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公开(公告)号：EP3617195B1
公开(公告)日：2024-08-28
申请号：EP18790125.1
申请日：2018-04-25
IPC分类号： C07D215/44 , C07C271/24 , C07D213/75 , C07D213/81 , C07D213/84 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/12 , C07D417/04 , A61P35/00
CPC分类号： C07C215/44 , A61P1/16 , A61P1/02 , A61P31/00 , A61P3/06 , A61P3/04 , A61P1/00 , A61P21/02 , A61P25/00 , A61P13/02 , A61P11/00 , A61P37/06 , A61P25/24 , A61P15/00 , A61P29/02 , A61P13/10 , A61P25/04 , A61P25/16 , A61P25/20 , A61P21/00 , A61P9/06 , A61P9/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P5/14 , A61P35/02 , A61P19/10 , A61P1/18 , A61P37/00 , A61P13/08 , A61P31/18 , A61P11/04 , A61P17/00 , A61P13/12 , A61P11/06 , A61P11/02 , A61P1/04 , A61P19/02 , A61P43/00 , A61P7/00 , A61P9/12 , A61P25/08 , A61P3/10 , C07C271/24 , C07C2602/1020170501 , C07D213/75 , C07B2200/0720130101 , C07D401/04 , C07D213/84 , C07D405/04 , C07D405/14 , C07D213/81 , C07D413/12 , C07D417/04
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公开(公告)号：EP4396159A1
公开(公告)日：2024-07-10
申请号：EP22865803.5
申请日：2022-09-01
发明人： PATTERSON, Kristin , HATCHER, Mark
IPC分类号： C07C211/43 , C07C211/57 , C07D209/56
CPC分类号： C07D233/88 , C07D263/44 , C07C227/08 , C07C227/18 , C07C2602/1020170501 , C07B2200/0720130101
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公开(公告)号：EP4428122A1
公开(公告)日：2024-09-11
申请号：EP23160617.9
申请日：2023-03-07
申请人： Vesper Bio Aps
IPC分类号： C07D221/04 , C07C229/14 , C07C309/04 , C07D311/58 , C07D319/18 , A61K31/198 , A61K31/353 , A61K31/357 , A61P9/00 , A61P13/12 , A61P17/00 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00
CPC分类号： C07D311/58 , C07C229/14 , C07C309/04 , C07D221/04 , C07D319/18 , A61P25/28 , A61P25/00 , A61P29/00 , A61P35/00 , A61P17/00 , A61P13/12 , A61P27/02 , A61P9/00 , C07C2602/0820170501 , C07C2602/1020170501
摘要： The present invention relates to compounds of Formula (I) or a pharmaceutically acceptable salt, solvate, hydrate, tautomer, optical isomer, N-oxide, and/or prodrug thereof. The present invention also relates to pharmaceutical compositions comprising the compounds of the invention, and to their use in the treatment or prevention of medical conditions in which modulation of sortilin is beneficial.
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公开(公告)号：EP4370113A1
公开(公告)日：2024-05-22
申请号：EP22842898.3
申请日：2022-07-14
发明人： ARALDI, Gian, Luca
IPC分类号： A61K31/353 , A61K9/00 , A61P29/00 , A61P3/04 , A61P31/12
CPC分类号： A61P31/12 , A61P29/00 , A61P3/04 , A61P25/28 , A61P25/00 , C07D311/62 , A61P27/02 , A61P1/16 , C07D405/12 , C07D311/60 , C07C69/84 , C07C2602/1020170501
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公开(公告)号：EP4065567B1
公开(公告)日：2024-09-11
申请号：EP20824397.2
申请日：2020-11-20
IPC分类号： C07D267/16 , C07C381/10 , C07D513/08 , C07D513/10 , C07D515/20 , C07C43/178 , C07C69/63 , C07C205/59 , C07C229/64 , C07C309/20 , C07C311/11 , C07F7/18
CPC分类号： C07D513/08 , C07D513/10 , C07D515/20 , C07D267/16 , C07C381/10 , C07C43/1781 , C07C2601/0420170501 , C07C69/63 , C07C2602/1020170501 , C07F7/1804 , C07C205/59 , C07C229/64 , C07C311/11 , C07C309/20
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公开(公告)号：EP3901128B1
公开(公告)日：2024-07-31
申请号：EP20382329.9
申请日：2020-04-22
IPC分类号： C07C45/34 , C07C49/647 , C07C49/643 , C07C49/637 , C07C49/617
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公开(公告)号：EP3152190B1
公开(公告)日：2024-07-31
申请号：EP15803863.8
申请日：2015-06-04
