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公开(公告)号：EP1663953A1
公开(公告)日：2006-06-07
申请号：EP04789074.4
申请日：2004-09-24
申请人： Methylgene, Inc.
发明人： MORADEI, Oscar , PAQUIN, Isabelle , LEIT, Silvana , FRECHETTE, Sylvie , VAISBURG, Arkadii , BESTERMAN, Jeffrey, M. , TESSIER, Pierre , MALLAIS, Tammy, C.
IPC分类号： C07C237/40 , C07C233/25 , C07C235/58 , C07C237/20 , C07C255/60 , C07C323/42 , C07D333/20 , A61K31/16 , A61K31/33 , A61K31/381 , A61P35/00 , C07D307/52 , C07D409/12 , C07D409/14 , C07D333/16
CPC分类号： C07F7/1856 , C07C233/25 , C07C235/58 , C07C237/20 , C07C237/40 , C07C255/60 , C07C323/42 , C07D207/325 , C07D207/327 , C07D207/335 , C07D209/08 , C07D213/73 , C07D233/54 , C07D233/84 , C07D249/06 , C07D257/04 , C07D263/57 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/40 , C07D307/52 , C07D307/54 , C07D307/84 , C07D319/18 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/34 , C07D333/36 , C07D333/58 , C07D333/60 , C07D333/70 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
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公开(公告)号：EP2007720B1
公开(公告)日：2013-12-25
申请号：EP07760170.6
申请日：2007-04-05
申请人： MethylGene Inc.
发明人： MORADEI, Oscar , PAQUIN, Isabelle , FRECHETTE, Sylvie , MALLAIS, Tammy , ROY, Simon , MACHAALANI, Roger , VAISBURG, Arkadii , BESTERMAN, Jeffrey M. , TESSIER, Pierre , MANCUSO, John , SMIL, David , LEIT, Silvana , DEZIEL, Robert
IPC分类号： C07D207/32 , C07D213/40 , C07D213/56 , C07D213/61 , C07D295/14 , C07D307/52 , C07D317/58 , C07D333/28 , C07D333/36 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
CPC分类号： C07D333/36 , C07C235/56 , C07C237/40 , C07C271/28 , C07D207/12 , C07D207/14 , C07D207/325 , C07D209/08 , C07D213/40 , C07D213/56 , C07D213/61 , C07D213/89 , C07D267/08 , C07D277/28 , C07D277/36 , C07D295/155 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/28 , C07D333/38 , C07D333/70 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
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公开(公告)号：EP2217588A1
公开(公告)日：2010-08-18
申请号：EP08845130.7
申请日：2008-11-03
申请人： Methylgene, Inc.
发明人： MALLAIS, Tammy , MORADEI, Oscar , AJAMIAN, Alain , TESSIER, Pierre , SMIL, David , FRECHETTE, Sylvie , MACHAALANI, Roger , LEIT, Silvana , BEAULIEU, Patrick , DÉZIEL, Robert , MANCUSO, John
IPC分类号： C07D333/38 , A61K31/16 , A61K31/381 , A61K31/415 , C07C259/10 , C07C311/16 , C07D231/14 , C07D267/18 , C07D277/56 , C07D333/20 , C07D333/70 , C07D413/04 , C07D513/04
CPC分类号： C07D277/593 , C07C259/10 , C07C311/29 , C07D207/327 , C07D207/34 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/14 , C07D235/18 , C07D239/28 , C07D239/38 , C07D261/18 , C07D263/34 , C07D267/20 , C07D277/30 , C07D277/64 , C07D307/85 , C07D307/91 , C07D317/60 , C07D333/24 , C07D333/38 , C07D401/04 , C07D403/10 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14
摘要： This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein L, M, n, R, W, X and Y are as defined in the specification.
摘要翻译： 本发明涉及用于抑制HDAC酶活性的化合物和方法。 更具体地说，本发明提供了式（I），（I）化合物和其N-氧化物，水合物，溶剂合物，药学上可接受的盐，前药和复合物，以及其外消旋和局部混合物，非对映异构体和对映异构体，其中L，M ，n，R，W，X和Y如说明书中所定义。
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公开(公告)号：EP2139850A1
公开(公告)日：2010-01-06
申请号：EP08748100.8
申请日：2008-04-09
申请人： Methylgene, Inc.
