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公开(公告)号：EP1572930A2
公开(公告)日：2005-09-14
申请号：EP03737682.9
申请日：2003-02-07
发明人： HAUSER, Hans-Peter , WEIMER, Thomas , ROMBERG, Val , KEE, Scott, M. , SLEEP, Darrell , LADNER, Robert, Charles , LEY, Arthur, C.
IPC分类号： C12N1/00
CPC分类号： A61K47/48315 , A01K2217/05 , A61K9/0019 , A61K31/7088 , A61K38/00 , A61K38/39 , A61K39/00 , A61K39/0005 , A61K47/643 , A61K48/00 , A61K2039/53 , C07K14/005 , C07K14/47 , C07K14/765 , C07K14/78 , C07K14/8114 , C07K2319/00 , C07K2319/31 , C12N15/62 , C12N2740/16122 , C12Y301/26003
摘要： The invention relates to albumin fusion proteins comprising an albumin fusion partner and a protease inhibitor fusion partner which may be a Kunitz domain protease inhibitor capable of inhibiting a serine protease, including neutrophil elastase, kallikrein, and plasm The fusion proteins exhibit extended shelf life and/or extended therapeutic activity in solution. The invention encompasses therapeutic albumin fusion proteins, compositions, pharmaceutical compositions, formulations and kits comprising the albumin fusion proteins, a well as nucleic acid molecules encoding the albumin fusion proteins, vectors comprising these nucleic acids, host cells transformed w these nucleic acids and vectors, and methods of making the encoded proteins using the nucleic acids, vectors and/or host cells. The invention also relates to compositions and methods for inhibiting neutrophil elastase, kallikrein, and plasmin, and to compositions an methods for treating cystic fibrosis and cancer.
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公开(公告)号：EP1326882A2
公开(公告)日：2003-07-16
申请号：EP01946519.4
申请日：2001-06-19
申请人： Dyax Corp.
CPC分类号： C07K7/06
摘要： Novel enterokinase cleavage sequences are provided. Also disclosed are methods for the rapid isolation of a protein of interest present in a fusion protein construct including a novel enterokinase cleavage sequence of the present invention and a ligand recognition sequence for capturing the fusion construct on a solid substrate. Preferred embodiments of the present invention show rates of cleavage up to thirty times that of the known enterokinase cleavage substrate (Asp)4-Lys-Ile.
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公开(公告)号：EP0573603B1
公开(公告)日：2003-06-25
申请号：EP92908481.2
申请日：1992-02-28
申请人： Dyax Corp.
发明人： LEY, Arthur, Charles , LADNER, Robert, Charles , GUTERMAN, Sonia, Kosow , ROBERTS, Bruce, Lindsay , MARKLAND, William , KENT, Rachel, Baribault
IPC分类号： C07K14/47
CPC分类号： C40B40/02 , A61K38/00 , C07K1/047 , C07K14/43522 , C07K14/8114 , C07K14/8117 , C12N7/00 , C12N15/1037 , C12N2795/18122
摘要： Novel small proteins which bind elastase or cathepsin G have been identified. These are useful as inhibitors of excessive elastase or cathepsin G activity in patients.
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公开(公告)号：EP0452413B1
公开(公告)日：2000-04-12
申请号：EP90902453.1
申请日：1990-01-05
申请人： Dyax Corp.
发明人： LADNER, Robert, Charles , GUTERMAN, Sonia, Kosow , KENT, Rachel, Baribault , LEY, Arthur, Charles
CPC分类号： C40B40/02 , A61K38/00 , C07K14/005 , C07K14/43581 , C07K14/811 , C12N15/1037 , C12N15/67 , C12N15/70 , C12N15/73 , C12N2740/16022 , C12N2795/10322
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公开(公告)号：EP1487969A2
公开(公告)日：2004-12-22
申请号：EP02794200.2
申请日：2002-12-06
申请人： Dyax Corp.
发明人： HOET, Rene , HOOGENBOOM, Henricus, Renerus, Jacobs, Mattheus , PIETERS, Henk , LADNER, Robert, Charles , HOGAN, Shannon , ROOKEY, Kristin
IPC分类号： C12N5/06 , G01N33/533 , G01N33/546 , G01N33/569 , A61L2/00
CPC分类号： B03C1/01 , B03C1/288 , G01N33/56983 , G01N35/0098 , G01N2500/10
摘要： The invention features apparati and methods for washing magnetically responsive particles such as paramagnetic beads. One exemplary apparatus includes a flow chamber having an inlet and an outlet; and at least a first magnetic field inducer. The apparatus is configured such that a first magnetic field can be selectively applied in the flow chamber. The apparatus can also apply a flow of fluid to the chamber in coordination with the selective application of the magnetic field.
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6.发明公开GENETICALLY ENGINEERED HUMAN-DERIVED KUNITZ DOMAINS THAT INHIBIT HUMAN NEUTROPHIL ELASTASE 失效基因工程人的Kunitz结构域的人中性粒细胞弹性INHIBIT
公开(公告)号：EP0797666A2
公开(公告)日：1997-10-01
申请号：EP95943819.0
申请日：1995-12-15
申请人： Dyax Corp.
发明人： LEY, Arthur, Charles , LADNER, Robert, Charles , GUTERMAN, Sonia, Kosow , ROBERTS, Bruce, Lindsay , MARKLAND, William , KENT, Rachel, Baribault
CPC分类号： C07K1/047 , A61K38/00 , C07K14/43522 , C07K14/805 , C07K14/8114 , C12N15/1037 , C40B40/02
摘要： This invention relates to novel proteins that inhibit human neutrophil elastase (hNE). A large fraction of the sequence of each of these proteins is identical to a known human protein which has very little or no inhibitory activity with respect to hNE.
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公开(公告)号：EP3348573B1
公开(公告)日：2020-04-22
申请号：EP17195757.4
申请日：2009-04-24
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公开(公告)号：EP2310415B8
公开(公告)日：2017-12-13
申请号：EP09734929.4
申请日：2009-04-24
申请人： Dyax Corp. , Biogen Hemophilia Inc.
发明人： TENHOOR, Christopher , MURUGANANDAM, Arumugam , LADNER, Robert, Charles , WOOD, Clive , BITONTI, Alan, J. , STATTEL, James , MCDONNELL, Kevin , LIU, Liming , DUMONT, Jennifer , SATO, Aaron
CPC分类号： C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535
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公开(公告)号：EP1663281B1
公开(公告)日：2013-12-25
申请号：EP04786615.7
申请日：2004-08-30
申请人： Dyax Corp.
CPC分类号： C07K14/8114 , A61K47/60 , A61K49/0002
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10.发明公开
公开(公告)号：EP1268524A2
公开(公告)日：2003-01-02
申请号：EP01923058.0
申请日：2001-04-03
申请人： Dyax Corp.
IPC分类号： C07K7/06 , C07K7/08 , G01N33/534 , G01N33/574 , A61K38/08 , A61K38/10 , C12N15/63 , A61P35/00
CPC分类号： C07K7/06 , C07K7/08 , C07K14/705
摘要： The present invention provides binding moieties for CEA, which have a variety of uses wherever detecting, isolating or localizing CEA, and particularly CEA as opposed to cross-reactive antigens such as NCA, is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding CEA, which is overexpressed in adenocarcinomas of endodermally derived digestive system epithelia and fetal colon. Such polypeptides and disclosed derivatives are useful, e.g., as imaging agents for CEA-expressing tumors.
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