IPC分类号： C07D209/04 , C07D409/04 , C07D217/26 , C07C15/24 , A61K31/03 , A61K31/404 , A61P35/00 , C07C259/10 , C07D215/48 , C07D215/54 , C07D209/08 , C07D209/42
CPC分类号： C07D409/04 , C07C259/10 , C07C2602/1020170501 , C07D215/48 , C07D209/08 , C07D209/42 , C07D215/54 , A61P35/00
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公开(公告)号：EP4384271A1
公开(公告)日：2024-06-19
申请号：EP22757335.9
申请日：2022-08-11
IPC分类号： A61P29/00 , C07C69/593 , C07C233/09 , C07C233/38 , C07D213/30 , C07D233/64 , C07D295/13 , C07D305/08 , C07D309/14 , C07D331/04 , C07D333/16 , A61K31/165 , A61K31/225 , A61K31/337 , A61K31/381
CPC分类号： C07C69/593 , C07D305/08 , C07D213/30 , C07D333/16 , C07C233/09 , C07C233/38 , C07D295/13 , C07D233/64 , C07D331/04 , C07D309/14 , A61P29/00 , C07C2601/0420170501 , C07C233/20 , C07C237/22 , C07B2200/0720130101 , C07C2602/1020170501
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公开(公告)号：EP4306524A3
公开(公告)日：2024-09-11
申请号：EP23193733.5
申请日：2018-08-29
发明人： BONNER, Daniel Kenneth , HAN, Sifei , HU, Luojuan , KARANAM, Ketki , MUTAMBA, James T. , PORTER, Christopher John Hamilton , SHYAM, Rishab R. , SIMPSON, Jamie , TREVASKIS, Natalie , QUACH, Tim
IPC分类号： A61K31/015 , A61K31/495 , A61K31/4985 , C07C13/12 , C07D473/32 , C07D473/34 , A61K45/06 , A61K47/54 , C07C69/34 , C07C69/40 , C07C69/42 , C07C69/58 , C07C69/708 , C07C69/96 , C07C233/25 , C07C235/74 , C07C271/24 , C07D311/80 , C07D307/88 , C07D409/12 , C07D489/02
CPC分类号： A61K45/06 , A61K47/543 , C07B2200/0720130101 , C07C69/34 , C07C69/40 , C07C69/42 , C07C69/58 , C07C69/708 , C07C69/96 , C07C233/25 , C07C235/74 , C07C271/24 , C07C2601/1620170501 , C07C2602/0820170501 , C07C2602/1020170501 , C07C2603/4020170501 , C07D307/88 , C07D311/80 , C07D409/12 , C07D489/02 , C07D498/18 , A61K47/542 , A61P37/02 , C07C13/12 , C07D209/08 , C07D333/56 , Y02A50/30
摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a provided lipid prodrug or a pharmaceutical composition thereof.
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公开(公告)号：EP4384493A1
公开(公告)日：2024-06-19
申请号：EP22855428.3
申请日：2022-08-09
申请人： Sironax Ltd
发明人： HOU, Weijie , ZHANG, Zhiyuan , XU, Yanping , JIANG, Yimin , XU, Xingyu , HAN, Jianguang
IPC分类号： C07C211/44 , C07D213/00 , C07D231/00 , C07D263/00 , A61K31/136 , A61K31/395 , A61P25/00 , A61P25/14 , A61P25/16
CPC分类号： A61P25/14 , A61P25/16 , A61P25/00 , C07D265/30 , C07D241/04 , C07D295/13 , C07D295/135 , C07D401/04 , C07D211/58 , C07D401/12 , C07D405/12 , C07D401/14 , C07D403/12 , C07D211/76 , C07D211/56 , C07D211/96 , C07D211/26 , C07D401/06 , C07D211/18 , C07D211/14 , C07D211/22 , C07D211/48 , C07D211/46 , C07D405/14 , C07D451/04 , C07D487/08 , C07D231/12 , C07D231/38 , C07D213/74 , C07D207/14 , C07D309/14 , C07D207/27 , C07D207/277 , C07D207/273 , C07D205/04 , C07D233/32 , C07D207/08 , C07D215/38 , C07D309/04 , C07D307/79 , C07D277/60 , C07D413/04 , C07D413/14 , C07D417/04 , C07D233/64 , C07D233/61 , C07D239/22 , C07D335/02 , C07D239/47 , C07D209/08 , C07D267/10 , C07D498/08 , C07D491/107 , C07D491/048 , C07F7/0816 , C07C2601/1420170501 , C07C211/53 , C07C217/52 , C07C237/24 , C07C217/08 , C07C2601/0820170501 , C07C2601/0420170501 , C07C2601/1820170501 , C07C215/42 , C07C2603/7420170501 , C07C2602/0820170501 , C07C2602/1020170501 , C07C217/84 , C07C215/44 , C07C2601/0220170501 , C07C211/48 , C07C229/48 , C07C2602/5020170501 , C07C215/10 , C07C217/90 , C07C275/14 , C07C275/26 , C07C307/08 , C07C2602/2220170501 , C07C215/16 , C07C211/51
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