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31.发明授权
公开(公告)号：EP2436786B1
公开(公告)日：2014-04-16
申请号：EP11196264.3
申请日：2007-07-12
申请人： The Ohio State University Research Foundation , The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services
发明人： Croce, Carlo , Schetter, Aaron , Harris, Curtis
IPC分类号： C12Q1/68
CPC分类号： C12N15/113 , C12N2310/113 , C12N2310/141 , C12N2320/30 , C12Q1/6809 , C12Q1/6886 , C12Q2525/207 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/178 , Y10T436/143333
摘要： The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
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公开(公告)号：EP2704739A1
公开(公告)日：2014-03-12
申请号：EP12722586.0
申请日：2012-05-04
发明人： PASTAN, Ira H. , WELDON, John , BEERS, Richard
CPC分类号： C07K16/30 , A61K39/0011 , A61K47/6829 , A61K47/6851 , C07K14/21 , C07K2317/56 , C07K2319/32 , C07K2319/50 , C07K2319/55 , C07K2319/70
摘要： Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to improved recombinant immunotoxins comprising anti-mesothelin antibodies, including Fv molecules with particularly high affinity for mesothelin, and a Pseudomonas Exotoxin moiety which has been modified to reduce its immunogenicity and protease sensitivity and providing a better cytotoxicity for cells which expresss mesothelin. The RITs are well-suited for the treatment of cancers of the ovary, stomach, squamous cells, mesotheliomas and other malignant cells expressing mesothelin.
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33.发明授权Micro-RNA-based methods and compositions for the diagnosis and treatment of colon related diseases 有权用于诊断和治疗结肠相关疾病的基于微RNA的方法和组合物
公开(公告)号：EP2455493B1
公开(公告)日：2014-01-08
申请号：EP11196250.2
申请日：2007-07-12
申请人： The Ohio State University Research Foundation , The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services
发明人： Croce, Carlo , Schetter, Aaron , Harris, Curtis
IPC分类号： C12Q1/68
CPC分类号： C12N15/113 , C12N2310/113 , C12N2310/141 , C12N2320/30 , C12Q1/6809 , C12Q1/6886 , C12Q2525/207 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/178 , Y10T436/143333
摘要： The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
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34.发明公开LEISHMANIA CANINE CHALLENGE MODEL BY SAND FLY BITES 有权HERAUSFORDERUNG EINES LEISHMANIA-HUNDEMODELLS DURCH SANDFLIEGENSTICHE
公开(公告)号：EP2640186A1
公开(公告)日：2013-09-25
申请号：EP11791135.4
申请日：2011-11-15
申请人： Merial Limited , The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services
IPC分类号： A01K67/027 , A61K39/008
CPC分类号： A01K67/027 , A01K2227/10 , A01K2267/0337 , A61K39/00 , Y02A50/41
摘要： The present invention provides a method for effectively and reproducibly infecting canines with Leishmania infantum using sand flies to vector the parasite. The inventive method comprises several steps, including ensuring canines are naïve to Leishmania, infecting the canines using bites of Leishmania-infected sand fly bites, and evaluating successful transmission of the Leishmania parasites.
摘要翻译： 本发明提供了一种利用沙蝇来有效地和可重复地感染利什曼原虫的犬的方法，用于载体寄生虫。 本发明的方法包括几个步骤，包括确保犬只对利什曼原住地幼稚，利用利什曼原虫感染的沙蝇咬伤的叮咬感染犬只，并评估利什曼原虫寄生虫的成功传播。
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公开(公告)号：EP1949108B1
公开(公告)日：2013-09-25
申请号：EP06844393.6
申请日：2006-11-17
发明人： CASTRO, Arnold, R. , WANG, Huiying
IPC分类号： G01N33/564 , G01N33/571 , G01N33/92
CPC分类号： G01N33/571 , G01N33/564 , G01N33/92 , G01N2333/20 , G01N2469/20
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公开(公告)号：EP2637692A2
公开(公告)日：2013-09-18
申请号：EP11840238.7
申请日：2011-11-14
申请人： Scott & White Healthcare , The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services , Wake Forest University School Of Medicine
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , A61K9/0019 , A61K39/39558 , A61K45/06 , A61K47/6809 , A61K47/6811 , A61K47/6849 , A61K47/6851 , C07K2317/24 , C07K2317/33 , C07K2317/35 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/92
摘要： The present invention is directed to particular antibodies and fragments thereof that find use in the detection, prevention and treatment of diseases and disorders associated with abnormal angiogenesis. In particular, these antibodies detect tumor endothelial marker 8 (TEM8) in its native and cell-surface expressed form. Also disclosed are improved methods for producing monoclonal antibodies, as well as pharmaceutical compositions and kits.
