公开(公告)号：EP3382025A1

公开(公告)日：2018-10-03

申请号：EP18172189.5

申请日：2010-06-04

申请人： Toyota Jidosha Kabushiki Kaisha

发明人： YONEKURA, Madoka ,  OHTO, Chikara ,  MURAMOTO, Nobuhiko ,  MITSUKAWA, Norihiro ,  TAKAGI, Masaru ,  MATSUI, Kyoko

IPC分类号： C12N15/29 ,  A01H5/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C07K14/415 ,  C07K19/00 ,  C12N15/82

CPC分类号： C12N15/8251 ,  C07K14/415

摘要： According to the present invention, a gene having a novel function that can cause an increase or decrease in seed protein content is searched for. A chimeric protein obtained by fusing a transcription factor consisting of a protein comprising an amino acid sequence shown in any of the even-numbered SEQ ID NOS: 1 to 76 and a functional peptide capable of converting an arbitrary transcription factor into a transcriptional repressor or a transcription factor consisting of a protein comprising an amino acid sequence shown in any of the even-numbered SEQ ID NOS: 77 to 84 is expressed in a plant.

公开(公告)号：EP3378931A1

公开(公告)日：2018-09-26

申请号：EP17162104.8

申请日：2017-03-21

申请人： Purac Biochem B.V.

发明人： de Bont, Johannes Adrianus Maria ,  Ruijssenaars, Harald Johan ,  Werij, Jan

IPC分类号： C12N1/15 ,  C12N1/19 ,  C07K14/385 ,  C12N9/02 ,  C12P17/04

CPC分类号： C12N9/0073 ,  C07K14/385 ,  C12P7/42 ,  C12P7/44 ,  C12P7/62 ,  C12P17/04

摘要： The invention relates to fungal cells for the production of FDCA. The fungal cell has genetic modification that reduces specific 2,5-furandicarboxylic acid (FDCA) decarboxylating monooxygenase activity in the cell, as compared to a corresponding parent cell lacking the genetic modification. The fungal cell can further be genetically modified to increase the cell's ability to oxidize furanic aldehydes to the corresponding furanic carboxylic acids. The invention also relates to a process for the production of 2,5-furan-dicarboxylic acid (FDCA) wherein the cells of the invention are used for oxidation of a furanic precursors of FDCA to FDCA.

公开(公告)号：EP2647707B1

公开(公告)日：2018-09-12

申请号：EP11845786.0

申请日：2011-11-30

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： NEZU, Junichi ,  ISHIGURO, Takahiro ,  NARITA, Atsushi ,  SAKAMOTO, Akihisa ,  KAWAI, Yumiko ,  IGAWA, Tomoyuki ,  KURAMOCHI, Taichi

IPC分类号： C12N15/09 ,  A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  C07K16/46 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C07K16/30

CPC分类号： C07K16/46 ,  A61K2039/505 ,  C07K16/2809 ,  C07K16/2863 ,  C07K16/30 ,  C07K16/303 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/30

摘要： By replacing the antigen-binding domain, the present inventors discovered novel polypeptide complexes that retain BiTE's strong anti-tumor activity and excellent safety properties, as well as have long half-life in blood and can damage various different target cells.

公开(公告)号：EP3080243B1

公开(公告)日：2018-09-05

申请号：EP14869116.5

申请日：2014-12-10

申请人： Yeda Research and Development Co., Ltd.

发明人： BAR-EVEN, Arren ,  MILO, Ron ,  NOOR, Elad ,  ZELCBUCH, Lior

IPC分类号： C12N1/13 ,  C12N1/15 ,  C12N1/21 ,  C12P7/00 ,  C12P21/02 ,  C12R1/185

CPC分类号： C12P7/40 ,  C12N1/20 ,  C12N9/1029 ,  C12N15/52 ,  C12P5/007 ,  C12P5/023 ,  C12P5/026 ,  C12P7/06 ,  C12P7/16 ,  C12P7/26 ,  C12P7/649 ,  C12Y203/01054 ,  Y02E50/17 ,  Y02E50/343

摘要： Uses of the microorganism and products comprising same are also disclosed.

