公开(公告)号：EP2970882A4

公开(公告)日：2016-10-26

申请号：EP14771001

申请日：2014-03-12

申请人： ALLOSOURCE

发明人： SHI YALING ,  DITTMAN BRIAN ,  ATKINSON BRENT ,  STILWELL REGINALD L

IPC分类号： A61L27/24 ,  A61L27/36 ,  A61L27/38 ,  C12N5/00 ,  C12N5/02 ,  C12N5/0775

CPC分类号： A61L27/60 ,  A61K35/28 ,  A61L27/24 ,  A61L27/3604 ,  A61L27/362 ,  A61L27/3641 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3834 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/64 ,  A61L2430/34 ,  A61L2430/40 ,  C12N5/0667 ,  C12N2533/92

摘要： The present invention provides compositions for treating soft tissue injuries comprising a collagen matrix and mesenchymal stem cells adhered to the collagen matrix. Methods of making and using compositions comprising a collagen matrix and mesenchymal stem cells adhered to the collagen matrix are also provided.

公开(公告)号：EP2943209A4

公开(公告)日：2016-10-26

申请号：EP14737892

申请日：2014-01-09

申请人： ISE PROFESSIONAL TESTING & CONSULTING SERVICES INC

发明人： EARLY RYANNE

IPC分类号： A61K35/56 ,  A61F2/00 ,  A61K9/10 ,  A61K9/14 ,  A61L27/36

CPC分类号： A61L27/3687 ,  A61K9/70 ,  A61K35/12 ,  A61K35/65 ,  A61K38/1703 ,  A61L27/3604 ,  A61L27/362 ,  A61L27/3625 ,  A61L27/3633 ,  A61L27/3691 ,  A61L27/38 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L27/60 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2430/34 ,  A61L2430/40 ,  C12N5/0625 ,  C12N2533/90 ,  C12N2533/92

摘要： The growth factor profile, connective tissue matrix constituents, and immunoprivileged status of urodele extracellular matrix (ECM) and accompanying cutaneous tissue, plus the presence of antimicrobial peptides there, render urodele-derived tissue an ideal source for biological scaffolds for xenotransplantation. In particular, a biological scaffold biomaterial can be obtained by a process that entails (A) obtaining a tissue sample from a urodele, where the tissue comprises ECM, inclusive of the basement membrane, and (B) subjecting the tissue sample to a decellularization process that maintains the structural and functional integrity of the extracellular matrix, by virtue of retaining its fibrous and non-fibrous proteins, glycoaminoglycans (GAGs) and proteoglycans, while removing sufficient cellular components of the sample to reduce or eliminate antigenicity and immunogenicity for xenograft purposes. The resultant urodele-derived biomaterial can be used to enhance restoration of skin homeostasis, to reduce the severity, duration and associated damage caused by post-surgical inflammation, and to promote progression of natural healing and regeneration processes. In addition, the biomaterial promotes the formation of remodeled tissue that is comparable in quality, function, and compliance to undamaged human tissue.

公开(公告)号：EP2968680A4

公开(公告)日：2016-10-19

申请号：EP14770108

申请日：2014-03-14

申请人： MEDICUS BIOSCIENCES LLC

发明人： ASKARI SYED H ,  CHOI YEON S ,  WAN PAUL YUJEN

IPC分类号： A61L27/52 ,  A61L26/00 ,  A61L27/18 ,  A61L27/54

CPC分类号： A61L26/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/00 ,  A61K31/155 ,  A61K31/505 ,  A61K31/573 ,  A61K31/635 ,  A61K31/728 ,  A61K31/785 ,  A61K31/795 ,  A61K33/00 ,  A61K35/28 ,  A61K45/06 ,  A61K47/00 ,  A61K47/10 ,  A61K47/34 ,  A61K49/0404 ,  A61K49/0409 ,  A61K49/0457 ,  A61L26/0066 ,  A61L26/008 ,  A61L27/18 ,  A61L27/3604 ,  A61L27/3695 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/206 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2400/06 ,  A61L2430/24 ,  A61L2430/34 ,  A61K2300/00 ,  C08L71/02

