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公开(公告)号：EP0771876B1
公开(公告)日：2002-07-10
申请号：EP96905023.6
申请日：1996-03-07
发明人： OZAKI, Akio , MORI, Hideo , SHIBASAKI, Takeshi
CPC分类号： C12N9/0071 , C12P13/24
摘要： A process for industrially producing cis-3-hydroxy-L-proline which is useful as a material in the synthesis of drugs or a food additive; an L-proline 3-hydroxylase gene useful in this process; a recombinant DNA containing this gene; a transformant containing this recombinant DNA; a process for producing L-proline 3-hydroxilase with the use of this transformant; and this enzyme.
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公开(公告)号：EP0759472B1
公开(公告)日：2002-06-12
申请号：EP96905024.4
申请日：1996-03-07
发明人： OZAKI, Akio , MORI, Hideo , SHIBASAKI, Takeshi
CPC分类号： C12N9/0071 , C12P13/24
摘要： A process for industrially producing trans-4-hydroxy-L-proline which is useful as a material in the synthesis of drugs or a food additive; an L-proline 4-hydroxylase gene useful in this process; a recombinant DNA containing this gene; a transformant containing this recombinant DNA; L-proline 4-hydroxylase obtained with the use of this transformant; and this enzyme.
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3.发明公开PROCESS FOR THE PREPARATION OF HMG-CoA REDUCTASE INHIBITORS 失效VERFAHRENFÜRDIE HERSTELLUNG VON INHIBITOREN DER HMG-CoA-REDUKTASE。
公开(公告)号：EP1020530A1
公开(公告)日：2000-07-19
申请号：EP98935282.8
申请日：1998-07-30
发明人： TAKANO, Yutaka , HASEGAWA, Masaru , MORI, Hideo , ANDO, Katsuhiko , OCHIAI, Keiko , MOTOYAMA, Hiroaki , OZAKI, Akio
摘要： Disclosed is a process for producing a compound represented by general formula (II-a):
(wherein R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R 2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (II-a)] or the lactone form of Compound (II-a) [hereinafter referred to as Compound (II-b)] which comprises subjecting a compound represented by general formula (I-a):
(wherein R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R 2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (I-a)] or the lactone form of Compound (I-a) [hereinafter referred to as Compound (I-b)] to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or Compound (II-b) in a reaction mixture to form Compound (II-a) or Compound (II-b) in the reaction mixture, and recovering Compound (II-a) or Compound (II-b) from the reaction mixture.摘要翻译： 公开了通式（II-a）表示的化合物的制备方法：其中R 1表示氢原子，取代或未取代的烷基或碱金属，R 2表示 取代或未取代的烷基或芳基）在下文中称为化合物（II-a）Ü或化合物（II-a）的内酯形式，以下称为化合物（II-b）Ü，其包括使通式 式（Ia）：
（其中R 1表示氢原子，取代或未取代的烷基或碱金属; R 2表示取代或未取代的烷基或芳基）在下文中 化合物（Ia）或化合物（Ia）的内酯形式以下称为化合物（Ib）ü来源于属于芽孢杆菌属的微生物的酶源的作用，并能够将化合物（Ia）或化合物（ Ib）化合物（II-a）或化合物（II-b）反应 离子混合物在反应混合物中形成化合物（II-a）或化合物（II-b），并从反应混合物中回收化合物（II-a）或化合物（II-b）。 -
公开(公告)号：EP1932910A1
公开(公告)日：2008-06-18
申请号：EP06783178.4
申请日：2006-09-05
发明人： ITO, Mikito , MASUDA, Kimie , MORI, Hideo , KATO, Makiko
CPC分类号： C12N9/0006 , C12N9/1085 , C12P7/56
摘要： The present invention provides microorganisms, in which the activity of 4-hydroxybenzoate polyprenyltransferase or 2-octaprenylphenol→2-octaprenyl-6-methoxyphenol flavin reductase is reduced or lost, and which have an ability to produce lactic acid, in particular, microorganisms comprising a chromosomal DNA in which a gene encoding a protein having 4-hydroxybenzoate polyprenyltransferase activity or a protein having 2-octaprenylphenol→2-octaprenyl-6-methoxyphenol flavin reductase activity is partially or completely defective; and a process for producing lactic acid using the microorganisms.
摘要翻译： 本发明提供了微生物，其中4-羟基苯甲酸酯聚异戊二烯基转移酶或2-辛二烯基苯酚†' - 2-辛烯基-6-甲氧基苯酚黄素还原酶的活性被降低或丧失，并且具有生产乳酸的能力，特别是包含 编码具有4-羟基苯甲酸酯聚丙烯酰基转移酶活性的蛋白质的基因或具有2-辛酰丙基苯酚†'2-辛酰基-6-甲氧基苯酚黄素还原酶活性的蛋白质的染色体DNA部分或完全缺陷; 以及使用微生物生产乳酸的方法。
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公开(公告)号：EP1930435A1
公开(公告)日：2008-06-11
申请号：EP06810701.0
申请日：2006-09-28
发明人： HIBI, Makoto , MORI, Hideo
CPC分类号： C07K14/195 , C12N2510/02 , C12P21/00
摘要： The present invention provides a process for producing a useful substance by use of a microorganism that lacks in their chromosomal DNA all or part of a gene encoding a protein having the amino acid sequence shown in SEQ ID NO: 1 or a gene encoding a protein having 80% or more, preferably 90% or more, more preferably 95% or more, even more preferably 97% or more, still more preferably 98% or more, and yet more preferably 99% or more homology with the amino acid sequence shown in SEQ ID NO: 1.
