公开(公告)号：EP4399284A1

公开(公告)日：2024-07-17

申请号：EP22776910.6

申请日：2022-09-06

Applicant: Global Bioenergies

Inventor： VILLIERS, Benoit ,  THIBAUT, Denis

IPC: C12N9/00 ,  C12P1/00

CPC classification number: C12N9/001 ,  C12N9/88 ,  C12Y402/01 ,  C12Y402/01055 ,  C12Y402/01017 ,  C12Y301/02 ,  C12Y301/0202 ,  C12Y301/02028 ,  C12Y208/03 ,  C12Y208/03008 ,  C12Y602/01013 ,  C12Y203/01019 ,  C12Y207/02007 ,  C12Y103/01086 ,  C12Y103/01044 ,  C12Y103/01009 ,  C12Y103/08001 ,  C12P5/026 ,  Y02E50/10

公开(公告)号：EP3013939A1

公开(公告)日：2016-05-04

申请号：EP14744471.5

申请日：2014-06-25

Applicant: Cellectis

Inventor： DUCHATEAU, Philippe ,  DABOUSSI, Fayza ,  SOURDIVE, David ,  EPINAT, Jean-Charles

IPC: C12N1/13 ,  C12N9/04 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/16 ,  C12P7/64 ,  C12N15/79 ,  C12R1/89

CPC classification number: C12N15/8247 ,  C12N9/0006 ,  C12N9/001 ,  C12N9/0071 ,  C12N9/1029 ,  C12N9/1241 ,  C12N9/16 ,  C12N15/79 ,  C12P7/64 ,  C12P7/6427 ,  C12Y101/01008 ,  C12Y103/01009 ,  C12Y114/19006 ,  C12Y203/01 ,  C12Y207/07009 ,  C12Y301/02022

Abstract: The invention provides engineered diatoms and methods of producing oil using diatoms. The invention also provides methods of modifying the lipids quantity and/or quality produced by diatom organisms through genome engineering. Also provided are oils, fuels, oleochemicals, chemical precursors, and other compounds manufactured from such modified diatoms.

Abstract translation: 本发明提供工程硅藻和使用硅藻生产油的方法。 本发明还提供了通过基因组工程改变由硅藻生物产生的脂质量和/或质量的方法。 还提供油​​，燃料，油化学品，化学前体和由这种改性的硅藻制造的其它化合物。

公开(公告)号：EP3283618A1

公开(公告)日：2018-02-21

申请号：EP16780590.2

申请日：2016-04-13

Applicant: William Marsh Rice University

Inventor： GONZALEZ, Ramon ,  CLOMBURG, James, M.

IPC: C12N1/21 ,  C12N15/70 ,  C12N15/33 ,  C12P7/64 ,  C12N9/02

CPC classification number: C12N9/1029 ,  C12N9/00 ,  C12N9/0006 ,  C12N9/001 ,  C12N9/88 ,  C12N15/70 ,  C12P7/04 ,  C12P7/42 ,  C12P7/6409 ,  C12P13/001 ,  C12P21/00 ,  C12Y101/011 ,  C12Y103/01009 ,  C12Y203/01016 ,  C12Y203/01038 ,  C12Y402/01059

Abstract: Methods of using microorganisms to make chemicals and fuels, including carboxylic acids, alcohols, hydrocarbons, and their alpha-, beta-, and omega-functionalized derivatives are described. Native or engineered thiolases are used condense a growing acyl-ACP and acetyl-ACP in combination with type II fatty acid synthesis. The resulting fatty acid biosynthesis cycle has an ATP yield analogous to the functional reverse β-oxidation cycle.

公开(公告)号：EP2882843A4

公开(公告)日：2016-04-06

申请号：EP13827193

申请日：2013-08-09

Applicant: OPX BIOTECHNOLOGIES INC

Inventor： LIAO HANS ,  SPINDLER EILEEN ,  WARNER JOSEPH R ,  LOUIE MICHAEL ,  RIBBLE WENDY ,  PRATHER BRITTNEY ,  EVANS RON ,  LIPSCOMB TANYA E W ,  LYNCH MICHAEL D

IPC: C12P7/40 ,  C12N15/52 ,  C12P7/64

CPC classification number: C12P7/6409 ,  C12N9/0006 ,  C12N9/001 ,  C12N9/1029 ,  C12N15/52 ,  C12P7/04 ,  C12P7/40 ,  C12R1/19 ,  C12Y101/01157 ,  C12Y103/01009 ,  C12Y203/01194

