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公开(公告)号：EP2871239A9
公开(公告)日：2015-06-24
申请号：EP13813664.3
申请日：2013-06-26
申请人： Takara Bio, Inc.
IPC分类号： C12N15/113 , C12N5/10 , C12N15/09
CPC分类号： C12N15/86 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/111 , C12N15/64 , C12N2310/141 , C12N2330/51 , C12N2501/65 , C12N2750/14143 , C12N2750/14151 , C12P19/34
摘要： According to the present invention, an AAV vector having a higher titer compared with those of conventional ones can be produced using a cell into which a nucleic acid capable of expressing miRNA is introduced artificially. An AAV vector produced using the cell and a composition containing the viral vector as an active ingredient are very useful as gene transfer means in the studies or clinical practice of gene therapies.
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公开(公告)号：EP2871239A1
公开(公告)日：2015-05-13
申请号：EP13813664.3
申请日：2013-06-26
申请人： Takara Bio, Inc.
IPC分类号： C12N15/113 , C12N5/10 , C12N15/09
CPC分类号： C12N15/86 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/111 , C12N15/64 , C12N2310/141 , C12N2330/51 , C12N2501/65 , C12N2750/14143 , C12N2750/14151 , C12P19/34
摘要： According to the present invention, an AAV vector having a higher titer compared with those of conventional ones can be produced using a cell into which a nucleic acid capable of expressing miRNA is introduced artificially. An AAV vector produced using the cell and a composition containing the viral vector as an active ingredient are very useful as gene transfer means in the studies or clinical practice of gene therapies.
摘要翻译： 根据本发明，可以使用其中人工引入了能够表达miRNA的核酸的细胞来生产与常规的AAV载体相比具有更高滴度的AAV载体。 使用该细胞和含有病毒载体作为活性成分的组合物产生的AAV载体作为基因治疗的研究或临床实践中的基因转移手段非常有用。
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公开(公告)号：EP2829606A1
公开(公告)日：2015-01-28
申请号：EP13763874.8
申请日：2013-03-14
申请人： Takara Bio, Inc.
CPC分类号： C12N15/86 , A61K35/13 , A61K48/00 , C12N5/0018 , C12N7/00 , C12N2740/10041 , C12N2740/10051 , C12N2740/10052
摘要： The present invention provides a method for producing a virus vector, which involves a step of culturing a cell capable of producing the virus vector in a culture medium containing a retinoic acid compound, a histone deacetylase-inhibiting substance and a substance capable of forming a chelate; and a culture medium for use in the production of a virus vector, which is characterized by containing a retinoic acid compound, a histone deacetylase-inhibiting substance and a substance capable of forming a chelate as active ingredients.
摘要翻译： 本发明提供一种病毒载体的制备方法，其包括在含有维甲酸化合物，组蛋白脱乙酰酶抑制物质和能够形成螯合物的培养基中培养能够产生病毒载体的细胞的步骤 ; 以及用于生产病毒载体的培养基，其特征在于含有视黄酸化合物，组蛋白脱乙酰酶抑制物质和能够形成螯合物的物质作为活性成分。
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公开(公告)号：EP2116600B1
公开(公告)日：2013-09-18
申请号：EP09167571.0
申请日：1999-04-21
申请人： TAKARA BIO INC.