摘要翻译： 本发明提供一种使用缺乏染色体DNA的微生物生产有用物质的方法，所述微生物全部或部分编码具有SEQ ID NO：1所示氨基酸序列的蛋白质的基因或编码蛋白质的基因，所述蛋白质具有 与上述氨基酸序列同源性为80％以上，优选为90％以上，更优选为95％以上，进一步优选为97％以上，进一步优选为98％以上，进一步优选为99％ SEQ ID NO：1。
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6.发明授权
公开(公告)号：EP1020530B1
公开(公告)日：2008-03-12
申请号：EP98935282.8
申请日：1998-07-30
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公开(公告)号：EP0458971B1
公开(公告)日：1996-01-03
申请号：EP90917691.9
申请日：1990-12-04
发明人： MORI, Hideo , IIDA, Akihiro , TESHIBA, Sadao , FUJIO, Tatsuro
IPC分类号： C12N9/12
CPC分类号： C12N9/1205 , C12P19/32
摘要： An inosine guanosine kinase and a process for producing 5'-nucleotides by using the same, said enzyme catalysing the formation of 5'-inosinic acid (5'-IMP) from inosine and adenosine triphosphate (ATP) or deoxyadenosine triphosphate (dATP) and the formation of 5'-guanylic acid (5'-GMP) from guanosine and ATP or dATP.
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8.发明公开
公开(公告)号：EP1939301A1
公开(公告)日：2008-07-02
申请号：EP06810702.8
申请日：2006-09-28
发明人： HARA, Kiyotaka , KATO, Makiko , MORI, Hideo
摘要： The present invention provides processes of producing useful substances, which include the steps of culturing in a medium microorganisms that lack from their chromosomal DNA all or part of a gene encoding a protein having the amino acid sequence shown in SEQ ID NO: 1 or a gene encoding a protein that is 80% or more homologous to the amino acid sequence shown in SEQ ID NO: 1 so as to produce and accumulate the useful substances in the culture, and recovering the useful substances from the culture.
摘要翻译： 本发明提供生产有用物质的方法，其包括以下步骤：在培养基中缺乏染色体DNA的微生物全部或部分编码具有SEQ ID NO：1所示氨基酸序列的蛋白质的基因或基因 编码与SEQ ID NO：1所示的氨基酸序列同源的80％以上的蛋白质，以在培养物中产生和积累有用物质，并从培养物中回收有用物质。
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公开(公告)号：EP1829965A1
公开(公告)日：2007-09-05
申请号：EP05809612.4
申请日：2005-11-25
发明人： MIZOGUCHI, Hiroshi , HARA, Kiyotaka , MORI, Hideo
IPC分类号： C12N15/09 , C12N1/20 , C12N1/21 , C12P7/64 , C12P13/00 , C12P13/04 , C12P17/00 , C12P19/00 , C12P19/30 , C12P19/38 , C12P21/02
摘要： According to the present invention, the E . coli mutant strain having chromosomal DNA that is at least 470 kbp shorter than that of a wild-type E . coli strain exhibits such a property that the number of the cells after a certain period of culture is greater than a wild-type strain. Thus, by culturing the mutant strain in a medium so as to generate and accumulate a useful substance in the culture, a useful substance such as proteins, peptides, amino acids, nucleic acids, vitamins, saccharides, organic acids, and lipids can be efficiently produced.
摘要翻译： 根据本发明，具有比野生型大肠杆菌菌株短至少470kbp的染色体DNA的大肠杆菌突变株显示出这样的性质，即培养一段时间后的细胞数目是 大于野生型菌株。 因此，通过在培养基中培养突变菌株以在培养物中产生并积累有用物质，可以有效地使蛋白质，肽，氨基酸，核酸，维生素，糖类，有机酸和脂质等有用物质 产生的。
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公开(公告)号：EP1788075A1
公开(公告)日：2007-05-23
申请号：EP05776635.4
申请日：2005-09-01
发明人： KATO, Makiko , MORI, Hideo , KATO, Jun-ichi
IPC分类号： C12N1/21 , C07G13/00 , C12N15/09 , C12P7/40 , C12P7/64 , C12P13/00 , C12P13/04 , C12P19/00 , C12P19/28
摘要： The present invention provides a microorganism which comprises a chromosomal DNA lacking a part or entire of the gene encoding a protein having the amino acid sequence as shown in SEQ ID NO: 1 or 2, or the gene encoding a protein having 80% or more homology with the amino acid sequence as shown in SEQ ID NO: 1 or 2, and has the ability to produce a useful substance; a process for producing a useful substance using said strain; especially a process for producing a useful substance which is selected from the group consisting of proteins, peptides, amino acids, nucleic acids, vitamins, saccharides, organic acids, and lipids.
摘要翻译： 本发明提供一种微生物，其含有缺乏编码具有SEQ ID NO：1或2所示的氨基酸序列的蛋白质的基因的一部分或全部的染色体DNA，或编码具有80％以上同源性的蛋白质的基因 具有SEQ ID NO：1或2所示的氨基酸序列，并具有产生有用物质的能力; 使用所述菌株生产有用物质的方法; 尤其是用于生产选自蛋白质，肽，氨基酸，核酸，维生素，糖类，有机酸和脂质的有用物质的方法。
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