Abstract:
Optically active butane-1,2,3,4-tetraol derivatives are of formula (I). The compounds may be used as doping agents for liquid crystals for a wide range of applications including solid state cholesteric filters for projection displays, circular polarisers optical filters, etc.
Abstract:
Novel compounds of Formula I are provided: its stereoisomers and/or pharmaceutically acceptable salts for the treatment of diabetes and diabetes-associated dyslipidemia, wherein R1 is selected from a group consisting of hydroxy, alkoxy, amine, alkyl, haloalkyl, NHSO 2 R, or NHCOR wherein R is selected from alkyl or cycloalkyl, NHR' wherein R' is alkyl or cycloalkyl optionally substituted by hydroxy or alkoxy; and n 1 and n 2 are independently selected from 0, 1, and 2. At least one of R 3 and R 4 and/or R 5 and R 6 form a cyclic ring of 3-8 carbon atoms optionally containing alkyl groups, hetero atoms, or functional groups such as O, N, SO 2 . Additionally, when R 3 and R 4 or R 5 and R 6 do not form a cyclic ring, then they may be independently selected from hydrogen, alkyl, branched alkyl, and cycloalkyl. L 1 is a linear aliphatic chain optionally containing from 4 to 16 carbon atoms. The chain may optionally be substituted one or more times by alkyl, branched alkyl, cycloalkyl, or aryl. R 2 is independently selected from hydrogen, alkoxy, hydroxy, alkyl, haloalkyl, cycloalkyl, heterocycloalkyl, heteroaryl, cyano, or COR 7 , wherein R 7 is selected from hydroxy, alkyl, alkoxy, or amine, NHR', NHSO2R, or NHCOR. Y 1 is oxygen or hydrogen. Y 2 is optional, wherein when Y2 is present, Y 1 and Y 2 are hydrogen. When Y 2 is not present, Y 1 is a carbonyl group.
Abstract:
The invention relates to a process for the preparation of polyols having 3 or 4 hydroxyl groups, from an aldehyde and formaldehyde in the presence of water, followed by hydrogenation of the aldolisation product in the presence of a hydrogenation catalyst at an elevated temperature. The aldehyde is obtained by an aldolisation reaction of an aldehyde having at least two alpha -hydrogen atoms and a formula according to R1CH2CHO, wherein R1 is selected from a group comprising hydrogen, alkyl groups having 1 - 7 carbon atoms which can have cycloalkyl substituents, cycloalkyl groups, aryl groups and aralkyl groups with 1 - 7 carbon atoms in the alkyl chain, with formaldehyde in the presence of water in an amount of 20 - 70 wt.%, preferably 40 - 60 wt.% and in the presence of an anion exchange resin. The hydrogenation is preferably carried out in the presence of water.
Abstract:
본 발명은 사이클로헥산 디카르복실산(Cyclohexane dicarboxylic acid, CHDA) 수소화 반응 과정에서 조절되는 특정 조건, 첨가제 투입 또는 반응물 첨가를 통하여 높은 트랜스 함량을 갖도록 할 수 있는 사이클로헥산 디메탄올 제조방법 및 이에 의해 제조된 사이클로헥산 디메탄올(Cyclohexane dimethanol, CHDM)에 관한 것이다.
Abstract:
A process for producing polyols from a low viscosity slurry comprising a thermally treated ligno-cellulosic biomass which has been subjected to a fiber shives reduction step is provided. Specifically, a continuous process for catalyzing the formation of polyol products, such as ethylene glycol and propylene glycol, from the low viscosity slurry is provided.
Abstract:
A process for the preparation of diols by a Lewis acid-catalysed aldehyde addition reaction on hydroxyalkynes followed by hydrogenation is described. The process provides a wide range of diols from simple, readily available starting materials. In particular the process is suitable for preparing chiral 1,4-diols suitable for the preparation of chiral phospholane ligands for use in asymmetric catalysis.
Abstract:
A process for producing polyols from a low viscosity slurry comprising a thermally treated ligno-cellulosic biomass which has been subjected to a fiber shives reduction step is provided. Specifically, a continuous process for catalyzing the formation of polyol products, such as ethylene glycol and propylene glycol, from the low viscosity slurry is provided.
Abstract:
The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.