公开(公告)号：EP2647697A4

公开(公告)日：2014-04-30

申请号：EP11845184

申请日：2011-12-01

申请人： NISSAN CHEMICAL IND LTD ,  REPROCELL INC

发明人： NISHINO TAITO ,  YUI MAKIKO ,  ASAI YASUYUKI

IPC分类号： C12N5/00 ,  A61K35/12 ,  A61K35/14 ,  A61K35/28 ,  A61K35/37 ,  A61K35/407 ,  A61K35/44 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P7/04 ,  A61P7/06 ,  A61P9/10 ,  A61P13/00 ,  A61P13/12 ,  A61P17/02 ,  A61P19/02 ,  A61P21/00 ,  A61P21/04 ,  A61P25/00

CPC分类号： C12N5/0647 ,  A61K35/28 ,  C07D231/22 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/26 ,  C12N2501/999

摘要： An expanding agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful as a therapy for various hematopoietic diseases and useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy is provided. A method of producing hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises expanding hematopoietic stem cells by culturing hematopoietic stem cells ex vivo in the presence of a compound represented by the formula following (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof (wherein R 1 to R 8 are as defined in the description).

公开(公告)号：EP2218716A4

公开(公告)日：2012-07-25

申请号：EP08858085

申请日：2008-12-06

申请人： NISSAN CHEMICAL IND LTD ,  REPROCELL INC

发明人： NISHINO TAITO ,  ISHIWATA NORIHISA ,  MIYAJI KATSUAKI ,  IWAMOTO SHUNSUKE ,  ASAI YASUYUKI ,  YUI MAKIKO

IPC分类号： C07D333/38 ,  A61K31/381 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4436 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K35/14 ,  A61K35/18 ,  A61K38/00 ,  A61K38/22 ,  A61K48/00 ,  A61P7/00 ,  A61P7/04 ,  A61P7/06 ,  A61P9/10 ,  A61P35/00

CPC分类号： C07D333/38 ,  A61K35/00 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C12N5/0647 ,  C12N2501/999

公开(公告)号：EP3006529A4

公开(公告)日：2016-12-07

申请号：EP14807602

申请日：2014-06-09

申请人： NISSAN CHEMICAL IND LTD

发明人： HIROI YOSHIOMI ,  OTANI AYAKO ,  KISHIOKA TAKAHIRO ,  NISHINO TAITO ,  OZAWA TOMOYUKI

IPC分类号： C12M3/00 ,  A61L31/00 ,  B05D7/24 ,  C08F230/02 ,  C09D133/14 ,  C09D133/26 ,  C09D143/02

CPC分类号： C09D133/14 ,  C08F230/02 ,  C08L43/02 ,  C08L101/02 ,  C09D5/16 ,  C09D143/02 ,  C09D201/02 ,  C12M23/20 ,  C08F220/34

摘要： The present invention provides: a cell cultivation vessel characterized in that the surface is coated with a copolymer comprising repeating units having organic groups represented by formula (a) and repeating units having organic groups represented by formula (b); a manufacturing method therefor; and a cell aggregate-manufacturing method using same (in the formulas, U a1 , U a2 , U b1 , U b2 and U b3 as well as An - are as set forth in the Description and the Claims).

公开(公告)号：EP2581442A4

公开(公告)日：2013-11-06

申请号：EP11795711

申请日：2011-06-13

申请人： NISSAN CHEMICAL IND LTD ,  UNIV CHIBA NAT UNIV CORP

发明人： NISHINO TAITO ,  IWAMA ATSUSHI

IPC分类号： A61K31/122 ,  A61K31/352 ,  C12N5/0789

CPC分类号： C12N5/0647 ,  A61K31/122 ,  A61K31/352 ,  C12N2500/62 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/26 ,  C12N2501/72 ,  C12N2501/727 ,  C12N2501/999

摘要： An expanding agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful as a therapy for various hematopoietic diseases and useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy is provided. A method of producing hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises expanding hematopoietic stem cells by culturing hematopoietic stem cells ex vivo in the presence of a compound represented by the formula following (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof (wherein R 1 to R 6 are as defined in the description).

