公开(公告)号：EP1636630A1

公开(公告)日：2006-03-22

申请号：EP04752701.5

申请日：2004-05-19

Applicant: Corning Incorporated

Inventor： CARRACCI, Stephen, J. ,  FONTAINE, Norman, H.

IPC: G02B27/10

CPC classification number: G01N21/253 ,  G01N2201/04 ,  G01N2201/10 ,  G02B27/1086

Abstract: An optical interrogation system and method are described herein that are capable of generating light beams that have desired optical properties which are directed towards a specimen array. In one embodiment, the optical interrogation system includes a light source, a diffractive element and a collimating optic (e.g., simple lens(es), f-θ lens(es), segmented mirror, fiber array). The light source emits a light beam to the diffractive optic which receives the light beam and outputs an array of light beams to the collimating optic. The collimating optic receives and conditions the light beams emitted from the diffractive optic and then outputs the conditioned light beams which have desired optical properties towards a specimen array. Several other embodiments of the optical interrogation system are also described herein.

公开(公告)号：EP2056090B1

公开(公告)日：2018-08-29

申请号：EP08167937.5

申请日：2008-10-30

Applicant: Sony Corporation

Inventor： Furuki, Motohiro ,  Imanishi, Shingo ,  Shinoda, Masataka ,  Suzuki, Akitoshi ,  Miyake, Kazushi

IPC: G01N15/14 ,  G01N21/64

CPC classification number: G01N15/1425 ,  G01N15/1436 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/6428 ,  G01N21/645 ,  G01N2015/1006 ,  G01N2015/1497 ,  G01N2021/058 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/10 ,  G01N2201/11

Abstract: A fine particle measuring method of performing optical measurement of fine particles introduced into a plurality of sample fluidic channels (111) provided at predetermined distances on a substrate (11) by scanning light to the sample fluidic channels (111) is disclosed. The method includes: sequentially irradiating the light to at least two or more reference regions provided together with the sample fluidic channels (111); detecting a change of optical property occurring in the light due to the reference regions; and controlling timing of emission of the light to the sample fluidic channels (111).

公开(公告)号：EP3222997A4

公开(公告)日：2017-11-29

申请号：EP15860167

申请日：2015-11-18

Applicant: SUMITOMO ELECTRIC INDUSTRIES ,  CYFUSE BIOMEDICAL K K ,  KYOTO STEM CELL INNOVATION INC

Inventor： SUGANUMA HIROSHI ,  OKUNO TAKUYA ,  MOTOMURA ASAKO ,  AKIEDA SHIZUKA ,  TSUJI MANAMI ,  OKINA YUNA ,  SUGIYAMA YOKO ,  AIBA KAZUHIRO ,  LIU LI

IPC: G01N21/359 ,  G01N21/47

CPC classification number: G01N21/255 ,  G01J3/42 ,  G01N17/004 ,  G01N21/01 ,  G01N21/359 ,  G01N21/4738 ,  G01N2021/0106 ,  G01N2201/10 ,  G01N2201/129 ,  G06F17/30247 ,  G06K9/00147 ,  G06K9/0055 ,  G06N99/005 ,  G06T2207/30024

Abstract: A quality evaluation method includes an acquisition step of acquiring spectral data related to transmitted light or diffusely reflected light from a cell mass by irradiating the cell mass with measurement light including near-infrared light, and an evaluation step of evaluating quality of the cell mass, based on the spectral data of the cell mass acquired in the acquisition step.

公开(公告)号：EP3168569A1

公开(公告)日：2017-05-17

申请号：EP14897276.3

申请日：2014-07-08

Applicant: NISSAN MOTOR CO., LTD.