公开(公告)号：EP1363654A2

公开(公告)日：2003-11-26

申请号：EP01986546.8

申请日：2001-12-20

Applicant: Mcleod, Rima W. ,  Muench, Stephen P. ,  Rafferty, John B. ,  Kyle, Dennis E. ,  Mui, Ernest ,  Kirisits, Michael ,  Mack, Douglas G. ,  Roberts, Craig W. ,  Samuel, Benjamin ,  Lyons, Russel E. ,  Milhous, Wilbur K. ,  Rice, David W. ,  Prigge, Sean

Inventor： Mcleod, Rima W. ,  Muench, Stephen P. ,  Rafferty, John B. ,  Kyle, Dennis E. ,  Mui, Ernest ,  Kirisits, Michael ,  Mack, Douglas G. ,  Roberts, Craig W. ,  Samuel, Benjamin ,  Lyons, Russel E. ,  Milhous, Wilbur K. ,  Rice, David W. ,  Prigge, Sean

IPC: A61K38/00

CPC classification number: A61K31/09 ,  A61K38/00 ,  C12N9/001 ,  C12Y103/01009 ,  Y02A50/411

Abstract: Discovery and characterization of an apicomplexan Fab I gene and encoded enzyme and discovery of the triclosan as a lead compound, provide means to rationally design novel inhibitory compositions useful for prevention and treatment of apicomplexan related diseases.

公开(公告)号：EP3283615A1

公开(公告)日：2018-02-21

申请号：EP16780890.6

申请日：2016-04-15

Applicant: William Marsh Rice University

Inventor： GONZALEZ, Ramon ,  CLOMBURG, James, M. ,  CHEONG, Seokjung

IPC: C12N1/20 ,  C12N1/21 ,  C12P7/44 ,  A61K38/45 ,  A61K38/51

CPC classification number: C12P13/001 ,  A61K35/00 ,  A61K38/00 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/1217 ,  C12N9/13 ,  C12N9/16 ,  C12N9/88 ,  C12N9/93 ,  C12N15/52 ,  C12P5/02 ,  C12P7/04 ,  C12P7/18 ,  C12P7/26 ,  C12P7/40 ,  C12P7/42 ,  C12P7/52 ,  C12P11/00 ,  C12Y101/01001 ,  C12Y101/01035 ,  C12Y101/011 ,  C12Y103/01009 ,  C12Y103/01038 ,  C12Y203/01008 ,  C12Y208/03008 ,  C12Y402/01017 ,  C12Y402/01059 ,  Y02A50/473 ,  Y02A50/481

Abstract: The use of microorganisms to make alpha-functionalized chemicals and fuels, (e.g. alpha-functionalized carboxylic acids, alcohols, hydrocarbons, amines, and their beta-, and omega-functionalized derivatives), by utilizing an iterative carbon chain elongation pathway that uses functionalized extender units. The core enzymes in the pathway include thiolase, dehydrogenase, dehydratase and reductase. Native or engineered thiolases catalyze the condensation of either unsubstituted or functionalized acyl-CoA primers with an alpha-functionalized acetyl-CoA as the extender unit to generate alpha-functionalized β-keto acyl-CoA. Dehydrogenase converts alpha-functionalized β-keto acyl-CoA to alpha-functionalized β-hydroxy acyl-CoA. Dehydratase converts alpha-functionalized β-hydroxy acyl-CoA to alpha-functionalized enoyl-CoA. Reductase converts alpha-functionalized enoyl-CoA to alpha-functionalized acyl-CoA. The platform can be operated in an iterative manner (i.e. multiple turns) by using the resulting alpha-functionalized acyl-CoA as primer and the aforementioned alpha-functionalized extender unit in subsequent turns of the cycle. Termination pathways acting on any of the four alpha-functionalized CoA thioester intermediates terminate the platform and generate various alpha-functionalized carboxylic acids, alcohols and amines with different β-reduction degree.

公开(公告)号：EP3099763A4

公开(公告)日：2017-08-02

申请号：EP15740946

申请日：2015-01-26

Applicant: UNIV RICE WILLIAM M

Inventor： GONZALEZ RAMON ,  CLOMBURG JAMES M ,  VICK JACOB E

IPC: C10L1/06

CPC classification number: C12P7/64 ,  C10L1/02 ,  C10L1/04 ,  C12N9/00 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/0071 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/88 ,  C12N15/52 ,  C12Y101/011 ,  C12Y101/03013 ,  C12Y102/01 ,  C12Y102/01003 ,  C12Y103/01009 ,  C12Y114/00 ,  C12Y203/01009 ,  C12Y206/00 ,  C12Y401/99005 ,  C12Y402/01059 ,  Y02E50/343