摘要： Provided herein are biocompatible hydrogel polymer matrices, which are prepared from biocompatible pre-formulations. The biocompatible pre-formulations comprise at least one nucleophilic compound, at least one electrophilic compound, and at least one cell. The biocompatible hydrogel polymer matrix is bioabsorbable and releases the cell at a target site, achieving a controlled delivery. The biocompatible hydrogel polymer matrix provides a solid support conducive for cell viability and functionality. The cells may grow on the hydrogel polymer surface of inside the hydrogel polymer matrix.

公开(公告)号：EP3067074A1

公开(公告)日：2016-09-14

申请号：EP13897090.0

申请日：2013-11-15

申请人： Sewon Cellontech Co., Ltd

发明人： YOO, Ji Chul ,  YEO, Se Ken ,  LEE, Myoung Sung ,  LEE, Jun Keun ,  KO, Chang Kwon ,  SUH, Dong Sam ,  CHANG, Cheong Ho

IPC分类号： A61L27/24 ,  A61L27/20 ,  A61L27/56

CPC分类号： A61L27/26 ,  A61L26/0023 ,  A61L26/0033 ,  A61L26/0052 ,  A61L26/0085 ,  A61L26/009 ,  A61L27/20 ,  A61L27/24 ,  A61L27/365 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/418 ,  A61L2300/604 ,  A61L2400/06 ,  A61L2430/02 ,  A61L2430/12 ,  A61L2430/34 ,  C08L5/08 ,  C08L89/06

摘要： The present invention relates to a biomaterial having enhanced rubber properties through natural cross-linkage of collagen and hyaluronic acid, a preparing method thereof, and a using method thereof. To this end, the present invention is characterized in that a rubber type biomaterial is prepared by natural cross-linkage of collagen and hyaluronic acid at a ratio of 2:1 to 7:1. The present invention as described above creates a novel material exhibiting rubber properties by providing the conditions for natural cross-linkage rather than chemical or physical cross-linkage and mixing at the optimum ratio of collagen and hyaluronic acid considering their molecular structural features, thereby significantly improving quality and reliability of products, thus meeting a variety of user or customer needs to present a good image.

摘要翻译： 本发明涉及一种具有通过胶原蛋白和透明质酸，及其制备方法的自然交联，以及使用它们的方法增强的橡胶性质的生物材料。 为此，本发明的特征在于在做了橡胶类型的生物材料是由胶原蛋白和透明质酸的自然交联以2:1的比率制备：1至7：第一 如上述说明的本发明创建一个新颖的材料通过提供一种用于自然交联，而不是化学或物理交联的条件和在胶原蛋白和透明质酸的最佳比例混合考虑它们的分子结构特征，从而显着提高参展橡胶性能 产品的质量和可靠性，从而满足各种用户或客户的需求呈现了良好的形象。

公开(公告)号：EP3065791A1

公开(公告)日：2016-09-14

申请号：EP14859356.9

申请日：2014-11-04

申请人： President and Fellows of Harvard College

发明人： LEWIS, Jennifer ,  KOLESKY, David B. ,  SCOTT, Mark A. ,  HOMAN, Kimberly A. ,  TRUBY, Ryan L. ,  GLADMAN, Amelia Sydney

IPC分类号： A61L27/38

CPC分类号： A61L27/507 ,  A61F2/06 ,  A61F2/105 ,  A61F2240/002 ,  A61L27/222 ,  A61L27/225 ,  A61L27/3633 ,  A61L27/3808 ,  A61L27/3813 ,  A61L27/3826 ,  A61L2430/34 ,  B29C64/106 ,  B29C64/40 ,  B33Y10/00 ,  B33Y80/00 ,  C12M33/00

摘要： A printed tissue construct comprises one or more tissue patterns, where each tissue pattern comprises a plurality of viable cells of one or more predetermined cell types. A network of vascular channels interpenetrates the one or more tissue patterns. An extracellular matrix composition at least partially surrounds the one or more tissue patterns and the network of vascular channels.