公开(公告)号：EP3363499A1

公开(公告)日：2018-08-22

申请号：EP18163771.1

申请日：2011-06-10

申请人： Kyowa Hakko Kirin Co., Ltd. ,  Kyushu University National University Corporation

发明人： TAKAYANAGI, Shin-ichiro ,  TOMURA, Hitomi ,  TAWARA, Tomonori ,  INAGAKI, Yoshimasa ,  AKASHI, Koichi ,  KUBOTA, Tsuguo ,  KIKUSHIGE, Yoshikane

IPC分类号： A61P7/00 ,  A61K39/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/08

CPC分类号： C07K16/2803 ,  C07K16/2818 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/92 ,  G01N33/56972

摘要： The present invention provides an anti-human TIM-3 antibody which binds to the amino acid sequence of the extracellular region of TIM-3 or its three-dimensional structure thereof and exhibits higher effector activity such as an antibody-dependent cellular cytotoxicity (ADCC activity) for diseases relating to a human TIM-3 expressing cell. The present invention provides a monoclonal antibody or antibody fragment thereof which binds to the amino acid sequence of the extracellular region of TIM-3 or its three-dimensional structure and exhibits ADCC activity; a hybridoma which produces the antibody; a DNA encoding the antibody; a vector comprising the DNA; a transformant which is obtainable by introducing the vector; a method for producing the antibody or the antibody fragment thereof which comprises using the hybridoma or the transformant; a therapeutic agent and a diagnostic agent comprising the antibody or the antibody fragment thereof as an active ingredient. In addition, the present invention provides an anti-human TIM-3 antibody having high ADCC activity by screening an anti-human TIM-3 antibody which competes with the monoclonal antibody or the antibody fragment thereof.

公开(公告)号：EP3351629A1

公开(公告)日：2018-07-25

申请号：EP16846543.3

申请日：2016-09-14

申请人： Tokyo Institute of Technology ,  LifeIS INC.

发明人： AIZAWA Yasunori ,  KITANO Shohei ,  KIDA Yuichiro

IPC分类号： C12N15/09 ,  A01K67/027 ,  C07K14/47 ,  C07K14/575 ,  C07K16/26 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12Q1/02 ,  C12Q1/68 ,  C12P21/08

CPC分类号： A01K67/027 ,  C07K14/47 ,  C07K14/575 ,  C07K16/26 ,  C12N5/10 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/68

摘要： An object of the present invention is to provide a method for identifying a physiologically active protein translated from an ORF other than mORF present on mRNA.
The object can be solved by a method for identifying a physiologically active protein, wherein an ORF which encodes a protein having a physiological activity, other than a main open reading frame (ORF) is identified in eukaryotic mRNA, comprising the steps of: (1) introducing an expression vector incorporating a candidate ORF to cells, and culturing the introduced cells, (2) detecting a protein bound to a candidate protein by immunoprecipitating the candidate protein translated from the candidate ORF, from the cultured cells, (3) determining a candidate protein in which another protein bound to the candidate protein is detected as a physiologically active protein.

公开(公告)号：EP3345616A1

公开(公告)日：2018-07-11

申请号：EP17196942.1

申请日：2007-03-30

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： IGAWA, Tomoyuki ,  TSUNODA, Hiroyuki

IPC分类号： A61K39/00 ,  A61P43/00 ,  C07K16/00 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N15/09 ,  C12N5/10 ,  C12P21/02

CPC分类号： C07K16/00 ,  C07K16/248 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/76

摘要： The present inventors devised methods for efficiently purifying bispecific antibodies using a chromatography column based on the difference in isoelectric points between the H chains of two types of antibodies, wherein the difference is introduced by modifying the amino acids present on the surface of the antibody variable regions of two types of antibodies that constitute a bispecific antibody. Furthermore, the inventors devised methods for efficiently purifying bispecific antibodies using a chromatography column by linking respective antigen binding sites (heavy chain variable regions) to the antibody constant regions having different isoelectric points, and then coexpressing these antibodies.

