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    METHOD FOR PRODUCING PHENYL PROPANE-BASED COMPOUNDS USING ENZYMES
    102.
    发明公开
    METHOD FOR PRODUCING PHENYL PROPANE-BASED COMPOUNDS USING ENZYMES 审中-公开
    VERFAHREN ZUR HERSTELLUNG VON VERBINDUNGEN AUF PHENYLPROPANBASIS UNTER VERWENDUNG VON ENZYMEN

    公开(公告)号：EP3106522A4

    公开(公告)日：2017-08-16

    申请号：EP15746275

    申请日：2015-02-09

    申请人： JAPAN AGENCY FOR MARINE-EARTH SCIENCE AND TECH

    发明人： OHTA YUKARI ,  HATADA YUJI ,  HASEGAWA RYOICHI ,  NISHI SHINRO

    IPC分类号： C12P7/22 ,  C12N1/20 ,  C12N9/02 ,  C12N15/09 ,  C12P7/24

    CPC分类号： C12P7/22 ,  C12N1/20 ,  C12N9/0004 ,  C12N9/13 ,  C12P7/24 ,  C12P7/26 ,  C12R1/01

    摘要： The object of the invention is to provide a method which, if compared with prior art, more specifically and efficiently produces a compound having a phenol propane structure from natural biomass containing lignins by causing enzymes to act on the biomass. The object is achieved by a method for producing a phenyl propane-based compound comprising a step of producing a phenyl propane-based compound by causing enzymes derived from microorganisms of the genus Novosphingobium to act on biomass containing lignins and/or lignin-related substances in the presence of NAD and reduction type glutathione.

    摘要翻译： 本发明的目的是提供一种方法，如果与现有技术相比，通过使酶作用于生物质上，从含有木质素的天然生物质更具体且高效地生产具有苯酚丙烷结构的化合物。 该目的通过用于制备苯基丙烷类化合物的方法来实现，所述方法包括通过使源自Novosphingobium属的微生物的酶作用于含有木质素和/或木质素相关物质的生物质来制备苯基丙烷类化合物的步骤 NAD和还原型谷胱甘肽的存在。

    MODIFIED MICROORGANISMS AND METHODS FOR PRODUCTION OF USEFUL PRODUCTS
    103.
    发明公开
    MODIFIED MICROORGANISMS AND METHODS FOR PRODUCTION OF USEFUL PRODUCTS 审中-公开
    修饰的微生物和生产有用产品的方法

    公开(公告)号：EP3201344A1

    公开(公告)日：2017-08-09

    申请号：EP15780795.9

    申请日：2015-09-30

    申请人： Zuvasyntha Limited

    发明人： GRADLEY, Michelle ,  PUDNEY, Alex ,  HELDT, Dana

    IPC分类号： C12P7/18 ,  C12P7/24 ,  C12N9/88

    CPC分类号： C12P7/24 ,  C07K2319/00 ,  C12N9/0008 ,  C12N9/88 ,  C12N15/52 ,  C12P7/18 ,  C12Y102/01003 ,  C12Y401/01001 ,  C12Y401/02004 ,  Y02P20/582

    摘要： Non-naturally occurring microbial organisms and related methods, processes and materials are for microbial organisms that include a genetic modification which enhances production of 3-hydroxybutanal or a downstream product of 3-hydroxybutanal such as 1,3-butanediol from endogenous central metabolic intermediates such as acetyl CoA or pyruvate which are converted to acetaldehyde. Two molecules of acetaldehyde are condensed to form the 3-hydroxybutanal using an aldolase capable of accepting acetaldehyde as both the acceptor and donor in an aldol condensation. The aldolase may be a deoxyribose phosphate aldolase type enzyme, and is typically introduced into the organisms. Energetically favorable pathways produce 3-hydroxybutanal or downstream products thereof.

