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1.发明授权Biomaterials based on hyaluronic acid for the anti-angiogenic therapy in the treatment of tumors 有权基于透明质酸的生物材料用于治疗肿瘤的抗血管生成治疗公开(公告)号：US07838510B2
公开(公告)日：2010-11-23
申请号：US10501030
申请日：2003-01-07
IPC分类号： A61K31/728 , A61K31/715
CPC分类号： A61L31/042 , C08L5/08
摘要： The use in the medical-surgical field of biomaterials based on hyaluronic acid derivatives, optionally in association with natural, synthetic or semisynthetic biopolymers, for suppressing the angiogenic process associated with tumor proliferation (in primary and secondary tumors) is disclosed.
摘要翻译： 公开了用于抑制与肿瘤增殖相关的血管生成过程（在原发性和继发性肿瘤中）的基于透明质酸衍生物的生物材料的医学外科领域，任选与天然的，合成的或半合成的生物聚合物结合。
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2.发明申请HYALURONIC ACID DERIVATIVE AND NEURAL STEM CELLS FOR SCI AND PNT REGENERATION 审中-公开用于SCI和PNT再生的羟丙酸衍生物和神经干细胞公开(公告)号：US20100136081A1
公开(公告)日：2010-06-03
申请号：US12470116
申请日：2009-05-21
CPC分类号： A61L27/20 , A61L27/383 , A61L27/3878 , A61L27/3895 , C08L5/08
摘要： A biomaterial for the treatment of spinal cord or of peripheral nerve injury, obtainable by: a) treating a hyaluronic acid derivative with a coating solution promoting Neuronal Stem Cells adhesion, branching and differentiation; b) contacting isolated Neuronal Stem Cells with the hyaluronic acid derivative obtained from step a) and culturing and expanding the absorbed cells in the presence of growth or neurotrophic factors selected from βFGF (basic fibroblast growth factor), CNTF (ciliary neurotrophic factor), BDNF (brain derived neurotrophic factor) and GDNF (glial derived neurotrophic factor) or mixtures thereof.
摘要翻译： 用于治疗脊髓或周围神经损伤的生物材料，其可通过以下方法获得：a）用涂覆溶液处理透明质酸衍生物，促进神经元干细胞粘附，分支和分化; b）使分离的神经元干细胞与从步骤a）获得的透明质酸衍生物接触，并在生长或神经营养因子存在下培养和扩增所吸收的细胞，所述生长或神经营养因子选自FGF（碱性成纤维细胞生长因子），CNTF（睫状神经营养因子） ，BDNF（脑源性神经营养因子）和GDNF（胶质衍生的神经营养因子）或其混合物。
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3.发明授权Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives 失效用于防止由透明质酸衍生物组成的手术后粘连的生物材料公开(公告)号：US07504386B2
公开(公告)日：2009-03-17
申请号：US10812587
申请日：2004-03-29
IPC分类号： A61K9/70 , A61K31/728
CPC分类号： A61L31/10 , A61L31/042 , A61L31/129 , C08L5/08
摘要： New biomaterials essentially constituted by esterified derivatives of hyaluronic acid or by cross-linked derivatives of hyaluronic acid for use in the surgical sector, particularly for use in the prevention of post-surgical adhesions.
摘要翻译： 新的生物材料基本上由透明质酸的酯化衍生物或透明质酸的交联衍生物构成，用于手术部门，特别是用于预防手术后粘连。
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公开(公告)号：US07968111B2
公开(公告)日：2011-06-28
申请号：US10467142
申请日：2002-02-06
IPC分类号： A61F2/00
CPC分类号： A61L27/3817 , A61L27/12 , A61L27/20 , A61L27/3852 , A61L27/3895 , A61L27/425 , A61L27/46 , C08L5/08
摘要： The invention concerns the preparation and use of a biocompatible, biocomponent material constituted by: (a) a three-dimensional matrix of hyaluronic acid derivatives witle a structure containing empty spaces; (b) a porous, three-dimensional matrix constituted by a ceramic material; (c) possibly containing pharmacologically or biologically active ingredients.
摘要翻译： 本发明涉及生物相容的生物组分材料的制备和使用，其由以下组成：（a）具有包含空白空间的结构的透明质酸衍生物的三维基质; （b）由陶瓷材料构成的多孔三维基体; （c）可能含有药理学或生物活性成分。
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5.发明授权Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants 有权使用透明质酸聚合物用于粘膜递送疫苗抗原和佐剂公开(公告)号：US07947309B2
公开(公告)日：2011-05-24
申请号：US12590548
申请日：2009-11-10
申请人： Derek O'Hagan , Alessandra Pavesio
发明人： Derek O'Hagan , Alessandra Pavesio
IPC分类号： A61K9/16 , A61K9/50 , A61K9/14 , A61K45/00 , A61K51/00 , A61K36/14 , A61K31/70 , C12Q1/68 , A01N43/04
CPC分类号： A61K47/36 , A61K9/0043 , A61K9/1652 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/543 , A61K2039/55544 , A61K2039/55555 , C12N2760/16134
摘要： Compositions are provided which include hyaluronic acid derivatives in combination with vaccine antigens, and optionally adjuvants, for mucosal delivery. Also provided are methods of making the compositions, as well as methods of immunization using the same.