公开(公告)号：EP2228434A4

公开(公告)日：2013-01-23

申请号：EP08857879

申请日：2008-12-05

申请人： NISSAN CHEMICAL IND LTD

发明人： NAKAMURA TAKANORI ,  MIYAMURA ATSUSHI ,  NISHINO TAITO ,  ISHIWATA NORIHISA ,  MIYAJI KATSUAKI

IPC分类号： C12N5/0789 ,  A61P7/00 ,  A61P7/06 ,  A61P9/10 ,  A61P19/08 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02

CPC分类号： C12N5/0647 ,  A61K2035/124 ,  C07D231/12 ,  C07D333/22 ,  C07D409/12 ,  C07D409/14 ,  C07D417/14 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/999

摘要： An object of the present invention is to expand CD34 + cells ex vivo efficiently in a short term using a biologically safe and inexpensively obtainable low molecular weight compound. A still another object of the present invention is to provide an expansion agent for CD34 + cells useful for treatment of various hematopoietic disorders caused by dysfunctional hematopoietic stem cells and/or hematopoietic progenitor cells. A method for expanding CD34 + cells, which comprises culturing CD34 + cells ex vivo in the presence of a compound represented by the formula (I) (wherein A, B, L 1 , L 2 , L 3 , L 4 , R 1 , R 2 , R 3 , X and Y are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound, or a solvate thereof.

公开(公告)号：EP3318585A4

公开(公告)日：2018-06-20

申请号：EP16821319

申请日：2016-07-01

申请人： NISSAN CHEMICAL IND LTD

发明人： HIROI YOSHIOMI ,  ENDO MASAHISA ,  ABE NATSUKI ,  NISHINO TAITO

IPC分类号： C08F230/02 ,  C09D5/16 ,  C09D143/02 ,  C09D201/02

CPC分类号： C08F230/02 ,  C09D5/1668 ,  C09D143/02 ,  C09D201/02 ,  C08F2220/1825 ,  C08F220/34

摘要： The present invention provides a copolymer or the like obtained by polymerizing a monomer mixture that includes at least compounds represented by formulas (A) and (B) (in the formulas, T a , T b , Q a , Q b , R a , R b , U a1 , U a2 , U a3 , U b1 , U b2 , U b3 , An - , and m are as defined in the description and claims). This copolymer can be used as an ion complex material having an exceptional ability to inhibit adhesion of biological materials.

公开(公告)号：EP3214209A4

公开(公告)日：2018-04-11

申请号：EP15855309

申请日：2015-10-30

申请人： NISSAN CHEMICAL IND LTD

发明人： UMEZAKI MAKIKO ,  KISHIOKA TAKAHIRO ,  NISHINO TAITO ,  AIHARA AYAKO ,  IWAMOTO SHUNSUKE ,  SAKUMA DAISUKE

IPC分类号： D01F6/00 ,  C07K14/705 ,  C07K17/08 ,  C12M1/00 ,  C12N1/00 ,  C12N5/071 ,  C12N11/08 ,  D01F1/10

CPC分类号： C12N11/08 ,  C07K14/705 ,  C07K17/08 ,  C12M1/00 ,  C12N1/00 ,  D01F1/10 ,  D01F6/00

摘要： An object of the present invention is to provide a ligand-bonded fiber wherein a ligand having affinity for a cell membrane receptor is immobilized on a fiber precursor, and a cell culture substrate capable of repeating ex vivo amplification of a cell expressing a cell membrane receptor by using the ligand-bonded fiber. A ligand-bonded fiber containing a ligand having affinity for a cell membrane receptor, and a fiber precursor bonded to the ligand.

