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    Substituted 2-Aminotetralins
    51.
    发明公开
    Substituted 2-Aminotetralins 失效
    取代的2-氨基嘌呤取代的2-氨基嘌呤

    公开(公告)号：EP0254989A3

    公开(公告)日：1988-09-21

    申请号：EP87110341

    申请日：1987-07-17

    申请人： Whitby Research Incorporated

    发明人： Horn, Alan S.

    IPC分类号： C07C91/28 ,  C07C93/14 ,  C07C93/26 ,  C07D209/08 ,  C07D333/54 ,  C07D307/78 ,  C07D333/58 ,  C07D231/56 ,  C07D249/18 ,  C07D311/58 ,  C07D471/04

    CPC分类号： C07D333/58 ,  C07D209/08

    摘要： Certain novel compounds having the structural formula
    where R₂, R₃ and R₄ are each selected from the group consisting of H and OA; A is H or is selected from the group consisting of hydrocarbyl radicals, e.g. lower alkyl radicals, i.e. methyl, ethyl, propyl, etc., or
    wherein R₅ is selected from the group consisting of hydrocarbyl radicals, e.g. alkyl and aromatic residues; n is 2 or 3; and R₁ is selected from the group consisting of organic radicals having fused aromatic rings, that is, radicals comprising at least two rings that share a pair of carbon atoms or share a carbon and nitrogen atom are useful for inducing a dopaminergic response and reducing the intraocular pressure in a mammal.

    Novel compounds with skin lightening properties
    57.
    发明公开
    Novel compounds with skin lightening properties 审中-公开
    Neuartige Verbindungen mit Hautaufhellungseigenschaften

    公开(公告)号：EP2746253A1

    公开(公告)日：2014-06-25

    申请号：EP12199046.9

    申请日：2012-12-21

    申请人： Unilever PLC

    发明人： The designation of the inventor has not yet been filed

    IPC分类号： C07D209/88 ,  C07D213/53 ,  C07D215/12 ,  C07D307/81 ,  C07D333/58 ,  A61Q19/02

    CPC分类号： C07D213/53 ,  A61K8/40 ,  A61K8/492 ,  A61K8/4926 ,  A61K8/4973 ,  A61K8/4986 ,  A61Q19/02 ,  C07D209/88 ,  C07D215/12 ,  C07D307/81 ,  C07D333/58

    摘要： This invention relates to novel compounds with skin lightening properties based on an aromatic hydrazine carboxyimidoamide structure, topical skin lightening compositions comprising the same and a method of skin lightening using the said compositions. In particular, the skin lightening benefit is selected from any one of the group consisting of treating melasma, treating post-inflammatory hyperpigmentation, treating age spots, treating dark spots and treating uneven skin tone.
    Desired skin colour is a major unmet consumer need around the world and especially in Asia. Consumers particularly desire even skin colour, absence of age spots (solar lentigines), absence of hyperpigmentation and lighter overall skin tone. One solution is to use biological actives that reduce the activity of melanocyte cells in skin. These cells, present in the basal layer of the epidermis, make the dark coloured pigment melanin and export it, in small export vesicles called melanosomes, to the neighbouring keratinocytes. It is well described in the literature that compounds which reduce melanin synthesis when topically applied to the skin will reduce skin darkness over time and can generate a more even skin tone.
    Tyrosinase is a very popular target for the regulation of melanocyte pigment production. However effective inhibitors of tyrosinase are bedevilled by safety issues causing, for example, melanocyte cell death, permanent depigmentation, irritation and allergic reactions. Often effective inhibitors kill melanocytes (for example hydroquinone) or cause sensitisation reactions. There is therefore a great need for safe and effective inhibitors of skin pigment production that work through an alternative safe mechanism.
    The inventors have observed that selected compounds of the same generic structure inhibit the production of soluble melanin by B16 mouse melanoma cells without cell toxicity.

