公开(公告)号：EP1000164B1

公开(公告)日：2005-11-23

申请号：EP98918556.6

申请日：1998-04-22

申请人： PIONEER HI-BRED INTERNATIONAL, INC.

发明人： ALBERTSEN, Marc, C. ,  HOWARD, John, A. ,  MADDOCK, Sheila

IPC分类号： C12N15/82 ,  C12N15/12 ,  A01H5/00

CPC分类号： C12N15/8222 ,  C07K14/465 ,  C12N15/8231 ,  C12N15/8257 ,  C12N15/8289

摘要： Male-sterile plants can be produced by increasing the endogenous concentration of avidin in the plant tissues. This effect can be achieved by producing transgenic plants containing an expression vector in which a promoter is operably linked to a DNA sequence encoding avidin. Methods for restoring male fertility are disclosed. Additionally, methods for production of seeds with one or more desired grain traits are provided.

公开(公告)号：EP1546195A1

公开(公告)日：2005-06-29

申请号：EP03792443.8

申请日：2003-08-22

申请人： Jyväskylän Yliopisto

发明人： KULOMAA, Markuu, Sakari ,  NORDLUND, Henri, Rainer ,  LAITINEN, Olli-Heikki ,  HYTÖNEN, Vesa

IPC分类号： C07K14/465

CPC分类号： C07K14/465

摘要： The present invention relates to new mutants of biotin binding proteins with improved properties, e.g., thermally stabilized compared to wild type proteins. Proteins, which bind biotin include chicken avidin and bacterial streptavidin, other poultry avidins, such as avidin proteins isolated from the duck, goose, ostrich and turkey, and chicken avidin-related proteins (AVRs).

公开(公告)号：EP1309680A2

公开(公告)日：2003-05-14

申请号：EP01927291.3

申请日：2001-04-24

申请人： YALE UNIVERSITY

发明人： SCHEPARTZ SHRADER, Alanna ,  CHIN, Jason, W., K. ,  ZUTSHI, Reena ,  RUTLEDGE, Stacey, Erin ,  KEHLBECK MARTIN, Joanne, D. ,  ZONDLO, Neal, Joseph

IPC分类号： C12N15/10 ,  C12N15/12 ,  C12N15/62 ,  G01N33/50 ,  G01N33/68 ,  C07K14/465 ,  C07K14/47

CPC分类号： C40B40/02 ,  C07K14/00 ,  C07K14/465 ,  C07K2319/00 ,  C12N15/1037 ,  C12N15/62

摘要： The present invention provides a protein scaffold, such as an avian pancreatic polypeptide, that can be modified by substitution of two or more amino acid residues that are exposed on the alpha helix domain of the polypeptide when the polypeptide is in a tertiary form.

公开(公告)号：EP1224311A1

公开(公告)日：2002-07-24

申请号：EP00972745.4

申请日：2000-10-12

申请人： BOEHRINGER INGELHEIM INTERNATIONAL GmbH

发明人： COTTEN, Matthew ,  GLOTZER, Jolanta ,  MICHOU, Anne-Isabelle

IPC分类号： C12N15/861 ,  A61K35/76

CPC分类号： C12N15/86 ,  C07K14/005 ,  C07K14/465 ,  C07K2319/20 ,  C12N7/00 ,  C12N2710/10221 ,  C12N2710/10222 ,  C12N2710/10243

摘要： Recombinant CELO virus or CELO virus DNA with a deletion or disruption of the Gam1 gene, optionally combined with deletions at the right or left end of the viral genome that allow insertion of large pieces of foreign DNA. The virus is useful as a vaccine for animals, in particular birds, and for gene therapy and vaccine applications in humans. The virus can also be used for recombinant protein production.

摘要翻译： 具有Gam1基因缺失或破坏的重组CELO病毒或CELO病毒DNA，任选地在病毒基因组的右端或左端结合缺失，允许插入大片外源DNA。 该病毒可用作动物特别是鸟类的疫苗，以及用于人类的基因治疗和疫苗应用。 该病毒也可用于重组蛋白质的生产。

公开(公告)号：EP0813545A4

公开(公告)日：2002-04-24

申请号：EP96911262

申请日：1996-03-07

申请人： UNIV YALE ,  IMP CANCER RES TECH

发明人： ISH-HOROWICZ DAVID ,  HENRIQUE DOMINGOS M P ,  LEWIS JULIAN H ,  MYAT ANNA M ,  ARTAVANIS-TSAKONAS SPYRIDON ,  MANN ROBERT S ,  GRAY GRACE E

IPC分类号： C12N15/09 ,  A61K31/70 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  A61P25/00 ,  A61P35/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/465 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C07K19/00 ,  C12N5/10 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/577 ,  C07K14/00 ,  A01N37/18 ,  A01N43/04 ,  C07H17/00 ,  C12N5/00 ,  C12P21/06

CPC分类号： C07K14/465 ,  A61K38/00 ,  C07K14/43504 ,  C07K14/43581 ,  C07K14/46 ,  C07K14/463 ,  C07K14/705

公开(公告)号：EP1197496A1

公开(公告)日：2002-04-17

申请号：EP00946453.8

申请日：2000-07-24

申请人： Kangawa, Kenji

发明人： KANGAWA, Kenji ,  KOJIMA, Masayasu ,  HOSODA, Hiroshi, Towa Minoo Homes A808 ,  MATSUO, Hisayuki ,  MINAMITAKE, Y., Suntory Inst. for Med. Res.& Dev.