公开(公告)号：EP3040455A4

公开(公告)日：2017-04-12

申请号：EP14839139

申请日：2014-08-29

申请人： NISSAN CHEMICAL IND LTD

发明人： UMEZAKI MAKIKO ,  KISHIOKA TAKAHIRO ,  NISHINO TAITO ,  OTANI AYAKO

IPC分类号： D01F6/52 ,  D01D5/00 ,  D04H1/728

CPC分类号： D01F6/16 ,  C08F220/20 ,  C08L33/14 ,  C08L33/26 ,  C08L2203/12 ,  C08L2312/00 ,  D01D5/0007 ,  D01D5/003 ,  D01D10/02 ,  D01F6/02 ,  D01F6/36 ,  D04H1/728

摘要： The present invention provides a composition for forming a fiber for the production of a fiber having organic solvent resistance, which can be produced conveniently, a fiber obtained by spinning the composition, and a biocompatible material containing the fiber. A composition for forming a fiber, containing (A) a polymer compound containing a unit structure represented by the formula (1), (B) a crosslinking agent, (C) an acid compound, and (D) a solvent. wherein each symbol is as described in the DESCRIPTION.

摘要翻译： 本发明提供一种用于制造纤维的组合物，该组合物用于生产具有耐溶剂性的纤维，其可以方便地制备通过纺丝该组合物获得的纤维，以及含有该纤维的生物相容性材料。 一种用于形成纤维的组合物，其含有（A）含有由式（1）表示的单元结构的高分子化合物，（B）交联剂，（C）酸化合物和（D）溶剂。 其中每个符号如说明中所述。

公开(公告)号：EP2878664A4

公开(公告)日：2016-03-16

申请号：EP13823078

申请日：2013-07-24

申请人： NISSAN CHEMICAL IND LTD ,  UNIV KYOTO

发明人： NISHINO TAITO ,  KANAKI TATSURO ,  OTANI AYAKO ,  SARUHASHI KOICHIRO ,  TOMURA MISAYO ,  IWAMA TAKEHISA ,  HORIKAWA MASATO ,  NAKATSUJI NORIO ,  OTSUJI TOMOMI

IPC分类号： C12N1/00 ,  C12N5/00

CPC分类号： A01H4/001 ,  C12N5/0025 ,  C12N5/0062 ,  C12N5/0068 ,  C12N2500/50 ,  C12N2533/70

摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like.

公开(公告)号：EP2233561A4

公开(公告)日：2013-01-16

申请号：EP08856980

申请日：2008-12-05

申请人： NISSAN CHEMICAL IND LTD

发明人： NAKAMURA TAKANORI ,  MIYAMURA ATSUSHI ,  NISHINO TAITO ,  ISHIWATA NORIHISA ,  MIYAJI KATSUAKI

IPC分类号： C12N5/0789 ,  A61P7/00 ,  A61P7/06 ,  A61P9/10 ,  A61P19/08 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02

CPC分类号： C12N5/0647 ,  A61K35/12 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/999

摘要： An object of the present invention is to expand CD34 + cells ex vivo efficiently in a short term using a biologically safe and inexpensively obtainable low molecular weight compound. A still another object of the present invention is to provide an expansion agent for CD34 + cells useful for treatment of various hematopoietic disorders caused by dysfunctional hematopoietic stem cells and/or hematopoietic progenitor cells. A method for expanding CD34 + cells, which comprises culturing CD34 + cells ex vivo in the presence of a compound represented by the formula (I) (wherein A, B, L 1 , L 2 , L 3 , L 4 , R 1 , R 2 , R 3 , X and Y are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.

摘要翻译： 本发明的目的是扩大的CD34 +细胞体外有效地使用生物安全且廉价地获得的低分子量化合物短期。 本发明的无声anOtherObject是提供扩张剂用于治疗由不正常的造血干细胞和/或造血祖细胞引起的各种造血病症CD34 +细胞。 一种用于扩展CD34 +细胞的方法，该方法包括培养的CD34 +细胞体外（在化合物的由式（I）表示的存在其中A，B，L 1，L 2，L 3，L 4，R 1， R 2，R 3，X和Y在说明书中定义），该化合物或其溶剂化物的互变异构体或药学上可接受的盐。