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238 条记录 (耗时 0.013 秒)

    Benzoxazine derivatives
    43.
    发明公开
    Benzoxazine derivatives 失效
    苯并恶嗪衍。

    公开(公告)号：EP0047005A1

    公开(公告)日：1982-03-10

    申请号：EP81106747.9

    申请日：1981-08-28

    申请人： DAIICHI SEIYAKU CO., LTD.

    发明人： Hayakawa, Isao, c/o Daiichi Seiyaku Laboratories ,  Hiramitsu, Tokiyuki Daiichi Seiyaku Laboratories ,  Tanaka, Yoshiaki,c/o Daiichi Seiyaku Laboratories

    IPC分类号： C07D498/06 ,  A61K31/535

    CPC分类号： C07C205/37 ,  C07D265/36

    摘要： Pyrido[1,2,3-de] [1,4]benzoxazine derivatives are described having the formula (1)
    wherein X is a halogen atom, R is a hydrogen atom or an alkyl group of 1 to 6 carbon atoms and Z represents mono-substituted, di-substituted or cyclic-substituted amino group which may contain a hetero atom and may have a substituent such as hydroxy, alkyl having 1 to 6 carbon atoms, amino, hydroxyalkyl having 1 to 6 carbon atoms or mono- or di-alkylamino having 1 to 6 carbon atoms in each alkyl moiety and the pharmaceutically acceptable salt thereof, having antibacterial activity.

    摘要翻译： 描述了具有式（I）的吡啶并[1,2,3-de] [1,4]苯并恶嗪衍生物其中X是卤素原子，R是氢原子或1〜 6个碳原子，Z表示可以含有杂原子并且可以具有取代基的单取代的，二取代的或环状取代的氨基，例如羟基，具有1至6个碳原子的烷基，氨基，具有1至6个碳原子的羟烷基 原子或每个烷基部分具有1至6个碳原子的单 - 或二 - 烷基氨基和其药学上可接受的盐，具有抗菌活性。

    Process for producing 4-amino-methylbicyclo(2,2,2)octane-1-carboxylic acid and intermediate compound therefor
    44.
    发明公开
    Process for producing 4-amino-methylbicyclo(2,2,2)octane-1-carboxylic acid and intermediate compound therefor 失效
    一种用于4-氨基甲基双环（2,2,2）辛烷-1-羧酸及其中间体的制备方法。

    公开(公告)号：EP0003409A1

    公开(公告)日：1979-08-08

    申请号：EP79300082.9

    申请日：1979-01-17

    申请人： DAIICHI SEIYAKU CO., LTD.

    发明人： Shimada, Sadakatsu ,  Yukimoto, Yusuke

    IPC分类号： C07C99/00 ,  C07C101/04

    CPC分类号： C07C255/45

    摘要： Process for producing 4-aminomethylbicyclo (2,2,2)octane-1-carboxylic acid and intermediate therefor 4-aminomethylbicyclo(2,2,2)octane-1-carboxylic acid or a pharmaceutically acceptable salt thereof is prepared by reacting a compound of the formula:
    (wherein R is a hydrogen atom or a lower alkyl group) with ethylene, under a pressure of 60 to 300 kg/cm 2 at a temperature of 100°-250°C. to produce a 4-cyanobicyclo(2,2,2,)oct-2-en-1-carboxylic acid of the formula:
    (wherein R is the same as defined above), catalytically reducing the bicyclo compound and hydrolyzing the reduction product.

    摘要翻译： 用于生产4-氨基甲基（2,2,2）辛烷-1-羧酸和中间为此4-氨基甲基（2,2,2）辛烷-1-羧酸或者其药学上可接受的盐是通过使化合物制备 下式：（worin R是氢原子或低级烷基）与乙烯，60至300公斤/厘米<2>的压力下在100℃-250℃的温度下，以产生 式的4- cyanobicyclo（2,2,2）辛-2-烯-1-甲酸的制备：（worin R为如上所定义的相同），催化还原的双环化合物和水解该还原产物。