    摘要翻译： 本发明涉及具有基于芳香族肼羧基亚氨基酰胺结构的皮肤发光性能的新型化合物，包含其的局部皮肤增亮组合物和使用所述组合物的皮肤增白方法。 特别地，皮肤发光益处选自治疗黑斑病，治疗炎症后色素沉着过度，治疗老年斑，治疗黑斑和治疗不均匀肤色的任一组。 所需的皮肤颜色是世界各地，特别是亚洲的主要未满足的消费者需求。 消费者特别希望皮肤颜色，缺少老年斑（太阳眼镜），缺乏色素沉着和更轻的整体肤色。 一种解决方案是使用降低皮肤黑素细胞活性的生物活性物质。 存在于表皮基底层的这些细胞使黑色色素变成黑色素并将其输出到邻近角质形成细胞的小出口囊泡中。 在文献中很好地描述了当局部施用于皮肤时减少黑色素合成的化合物将随着时间的推移减少皮肤黑暗，并且可以产生更均匀的皮肤色调。 酪氨酸酶是调节黑素细胞色素生产的非常受欢迎的目标。 然而，有效的酪氨酸酶抑制剂受到安全问题的困扰，导致例如黑素细胞死亡，永久色素沉着，刺激和过敏反应。 通常有效的抑制剂可杀死黑素细胞（例如氢醌）或引起致敏反应。 因此，非常需要安全有效的皮肤颜料生产抑制剂，其通过替代的安全机制起作用。 本发明人已经观察到，相同通用结构的选定化合物抑制B16小鼠黑素瘤细胞产生可溶性黑色素而没有细胞毒性。

    POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, AND OPTICALLY ANISOTROPIC BODY
    58.
    发明公开
    POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, AND OPTICALLY ANISOTROPIC BODY 有权
    可聚合化合物，可聚合组合物，聚合物和光学各向异性体

    公开(公告)号：EP2698388A1

    公开(公告)日：2014-02-19

    申请号：EP12771107.5

    申请日：2012-04-12

    申请人： Zeon Corporation

    发明人： SAKAMOTO Kei ,  OKUYAMA Kumi

    IPC分类号： C08F20/36 ,  C07C251/88 ,  C07D209/86 ,  C07D277/82 ,  C07D317/58 ,  C07D333/58 ,  C09K19/38 ,  C09K19/54 ,  G02B5/30 ,  G02F1/13363

    CPC分类号： C08F28/06 ,  C07C251/88 ,  C07D209/56 ,  C07D209/86 ,  C07D277/82 ,  C07D317/58 ,  C07D333/58 ,  C08F24/00 ,  C08F26/06 ,  C08F222/1006 ,  C09K19/32 ,  C09K19/322 ,  C09K19/3477 ,  C09K19/3491 ,  C09K19/3497 ,  C09K2019/0444 ,  C09K2019/0448 ,  C09K2019/3408 ,  G02B5/3083

    摘要： The invention provides a polymerizable compound represented by formula (I), a polymerizable composition, and a polymer that have a practical low melting point, can be produced at low cost, and can produce an optical film that achieves uniform conversion of polarized light over a wide wavelength band, and an optically anisotropic article. In the formula: Y 1 -Y 6 represent a single bond, -O-, -O-C(=O)-, -C(=O)-O-, or the like; G 1 and G 2 represent a bivalent aliphatic group, or the like, of C1-20; Z 1 and Z 2 represent a C2-10 alkenyl group or the like; A x represents a C2-30 organic group, or the like, having at least one aromatic ring selected from an aromatic hydrocarbon ring and a hetero-aromatic ring; A y represents a hydrogen atom, a C1-6 alkyl group, or a C2-30 organic group, or the like, having at least one aromatic ring selected from an aromatic hydrocarbon ring and a hetero-aromatic ring; A 1 represents a trivalent aromatic group or the like; A 2 and A 3 represent a bivalent aromatic group or the like; Q 1 represents a hydrogen atom, a C1-6 alkyl group, or the like. A x and A y may form a ring together.

    摘要翻译： 本发明提供具有实用的低熔点的由式（I）表示的可聚合化合物，可聚合组合物和聚合物，可以低成本生产，并且可以制备实现偏振光在 宽波长带和光学各向异性制品。 在式中，Y 1 -Y 6表示单键，-O - ， - O-C（= O） - ，-C（= O）-O-等; G1和G2代表C1-20的二价脂族基团等; Z1和Z2表示C2-10链烯基等; Ax表示具有选自芳香族烃环和杂芳香族环中的至少一个芳香族环的碳原子数2〜30的有机基团等。 A y表示具有选自芳香族烃环和杂芳香环中的至少一个芳香环的氢原子，C 1-6烷基或C 2-30有机基团等; A1表示三价芳族基团等; A2和A3代表二价芳族基团等; Q1代表氢原子，C1-6烷基等。 Ax和Ay可能会形成一个戒指。