公开(公告)号：EP2998026A3

公开(公告)日：2016-07-13

申请号：EP15182577.5

申请日：2015-08-26

申请人： Academia Sinica

发明人： CHANG, Ying-Chih ,  LAI, Jr-Ming ,  WU, Jen-Chia

IPC分类号： B01L3/00

CPC分类号： B01L3/502753 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/08 ,  B01L2300/0809 ,  B01L2300/16 ,  B01L2400/086

摘要： The disclosure provides for compositions and methods for the collection of rare cells using an interspersed microstructure design.

摘要翻译： 本公开内容提供了使用散布微结构设计来收集稀有细胞的组合物和方法。

公开(公告)号：EP3030645A1

公开(公告)日：2016-06-15

申请号：EP14835196.8

申请日：2014-08-07

申请人： Illumina, Inc.

发明人： STONE, Michael ,  VERKADE, Drew

IPC分类号： C12M1/38 ,  C12Q1/68

CPC分类号： C12Q1/6874 ,  B01L3/021 ,  B01L3/0268 ,  B01L3/0275 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/527 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/0621 ,  B01L2200/16 ,  B01L2300/0654 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/168 ,  B01L2400/02 ,  B01L2400/0622 ,  B01L2400/086 ,  G01N21/6428 ,  G01N21/6456 ,  G01N35/1002 ,  G01N35/1016 ,  G01N35/1065 ,  G01N35/1097 ,  G01N2035/00237 ,  Y10T436/2575

摘要： A fluidic system that includes a reagent manifold comprising a plurality of channels configured for fluid communication between a reagent cartridge and an inlet of a flow cell; a plurality of reagent sippers extending downward from ports in the manifold, each of the reagent sippers configured to be placed into a reagent reservoir in a reagent cartridge so that liquid reagent can be drawn from the reagent reservoir into the sipper; at least one valve configured to mediate fluid communication between the reservoirs and the inlet of the flow cell. The reagent manifold can also include cache reservoirs for reagent re-use.

公开(公告)号：EP3023335A1

公开(公告)日：2016-05-25

申请号：EP15200612.8

申请日：2012-04-02

申请人： Biosurfit, S.A.

发明人： ALBUQUERQUE, Carlota ,  TENREIRO, Tânia ,  REIS, Nuno ,  GARCIA DA FONSECA, João ,  MARQUES CALEIRO CABEÇA, Ricardo Manuel

IPC分类号： B65B11/52 ,  B01L3/02 ,  B01L3/00 ,  G01N1/28

CPC分类号： G01N1/28 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/523 ,  B01L2200/0642 ,  B01L2200/0689 ,  B01L2200/16 ,  B01L2300/0806 ,  B01L2300/087 ,  B01L2300/123 ,  B01L2400/0409 ,  B01L2400/0481 ,  B01L2400/0638 ,  B01L2400/0683 ,  B01L2400/086 ,  Y10T436/2575

摘要： Disclosed embodiments provide improved mechanisms for storing and introducing liquid volumes in a liquid handling device and, in particular, improved mechanisms for rupturing a liquid store to introduce liquid into the device, improvements to the stability of a liquid receiving chamber inside the device and improvements to liquid handling in the receiving chamber.

摘要翻译： 公开的实施例提供用于在液体处理装置中存储和引入液体体积的改进机构，并且特别地，用于破裂液体储存器以将液体引入装置的改进机构，改善装置内的液体接收室的稳定性， 接收室中的液体处理。

公开(公告)号：EP2872523A4

公开(公告)日：2016-05-25

申请号：EP12863486

申请日：2012-12-21

申请人： ABBOTT MOLECULAR INC

发明人： MARBLE HERBERT A ,  LAFFLER THOMAS

IPC分类号： C12N15/10 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/68

CPC分类号： B01L7/54 ,  B01L3/502784 ,  B01L7/525 ,  B01L2400/0415 ,  B01L2400/0433 ,  B01L2400/0445 ,  B01L2400/086 ,  C07H21/00 ,  C12P19/34 ,  C12Q1/686 ,  C12Q2527/15 ,  C12Q2563/159 ,  C12Q2565/629

摘要： Provided herein are systems, devices, and methods for generating thermal gradients in channels and uses thereof. In particular, provided herein are system, methods, and devices employing first and second thermal layers positioned around a channel in order to create a thermal gradient across a cross-section of the channel having, for example, a nucleic acid denaturation zone, a nucleic acid annealing zone, and a nucleic acid polymerization zone. Such devices find use in, for example, nucleic acid amplification procedures, including digital polymerase chain reaction (dPCR) to temperature cycle droplets for amplification of nucleic acid templates within the droplets.