摘要翻译： 印刷的组织结构包括一个或多个组织图案，其中每个组织图案包括一个或多个预定细胞类型的多个活细胞。 血管通道网络穿过一个或多个组织模式。 细胞外基质组合物至少部分地围绕血管通道的一个或多个组织模式和网络。 印刷具有嵌入脉管系统的组织构建体的方法包括在衬底上沉积一个或多个包含多个活细胞的细胞细丝，以形成一个或多个组织图案。 一个或多个组织图案中的每一个包括一个或多个预定的细胞类型。 一个或多个牺牲丝，每个包含短暂的油墨，沉积在基底上，以形成互穿一个或多个组织图案的血管图案。 血管图案和一个或多个组织图案至少部分地被细胞外基质组合物包围。 然后除去逸散性油墨以在细胞外基质组合物中产生血管通道，从而在组织构建体中形成互穿血管网络。

公开(公告)号：EP3065708A1

公开(公告)日：2016-09-14

申请号：EP14796025.6

申请日：2014-11-04

申请人： invenres GmbH ,  Gerashchenko, Igor ,  Chepliaka, Oleksii

发明人： GERASHCHENKO, Igor ,  CHEPLIAKA, Oleksii ,  TAUSCH, Andreas

IPC分类号： A61K9/14 ,  A61K9/00

CPC分类号： A61K9/143 ,  A61K9/0014 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1611 ,  A61K9/1641 ,  A61K31/167 ,  A61K31/5415 ,  A61K38/48 ,  A61K45/06 ,  A61L15/18 ,  A61L15/225 ,  A61L15/26 ,  A61L15/28 ,  A61L15/32 ,  A61L15/44 ,  A61L15/60 ,  A61L26/0004 ,  A61L26/0019 ,  A61L26/0023 ,  A61L26/0038 ,  A61L26/0052 ,  A61L26/0066 ,  A61L26/008 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/412 ,  A61L2300/45 ,  A61L2300/606 ,  A61L2300/62 ,  A61L2400/04 ,  A61L2420/06 ,  A61L2430/34 ,  C08G77/04 ,  C08G77/06

摘要： Thus, the present invention provides a composition in powder form comprising highly dispersed silica particles, polymethylsiloxane particles, and at one or both of a cationic surfactant and an antimicrobial substance, wherein at least 25% by weight of the cationic surfactant is present in primary polymethylsiloxane particles carrying the cationic surfactant on their surface and/or in agglomerates of these primary particles, and/or at least 25% by weight, of the antimicrobial substance is present in primary highly dispersed silica particles carrying the antimicrobial substance on their surface and/or in agglomerates of these primary particles.

公开(公告)号：EP3055000A1

公开(公告)日：2016-08-17

申请号：EP15808663.7

申请日：2015-12-15

申请人： Geistlich Pharma AG

发明人： IMHOF, Cornel ,  SCHLOESSER, Lothar ,  STIEFEL, Niklaus ,  WÜEST, Martin

IPC分类号： A61L27/56 ,  A61L27/24 ,  A61F2/00

CPC分类号： A61L27/56 ,  A61L27/26 ,  A61L27/3604 ,  A61L27/362 ,  A61L27/3625 ,  A61L27/3629 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  A61L2430/34

摘要： - A resilient resorbable chemically crosslinked collagen sponge for promoting soft tissue volume augmentation in the oral region, comprising 60-96 % (w/w) collagen and 4-40 % (w/w) elastin, which shows by mercury intrusion porosimetry interconnected pores with a median pore diameter between 50 and 90 μιτι and at least 80 % porosity with a pore diameter more than 10 μιη; an onset temperature of 45 to 57 °C and a density in dry state from 50 to 65 mg/cm3. -A process for preparing that resilient resorbable chemically crosslinked collagen sponge, and - That resilient resorbable chemically crosslinked collagen sponge for use as an implant in the oral cavity for soft tissue volume augmentation