Abstract: This disclosure describes enzymes from the type II (a discrete set of enzymes) fatty acid synthesis (“FAS”) pathway that can be used in combination with thiolases to operate a functional reversal of the β-oxidation cycle. A combination of thiolases with one or more of 3-oxoacyl-[acyl-carrier-protein] reductase (FabG, others), 3-hydroxyacyl-[acp] dehydratase (FabA, FabZ, others), and enoyl-[acyl-carrier-protein] reductase (FabI, FabK, FabL, FabV, others) yields a functional reversal of the β-oxidation cycle. If only one or two enzymes are used, the remaining enzymes will be traditional beta oxidation enzymes. Once this cycle is coupled with the appropriate priming and termination pathways, the production of carboxylic acids, alcohols, hydrocarbons, amines and their α-, β-, and ω-functionalized derivatives from renewable carbon sources can be achieved.

Abstract translation: 本公开描述了可以与硫解酶组合用于操作β-氧化循环的功能性反转的II型（一组离散的酶）脂肪酸合成（“FAS”）途径的酶。 硫解酶与一种或多种3-氧酰基 - [酰基 - 载体 - 蛋白]还原酶（FabG等），3-羟基酰基 - [acp]脱水酶（FabA，FabZ等）和烯酰基 - [酰基载体 蛋白]还原酶（FabI，FabK，FabL，FabV等）产生β-氧化循环的功能性反转。 如果只使用一种或两种酶，剩余的酶将是传统的β氧化酶。 一旦该循环与适当的引发和终止途径相结合，可以实现从可再生碳源生产羧酸，醇，烃，胺和它们的α-，β-和ω-官能化衍生物。

公开(公告)号：EP2931742A2

公开(公告)日：2015-10-21

申请号：EP13826804.0

申请日：2013-12-11

Applicant: REG Life Sciences, LLC

Inventor： SIMPSON, David ,  DA COSTA, Bernardo ,  RUDE, Mathew ,  TRINH, Na ,  POPOVA, Emanuela ,  VENKITESWARAN, Sankaranarayanan ,  HELMAN, Noah ,  HOLDEN, Kevin

IPC: C07K14/195 ,  C12N9/00 ,  C12P7/64

CPC classification number: C12P7/6436 ,  C07K14/195 ,  C07K14/245 ,  C12N9/00 ,  C12N9/001 ,  C12N9/1288 ,  C12N9/16 ,  C12P5/02 ,  C12P7/04 ,  C12P7/64 ,  C12P7/6409 ,  C12P7/649 ,  C12Y103/01009 ,  C12Y207/08 ,  C12Y301/02 ,  Y02E50/13

Abstract: The disclosure relates to recombinant microorganisms that exhibit an increased expression of an acyl carrier protein (ACP) resulting in production of fatty acid derivatives. The disclosure further relates to methods of using the recombinant microorganisms in fermentation cultures in order to produce fatty acid derivatives and related compositions.

公开(公告)号：EP2576799B1

公开(公告)日：2017-04-26

申请号：EP11721794.3

申请日：2011-05-30

Applicant: Universität des Saarlandes

Inventor： WENZEL, Silke ,  RACHID, Shwan ,  GEMPERLEIN, Katja ,  MÜLLER, Rolf

IPC: C12P7/64 ,  C12N9/02 ,  C12N9/10 ,  C12N15/52

CPC classification number: C12P7/6427 ,  C12N9/001 ,  C12N9/1029 ,  C12N15/52 ,  C12P7/64 ,  C12Y103/01009 ,  C12Y203/01051 ,  Y02P20/52

公开(公告)号：EP2882843A1

公开(公告)日：2015-06-17

申请号：EP13827193.7

申请日：2013-08-09

Applicant: OPX Biotechnologies Inc.

Inventor： LIAO, Hans ,  SPINDLER, Eileen ,  WARNER, Joseph, R. ,  LOUIE, Michael ,  RIBBLE, Wendy ,  PRATHER, Brittney ,  EVANS, Ron ,  LIPSCOMB, Tanya, E. W. ,  LYNCH, Michael, D.

IPC: C12N1/20 ,  C12N15/74

CPC classification number: C12P7/6409 ,  C12N9/0006 ,  C12N9/001 ,  C12N9/1029 ,  C12N15/52 ,  C12P7/04 ,  C12P7/40 ,  C12R1/19 ,  C12Y101/01157 ,  C12Y103/01009 ,  C12Y203/01194

Abstract: This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a fatty acid or fatty acid derived product, wherein the modified microorganism produces fatty acyl-CoA intermediates via a malonyl-CoA dependent but malonyl-ACP independent mechanism.