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公开(公告)号：EP4377007A1
公开(公告)日：2024-06-05
申请号：EP22755311.2
申请日：2022-08-01
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2.发明公开NOVEL RUTHENIUM COMPLEXES AND THEIR USES IN PROCESSES FOR FORMATION AND/OR HYDROGENATION OF ESTERS, AMIDES AND DERIVATIVES THEREOF 审中-公开新钌和它们在程序对教育和/或加氢酯，酰胺及其衍生物的
公开(公告)号：EP2629889A2
公开(公告)日：2013-08-28
申请号：EP11788587.1
申请日：2011-10-11
发明人： MILSTEIN, David , BALARAMAN, Ekambaram , GUNANATHAN, Chidambaram , GNANAPRAKASAM, Boopathy , ZHANG, Jing
IPC分类号： B01J31/18
CPC分类号： C07K5/12 , B01J31/18 , B01J31/189 , B01J31/2404 , B01J31/2409 , B01J31/248 , B01J31/2485 , B01J2231/40 , B01J2231/49 , B01J2231/643 , B01J2231/763 , B01J2531/0244 , B01J2531/821 , C07B41/02 , C07B41/08 , C07B41/12 , C07B43/04 , C07B43/06 , C07C29/136 , C07C29/149 , C07C29/177 , C07C41/16 , C07C41/26 , C07C45/002 , C07C45/006 , C07C51/00 , C07C51/02 , C07C51/23 , C07C51/295 , C07C67/00 , C07C67/03 , C07C67/297 , C07C209/00 , C07C209/62 , C07C213/00 , C07C213/02 , C07C231/02 , C07C231/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D207/06 , C07D207/08 , C07D211/12 , C07D213/38 , C07D241/08 , C07D241/12 , C07D295/023 , C07D295/027 , C07D295/185 , C07D305/06 , C07D307/14 , C07D307/33 , C07D307/44 , C07D307/52 , C07D307/83 , C07D309/30 , C07D487/14 , C07F9/58 , C07F9/65583 , C07F15/0046 , C07F15/0053 , C07K1/00 , C08G69/00 , Y02P20/52 , C07C233/05 , C07C235/06 , C07C233/07 , C07C235/16 , C07C235/14 , C07C235/10 , C07C211/27 , C07C211/07 , C07C211/35 , C07C211/46 , C07C211/10 , C07C215/28 , C07C217/58 , C07C69/14 , C07C69/24 , C07C31/125 , C07C31/12 , C07C49/78 , C07C49/04 , C07C49/10 , C07C49/08 , C07C49/403 , C07C31/205 , C07C31/202 , C07C31/04 , C07C31/08 , C07C33/20 , C07C33/22 , C07C31/1355 , C07C31/10 , C07C43/13 , C07C69/78 , C07C69/75 , C07C53/124 , C07C53/126 , C07C59/125 , C07C57/32 , C07C61/08 , C07C57/30 , C07C65/21 , C07C63/08 , C07C63/06
摘要： The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to the novel uses of certain pyridine Ruthenium catalysts.