发明人： Asada, Kiyozo , Sato, Yoshimi , Uemori, Takashi , Fujita, Tomoko , Miyake, Kazue , Takeda, Osamu , Mukai, Hiroyuki , Kato, Ikunoshin
CPC分类号： C12P19/34 , C12N9/1252 , C12N9/96 , C12Q1/6806 , Y10S435/975 , C12Q2521/107
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85.发明公开
公开(公告)号：EP2471901A4
公开(公告)日：2013-06-26
申请号：EP10811841
申请日：2010-08-24
申请人： TAKARA BIO INC
发明人： KATAYAMA YOSHINORI , SAKAI KENSUKE , YOSHIOKA HIROFUMI , TAKAKURA HIKARU , CHONO HIDETO , SAITO NAOKI , MINENO JUNICHI
CPC分类号： C12N5/0636 , C12N2501/385 , C12N2501/515 , C12N2501/58 , C12N2510/00
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公开(公告)号：EP2468850A4
公开(公告)日：2013-02-20
申请号：EP10809959
申请日：2010-08-17
申请人： TAKARA BIO INC
发明人： TANABE MASASHIGE , ISONO TOMOMI , ENOKI TATSUJI
CPC分类号： A01N1/0221
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公开(公告)号：EP2305793B1
公开(公告)日：2012-10-17
申请号：EP10185168.1
申请日：2003-03-25
申请人： TAKARA BIO INC.
发明人： Ideno, Mitsuko , Kato, Ikunoshin , Sagawa, Hiroaki
IPC分类号： A61K35/14 , A61P37/02 , A61P35/00 , A61P31/04 , C12N5/0783
CPC分类号： C12N5/0638 , A61K2035/124 , C12N5/0636 , C12N2501/58 , C12N2510/00
摘要： The present invention relates to a method for preparing a cytotoxic lymphocyte characterized in that the method comprises the step of carrying out at least one of induction, maintenance and expansion of a cytotoxic lymphocyte in the presence of fibronectin, a fragment thereof or a mixture thereof.
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公开(公告)号：EP1757698B1
公开(公告)日：2012-05-23
申请号：EP05739279.7
申请日：2005-05-12
申请人： Takara Bio, Inc.
发明人： SATO, Yoshimi, c/o Takara Bio Inc. , NISHIWAKI, Kazue, c/o Takara Bio Inc. , SHIMADA, Nana, c/o Takara Bio Inc. , HOKAZONO, Shigekazu, c/o Takara Bio Inc. , UEMORI, Takashi, c/o Takara Bio Inc. , MUKAI, Hiroyuki, c/o Takara Bio Inc. , KATO, Ikunoshin, c/o Takara Bio Inc.
CPC分类号： C12Q1/686 , C12N9/1252 , C12Q2521/101
摘要： A polypeptide having a high fidelity DNA polymerase activity and thus being useful as a genetic engineering reagent; a gene encoding this polypeptide; a method of producing the polypeptide; and a method of amplifying a nucleic acid by using the polypeptide.
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公开(公告)号：EP1762609B1
公开(公告)日：2012-04-04
申请号：EP06019209.3
申请日：2006-09-13
申请人： TAKARA BIO INC.
发明人： Yoshioka, Hirofumi , Katayama, Yasushi , Tomura, Daisuke , Funakoshi, Masao , Matsumoto, Kazuya , Mineno, Junichi , Takesako, Kazutoh , Kato, Ikunoshin
CPC分类号： C12N5/0037 , C12N2500/84 , C12N2510/02
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公开(公告)号：EP1225229B1
公开(公告)日：2011-10-19
申请号：EP00969984.4
申请日：2000-10-23
申请人： TAKARA BIO INC.
发明人： UENO, Takashi , MATSUMURA, Hajime , TANAKA, Keiji , IWASAKI, Tomoko , UENO, Mitsuhiro , FUJINAGA, Kei , ASADA, Kiyozo , KATO, Ikunoshin
CPC分类号： C12N15/86 , C12N2710/10343 , C12N2800/30
摘要： A method of transferring a foreign gene into cells, characterized by involving: the step of transferring into the cells with the use of an adenovirus vector, a first nucleic acid, which has a sequence provided with adeno-associated virus-origin ITRs in both sides of the target foreign gene to be transferred, and a second nucleic acid, which has an adeno-associated virus-origin rep gene and a promoter for expressing this gene and carries a stuffer sequence inserted thereinto sandwiched in two recombinase recognition sequences and located between the rep gene and the promoter; and the step of expressing the Rep protein under the action of recombinase in the cells obtained in the above step to thereby integrate the target foreign gene into the chromosomal DNA.
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