公开(公告)号：EP3252074A4

公开(公告)日：2018-07-11

申请号：EP16743511

申请日：2016-01-29

申请人： UNIV SAITAMA MEDICAL ,  DAIICHI SANKYO CO LTD

发明人： KATAGIRI TAKENOBU ,  OSAWA KENJI ,  TSUKAMOTO SHO ,  TSUJI SHINNOSUKE ,  KAWAGUCHI YOSHIROU ,  NAKAMURA KENSUKE

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K45/00 ,  A61P19/08 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/08

CPC分类号： C07K16/2863 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61P7/06 ,  A61P19/08 ,  A61P35/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92

摘要： This application provides: an antibody which specifically binds to an ALK2 protein and has an activity of inhibiting BMP signal transduction mediated by ALK2; a method for producing the antibody; and a pharmaceutical composition comprising the antibody, for treating and/or preventing ectopic ossification and/or bone dysplasia, anemia, or diffuse intrinsic pontine glioma (DIPG).

公开(公告)号：EP3342874A1

公开(公告)日：2018-07-04

申请号：EP16839312.2

申请日：2016-08-24

申请人： RIKEN

发明人： NODA Shuhei ,  SHIRAI Tomokazu

IPC分类号： C12P7/22 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12P7/40 ,  C12P7/42 ,  C12P13/22 ,  C12N15/09

CPC分类号： C12P13/225 ,  C12N15/09 ,  C12P7/22 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/46 ,  C12P13/001 ,  C12P13/22

摘要： The present invention provides a method for producing an aromatic compound such as salicylic acid and a derivative thereof with high productivity using a microorganism. The present invention provides: a method for producing a microorganism having a sugar metabolic pathway modified, including suppressing the expression of a gene encoding a phosphotransferase system enzyme of the microorganism, suppressing the expression of a gene encoding pyruvate kinase of the microorganism, and introducing, into the microorganism, one or more genes encoding an enzyme that enables the microorganism to synthesize an aromatic compound from chorismic acid or isochorismic acid; a modified microorganism obtained by the method; and a method for producing an aromatic compound and a derivative thereof, including culturing the microorganism, and recovering an aromatic compound or the like from the culture.

公开(公告)号：EP3341471A2

公开(公告)日：2018-07-04

申请号：EP16839987.1

申请日：2016-08-23

申请人： White Dog Labs, Inc.

发明人： TRACY, Bryan P. ,  EYAL, Aharon M. ,  JONES, Shawn William ,  WIEDEL, Carrissa A.

IPC分类号： C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N15/52

CPC分类号： C12P7/28 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1029 ,  C12N9/1217 ,  C12P7/04 ,  C12Y101/01001 ,  C12Y102/0101 ,  C12Y102/01057 ,  C12Y102/07005 ,  C12Y203/01019 ,  C12Y207/02007

摘要： The present invention provides microorganisms capable of converting acetyl-coA into crotyl alcohol as well as fermentation methods for producing crotyl alcohol, either alone, or in combination with acetone and/or isopropanol. The microorganisms may be genetically engineered to express and/or disrupt one or more of the following enzymes: acetaldehyde dehydrogenase, alcohol dehydrogenase, bifunctional acetaldehyde/alcohol dehydrogenase, aldehyde oxidoreductase, phosphotransacetylase, acetate kinase, CoA-transferase A, CoA-transferase B, acetoacetate decarboxylase, secondary alcohol dehydrogenase, butyryl-CoA dehydrogenase (BCD), and/or trans-2-enoyl-CoA reductase (TER).