金属担持触媒、金属担持触媒の保存方法及びアルコールの製造方法
    1.
    发明申请
    金属担持触媒、金属担持触媒の保存方法及びアルコールの製造方法 审中-公开
    金属负载型催化剂,金属负载型催化剂储存方法,以及酒精制造方法

    公开(公告)号:WO2015178459A1

    公开(公告)日:2015-11-26

    申请号:PCT/JP2015/064640

    申请日:2015-05-21

    Abstract:  本発明は触媒活性及び選択率が高く、空気中での取り扱いが可能な金属担持触媒を提供することを目的とする。本発明はRu及びSnを含み、粉末X線回折分析の2θ=43°のピークの半値幅が3.61°以下であり、かつ[X/Y]×100で表される酸化率が38%以上である金属担持触媒に関する。Xは、前記金属担持触媒を昇温還元に供し、次いで常温酸化を行なった際に、前記金属担持触媒を酸化するために要した酸素のモル数を表し、Yは、前記金属担持触媒に担持された金属の総モル数を表す。

    Abstract translation: 本发明的目的是提供一种具有高催化活性和选择性并可在空气中处理的金属负载型催化剂。 本发明涉及包含Ru和Sn的金属负载催化剂,具有X射线粉末衍射分析2θ= 43°峰半峰宽为3.61°以下,氧化速度为[X / Y]× 100%为38%以上。 X表示当金属负载催化剂用于温度程序化还原时氧化金属负载型催化剂所需的氧摩尔数,此后进行常温氧化。 Y表示由金属负载的催化剂负载的金属的总摩尔数。

    METHODS AND COMPOSITIONS FOR TREATMENT OF DIABETES AND DYSLIPIDEMIA
    3.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATMENT OF DIABETES AND DYSLIPIDEMIA 审中-公开
    用于治疗糖尿病和DYSLIPIDEMIA的方法和组合物

    公开(公告)号:WO2012040177A1

    公开(公告)日:2012-03-29

    申请号:PCT/US2011/052318

    申请日:2011-09-20

    Abstract: Novel compounds of Formula I are provided: its stereoisomers and/or pharmaceutically acceptable salts for the treatment of diabetes and diabetes-associated dyslipidemia, wherein R1 is selected from a group consisting of hydroxy, alkoxy, amine, alkyl, haloalkyl, NHSO 2 R, or NHCOR wherein R is selected from alkyl or cycloalkyl, NHR' wherein R' is alkyl or cycloalkyl optionally substituted by hydroxy or alkoxy; and n 1 and n 2 are independently selected from 0, 1, and 2. At least one of R 3 and R 4 and/or R 5 and R 6 form a cyclic ring of 3-8 carbon atoms optionally containing alkyl groups, hetero atoms, or functional groups such as O, N, SO 2 . Additionally, when R 3 and R 4 or R 5 and R 6 do not form a cyclic ring, then they may be independently selected from hydrogen, alkyl, branched alkyl, and cycloalkyl. L 1 is a linear aliphatic chain optionally containing from 4 to 16 carbon atoms. The chain may optionally be substituted one or more times by alkyl, branched alkyl, cycloalkyl, or aryl. R 2 is independently selected from hydrogen, alkoxy, hydroxy, alkyl, haloalkyl, cycloalkyl, heterocycloalkyl, heteroaryl, cyano, or COR 7 , wherein R 7 is selected from hydroxy, alkyl, alkoxy, or amine, NHR', NHSO2R, or NHCOR. Y 1 is oxygen or hydrogen. Y 2 is optional, wherein when Y2 is present, Y 1 and Y 2 are hydrogen. When Y 2 is not present, Y 1 is a carbonyl group.

    Abstract translation: 提供式I的新型化合物:其用于治疗糖尿病和糖尿病相关血脂异常的其立体异构体和/或药学上可接受的盐,其中R 1选自羟基,烷氧基,胺,烷基,卤代烷基,NHSO 2 R或NHCOR 其中R选自烷基或环烷基,NHR',其中R'是任选被羟基或烷氧基取代的烷基或环烷基; 并且n1和n2独立地选自0,1和2. R3和R4和/或R5和R6中的至少一个形成3-8个碳原子的环状环,任选地含有烷基,杂原子或官能团,例如 作为O,N,SO 2。 此外,当R3和R4或R5和R6不形成环时,它们可以独立地选自氢,烷基,支链烷基和环烷基。 L1是任选含有4至16个碳原子的直链脂族链。 该链可以任选地被烷基,支链烷基,环烷基或芳基取代一次或多次。 R 2独立地选自氢,烷氧基,羟基,烷基,卤代烷基,环烷基,杂环烷基,杂芳基,氰基或COR 7,其中R 7选自羟基,烷基,烷氧基或胺,NHR',NHSO 2 R或NHCOR。 Y1是氧或氢。 Y2是任选的,其中当存在Y2时,Y1和Y2是氢。 当不存在Y2时,Y1是羰基。

    PROCESS FOR THE PREPARATION OF POLYOLS
    4.
    发明申请
    PROCESS FOR THE PREPARATION OF POLYOLS 审中-公开
    制备多元醇的方法

    公开(公告)号:WO01002330A1

    公开(公告)日:2001-01-11

    申请号:PCT/FI2000/000602

    申请日:2000-06-30

    Abstract: The invention relates to a process for the preparation of polyols having 3 or 4 hydroxyl groups, from an aldehyde and formaldehyde in the presence of water, followed by hydrogenation of the aldolisation product in the presence of a hydrogenation catalyst at an elevated temperature. The aldehyde is obtained by an aldolisation reaction of an aldehyde having at least two alpha -hydrogen atoms and a formula according to R1CH2CHO, wherein R1 is selected from a group comprising hydrogen, alkyl groups having 1 - 7 carbon atoms which can have cycloalkyl substituents, cycloalkyl groups, aryl groups and aralkyl groups with 1 - 7 carbon atoms in the alkyl chain, with formaldehyde in the presence of water in an amount of 20 - 70 wt.%, preferably 40 - 60 wt.% and in the presence of an anion exchange resin. The hydrogenation is preferably carried out in the presence of water.

    Abstract translation: 本发明涉及在水存在下由醛和甲醛制备具有3或4个羟基的多羟基化合物的方法,然后在高温下在氢化催化剂存在下氢化醛醇化产物。 醛通过具有至少两个α-氢原子和根据R 1 CH 2 CHO的式的醛的醛醇化反应获得,其中R 1选自氢,可具有环烷基取代基的具有1-7个碳原子的烷基, 在烷基链中具有1-7个碳原子的环烷基,芳基和芳烷基,在水存在下用甲醛,其量为20-70重量%,优选40-60重量%,并且在 阴离子交换树脂。 氢化优选在水的存在下进行。

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