摘要翻译： 本发明涉及： - 弹性可再吸收的化学交联胶原海绵，用于促进口腔区域中的软组织体积增加，包括60-96％（w / w）胶原蛋白和4-40％（w / w）弹性蛋白，其显示为 水银侵入孔隙率相互连通的孔，中孔直径在50至90μm之间，孔径至少为80％，孔直径大于10μm，起始温度为45至57℃，干燥状态密度为50至65mg / cm 3。 - 制备该弹性可再吸收的化学交联的胶原海绵的方法，以及 - 用于口腔中用于软组织体积增加的植入物的可弹性吸收的化学交联的胶原海绵

公开(公告)号：EP2866608A4

公开(公告)日：2016-07-06

申请号：EP13809864

申请日：2013-06-21

申请人： ELC MAN LLC

发明人： COHEN ISAAC DAVID ,  BRATESCU DANIELA ,  KNIGHT E ALTHEA ,  MAMMONE THOMAS

IPC分类号： A45D34/04 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16 ,  A61M37/00

CPC分类号： A61M37/0015 ,  A45D34/04 ,  A61L31/042 ,  A61L31/141 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/40 ,  A61L2300/62 ,  A61L2430/34 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61M2037/0061

公开(公告)号：EP3034103A1

公开(公告)日：2016-06-22

申请号：EP14197987.2

申请日：2014-12-15

申请人： Geistlich Pharma AG

发明人： Imhof, Cornel ,  Schlösser, Lothar ,  Stiefel, Niklaus ,  Wüest, Martin

IPC分类号： A61L27/56 ,  A61L27/24 ,  A61F2/00

CPC分类号： A61L27/56 ,  A61L27/26 ,  A61L27/3604 ,  A61L27/362 ,  A61L27/3625 ,  A61L27/3629 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  A61L2430/34

摘要： The invention relates to:
- A resilient resorbable chemically crosslinked collagen sponge for promoting soft tissue volume augmentation in the oral region, comprising 60-96 % (w/w) collagen and 4-40 % (w/w) elastin, which shows by mercury intrusion porosimetry interconnected pores with a median pore diameter between 50 and 90 µm and at least 80 % porosity with a pore diameter more than 10 µm, an onset temperature of 45 to 57 °C and a density in dry state from 50 to 65 mg/cm 3 .
- A process for preparing that resilient resorbable chemically crosslinked collagen sponge, and
- That resilient resorbable chemically crosslinked collagen sponge for use as an implant in the oral cavity for soft tissue volume augmentation

摘要翻译： 本发明涉及： - 弹性可再吸收的化学交联胶原海绵，用于促进口腔区域中的软组织体积增加，包括60-96％（w / w）胶原蛋白和4-40％（w / w）弹性蛋白，其显示为 水银侵入孔隙率相互连通的孔，中孔直径在50至90μm之间，孔径至少为80％，孔直径大于10μm，起始温度为45至57℃，干燥状态密度为50至65mg / cm 3。 - 制备该弹性可再吸收的化学交联的胶原海绵的方法，以及 - 用于口腔中用于软组织体积增加的植入物的可弹性吸收的化学交联的胶原海绵

公开(公告)号：EP2772273B9

公开(公告)日：2016-05-18

申请号：EP14170084.9

申请日：2010-08-25

申请人： FIDIA FARMACEUTICI S.p.A.

发明人： D'Este, Matteo ,  Renier, Davide

IPC分类号： A61L27/26 ,  A61L27/52 ,  A61L27/58 ,  C08L5/08 ,  C08B37/00

CPC分类号： A61L27/54 ,  A61L27/26 ,  A61L2300/402 ,  A61L2300/602 ,  A61L2430/34 ,  C08B37/0003 ,  C08B37/0072 ,  C08J3/005 ,  C08J3/075 ,  C08J3/14 ,  C08J3/24 ,  C08J2305/08 ,  C08L5/08 ,  C08L2205/02