发明人： TESSIER, Pierre , LEIT, Silvana , SMIL, David , DÉZIEL, Robert , AJAMIAN, Alain , CHANTIGNY, Yves, Andre , DOMINGUEZ, Celia
IPC分类号： C07C259/06 , A61K31/16 , A61K31/18 , A61K31/33 , C07C311/19 , C07C323/50 , C07D521/00
CPC分类号： C07D307/79 , C07C259/06 , C07C275/42 , C07C311/08 , C07C311/21 , C07C323/52 , C07D205/04 , C07D207/263 , C07D207/337 , C07D209/08 , C07D209/44 , C07D211/34 , C07D211/46 , C07D211/52 , C07D211/64 , C07D211/76 , C07D213/56 , C07D213/64 , C07D213/70 , C07D213/74 , C07D215/26 , C07D219/04 , C07D231/14 , C07D233/84 , C07D235/16 , C07D235/28 , C07D239/26 , C07D239/34 , C07D239/38 , C07D239/42 , C07D249/06 , C07D267/20 , C07D277/36 , C07D277/74 , C07D285/12 , C07D295/088 , C07D295/155 , C07D295/192 , C07D295/205 , C07D295/26 , C07D311/84 , C07D317/50 , C07D333/24 , C07D401/04 , C07D401/06 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D471/04 , C07D491/08 , C07D491/10 , C07D513/04
摘要： This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.
摘要翻译： 本发明涉及用于抑制组蛋白脱乙酰酶的化合物。 更特别地，本发明提供式（I）的式化合物和其N-氧化物，水合物，溶剂合物，药学上可接受的盐，前药和复合物以及其外消旋和局部混合物，非对映异构体和对映异构体，其中基团L， M，X和Y如本文所定义。
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公开(公告)号：EP2007720A1
公开(公告)日：2008-12-31
申请号：EP07760170.6
申请日：2007-04-05
申请人： Methylgene, Inc.
发明人： MORADEI, Oscar , PAQUIN, Isabelle , FRECHETTE, Sylvie , MALLAIS, Tammy , ROY, Simon , MACHAALANI, Roger , VAISBURG, Arkadii , BESTERMAN, Jeffrey M. , TESSIER, Pierre , MANCUSO, John , SMIL, David , LEIT, Silvana , DEZIEL, Robert
IPC分类号： C07D207/32 , C07D213/40 , C07D213/56 , C07D213/61 , C07D295/14 , C07D307/52 , C07D317/58 , C07D333/28 , C07D333/36 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
CPC分类号： C07D333/36 , C07C235/56 , C07C237/40 , C07C271/28 , C07D207/12 , C07D207/14 , C07D207/325 , C07D209/08 , C07D213/40 , C07D213/56 , C07D213/61 , C07D213/89 , C07D267/08 , C07D277/28 , C07D277/36 , C07D295/155 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/28 , C07D333/38 , C07D333/70 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds which are derivatives of benzamide and suitable in methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions .
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公开(公告)号：EP2139850B1
公开(公告)日：2018-09-12
申请号：EP08748100.8
申请日：2008-04-09
申请人： MethylGene Inc.
发明人： TESSIER, Pierre , LEIT, Silvana , SMIL, David , DÉZIEL, Robert , AJAMIAN, Alain , CHANTIGNY, Yves, Andre , DOMINGUEZ, Celia
IPC分类号： C07C259/06 , A61K31/16 , A61K31/18 , A61K31/33 , C07C311/19 , C07C323/50 , C07D521/00 , A61P35/00
CPC分类号： C07D307/79 , C07C259/06 , C07C275/42 , C07C311/08 , C07C311/21 , C07C323/52 , C07D205/04 , C07D207/263 , C07D207/337 , C07D209/08 , C07D209/44 , C07D211/34 , C07D211/46 , C07D211/52 , C07D211/64 , C07D211/76 , C07D213/56 , C07D213/64 , C07D213/70 , C07D213/74 , C07D215/26 , C07D219/04 , C07D231/14 , C07D233/84 , C07D235/16 , C07D235/28 , C07D239/26 , C07D239/34 , C07D239/38 , C07D239/42 , C07D249/06 , C07D267/20 , C07D277/36 , C07D277/74 , C07D285/12 , C07D295/088 , C07D295/155 , C07D295/192 , C07D295/205 , C07D295/26 , C07D311/84 , C07D317/50 , C07D333/24 , C07D401/04 , C07D401/06 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D471/04 , C07D491/08 , C07D491/10 , C07D513/04
摘要： This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.