摘要翻译： 本文提供了用于在通道中产生热梯度的系统，装置和方法及其用途。 特别地，本文提供的是采用围绕通道定位的第一和第二热层的系统，方法和装置，以便跨越具有例如核酸变性区的通道的横截面产生热梯度，核酸 酸退火区和核酸聚合区。 这样的装置可用于例如核酸扩增程序，包括数字聚合酶链反应（dPCR）到温度循环液滴，用于扩增液滴内的核酸模板。

公开(公告)号：EP3013223A1

公开(公告)日：2016-05-04

申请号：EP14817669.6

申请日：2014-06-26

申请人： University of Washington through its Center for Commercialization

发明人： SNIADECKI, Nathan J. ,  WHITE, Nathan J. ,  TING, Lucas H. ,  KARCHIN, Ari

IPC分类号： A61B5/026 ,  G01N33/48 ,  G01N33/86

CPC分类号： G01N33/86 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2300/025 ,  B01L2300/027 ,  B01L2300/0627 ,  B01L2300/0663 ,  B01L2300/0819 ,  B01L2300/0832 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0487 ,  B01L2400/086 ,  G01N2800/224

摘要： The present technology relates generally to fluidics devices for measuring platelet coagulation and associated systems and methods. In some embodiments, a fluidics device includes an array of microstructures including pairs of generally rigid blocks and generally flexible posts. The fluidics device further includes at least one fluid channel configured to accept the array. The fluidics device can further include a measuring element configured to measure a degree of deflection of one or more of the flexible posts in the array. In some embodiments, the fluidics device comprises a handheld device and usable for point of care testing of platelet forces and coagulation.

公开(公告)号：EP2851685A4

公开(公告)日：2016-04-27

申请号：EP13790198

申请日：2013-05-14

申请人： NANOENTEK INC ,  HUR DAE SUNG ,  KIM JAE JEONG ,  KIM YU RAE

发明人： HUR DAE SUNG ,  KIM JAE JEONG ,  KIM YU RAE

IPC分类号： G01N33/50 ,  B01L3/00 ,  G01N33/48

CPC分类号： G01N1/00 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2300/089 ,  B01L2400/086 ,  G01N33/48 ,  G01N35/08 ,  G01N2001/002

公开(公告)号：EP2964390A1

公开(公告)日：2016-01-13

申请号：EP14760637.0

申请日：2014-03-05

申请人： President and Fellows of Harvard College

发明人： WEITZ, David, A. ,  AMSTAD, Esther ,  SPERLING, Ralph, Alexander

IPC分类号： B01L3/00

CPC分类号： B01F13/0069 ,  B01F3/0807 ,  B01F5/0602 ,  B01F5/0661 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/123 ,  B01L2300/161 ,  B01L2400/0487 ,  B01L2400/086

摘要： Devices and methods for dividing droplets are generally described. In some embodiments, an article may comprise a fluidic channel comprising an array of obstructions. In certain embodiments, the arrangement of obstructions in the array may affect the flow path of fluid in the channel. For example, the array of obstructions may be used to convert a polydisperse population of droplets into a relatively monodisperse population of droplets. Passing a polydisperse population of droplets through the array may result in the division of droplets such that the population of droplets exiting the array has a narrower distribution in the characteristic dimensions of the droplets. The arrangement of obstructions in the array may allow for high-throughput production of a substantially monodisperse population of droplets in some cases. In some embodiments, the population of droplets exiting the array may be converted into particles.

公开(公告)号：EP2939030A1

公开(公告)日：2015-11-04

申请号：EP13820766.7

申请日：2013-12-20

申请人： Ventana Medical Systems, Inc.

