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    DESIGN OF AN IC-PROCESSED POLYMER NANO-LIQUID CHROMATOGRAPHY SYSTEM ON-A-CHIP AND METHOD OF MAKING IT
    4.
    发明公开
    DESIGN OF AN IC-PROCESSED POLYMER NANO-LIQUID CHROMATOGRAPHY SYSTEM ON-A-CHIP AND METHOD OF MAKING IT 审中-公开
    EXECUTION IC EDITED高分子纳米液系统用于生产芯片和过程

    公开(公告)号：EP1673152A4

    公开(公告)日：2009-04-01

    申请号：EP04786516

    申请日：2004-08-17

    申请人： CALIFORNIA INST OF TECHN ,  HOPE CITY

    发明人： TAI YU-CHONG ,  HE QING ,  XIE JUN ,  PANG CHANGLIN ,  LEE TERRY D

    IPC分类号： B01D15/08 ,  G01N30/60 ,  G01N30/64

    CPC分类号： H05K3/284 ,  G01N30/6047 ,  G01N30/6095 ,  G01N2030/645 ,  G03F1/80 ,  G01N2030/625

    摘要： Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, frits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC.

    MICROELECTROMECHANICAL SYSTEM SENSOR ASSEMBLY
    5.
    发明公开
    MICROELECTROMECHANICAL SYSTEM SENSOR ASSEMBLY 审中-公开
    微机电传感器系统

    公开(公告)号：EP1252484A4

    公开(公告)日：2006-08-09

    申请号：EP00991691

    申请日：2000-11-30

    申请人： CALIFORNIA INST OF TECHN

    发明人： TAI YU-CHONG ,  WU SHUYUN ,  LIN QIAO

    IPC分类号： G01F1/684

    CPC分类号： G01F1/6845

    摘要： A sensor assembly (100) has a substrate (102) with a microchannel (104) formed therein through which a fluid flows. At least one sensor (106) is proximate to the microchannel. The temperature of the at least one sensor or fluid indicates the condition of the fluid including the flow rate and the presence of gas bubbles and particulate substance.

    MULTI-LAYER PACKAGING SCHEME FOR IMPLANT ELECTRONICS
    6.
    发明公开
    MULTI-LAYER PACKAGING SCHEME FOR IMPLANT ELECTRONICS 有权
    MEHRSCHICHTVERPACKUNGSSCHEMAFÜRIMPLANTATELEKTRONIK

    公开(公告)号：EP3046869A4

    公开(公告)日：2017-04-26

    申请号：EP14846305

    申请日：2014-09-12

    申请人： CALIFORNIA INST OF TECHN

    发明人： TAI YU-CHONG ,  CHANG HAN-CHIEH

    IPC分类号： B81C1/00 ,  A61B50/30 ,  A61F2/14 ,  A61N1/36 ,  A61N1/372 ,  A61N1/375 ,  H01L21/56 ,  H01L23/00 ,  H01L23/02 ,  H01L23/31 ,  H05K5/06

    CPC分类号： H01L23/3135 ,  A61B50/30 ,  A61F2/14 ,  A61N1/36046 ,  A61N1/37211 ,  A61N1/3758 ,  B81C1/00 ,  H01L21/56 ,  H01L23/564 ,  H01L2924/0002 ,  H01L2924/00

    摘要： The present invention provides a micropackaged device comprising: a substrate for securing a device with a corrosion barrier affixed to the substrate, wherein the corrosion barrier comprises a first thin-film layer, a metal film coating the thin-film layer and a second thin-film layer to provide a sandwich layer; and optionally at least one feedthrough disposed in the substrate to permit at least one input and or at least one output line into the micropackaged device, wherein the micropackaged device is encapsulated by the corrosion barrier. Methods of producing the micropackaged device are also disclosed.

    摘要翻译： 本发明提供了一种微包装装置，包括：基底，用于固定具有附着于基底的腐蚀屏障的装置，其中腐蚀屏障包括第一薄膜层，覆盖薄膜层的金属膜和第二薄膜层， 薄膜层以提供夹心层; 以及可选地设置在所述基底中的至少一个馈通，以允许至少一个输入和/或至少一个输出线进入所述微包装装置，其中所述微包装装置由所述腐蚀屏障封装。 还公开了制造微封装器件的方法。

    METHODS AND DESIGN OF MEMBRANE FILTERS
    9.
    发明公开
    METHODS AND DESIGN OF MEMBRANE FILTERS 审中-公开
    VERFAHREN UND ENTWURFFÜR膜片

    公开(公告)号：EP2577296A4

    公开(公告)日：2015-07-15

    申请号：EP11787514

    申请日：2011-05-27

    申请人： CALIFORNIA INST OF TECHN

    发明人： TAI YU-CHONG ,  LU BO

    IPC分类号： G01N33/48 ,  B01D65/10 ,  C40B30/04 ,  G01N33/15 ,  G01N33/50 ,  G01N33/574

    CPC分类号： G01N33/5011 ,  B01D65/10

    摘要： The present invention provides methods for designing a filtration systems for capturing viable tumor cells, such as circulating tumor cells at high efficiency and high viability. The methods involve development of a set of “key engineering design parameters” that are crucial to achieve high tumor cell viability. These important design parameters include the filter geometry design, fluid delivery method, drive pressure and filtration time.

    摘要翻译： 本发明提供了用于设计用于捕获活肿瘤细胞的过滤系统的方法，例如以高效率和高生存力循环肿瘤细胞。 该方法涉及开发一组对实现高肿瘤细胞活力至关重要的“关键工程设计参数”。 这些重要的设计参数包括过滤器几何设计，流体输送方法，驱动压力和过滤时间。