Patent search ap:("ヘキスト・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング") AND inv:"ハンス・ヨーヘン・ラング" Page 1

1.

发明专利
Sulfonamide - substituted compounds, processes for their preparation, pharmaceutical or their use and pharmaceutical preparations containing them as a diagnostic agent 失效

公开(公告)号：JP4317601B2

公开(公告)日：2009-08-19

申请号：JP34546997

申请日：1997-12-15

Applicant: ヘキスト・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング

Inventor： ウーヴエ・ゲルラハ , クラウス・ヴアイトマン , ハンス・ヨーヘン・ラング , ヨーアヒム・ブレンデル

IPC: C07D215/42 , C07D239/22 , A61K31/33 , A61K31/35 , A61K31/352 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4706 , A61K31/505 , A61K31/535 , A61K31/536 , A61K31/54 , A61K31/545 , A61P1/00 , A61P1/04 , A61P9/00 , A61P19/02 , A61P29/00 , A61P43/00 , C07D207/325 , C07D211/14 , C07D213/06 , C07D213/75 , C07D217/22 , C07D239/94 , C07D241/04 , C07D265/06 , C07D265/16 , C07D265/20 , C07D277/20 , C07D295/08 , C07D295/12 , C07D311/68 , C07D311/70 , C07D333/10 , C07D335/00 , C07D417/04

CPC classification number: C07D217/22 , C07D215/42 , C07D239/94 , C07D265/16

2.

发明专利
Substituted sulfonic imide dummy de, their preparation, their use as medicaments or diagnostic agents and drugs containing them 失效

公开(公告)号：JP3924028B2

公开(公告)日：2007-06-06

申请号：JP29139696

申请日：1996-11-01

Applicant: ヘキスト・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング

Inventor： アンドレーアス・ヴアイヒエルト , ウードー・アルブス , ヴオルフガング・シヨルツ , ハインツ−ヴエルナー・クレーマン , ハンス・ヨーヘン・ラング , ヤン−ローベルト・シユヴアルク , ヨーアヒム・ブレンデル

IPC: A61K31/165 , C07C381/10 , A61K31/18 , A61P1/16 , A61P3/08 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/02 , A61P15/00 , A61P35/00 , A61P41/00 , A61P43/00 , C07C279/18 , C07C313/02 , C07C313/06

CPC classification number: C07C381/10 , Y10S514/824 , Y10S514/825 , Y10S514/826 , Y10S514/851 , Y10S514/866 , Y10S514/893

Abstract: Sulphonimidamides of formula R1N=S(O)(R2)N(R4)(R3) (I) and their salts are new: at least one of R1-R3 = a benzoylguanidine group of formula (a) optionally substituted in the phenyl ring by 1-4 of 1-8C alkyl, 2-8C alkenyl, (CH2)mR14, halo, CN, CF3, R22SO2, R23R24NCO, R25CO, R26R27NSO2, OR35, SR35 or NR35R36; m = 0-2; R14 = 3-8C cycloalkyl, phenyl optionally substituted by 1-3 of F, Cl, CF3, Me, OMe or NR15R16; R15, R16 = H or Me; R22, R23, R25, R26 = 1-8C alkyl, 2-8C alkenyl, (CH2)nR29 or CF3; or R23+R24, R26+R27 = 5-6 methylene groups with optionally one CH2 replaced by O, S, NH, NMe or N-benzyl; or R23, R25, R26 = H; n = 0-4; R29 = 3-7C cycloalkyl, phenyl optionally substituted by 1-3 of F, Cl, CF3, Me, OMe or NR30R31; R30, R31 = H or 1-4C alkyl; R24, R27 = H or 1-4C alkyl; R35, R36 = H or 1-6C alkyl; or R35+R36 = 4-7 methylene groups with optionally one CH2 replaced by O, S, NH, NMe or N-benzyl; or R35 = phenyl optionally substituted by 1-3 of F, Cl, CF3, Me, OMe, SO2R5, SO2NR6R7 or NR32R33; R5 = 1-6C alkyl; R6, R7 = H or 1-4C alkyl; R32, R33 = H or 1-4C alkyl; or R35 = 1-9C heteroaryl optionally substituted by 1-3 of F, Cl, CF3, CH3, OMe, OH, NH2, NHMe or N(Me)2; the remaining R1-R3 = 1-8C alkyl or (CH2)pR10; or the remaining R1, R2 = H; p = 0-4; R10 = phenyl optionally substituted by 1-3 of F, Cl, CF3, Me, OMe, SO2NR17R8 or SO2R9; R17, R8 = H or 1-4C alkyl; R9 = 1-4C alkyl; and R4 = H or 1-4C alkyl.