发明人： BARNES, Bryan ,  BROWN, Patrick ,  HOLUBEC, Mirek ,  KETTERER, Matthew ,  KRAM, Brian Howard ,  MARSHALL, Kevin David ,  PANG, Lizhen ,  TALUCCI, Kevin

IPC分类号： G01N35/00 ,  G01N1/31 ,  B01L9/00

CPC分类号： G01N1/312 ,  B01L3/50273 ,  B01L7/00 ,  B01L9/52 ,  B01L2300/0822 ,  B01L2300/1827 ,  B01L2300/1838 ,  B01L2400/0406 ,  B01L2400/0475 ,  B01L2400/086 ,  G01N35/00029 ,  G01N2035/00059 ,  G01N2035/00138 ,  G01N2035/00376

摘要： At least some embodiments of the technology are directed to an automated slide processing apparatus configured to apply at least one reagent to a specimen carried by a microscope slide. The slide processing station can include a support element with a support surface, at least one vacuum port, and a sealing member having a non-round shape. In an uncompressed state, the sealing member can extend upwardly beyond the support surface. In a compressed state, the sealing member can be configured to maintain an airtight seal with a backside of the microscope slide as the microscope slide is pulled against the support surface by a vacuum drawn via the at least one vacuum port.

公开(公告)号：EP2938999A2

公开(公告)日：2015-11-04

申请号：EP13824703.6

申请日：2013-12-20

申请人： Ventana Medical Systems, Inc.

发明人： MARSHALL, Kevin, David ,  HARRISON, Joshua David, Kenneth ,  KETTERER, Matthew ,  KRAM, Brian, Howard

IPC分类号： G01N1/31 ,  G01N35/00 ,  B01L9/00

CPC分类号： G01N1/312 ,  B01L3/50273 ,  B01L7/00 ,  B01L9/52 ,  B01L2300/0822 ,  B01L2300/1827 ,  B01L2300/1838 ,  B01L2400/0406 ,  B01L2400/0475 ,  B01L2400/086 ,  G01N35/00029 ,  G01N2035/00059 ,  G01N2035/00138 ,  G01N2035/00376

摘要： At least some embodiments of the technology are directed to an automated slide processing apparatus configured to apply at least one reagent to a specimen carried by a microscope slide. The slide processing station can include a support element with a support surface, at least one vacuum port, and a sealing member having a non-round shape. In an uncompressed state, the sealing member can extend upwardly beyond the support surface. In a compressed state, the sealing member can be configured to maintain an airtight seal with a backside of the microscope slide as the microscope slide is pulled against the support surface by a vacuum drawn via the at least one vacuum port.

公开(公告)号：EP2936115A1

公开(公告)日：2015-10-28

申请号：EP13811364.2

申请日：2013-12-19

申请人： Danmarks Tekniske Universitet

发明人： OKKELS, Fridolin

IPC分类号： G01N11/08

CPC分类号： G01N11/04 ,  B01L3/502746 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0883 ,  B01L2400/086 ,  G01N11/08

摘要： The invention relates in particular to a device for determining one or more fluid properties of a fluid. The device preferably comprises a flow distributor comprising a cavity, an inlet to the cavity, one or more outlets from the cavity, and one or more flow deflecting elements present in the cavity and/or one or more flow dividing wall elements of the cavity, wherein the one or more flow deflecting elements and/or the flow dividing wall elements being arranged in such a manner that it provides sub-streams of different strength through the outlet. Furthermore, the device comprises an analyser downstream of the outlet of the flow distributor comprising means adapted to provide a read-out indicative of the strengths of sub-streams.

摘要翻译： 本发明特别涉及用于确定流体的一种或多种流体性质的装置。 该装置优选地包括流动分配器，其包括空腔，腔的入口，来自空腔的一个或多个出口以及存在于空腔中的一个或多个流动偏转元件和/或空腔的一个或多个分流壁元件， 其中所述一个或多个流动偏转元件和/或所述分流壁元件以这样的方式布置，使得其通过所述出口提供不同强度的子流。 此外，该装置包括在流量分配器的出口下游的分析器，包括适于提供指示子流的强度的读出的装置。