Abstract:
PROBLEM TO BE SOLVED: To provide a method for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. SOLUTION: Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7430 Ester Hydrolase also are provided. In one embodiment, this invention comprises following steps: (a) identifying a non-nucleotide prototype compound, (b) substituting the prototype compound with phosphonate-containing group to form a candidate compound, and (c) determining the anti-HIV activity of the candidate compound. COPYRIGHT: (C)2009,JPO&INPIT