摘要翻译： 本发明涉及新的钌络合物和相关的硼氢化物，及对（1）酰胺（包括聚酰胺），以醇和cardamines的氢化使用; （2）制备的酰胺从醇与cardamines（包括通过使二元醇与二胺或由氨基醇的聚合制备聚酰胺（例如，多肽））; （3）酯的氢化，以醇（包括环状酯的氢化（内酯），环状二酯（二 - 内酯）或聚酯）; （4）的有机碳酸酯（包括聚碳酸酯）醇类和氨基甲酸酯类（包括聚氨基甲酸酯）或尿素衍生物为醇和cardamines的加氢; （5）的醇脱氢以酯的耦合; （6）仲醇到酮的加氢; （7）酯的酰胺化（从酯和cardamines酰胺的合成）; （8）使用酯醇的酰化; （9）与水的醇的偶联以形成羧酸; 和（10）的β-氨基醇的脱氢以形成吡嗪。 本发明还涉及某些吡啶钌配合物的新颖用途。
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公开(公告)号：EP4263906A1
公开(公告)日：2023-10-25
申请号：EP21840968.8
申请日：2021-12-21
申请人： Université Paris Cité , Centre National de la Recherche Scientifique , Yeda Research and Development Co. Ltd
发明人： VON WOLFF, Niklas , MILSTEIN, David
IPC分类号： C25B1/02 , C25B1/23 , C25B3/07 , C25B3/23 , C25B9/15 , C25B11/054 , C25B11/065 , C25B11/085
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公开(公告)号：EP4015673A1
公开(公告)日：2022-06-22
申请号：EP20216238.4
申请日：2020-12-21
申请人： Université de Paris , Centre national de la recherche scientifique , Yeda Research and Development Co. Ltd
发明人： VON WOLFF, Niklas , MILSTEIN, David
IPC分类号： C25B1/02 , C25B1/23 , C25B3/07 , C25B3/23 , C25B9/15 , C25B11/054 , C25B11/065 , C25B11/085
摘要： A use of an acceptor-less dehydrogenation catalyst for an electrocatalytic oxidation of an alcohol to an ester or/and an acid under electrochemical conditions,
the acceptor-less dehydrogenation catalyst being represented by the structure of any one of the formulae F1, F2, or F3:
M being selected from the group consisting of Fe, Co, Ni, Ru, Rh, Pd, Os, Pt, Ir, Mn;
L and X being ligands; X is an anionic ligand, L is a neutral ligand,
Z being selected from the group consisting of C, N;
R' being an organic substituent of the aromatic ring;
E' is selected in the group consisting of N, P, C, O and/or S-donors;
R being an organic substituent, typically selected from the group consisting of i Pr, t Bu, Ph, Et, Me, Bn, H.-
5.发明公开
公开(公告)号：EP3906213A1
公开(公告)日：2021-11-10
申请号：EP19835832.7
申请日：2019-12-30
发明人： MILSTEIN, David , ZOU, You-Quan , ANABY, Aviel
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6.发明公开
公开(公告)号：EP3921277A1
公开(公告)日：2021-12-15
申请号：EP20708679.4
申请日：2020-02-06
发明人： MILSTEIN, David , XIE, Yinjun
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7.发明公开RUTHENIUM COMPLEXES AND THEIR USES AS CATALYSTS IN PROCESSES FOR FORMATION AND/OR HYDROGENATION OF ESTERS, AMIDES AND RELATED REACTIONS 审中-公开钌配合物及其在催化剂中用于形成和/或氢化酯，酰胺和相关反应的过程
公开(公告)号：EP3188832A1
公开(公告)日：2017-07-12
申请号：EP15781154.8
申请日：2015-09-03
IPC分类号： B01J31/28 , C07C209/00 , C07C209/50 , C07F15/00 , C07C213/00 , C07C227/02 , C07C231/02 , C07C231/08 , C07C231/10 , C07C29/149 , C07C67/00
CPC分类号： C07F15/0046 , B01J31/24 , B01J31/2404 , B01J31/28 , B01J2231/641 , B01J2231/763 , B01J2531/0244 , B01J2531/821 , C07C29/149 , C07C67/00 , C07C67/40 , C07C209/00 , C07C209/50 , C07C213/00 , C07C227/02 , C07C231/02 , C07C231/08 , C07C231/10 , C07C249/02 , C07C2601/14 , C07D207/16 , C07D241/08 , C07C69/24 , C07C69/78 , C07C69/92 , C07C69/708 , C07C69/63 , C07C31/125 , C07C31/08 , C07C35/08 , C07C31/12 , C07C31/20 , C07C31/38 , C07C33/22 , C07C33/20 , C07C233/36 , C07C237/08 , C07C211/10 , C07C215/08 , C07C229/08 , C07C229/12 , C07C229/56 , C07C233/11 , C07C229/14 , C07C233/05 , C07C211/03 , C07C229/36
摘要： The present invention relates to novel Ruthenium complexes of formulae A1-A4 and their use, inter alia, for (1) dehydrogenative coupling of alcohols to esters; (2) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones), or polyesters); (3) preparing amides from alcohols and amines—(including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or polymerization of amino alcohols and/or forming cyclic dipeptides from p-aminoalcohols; (4) hydrogenation of amides (including cyclic dipeptides, polypeptides and polyamides) to alcohols and amines; (5) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (6) dehydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water and a base to form carboxylic acids; and (10) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. The present, invention further relates to the use of certain known Ruthenium complexes for the preparation of amino acids or their salts from amino alcohols.