IPC分类号： C07K14/47 ,  C12N15/12 ,  C12N1/21 ,  C12P21/02 ,  C07K16/18 ,  A61K38/18 ,  A61P5/06 ,  A61P19/08 ,  A61K45/00 ,  A61K48/00 ,  G01N33/53

CPC分类号： C07K14/575 ,  A01K2217/05 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/42 ,  A61K48/00 ,  C07K14/461 ,  C07K14/463 ,  C07K14/465 ,  C07K14/47 ,  C07K14/4702

摘要： The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明提供诱导生长激素分泌的具有增加细胞内钙离子浓度的活性的新型肽类化合物，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸置换 化合物或其药学上可接受的盐。

公开(公告)号：EP0902834A4

公开(公告)日：2001-09-26

申请号：EP96937780

申请日：1996-10-28

申请人： SQUIBB BRISTOL MYERS CO

发明人： BURTON STEVEN J ,  PEARSON JAMES C ,  EDWARDSON PETER A D

IPC分类号： C12N11/10 ,  A61L2/00 ,  A61L24/10 ,  C07K1/22 ,  C07K14/36 ,  C07K14/465 ,  C07K14/75 ,  C07K17/10 ,  C12N11/16 ,  C12P21/06 ,  C12N11/00 ,  C12N11/02 ,  G01N33/53

CPC分类号： C07K14/36 ,  A61L2/0035 ,  A61L24/106 ,  C07K1/22 ,  C07K14/465 ,  C07K14/75 ,  C07K17/10 ,  C12P21/06 ,  Y10S435/966 ,  Y10S435/967 ,  Y10S435/972 ,  Y10S530/81 ,  Y10S530/812 ,  Y10S530/813

摘要： Compositions and methods for avidin immobilized on an inert support material, e.g., agarose, are disclosed. The compositions have high activity levels of avidin and may further include a bulking agent, e.g., maltose, and a protectant to maintain the stability and integrity of the avidin agarose during lyophilization and terminal sterilization processes. These compositions have applicability in any instance wherein avidin, agarose and/or the avidin/biotin technology are useful. In particular, the present compositions are useful in an enzyme capture system to prepare fibrin monomer useful for fibrin sealants.

公开(公告)号：EP0713395A4

公开(公告)日：2000-01-19

申请号：EP94923410

申请日：1994-07-12

申请人： NEORX CORP

发明人： GUSTAVSON LINDA M ,  ANDERSON DAVID C ,  MORGAN ALTON C JR

IPC分类号： A61K38/00 ,  A61K47/48 ,  C07K14/36 ,  C07K14/465 ,  C07K14/47 ,  C07K14/72 ,  C07K14/76 ,  A61K39/44

CPC分类号： B82Y5/00 ,  A61K38/00 ,  A61K47/62 ,  A61K47/6883 ,  A61K47/6897 ,  A61K47/6898 ,  C07K14/36 ,  C07K14/465 ,  C07K14/47 ,  C07K14/473 ,  C07K14/721 ,  C07K14/723 ,  C07K14/76

摘要： Polymeric carriers are polypeptides comprising at least one drug-binding domain that non-covalently binds a drug. A polymeric carrier may be attached to an antibody specific for desired target cells to form immunoconjugates that deliver a drug to the target cells in vivo. A polymeric carrier may be attached to a proteinaceous or a non-proteinaceous ligand or anti-ligand to form a conjugate useful in pretargeting protocols to deliver a drug to target cells in vivo. The carriers are derived from drug-binding proteins and produced through peptide synthesis or recombinant DNA technology.

公开(公告)号：EP0876400A2

公开(公告)日：1998-11-11

申请号：EP97903858.0

申请日：1997-01-15

申请人： THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： LAUFER, Edward, M. ,  OROZCO, Olivia, E. ,  TABIN, Clifford, J.

IPC分类号： C07K14 ,  A61K38

CPC分类号： C07K14/465 ,  A01K2217/05 ,  A61K38/00 ,  C12N2799/027

摘要： Isolated DNA encoding a protein or polypeptide having at least one biological activity of a vertebrate fringe protein, as well as the protein or polypeptide encoded thereby, are described. Assays for identifying agents which alter the expression of the described fringe genes and assays for agents which alter the production of angiogenic precursors, the formation of the apical ectodermal ridge and the subdivisions of the neural tube are also described.

公开(公告)号：EP0868521A2

公开(公告)日：1998-10-07

申请号：EP96945282.0

申请日：1996-12-20

申请人： Somatogen Inc.

发明人： ANTHONY-CAHILL, Spencer, J. ,  EPP, Janet, K. ,  KERWIN, Bruce, A. ,  OLINS, Peter, O. ,  MATHEWS, Antony, J.

IPC分类号： C07K14

CPC分类号： C07K14/005 ,  C07K14/39 ,  C07K14/465 ,  C07K14/4746 ,  C07K14/78 ,  C07K14/805 ,  C07K2319/00 ,  C12N2795/10322

摘要： The present invention relates to globins containing non-naturally occurring binding domains. Such non-naturally occurring binding domains can be oligomerizing domains or can be ligand binding domains. The present invention also relates to multimeric hemoglobins comprised of at least one globin containing at least one non-naturally occurring binding domain.