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7.发明公开BENZODIAZEPINE AND BENZOPIPERAZINE ANALOG INHIBITORS OF HISTONE DEACETYLASE 审中-公开组蛋白去乙酰苯二氮卓和BENZOPIPERAZINANALOGA作为抑制剂
公开(公告)号：EP1940805A1
公开(公告)日：2008-07-09
申请号：EP06790581.0
申请日：2006-08-25
申请人： Methylgene, Inc.
发明人： LEIT, Silvana , WAHHAB, Amal , ALLAN, Martin , SMIL, David , TESSIER, Pierre , DEZIEL, Robert , CHANTIGNY, Yves, André
IPC分类号： C07D243/14 , C07D241/44 , C07D207/16 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D241/44 , C07D223/16 , C07D241/50 , C07D243/10 , C07D243/14 , C07D243/24 , C07D243/30 , C07D401/12 , C07D403/04 , C07D403/06 , C07D409/06 , C07D409/12 , C07D409/14
摘要： This invention relates to compounds for the inhibition of histone deacetylase More particularly, the invention provides for compounds of formula (I): wherein A, B, D, E, X1, X2, X3, X4 and n are as defined in the specification A method of inhibiting histone deacetylase in a cell, the method comprising contacting the cell with a compound of formula (I), in an amount sufficient to inhibit histone deacetylase, is also disclosed.
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公开(公告)号：EP1863804A1
公开(公告)日：2007-12-12
申请号：EP06741367.4
申请日：2006-03-31
申请人： Methylgene, Inc.
发明人： LEIT DE MORADEI, Silvana, Marcela , TESSIER, Pierre , SMIL, David , WAHHAB, Amal , DEZIEL, Robert , MANKU, Sukhdev , MANCUSO, John , THERRIEN, Eric , ALLAN, Martin , CHANTIGNY, Yves, Andre , AJAMIAN, Alain , BEAULIEU, Patrick
IPC分类号： C07D417/04 , A61K31/18 , A61K31/66 , A61K31/195 , A61K31/34 , A61K31/404 , A61K31/4184 , A61K31/4192 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/44 , A61K31/4427 , A61K31/47 , A61K31/495 , A61K31/505 , C07C237/38 , C07C311/21 , C07C323/33 , C07C323/60 , C07D207/16
CPC分类号： C07D209/14 , C07C237/22 , C07C309/51 , C07C311/13 , C07C311/29 , C07C311/46 , C07C311/51 , C07C311/59 , C07C317/22 , C07C317/32 , C07C317/44 , C07C323/60 , C07C2601/14 , C07C2603/32 , C07D209/42 , C07D209/46 , C07D213/30 , C07D213/32 , C07D213/40 , C07D213/70 , C07D213/89 , C07D215/40 , C07D235/14 , C07D239/38 , C07D241/52 , C07D277/82 , C07D285/12 , C07D285/135 , C07D295/185 , C07D307/42 , C07D307/81 , C07D317/58 , C07D333/16 , C07D333/24 , C07D333/34 , C07D401/06 , C07D405/12 , C07D409/06 , C07D409/12
摘要： This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I); wherein Y, L, Z, W, X, Q, R1, R2 and R3 are as defined in the specification.
摘要翻译： 本发明涉及用于抑制组蛋白脱乙酰酶的化合物。 更具体地说，本发明提供了式（I）的化合物; 其中Y，L，Z，W，X，Q，R1，R2和R3如说明书中所定义。
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