    摘要翻译： 本发明提供非天然存在的微生物有机体和相关方法，工艺和材料，其中微生物有机体包括遗传修饰，其增强3-羟基丁醛或3-羟基丁醛如1,3-丁二醇的下游产物从内源中央代谢产物 中间体例如乙酰CoA或丙酮酸转化为乙醛，由此使用能够接受乙醛作为醛醇缩合中的受体和供体的醛缩酶使两分子乙醛缩合形成所述3-羟基丁醛。 醛缩酶可以是脱氧核糖磷酸醛缩酶型酶，并且通常被引入到生物体中。 本发明为生产3-羟基丁醛或其下游产物提供了有利的有利途径。

    METHOD FOR PRODUCING 3-HYDROXYPROPANAL
    104.
    发明公开
    METHOD FOR PRODUCING 3-HYDROXYPROPANAL 审中-公开
    生产3-羟基丙酸的方法

    公开(公告)号：EP3183354A1

    公开(公告)日：2017-06-28

    申请号：EP15756213.3

    申请日：2015-08-19

    申请人： Verdant Bioproducts Limited

    发明人： FINNEGAN, Irene

    IPC分类号： C12P7/24

    CPC分类号： C12P7/24 ,  B01D3/145 ,  B01D61/147 ,  B01D2311/2669 ,  C12N1/20 ,  C12P7/62

    摘要： There is described a method for producing 3-hydroxypropanal, the method comprising: culturing an Acetobacter lovaniensis bacterium in a growth medium containing phosphate at a level which is more than 1 g/litre and nitrate at a level which is more than 0.1 g/litre, wherein culturing of the bacterium produces the 3-hydroxypropanal. The 3-hydroxypropanal can be separated from the growth medium or, when the microorganism has converted some or all of the 3-hydroxypropanal to 3-hydroxypropionic acid and/or a 3-hydroxypropionate ester, it may be separated as 3-hydroxypropionic acid or a 3-hydroxypropionate ester. The separated product can be converted into other chemicals such as an ester of 3-hydroxypropionic acid, 3-hydroxypropionic acid, 3-hydroxypropionate salts (including ammonium, sodium and calcium 3-hydroxypropionate), acrylic acid, acrylates, acrylamide, acrylonitrile, acrolein and 1,3 propanediol.

    摘要翻译： 描述了一种生产3-羟基丙醛的方法，该方法包括：在含有大于1克/升的磷酸盐和大于0.1克/升的硝酸盐的生长培养基中培养洛氏醋杆菌（Acetobacter lovaniensis）细菌 其中培养细菌产生3-羟基丙醛。 可以从生长培养基中分离3-羟基丙醛，或者当微生物已经将部分或全部3-羟基丙醛转化为3-羟基丙酸和/或3-羟基丙酸酯时，可以将其分离为3-羟基丙酸或 3-羟基丙酸酯。 分离的产物可以转化成其它化学品，例如3-羟基丙酸，3-羟基丙酸，3-羟基丙酸盐（包括铵，3-羟基丙酸钠和钙），丙烯酸，丙烯酸酯，丙烯酰胺，丙烯腈，丙烯醛 和1,3丙二醇。

    PROCESSES TO PREPARE ELONGATED 2-KETOACIDS AND C6-C10 COMPOUNDS THEREFROM VIA GENETIC MODIFICATIONS TO MICROBIAL METABOLIC PATHWAYS
    105.
    发明公开
    PROCESSES TO PREPARE ELONGATED 2-KETOACIDS AND C6-C10 COMPOUNDS THEREFROM VIA GENETIC MODIFICATIONS TO MICROBIAL METABOLIC PATHWAYS 审中-公开
    用于生产芒2酮酸，和C6-C10化合物及其遗传修改到​​微生物代谢DUE

    公开(公告)号：EP3080285A1

    公开(公告)日：2016-10-19

    申请号：EP14824634.1

    申请日：2014-12-10

    申请人： Dow Global Technologies LLC

    发明人： SANGHANI, Paresh C. ,  STOWERS, Christopher C. ,  RODRIGUEZ, Brandon A. ,  VENKATESWARAN, Amudhan

    IPC分类号： C12P7/26 ,  C12P7/40 ,  C12N9/10 ,  C12N9/04 ,  C12P7/24

    CPC分类号： C12P7/6409 ,  C12N1/14 ,  C12N1/20 ,  C12N9/0006 ,  C12N9/1025 ,  C12N9/88 ,  C12N15/52 ,  C12P7/24 ,  C12P7/26 ,  C12P7/40 ,  C12Y101/01085 ,  C12Y203/03013 ,  C12Y402/01033

