公开(公告)号：EP1838248A2

公开(公告)日：2007-10-03

申请号：EP06718593.4

申请日：2006-01-17

申请人： Osteotech, Inc.

发明人： MORRIS, John, W. ,  RICHARDS, Cristy, J. ,  SHIMP, Lawrence, A. ,  MILLER, Timothy, R. ,  ROSENTHAL, Daniel

IPC分类号： A61F2/28 ,  A61F2/44 ,  A61L27/36 ,  A61F2/30 ,  A61F2/00

CPC分类号： A61L27/50 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/442 ,  A61F2/4455 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/2839 ,  A61F2002/30057 ,  A61F2002/30062 ,  A61F2002/30075 ,  A61F2002/30131 ,  A61F2002/30153 ,  A61F2002/30224 ,  A61F2002/30563 ,  A61F2002/30579 ,  A61F2002/30599 ,  A61F2002/30957 ,  A61F2002/4475 ,  A61F2210/0004 ,  A61F2210/0061 ,  A61F2230/0013 ,  A61F2230/0019 ,  A61F2230/0069 ,  A61F2250/0063 ,  A61F2310/00293 ,  A61F2310/00359 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L2430/02

摘要： An osteoimplant comprising an expandable, biocompatible material. The expandable material may be demineralized bone particles such as demineralized cancellous chips or demineralized cortical fibers or may be another material such as a polymer. The osteoimplant has a first state and a second expanded state. The osteoimplant may be used with another device or on its own. The osteoimplant may be inserted into a device such as an intervertebral body fusion device in the compressed state. The osteoimplant may be rehydrated to expand to an increased size, for example as far as permitted by the confines of the intervertebral body fusion device and spinal endplates, thereby aiding in greater vertebral endplate contact and conformity in spinal surgery.

公开(公告)号：EP1494624A4

公开(公告)日：2007-04-04

申请号：EP03726166

申请日：2003-03-31

申请人： OSTEOTECH INC

发明人： MORRIS JOHN W ,  PETERSEN KENNETH C ,  SHIMP LAWRENCE A ,  DAUGHERTY MARK P

IPC分类号： A61F2/00 ,  A61F2/28 ,  A61F2/46 ,  A61L27/36 ,  A01N1/00

CPC分类号： A61L27/3683 ,  A01N1/00 ,  A61F2/4644 ,  A61F2002/2835 ,  A61F2002/4645 ,  A61F2002/4649 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/365 ,  A61L2430/02 ,  A61L2430/40

摘要： The present invention relates to a method for making bone particles from bone of a variety of sizes and a workpiece forming and holding device for use with the method. The workpiece forming device includes a base and a base frame attached to the surface of the base. An apparatus for forming a solidified mass of bone and immobilization medium is also provided which includes the workpiece forming device and a detachable former member enclosing the base frame. Bone is immersed in an immobilization medium within such workpiece forming device, which is solidified to form a solidified mass of bone and immobilization medium and then subdivided to provide particles of bone in association to with immobilization medium. The immobilization medium may be optionally removed to leave bone particles suitable for use in orthopedic applications including implants.

公开(公告)号：EP1742595A2

公开(公告)日：2007-01-17

申请号：EP05741807.1

申请日：2005-05-04

申请人： Osteotech, Inc.,

发明人： WINTERBOTTOM, John, M. ,  BELANEY, Ryan ,  KNAACK, David ,  BOYCE, Todd, M. ,  SHIMP, Lawrence, A. ,  LEE, Samuel ,  KAES, David

IPC分类号： A61F2/00

CPC分类号： A61F2/28 ,  A61F2/4644 ,  A61F2002/30062 ,  A61F2002/3093 ,  A61F2002/4645 ,  A61F2210/0004 ,  A61F2310/00179

摘要： An implant including a cell conducting phase and a binder phase. At least a portion of the surface of the implant includes the cell conducting phase, and the cell conducting phase defines a path from the surface of the implant to an interior of the implant.

公开(公告)号：EP0880345B1

公开(公告)日：2006-04-05

申请号：EP97901455.2

申请日：1997-01-16

申请人： Osteotech, Inc.