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公开(公告)号：EP2633082A2
公开(公告)日：2013-09-04
申请号：EP11837012.1
申请日：2011-10-26
CPC分类号： C12Q1/689 , C12Q2600/158 , C12Q2600/16 , G01N2333/255 , Y02A50/451
摘要： Processes for the serotype specific detection and identification of one or more Salmonella serotypes are provided. A family of specific primers and probes are provided that allow screening of biological or environmental samples for robust, rapid, and reproducible detection and identification of one or more Salmonella serotypes in the sample.
摘要翻译： 提供了血清型特异性检测和鉴定一种或多种沙门氏菌血清型的方法。 提供了一系列特异性引物和探针，其允许筛选生物或环境样品以便对样品中的一种或多种沙门氏菌血清型进行稳健，快速和可重现的检测和鉴定。
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38.发明公开IDENTIFICATION OF ANTIBODIES SPECIFIC FOR LYSSAVIRUSES AND METHODS OF THEIR USE 有权特定用于病毒的抗体的鉴定及其使用方法
公开(公告)号：EP2630242A1
公开(公告)日：2013-08-28
申请号：EP11835004.0
申请日：2011-10-18
发明人： SMITH, Todd, G. , WU, Xianfu
IPC分类号： C12N15/13 , C07K16/00 , G01N33/53 , A61K39/395 , C12N15/85
CPC分类号： C07K16/10 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C12N2760/20145 , C12N2810/6081 , C12Q1/00 , G01N33/56983 , G01N2333/145 , G01N2500/10
摘要： Described herein is a method of identifying a monoclonal antibody (or antigen-binding fragment thereof) that specifically binds a plurality of lyssaviruses for use in post-exposure rabies prophylaxis or in the treatment of clinical rabies. The method includes using a naïve antibody phage display library to screen for phage clones that bind whole recombinant rabies virus or cells expressing glycoprotein from multiple lyssaviruses (such as RABV, MOKV and WCBV) and/or specifically bind recombinant glycoprotein from different lyssaviruses.
摘要翻译： 本文描述了鉴定特异性结合多种狂犬病病毒的单克隆抗体（或其抗原结合片段）用于暴露后狂犬病预防或用于临床狂犬病治疗的方法。 该方法包括使用幼稚抗体噬菌体展示文库来筛选结合完整重组狂犬病毒的噬菌体克隆或表达来自多个狂犬病病毒（例如RABV，MOKV和WCBV）的糖蛋白的细胞和/或特异性结合来自不同狂犬病病毒的重组糖蛋白。
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公开(公告)号：EP2489739A3
公开(公告)日：2013-08-28
申请号：EP11189805.2
申请日：2006-04-21
申请人： University of Florida Research Foundation, Inc. , The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services , Cornell Research Foundation, Inc.
发明人： Crawford, Patti C. , Gibbs, Paul J. , Dubovi, Edward J. , Donis, Ruben O. , Castleman, William L. , Cox, Nancy J. , Katz, Jacqueline , Klimov, Alexander I.
IPC分类号： C12N15/44 , C07K14/11 , A61K39/145
摘要： The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of the present invention. The subject invention also pertains to compositions and methods for identifying a virus of the invention and diagnosing infection of an animal with a virus of the invention.
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40.发明授权
公开(公告)号：EP2360281B1
公开(公告)日：2013-07-03
申请号：EP11151493.1
申请日：2007-02-12
IPC分类号： C12Q1/68
CPC分类号： C12Q1/701 , C12Q1/6837
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