    摘要： Modification of metabolic pathways includes genetically engineering at least one enzyme involved in elongating 2-ketoacids during leucine biosynthesis, and preferably at least isopropylmalate dehydrogenase or synthase (LeuB or LeuA in E. coli), to include at least such non-native enzyme, enzyme complex, or combination thereof to convert 2-ketobutyrate or 2-ketoisovalerate to a C7-C11 2-ketoacid, wherein the production of such is at a higher efficiency than if a purely native pathway is followed. The C7-C11 2-ketoacid may then be converted, via a native or genetically engineered thiamin dependent decarboxylase, to form a C6-C10 aldehyde having one less carbon than the C7-C11 2-ketoacid being converted. In some embodiments the C6-C10 aldehyde may then be converted via additional native or genetically engineered enzymes to form other C6-C10 products, including alcohols, carboxylic acids, and alkanes. This genetic engineering offers the opportunity for commercial scale of in vivo biosynthetic processes that may be more cost-efficient than non-biobased approaches to produce the same products.

    摘要翻译： 代谢途径的修饰包括在亮氨酸生物合成期间拉长2-酮酸涉及基因工程的至少一种酶，和优选至少异丙基脱氢酶或合成酶（Leub或在的leuA大肠杆菌），至少包括寻求非天然酶，酶 复杂的，或它们的组合，以2-酮丁酸或2-酮异戊酸转化为C7-C11 2-酮酸，worin生产这种处于比如果纯粹天然途径之后更高的效率。 然后，C7-C11 2-酮酸可以被转换，通过天然或基因工程改造的硫胺依赖性脱羧酶，以形成具有一个比所述C7-C11 2-酮酸转化更少碳一个C6-C10醛。 在一些实施方案中，C6-C10醛然后可以通过额外的天然的或基因工程改造的酶转化形成其他C6-C10产品，包括醇，羧酸，和烷烃。 这种基因工程提供了体内生物合成过程中的商业规模也可能是更具成本效益比非生物基途径生产相同产品的机会。

    CONTINUOUS BIOTRANSFORMATION OF SUBSTITUTED AROMATIC CARBOXYLIC ACIDS TO THEIR SELECTIVE ALDEHYDES AND ALCOHOLS
    110.
    发明公开
    CONTINUOUS BIOTRANSFORMATION OF SUBSTITUTED AROMATIC CARBOXYLIC ACIDS TO THEIR SELECTIVE ALDEHYDES AND ALCOHOLS 审中-公开
    KONTINUIERLICHE BIOTRANSFORMATION SUBSTITUIERTER AROMATISCHERCARBONSÄURENZU SELEKTIVER ALDEHYDEN UND ALKOHOLEN

    公开(公告)号：EP2890800A2

    公开(公告)日：2015-07-08

    申请号：EP13815584.1

    申请日：2013-08-28

    申请人： Privi Biotechnologies Pvt. Ltd.

    发明人： YEOLE, Mahendra, M. ,  LALI, Arvind, M.

    IPC分类号： C12P7/22 ,  C12P7/24 ,  C12P7/42

    CPC分类号： C12P13/001 ,  C12P7/22 ,  C12P7/24 ,  C12R1/645 ,  Y02P20/582

    摘要： The present invention discloses a novel method for biological reduction of the carboxylic acids to their corresponding aldehydes and/or alcohols with high productivity and high yield by using fungus in the category of basidiomycetes. This reduction is specific and selective for its functional group (—COOH), without affecting other functional group such as—R groups (—OH, —NH2, -alkyl, -alkyoxy) and their position, number on aromatic ring. The method of the invention relates to reduction of aryl acids to aldehyde and/or alcohols by employing a white rot fungus—Pycnoporus cinnabarinus, an organism of basidiomycete species, grown in vessel/column. The biotransformation was performed in vessel/column/fermentor with pH control, dissolved oxygen, membrane system, product extractor is attached.

    摘要翻译： 本发明公开了通过使用担子菌类中的真菌，以高生产率和高产率将羧酸生物还原成其相应的醛和/或醇的新方法。 这种还原对于其官能团（-COOH）是特异性和选择性的，而不影响其它官能团如-R基（-OH，-NH 2， - 烷基， - 烷氧基）及其在芳环上的位置数。 本发明的方法涉及通过使用生长在容器/柱中的白腐霉真菌（Pycnoporus cinnabarinus），担子菌种的生物体将芳基酸还原成醛和/或醇。 生物转化在带有pH控制，溶解氧，膜系统，产品提取器的容器/柱/发酵罐中进行。