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公开(公告)号：EP1723421A1
公开(公告)日：2006-11-22
申请号：EP05724263.8
申请日：2005-03-02
发明人： WEINBERG, Marc, S. , BORENSTEIN, Jeffrey , DUBÉ, Christopher, E. , HOPKINS, Ralph , CARLEN, Edwin
IPC分类号： G01N33/543 , G01N29/02 , C12Q1/68
CPC分类号： G01N33/54373 , G01N27/227 , G01N27/3276 , G01N2291/02863 , Y10S436/806
摘要： Electrostatic capacitance measurements are used to detect chemical or biological analytes, or chemical interactions, with great sensitivity. A diaphragm is coated with a material capable of selectively interacting with an analyte of interest, and interaction of the analyte with the coating exerts stresses tangential to the diaphragm's surface. These stresses cause diaphragm displacements that are sensed as varying capacitance.
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公开(公告)号：EP3676003A1
公开(公告)日：2020-07-08
申请号：EP18766532.8
申请日：2018-08-29
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3.发明公开NANOTOPOGRAPHIC COMPOSITIONS AND METHODS FOR CELLULAR ORGANIZATION IN TISSUE ENGINEERED STRUCTURES 审中-公开用于组织工程结构的细胞组织的纳米组合物和方法
公开(公告)号：EP1668117A2
公开(公告)日：2006-06-14
申请号：EP04820720.3
申请日：2004-08-18
IPC分类号： C12N5/00
CPC分类号： A61L27/3886 , A61L27/50 , B33Y80/00 , C12N5/0075 , C12N5/067 , C12N2535/10
摘要： The present invention relates to tissue engineered compositions and methods comprising nanotopographic surface topography ('nanotopography') for use in modulating the organization and/or function of multiple cell types.
摘要翻译： 本发明涉及用于调节多种细胞类型的组织和/或功能的包含纳米表面形貌（“纳米形貌”）的组织工程组合物和方法。
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公开(公告)号：EP3831923A1
公开(公告)日：2021-06-09
申请号：EP20211221.5
申请日：2020-12-02
发明人： BORENSTEIN, Jeffrey , MOORE, Nathan , DOTY, Daniel , HAGGERTY, Timothy , CHAREST, Joseph , GIMBEL, Alla , MOTT, Vienna , ISENBERG, Brett , AZIZGOLSHANI, Hesham , CAIN, Brian , MESCHER, Mark
摘要： A microfluidic device for modeling a tumor-immune microenvironment can include a multiwell plate defining a plurality of microenvironment units fluidically coupled with a plurality of wells. Each microenvironment unit of the plurality of microenvironment units can include one or more compartments. Each microenvironment unit can include a trapping feature positioned within the one or more compartments. The trapping feature can be defined by a portion of at least one of a sidewall or a floor of the one or more compartments. The trapping feature can restrict movement of a tissue sample introduced into the one or more compartments and to allow fluid to flow past the tissue sample. The microfluidic device can include a plurality of micropumps each coupled with a respective well and configured to control movement of a respective fluid sample through each respective well.
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公开(公告)号：EP3676004A1
公开(公告)日：2020-07-08
申请号：EP18766533.6
申请日：2018-08-29
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公开(公告)号：EP2214590B1
公开(公告)日：2016-08-31
申请号：EP08852120.8
申请日：2008-11-19
发明人： KARP, Jeffrey , ALBORZ, Mahdavi , FERREIRA, Lino , CARTER, David , ZUMBUEHL, Andreas , BORENSTEIN, Jeffrey , CHAN, Edwin , BETTINGER, Christopher , LANGER, Robert
CPC分类号： A61F2/0077 , A61F2002/30448 , A61F2013/00774 , A61F2220/0016 , A61F2220/005 , A61K9/0019 , A61L15/42 , A61L15/58 , A61L15/64 , A61L31/005 , A61L31/14 , A61L31/148 , B29C65/18 , B29C65/52 , B29C66/1122 , B31B70/81 , B31B2160/10 , C04B37/005
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公开(公告)号：EP2214590A1
公开(公告)日：2010-08-11
申请号：EP08852120.8
申请日：2008-11-19
发明人： KARP, Jeffrey , ALBORZ, Mahdavi , FERREIRA, Lino , CARTER, David , ZUMBUEHL, Andreas , BORENSTEIN, Jeffrey , CHAN, Edwin , BETTINGER, Christopher , LANGER, Robert
IPC分类号： A61F2/02
CPC分类号： A61F2/0077 , A61F2002/30448 , A61F2013/00774 , A61F2220/0016 , A61F2220/005 , A61K9/0019 , A61L15/42 , A61L15/58 , A61L15/64 , A61L31/005 , A61L31/14 , A61L31/148 , B29C65/18 , B29C65/52 , B29C66/1122 , B31B70/81 , B31B2160/10 , C04B37/005
摘要： An adhesive article includes a biocompatible and at least partially biodegradable substrate having a surface; and a plurality of protrusions extending from the surface. The protrusions include a biocompatible and at least partially biodegradable material, and have an average height of less than approximately 1,000 micrometers.
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8.发明公开
公开(公告)号：EP1364398A1
公开(公告)日：2003-11-26
申请号：EP02708936.6
申请日：2002-01-02
发明人： BORENSTEIN, Jeffrey
CPC分类号： B81C1/00119 , B81B2201/0235 , B81C1/00357 , B81C2201/0132 , B81C2201/014 , B81C2201/019 , B81C2201/0191
摘要： The invention provides a general fabrication method for producing MicroElectroMechanical Systems (MEMS) and related devices using Silicon-On-Insulator (SOI). One first obtains an SOI wafer that has (i) a handle layer, (ii) a dielectric layer, and (iii) a device layer. A mesa etch has been made on the device layer of the SOI wafer and a structural etch has been made on the dielectric layer of the SOI wafer. One then obtains a substrate (such as glass or silicon), where a pattern has been etched onto the substrate. The SOI wafer and the substrate are bonded together. Then the handle layer of the SOI wafer is removed, followed by the dielectric layer of the SOI wafer.
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