of formula (I), wherin Y is (a), (b) or (c), wherein A is (d), (e) or (f), wherein B is (g), (h) or (i), and compositions containing the same are disclosed which are particularly suitable for use as monomers for imparting wet adhesion and/or self-crosslinking properties to polymers, especially in aqueous emulsion systems used to make latex paints. Compositions containing the same, as well as additional uses thereof are also disclosed.

    Abstract translation: 其中A是（d），（e）或（f），其中B是（g）（a），（b）或（c） ，（h）或（i），以及含有该组合物的组合物特别适合用作向聚合物赋予湿粘合性和/或自交联性的单体，特别是在用于制备乳胶漆的水性乳液体系中。 还公开了含有该组合物的组合物，以及其额外用途。

    N-(2-HYDROXYALKANOYL) -N,N'-DIALKYLUREAS FOR THEIR PREPARATION
    7.
    发明申请
    N-(2-HYDROXYALKANOYL) -N,N'-DIALKYLUREAS FOR THEIR PREPARATION 审中-公开
    用于制备的N-（2-羟基烷基）-N，N'-二烷基

    公开(公告)号：WO2006122782A1

    公开(公告)日：2006-11-23

    申请号：PCT/EP2006/004674

    申请日：2006-05-17

    Applicant: CHORISIS S.R.L. ,  GALLIANI, Guido ,  ORLANDI, Marco ,  RINDONE, Bruno ,  TERRANEO, Alberto

    Inventor： GALLIANI, Guido ,  ORLANDI, Marco ,  RINDONE, Bruno ,  TERRANEO, Alberto

    IPC: C08G71/00 ,  C07C273/18 ,  C07C275/50

    CPC classification number: C08G18/3829 ,  C07C275/50

    Abstract: N-(2-hydroxyalkanoyl) -N, N' -dialkylureas of general formula (I) are described A-X-(A) n , where A: m = 0 or m = 1; when m = 0, X = R''' , where R''' is an aliphatic, cycloaliphatic, arylaliphatic radical, C 1 -C 18 ; when m = 1, X = -(CH 2 ) n -, where n is an integer from 1 and 20, preferably from 2 to 6; R is chosen among H, and alkyl radicals C 1 -C 8 , possibly substituted with halogen atoms; R' is an aliphatic, cycloaliphatic, arylaliphatic radical, C 1 -C 18 ; R'' is chosen among H, aliphatic, cycloaliphatic, arylaliphatic radical, C 1 -C 18 . The preparation of said compounds is described, as well as the preparation of corresponding polymers.

    Abstract translation: 描述了通式（I）的N-（2-羟基烷酰基）-N，N'-二烷基脲A-X-（A）N，其中A：m = 0或m = 1; 当m = 0时，X = R“'，其中R”'是脂族，环脂族，芳基脂族基团，C 1 -C 18烷基; 当m = 1时，X = - （CH 2 CH 2）n - ，其中n为1和20，优选2至6的整数; R选自H和可能被卤素原子取代的烷基C 1 -C 8烷基; R'是脂族，脂环族，芳基脂族基团，C 1 -C 18烷基; R“选自H，脂族，脂环族，芳基脂族基，C 1 -C 18。 描述了所述化合物的制备，以及相应聚合物的制备。

    UREA/UREIDO FUNCTIONAL POLYMERIZABLE MONOMERS
    10.
    发明申请
    UREA/UREIDO FUNCTIONAL POLYMERIZABLE MONOMERS 审中-公开
    UREA / UREIDO功能可聚合单体

    公开(公告)号：WO1997049676A1

    公开(公告)日：1997-12-31

    申请号：PCT/US1997011197

    申请日：1997-06-24

    Applicant: CYTEC TECHNOLOGY CORP.

    Inventor： CYTEC TECHNOLOGY CORP. ,  SINGH, Balwant ,  DILEONE, Roland, Ralph ,  CHANG, Laurence, W. ,  SIESEL, David, A.

    IPC: C07C275/50

    CPC classification number: C07D207/408 ,  C07C275/50 ,  C07C275/52 ,  C07C2601/16 ,  C07C2602/42 ,  C07D207/456 ,  C08F22/38

    Abstract: This invention relates to ethylenically unsaturated polymerizable monomers of formula (I) wherein Y is (a, b, c, d, e, f, g, h or i) wherein A is (j, k, l, m, n or o) wherein each R is individually H, -(-CqH2q-O-)m-R , (p), etc., which are particularly suitable for use as wet adhesion promoters and in the preparation of self-crosslinking polymers. More specifically, the polymerizable monomers of the present invention are useful to promote adhesion in polymers and copolymers, and especially in aqueous emulsion copolymer latices which are used to prepare latex paints, as well as in the preparation of self-crosslinking polymers for coating systems.

    Abstract translation: 本发明涉及式（I）的烯属不饱和可聚合单体，其中Y是（a，b，c，d，e，f，g，h或i）其中A是（j，k，l，m，n或o ），其中每个R独立地为H， - （ - CqH2q-O-）mR 2，（p）等，它们特别适合用作湿粘合促进剂和制备自交联聚合物。 更具体地，本发明的可聚合单体可用于促进聚合物和共聚物中的粘合，特别是用于制备胶乳涂料的水乳液共聚物胶乳以及用于涂料体系的自交联聚合物的制备。

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