摘要翻译： 本发明涉及式A1-A4的新型钌络合物及其用于（1）醇与酯的脱氢偶联; （2）将酯氢化为醇（包括环酯（内酯）或环状二酯（二内酯）或聚酯的氢化）; （3）由醇和胺制备酰胺 - （包括通过使二醇和二胺反应和/或氨基醇聚合和/或由对氨基醇形成环状二肽来制备聚酰胺（例如多肽）;（4）酰胺的氢化 （包括环二肽，多肽和聚酰胺）;（5）有机碳酸酯（包括聚碳酸酯）氢化成醇或氨基甲酸酯（包括聚氨基甲酸酯）或脲衍生物氢化成醇和胺;（6）仲醇脱氢成 酮;（7）酯的酰胺化（即由酯和胺合成酰胺）;（8）用酯酰化醇;（9）醇与水和碱偶合形成羧酸;和（10）制备 本发明进一步涉及某些已知的钌络合物在制备氨基酸中的用途，所述氨基酸或氨基酸与水和碱偶联， 或其氨基醇的盐。
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公开(公告)号：EP1848466A2
公开(公告)日：2007-10-31
申请号：EP06701708.7
申请日：2006-01-31
发明人： DEGANI, Hadassa , MILSTEIN, David
IPC分类号： A61K49/10
CPC分类号： A61K49/085 , A61K49/10
摘要： The invention relates to bifunctional conjugates comprising a receptor ligand moiety and a metal binding moiety and complexes thereof with paramagnetic lanthanide or transition metals, and to the use of the metal complexes as contrast agents in magnetic resonance imaging (MRI) of tumors and other abnormalities.
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公开(公告)号：EP3919466A1
公开(公告)日：2021-12-08
申请号：EP21188073.7
申请日：2017-02-08
发明人： MILSTEIN, David , VOGT, Matthias , NERUSH, Alex , MUKHERJEE, Arup , ESPINOSA-JALAPA, Noel Angel , CHAKRABORTY, Subrata
IPC分类号： C07B41/02 , C07B41/06 , C07B41/12 , C07B43/00 , C07B43/06 , C07B43/08 , C07F13/00 , C07C29/149 , C07C67/40 , C07C231/10 , C07C249/02 , C07C253/30
摘要： The present invention relates to novel manganese complexes and their use, inter alia , for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C-C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. (12) preparation of amides (including formamides, cyclic dipeptides, diamide, lactams, polypeptides and polyamides) by dehydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.
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公开(公告)号：EP2629889B1
公开(公告)日：2019-04-03
申请号：EP11788587.1
申请日：2011-10-11
发明人： MILSTEIN, David , BALARAMAN, Ekambaram , GUNANATHAN, Chidambaram , GNANAPRAKASAM, Boopathy , ZHANG, Jing
IPC分类号： C07D487/14 , C07C29/136 , C07C29/149 , C07C29/17 , C07C67/00 , C07C67/03 , C07D309/30 , C07C41/16 , C07C45/00 , C07F15/00 , C07C209/62 , C07C213/00 , C07D241/08 , C07D241/12 , C07C231/02 , C07C231/10 , C07D207/08 , C07D295/023 , C07D213/38 , C07C51/23
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