发明人： DOWD, Michael ,  SCARBOROUGH, Nelson ,  DAUGHERTY, Mark ,  McMICKLE, Jack

IPC分类号： A61F2/28 ,  A61L27/00

CPC分类号： A61L27/3691 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/4644 ,  A61F2002/30957 ,  A61F2002/4649 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L27/3687 ,  A61L2430/40 ,  Y10S623/901 ,  Y10S623/919

摘要： A process for fabricating shaped material from demineralized bone particles includes the steps of applying a liquid slurry of demineralized bone particles to a support, removing excess liquid from the demineralized bone particles to provide a coherent shaped mass of demineralized bone particles (50), and warming the shaped mass of demineralized bone particles at a predetermined temperature and for a predetermined time period (60). The resultant bone mass exhibits enhanced tensile strength and minimal bone particle disassociation upon rehydration thereby improving product handling and application at the operative site.

公开(公告)号：EP1578957A1

公开(公告)日：2005-09-28

申请号：EP03797000.1

申请日：2003-12-12

申请人： Osteotech, Inc.

发明人： WINTERBOTTOM, John, M. ,  KAES, David

IPC分类号： C12N5/00 ,  A61K9/00

CPC分类号： A61L24/00 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L27/3847 ,  A61L27/40 ,  A61L27/446 ,  A61L27/46 ,  A61L2430/02 ,  C08L67/04

摘要： A composite osteoimplant. The osteoimplant includes a polymer and bone-derived particles. The composite is adapted and constructed to be formable during or immediately prior to implantation and to be set after final surgical placement.

公开(公告)号：EP1328304B1

公开(公告)日：2005-02-09

申请号：EP01988599.5

申请日：2001-10-23

申请人： Osteotech, Inc., ,  Shimp, Lawrence A.

发明人： SHIMP, Lawrence, A.

IPC分类号： A61L27/50 ,  A61L27/54

CPC分类号： A61B17/7095 ,  A61B17/7097 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2430/38

摘要： A flowable vertebral augmentation composition for the treatment and repair of a vertebral body defect, e.g., an osteoporotic condition, contains biocompatible, optionally osteoconductive, support elements that are resistant to deformation or fracture under the normal physiologic loads to which the repair site is subject, the support elements being incorporable into the repair site, at least one osteoinductive susbtance and an amount of biocompatible carrier sufficient to render the augmentation composition flowable, the carrier having the capacity to be cleared from the repair site.

公开(公告)号：EP1150624B1

公开(公告)日：2004-12-29

申请号：EP99905808.4

申请日：1999-02-05

申请人： Osteotech, Inc.,

发明人： BOYCE, Todd, M. ,  MANRIQUE, Albert ,  SCARBOROUGH, Nelson, L. ,  RUSSELL, James, L.

IPC分类号： A61F2/28 ,  A61L27/00

CPC分类号： A61L27/3683 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/442 ,  A61F2/4455 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/2839 ,  A61F2002/2882 ,  A61F2002/30059 ,  A61F2002/30113 ,  A61F2002/30125 ,  A61F2002/30138 ,  A61F2002/30153 ,  A61F2002/30154 ,  A61F2002/30224 ,  A61F2002/30261 ,  A61F2002/30448 ,  A61F2002/30599 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30971 ,  A61F2002/448 ,  A61F2220/005 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/0017 ,  A61F2230/0019 ,  A61F2230/0021 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2250/0063 ,  A61F2310/00293 ,  A61L27/3608 ,  A61L27/365 ,  A61L2430/02

摘要： A bone-derived implant (20) is provided which is made up of one or more layers (22, 23) of fully mineralized or partially demineralized cortical bone and, optionally, one or more layers (22, 23) of some other material. The layers (22, 23) constituting the implant (20) are assembled into a unitary structure to provide an implant (20) exhibiting good overall load-supporting properties.

公开(公告)号：EP1439802A2

公开(公告)日：2004-07-28

申请号：EP02778655.7

申请日：2002-10-28

申请人： Osteotech, Inc.

