公开(公告)号：EP2069396A2

公开(公告)日：2009-06-17

申请号：EP07837882.5

申请日：2007-09-07

申请人： Ambrx, Inc.

发明人： SHEFFER, Joseph ,  NORMAN, Thea ,  DIMARCHI, Richard, D. ,  PUTNAM, Anna-maria A., Hays ,  FENG, Tian ,  CHU, Stephanie ,  KRAWITZ, Denise ,  CHO, Ho, Sung

IPC分类号： C07K14/435 ,  C07K14/765 ,  C07K16/42 ,  C07K16/46

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/765 ,  C07K19/00 ,  C07K2319/00

摘要： Modified human plasma polypeptides or Fc and uses thereof are provided.

公开(公告)号：EP1937824A4

公开(公告)日：2009-06-17

申请号：EP05853071

申请日：2005-12-01

申请人： AMBRX INC

发明人： TIAN FENG

IPC分类号： C12P13/20 ,  C12N9/10 ,  C12N15/11 ,  C12N15/12 ,  C12N15/54 ,  C12P13/06 ,  C12P21/00

CPC分类号： C12N15/11 ,  C12N9/93 ,  C12P21/02

摘要： Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA’s, orthogonal aminoacyl- tRNA synthetases, and orthogonal pairs of tRNA’s /synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.

公开(公告)号：EP1978989A2

公开(公告)日：2008-10-15

申请号：EP06849074.7

申请日：2006-12-27

申请人： Ambrx, Inc.

发明人： MIAO, Zhenwei ,  LIU, Junjie

IPC分类号： A61K38/16

CPC分类号： C07K1/1072 ,  C07D231/12 ,  C07K14/61 ,  C12N9/93

摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one heterocycle, aldol-based, dicarbonyl, and/or diamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one heterocycle, aldol-based, dicarbonyl, and/or diamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

公开(公告)号：EP1836298A4

公开(公告)日：2008-07-09

申请号：EP05852740

申请日：2005-12-01

申请人： AMBRX INC

发明人： PAULSEL ANDREW ,  CHO HO SUNG

IPC分类号： C12N15/52 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N15/63 ,  C12P21/02

CPC分类号： C12N9/93 ,  C12P21/02

公开(公告)号：EP1836316A2

公开(公告)日：2007-09-26

申请号：EP05857169.6

申请日：2005-12-21

申请人： Ambrx, Inc.

发明人： BUECHLER, Ying ,  LIEU, Ricky ,  ONG, Michael ,  BUSSELL, Stuart ,  KNUDSEN, Nick ,  CHO, Ho Sung

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C07K14/61 ,  A61K38/27

CPC分类号： C07K14/61

摘要： The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.

公开(公告)号：EP1836314A2

公开(公告)日：2007-09-26

申请号：EP05855151.6

申请日：2005-12-21

申请人： Ambrx, Inc.

发明人： CHO, Ho, Sung ,  DANIEL, Thomas, O. ,  DIMARCHI, Richard, D. ,  HAYS, Anna-Maria ,  WILSON, Troy, E. ,  SIM, Bee-Cheng ,  LITZINGER, David, C.

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C07K14/61 ,  A61K38/27

CPC分类号： A61K38/27 ,  A61K9/0019 ,  A61K9/19 ,  A61K47/02 ,  A61K47/183 ,  A61K47/26 ,  C07K14/61 ,  C08G65/33396

摘要： Modified growth hormone polypeptide and uses thereof are provided.

公开(公告)号：EP1836298A2

公开(公告)日：2007-09-26

申请号：EP05852740.9

申请日：2005-12-01

申请人： AMBRX, INC.

发明人： PAULSEL, Andrew ,  CHO, Ho Sung

IPC分类号： C12N9/22 ,  C12P21/02

CPC分类号： C12N9/93 ,  C12P21/02

摘要： Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA’s, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA’s/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.

公开(公告)号：EP1828224A2

公开(公告)日：2007-09-05

申请号：EP05855215.9

申请日：2005-12-21

申请人： Ambrx, Inc.

发明人： MIAO, Zhenwei ,  LIU, Junjie ,  NORMAN, Thea ,  DRIVER, Russell

IPC分类号： C07K1/02

CPC分类号： C07C225/10 ,  A61K31/198 ,  A61K38/17 ,  A61K47/08 ,  A61K47/10 ,  A61K47/34 ,  A61K47/60 ,  C07C229/36 ,  C07C237/32 ,  C07C251/28 ,  C07C251/54 ,  C07C251/60 ,  C07C251/86 ,  C07C323/63 ,  C07C2601/08 ,  C07D209/38 ,  C07D209/46 ,  C07D307/83 ,  C07D307/88 ,  C07D307/89 ,  C07D317/22 ,  C07D317/26 ,  C07D317/28 ,  C07D317/30 ,  C07D333/72 ,  C07K14/61 ,  C12P21/02 ,  G01N33/5008 ,  G01N33/68 ,  G01N33/6848 ,  G01N2500/00 ,  Y02A50/473 ,  Y02P20/55

摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oximine, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

公开(公告)号：EP1740608A2

公开(公告)日：2007-01-10

申请号：EP05712243.4

申请日：2005-01-28

申请人： AMBRX, INC.

发明人： CHO, Ho Sung ,  DANIEL, Thomas ,  DiMARCHI, Richard ,  HAYS, Anna-Maria ,  WILSON, Troy ,  SIM, Bee-Cheng ,  LITZINGER, David

IPC分类号： C07K14/435

CPC分类号： C07H21/04 ,  A61K38/21 ,  A61K38/27 ,  A61K47/60 ,  C07K14/475 ,  C07K14/52 ,  C07K14/575 ,  C07K14/61 ,  C08G65/33396 ,  G01N33/6875 ,  G01N2500/00

摘要： Modified human growth hormone polypeptides and uses thereof are provided.

公开(公告)号：EP1675620A4

公开(公告)日：2006-12-27

申请号：EP04794581

申请日：2004-10-07

申请人： AMBRX INC

发明人： WILSON TROY E

IPC分类号： A61K47/34 ,  A61K47/48 ,  C08F8/00 ,  C08F8/30 ,  C08F16/06 ,  C08F216/16 ,  C08G2/28 ,  C08G59/00 ,  C08G65/08 ,  C08G65/325 ,  C08G65/48 ,  C12N20060101

CPC分类号： C08G65/325 ,  C08F8/02 ,  C08F8/30 ,  C08F216/16 ,  C08G65/329 ,  C08G65/333

摘要： The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification of proteins with PEG derivatives, which involves the selective incorporation of non-genetically encoded amino acids, e.g., those amino acids containing an azide or acetylene moiety, into proteins in response to a selector codon and the subsequent modification of those amino acids with a suitably reactive PEG derivative.