Inventor： SHIBAYAMA, Hirohisa ,  SHIOTANI, Eiji ,  SAKURAI, Satoru ,  SUGIYAMA, Kiyokazu ,  SHIMIZU, Akira ,  TERADA, Daisuke ,  NOSHI, Yoshitsugu ,  UTSUMI, Yoshito

IPC: G01B11/30 ,  B23Q17/24 ,  B24B33/02 ,  G01B11/22 ,  G01N21/88

CPC classification number: G06T7/0004 ,  B05B9/01 ,  B05B13/06 ,  B23Q17/24 ,  B24B33/02 ,  G01B11/22 ,  G01B11/30 ,  G01N21/88 ,  G01N21/954 ,  G01N2021/9548 ,  G01N2201/10 ,  G01N2201/12 ,  G06T7/507 ,  G06T7/62 ,  G06T2207/30108 ,  G06T2207/30148

Abstract: Provided is a defect detection device (1) capable of measuring the volume of surface defects. The defect detection device (1) includes: an imaging device (3) configured to image an image of an inspection object; a binarization processing unit (11) configured to subject the image to first and second binarization processing by use of different first and second binarization thresholds, so as to calculate first and second sizes for an identical defect in the image; a ratio calculation unit (12) configured to calculate a first ratio of the second size to the first size; and a depth determination unit (13) configured to determine a depth of the defect depending on the first ratio.

Abstract translation: 提供了一种能够测量表面缺陷的体积的缺陷检测装置（1）。 缺陷检测装置（1）包括：成像装置（3），被配置为对检查对象的图像进行成像; 二值化处理单元，被配置为通过使用不同的第一和第二二值化阈值对图像进行第一和第二二值化处理，以计算图像中的相同缺陷的第一和第二尺寸; 比率计算单元（12），被配置为计算第二尺寸与第一尺寸的第一比例; 以及深度确定单元（13），被配置为根据所述第一比率确定所述缺陷的深度。

公开(公告)号：EP2992115A4

公开(公告)日：2016-12-14

申请号：EP14795452

申请日：2014-04-30

Applicant: CALIFORNIA INST OF TECHN

Inventor： CAI LONG ,  LUBECK ERIC ,  ZHIYENTAYEV TIMUR ,  COSKUN AHMET ,  HE TING-FANG ,  SOHN CHANG HO ,  SHAH SHEEL

IPC: C12Q1/68

CPC classification number: C12Q1/6841 ,  C12N15/1065 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2201/068 ,  G01N2201/10 ,  G02B21/06 ,  G02B21/16 ,  C12Q2537/143 ,  C12Q2565/102 ,  C12Q2565/601

Abstract: The present invention, among other things, provides technologies for detecting and/or quantifying nucleic acids in cells, tissues, organs or organisms. In some embodiments, through sequential barcoding, the present invention provides methods for high-throughput profiling of a large number of targets, such as transcripts and/or DNA loci.

Abstract translation: 本发明尤其提供了用于在细胞，组织，器官或生物体中检测和/或定量核酸的技术。 在一些实施方案中，通过顺序条码，本发明提供了用于大量目标如转录物和/或DNA基因座的高通量分析的方法。

公开(公告)号：EP2868449B1

公开(公告)日：2016-09-21

申请号：EP14190075.3

申请日：2014-10-23

Applicant: Graphtec Corporation

Inventor： Noguchi, Masatoshi ,  Umezawa, Tamao

IPC: B26D5/00 ,  B26D5/34

CPC classification number: G01N21/55 ,  B26D5/005 ,  B26D5/34 ,  B26F1/3813 ,  G01N2201/10

公开(公告)号：EP2926149A4

公开(公告)日：2016-06-01

申请号：EP13857875

申请日：2013-11-27

Applicant: XU XIAOJI ,  WALKER GILBERT C

Inventor： XU XIAOJI ,  WALKER GILBERT C

IPC: G01Q30/02 ,  G01N21/359 ,  G01Q60/06

CPC classification number: G01N21/359 ,  B82Y20/00 ,  G01B9/0203 ,  G01N2201/06113 ,  G01N2201/10 ,  G01Q10/00 ,  G01Q30/02 ,  G01Q60/06 ,  G01Q60/22

Abstract: The present disclosure provides a procedure to obtain the absorption profiles of molecular resonance with ANSOM. The method includes setting a reference field phase to phi=0.5 pi relative to the near-field field, and reference amplitude A>=5|alphaeff|. The requirement on phase precision is found to be

Abstract translation: 本公开提供了获得与ANSOM的分子共振的吸收曲线的程序。 该方法包括将参考场相位设置为相对于近场场的phi =0.5π，参考幅度A> = 5 |αeff|。 相位精度的要求为<0.3 pi。 该方法使ANSOM能够以纳米级空间分辨率执行振动光谱。

公开(公告)号：EP2986967A1

公开(公告)日：2016-02-24

申请号：EP14785445.9

申请日：2014-04-15

Applicant: Koninklijke Philips N.V.