发明人： WINTERBOTTOM, John ,  MARTZ, Erik, O. ,  KAES, David, R. ,  ROSENTHAL, Daniel, Evan

IPC分类号： A61F2/44

CPC分类号： A61F2/4455 ,  A61B17/2816 ,  A61B17/282 ,  A61B17/2833 ,  A61B2017/2845 ,  A61F2/28 ,  A61F2/442 ,  A61F2/4465 ,  A61F2/4611 ,  A61F2002/2825 ,  A61F2002/2835 ,  A61F2002/2839 ,  A61F2002/30131 ,  A61F2002/30153 ,  A61F2002/302 ,  A61F2002/3023 ,  A61F2002/30235 ,  A61F2002/30772 ,  A61F2002/30774 ,  A61F2002/30789 ,  A61F2002/3082 ,  A61F2002/30904 ,  A61F2002/4475 ,  A61F2002/448 ,  A61F2002/4622 ,  A61F2002/4623 ,  A61F2002/4627 ,  A61F2002/4628 ,  A61F2002/4649 ,  A61F2002/4681 ,  A61F2230/0013 ,  A61F2230/0019 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61F2310/00023

摘要： Spinal and other implants may be bone or synthetic material shaped as rings, C-shaped or rectangular and so on. The implants have one or more recesses aligned in an insertion direction at either or both outer peripheral sides of the implant. In a ring implant, e.g., formed from a transverse slice of the diaphysis of a long bone or otherwise, the recesses are aligned overlying the opposing sides of the ring parallel to the insertion direction, which sides are stronger than the more central region overlying and aligned with a central chamber in the implant. One or two spaced recesses on opposite sides (150) of an implant have surface(s) transverse to the insertion direction receive the tips of implant insertion gripping jaws for receiving an insertion load imparted by the tips.

公开(公告)号：EP1408884A1

公开(公告)日：2004-04-21

申请号：EP02753372.8

申请日：2002-07-12

申请人： Osteotech, Inc., ,  Kaes, David R. ,  Morris, John W. ,  Shimp, Lawrence A. ,  Winterbottom, John ,  Geisler, Fred

发明人： KAES, David, R. ,  MORRIS, John, W. ,  SHIMP, Lawrence, A. ,  WINTERBOTTOM, John ,  GEISLER, Fred

IPC分类号： A61F2/28 ,  A61F2/44

CPC分类号： A61F2/28 ,  A61B17/86 ,  A61F2/30965 ,  A61F2/4455 ,  A61F2/446 ,  A61F2002/2839 ,  A61F2002/30057 ,  A61F2002/30059 ,  A61F2002/30062 ,  A61F2002/30131 ,  A61F2002/30176 ,  A61F2002/30354 ,  A61F2002/30405 ,  A61F2002/30492 ,  A61F2002/30578 ,  A61F2002/30677 ,  A61F2002/30777 ,  A61F2002/30785 ,  A61F2002/30836 ,  A61F2002/30841 ,  A61F2002/3085 ,  A61F2002/30904 ,  A61F2002/4475 ,  A61F2002/449 ,  A61F2210/0004 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00131 ,  A61F2310/00293 ,  A61F2310/00365

摘要： An implant unit used in surgery has a body made from osteogenic implantable material and including an implant portion and a retaining portion, which is coupled to and extends transversely to the implant portion. The retaining portion is attached to the sidewall of the adjoining vertebral body or mammal bone to prevent displacement of the implant portion relative to the vertebral body or mammal bone and to accelerate fusion therebetween.

公开(公告)号：EP1383549A1

公开(公告)日：2004-01-28

申请号：EP02714875.8

申请日：2002-02-12

申请人： Osteotech, Inc.,

发明人： SHIMP, Lawrence, A. ,  SYBERT, Daryl, R.

IPC分类号： A61L27/36 ,  A61L27/40 ,  A61L27/54 ,  A61F2/30 ,  A61F2/44

CPC分类号： A61L27/3843 ,  A61F2/28 ,  A61F2/3872 ,  A61F2/442 ,  A61F2/4644 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/30018 ,  A61F2002/30059 ,  A61F2002/302 ,  A61F2002/30677 ,  A61F2002/30678 ,  A61F2002/4649 ,  A61F2230/0065 ,  A61F2250/0029 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/3645 ,  A61L27/3658 ,  A61L27/3683 ,  A61L27/3695 ,  A61L27/40 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2430/02

摘要： An implant which is particularly suitable for the repair and/or replacement of a skeletal joint, e.g., a vertebral joint, includes a unit of monolithic bone possessing at least one demineralized region exhibiting properties of flexibility and resilience, the demineralized region having diminished or insignificant capacity for promoting new bone growth.