Inventor： BERG, Tommy Winther ,  SPILLUM, Erik ,  VALVIK, Martin Christian ,  OLESEN, Tom

IPC: G01N21/00

CPC classification number: G01N15/0211 ,  G01N15/0227 ,  G01N15/06 ,  G01N15/10 ,  G01N15/1463 ,  G01N21/07 ,  G01N21/272 ,  G01N21/51 ,  G01N21/53 ,  G01N33/146 ,  G01N2015/0053 ,  G01N2015/0065 ,  G01N2015/0088 ,  G01N2015/025 ,  G01N2015/0294 ,  G01N2015/0687 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1087 ,  G01N2015/1093 ,  G01N2015/1493 ,  G01N2015/1497 ,  G01N2201/10

Abstract: An optical system suitable for determining a characteristic as a function of time of at least a part of a liquid volume comprising a plurality of objects. The optical system provides a fast detection of a change in the liquid volume. The optical system comprises - an optical detection assembly comprising at least one image acquisition device configured to acquire images of an image acquisition area; - a sample device comprising at least one sample container suitable for holding a sample of said liquid volume; - a translating arrangement configured to translate said image acquisition area through at least one part of said sample container to perform a scan along a scanning path through said part of said sample container; and - an image analyzing processing system. The optical system is programmed to perform consecutive scans through said at least one part of said sample container, wherein each scan comprises acquiring images at a plurality of image acquiring positions of the image acquisition area by the optical detection assembly along at least one scanning path of the scan. The image analyzing processing system is programmed to determine a set of features in the form of a set of values for each of a plurality of objects captured on said images from each respective scan and to determine for each scan at least one derived result, the derived result is derived from a plurality of the sets of values, and to present said derived result obtained from the respective, consecutive scans as a function of time.

公开(公告)号：EP2828646A4

公开(公告)日：2015-12-23

申请号：EP13763512

申请日：2013-03-07

Applicant: KLA TENCOR CORP

Inventor： HESS CARL E ,  SHI RUI-FANG

IPC: G03F1/84 ,  G01N21/956

CPC classification number: G01N21/95 ,  G01M11/00 ,  G01N21/95607 ,  G01N2021/9511 ,  G01N2021/95676 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/10 ,  G03F1/84

公开(公告)号：EP2888596A1

公开(公告)日：2015-07-01

申请号：EP13821221.2

申请日：2013-08-20

Applicant: President and Fellows of Harvard College

Inventor： GRINOLDS, Michael, S. ,  HONG, Sungkun ,  MALETINKSY, Patrick ,  YACOBY, Amir

IPC: G01Q60/54 ,  G01N24/10 ,  G01R33/032 ,  G01Q70/14 ,  G01R33/12 ,  G01R33/24 ,  G01R33/60

CPC classification number: G01Q70/14 ,  G01N21/645 ,  G01N24/10 ,  G01N2201/10 ,  G01Q30/025 ,  G01Q60/08 ,  G01Q60/38 ,  G01Q60/54 ,  G01R33/022 ,  G01R33/032 ,  G01R33/1284 ,  G01R33/323 ,  G01R33/60

Abstract: A sensing probe may be formed of a diamond material comprising one or more spin defects that are configured to emit fluorescent light and are located no more than 50 nm from a sensing surface of the sensing probe. The sensing probe may include an optical outcoupling structure formed by the diamond material and configured to optically guide the fluorescent light toward an output end of the optical outcoupling structure. An optical detector may detect the fluorescent light that is emitted from the spin defects and that exits through the output end of the optical outcoupling structure after being optically guided therethrough. A mounting system may hold the sensing probe and control a distance between the sensing surface of the sensing probe and a surface of a sample while permitting relative motion between the sensing surface and the sample surface.