摘要翻译： 提供了组合物，其包括与疫苗抗原组合的透明质酸衍生物和用于粘膜递送的任选的佐剂。 还提供了制备组合物的方法以及使用其的免疫方法。
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6.发明申请公开(公告)号：US20080220053A1
公开(公告)日：2008-09-11
申请号：US11792976
申请日：2005-12-12
CPC分类号： A61L24/0015 , A61L15/32 , A61L15/44 , A61L24/10 , A61L31/043 , A61L31/16 , A61L2300/414 , A61L2300/418 , A61L2400/04
摘要： A process for the preparation of polymer scaffolds containing a pharmacologically and/or biologically active protein molecule involving the following steps: neutralisation of the scaffold with a basic substance or a buffer solution; drying the scaffold; imbibition of the scaffold with a predefined quantity of a pharmacologically and/or biologically active protein molecule.
摘要翻译： 一种制备含有药理学和/或生物活性蛋白质分子的聚合物支架的方法，包括以下步骤：用碱性物质或缓冲溶液中和支架; 干燥脚手架; 用预定量的药理学和/或生物活性蛋白质分子吸收支架。
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7.发明授权Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants 失效使用透明质酸聚合物用于粘膜递送疫苗抗原和佐剂公开(公告)号：US06824793B1
公开(公告)日：2004-11-30
申请号：US09724661
申请日：2000-11-28
申请人： Derek O'Hagan , Alessandra Pavesio
发明人： Derek O'Hagan , Alessandra Pavesio
IPC分类号： A61K916
CPC分类号： A61K47/36 , A61K9/0043 , A61K9/1652 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/543 , A61K2039/55544 , A61K2039/55555 , C12N2760/16134
摘要： Compositions are provided which include hyaluronic acid derivatives in combination with vaccine antigens, and optionally adjuvants, for mucosal delivery. Also provided are methods of making the compositions, as well as methods of immunization using the same.
摘要翻译： 提供了组合物，其包括与疫苗抗原组合的透明质酸衍生物和用于粘膜递送的任选的佐剂。 还提供了制备组合物的方法以及使用其的免疫方法。
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8.发明授权Biocompatible material and prosthetic device made thereof for the replacement, repair and regeneration of meniscus 有权由其制成的生物相容性材料和假体装置用于更换，修复和再生半月板公开(公告)号：US08901202B2
公开(公告)日：2014-12-02
申请号：US11793409
申请日：2005-12-14
IPC分类号： A61F2/00 , A61L24/00 , C08B37/00 , C08G63/48 , A61F2/38 , A61F2/30 , A61L27/26 , A61L27/34 , A61L27/48 , A61L27/56 , A61F2/28
CPC分类号： A61F2/3872 , A61F2/30756 , A61F2/30965 , A61F2002/2867 , A61F2002/30062 , A61F2002/30133 , A61F2002/30957 , A61F2002/30971 , A61F2210/0004 , A61F2230/0015 , A61F2310/00365 , A61L27/26 , A61L27/34 , A61L27/48 , A61L27/56 , C08L67/04 , C08L5/08
摘要： Herein described is a biocompatible material comprising a polymer matrix based on hyaluronic acid derivatives and poly-εCaprolactone, the process for preparing this material, a prosthetic device constituted by this biocompatible material and a reinforcing material, the process for preparing the prosthetic device, and its use for the partial or total replacement of meniscus, and regeneration of the meniscal fibrocartilage.
摘要翻译： 本文描述了一种生物相容性材料，其包含基于透明质酸衍生物和聚己内酯的聚合物基质，该制备该材料的方法，由该生物相容性材料和增强材料构成的假体装置，制备该假体装置的方法， 并用于部分或全部更换半月板，再生半月板纤维软骨。
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9.发明申请Biocompatible Material and Prosthetic Device Made Thereof for the Replacement, Repair and Regeneration of Meniscus 有权生物相容材料及其修补装置用于更换，修复和再生半月板公开(公告)号：US20080097605A1
公开(公告)日：2008-04-24
申请号：US11793409
申请日：2005-12-14
IPC分类号： A61F2/02
CPC分类号： A61F2/3872 , A61F2/30756 , A61F2/30965 , A61F2002/2867 , A61F2002/30062 , A61F2002/30133 , A61F2002/30957 , A61F2002/30971 , A61F2210/0004 , A61F2230/0015 , A61F2310/00365 , A61L27/26 , A61L27/34 , A61L27/48 , A61L27/56 , C08L67/04 , C08L5/08
摘要： Herein described is a biocompatible material comprising a polymer matrix based on hyaluronic acid derivatives and poly-εCaprolactone, the process for preparing this material, a prosthetic device constituted by this biocompatible material and a reinforcing material, the process for preparing the prosthetic device, and its use for the partial or total replacement of meniscus, and regeneration of the meniscal fibrocartilage.
摘要翻译： 本文描述的是包含基于透明质酸衍生物和聚ε-己内酯的聚合物基质的生物相容性材料，该材料的制备方法，由该生物相容性材料和增强材料构成的假体装置，其制备方法 用于局部或全部更换半月板，再生半月板纤维软骨。
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10.发明授权Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins 失效用于输送成骨蛋白质的透明质酸衍生物的可注射载体制剂公开(公告)号：US07189392B1
公开(公告)日：2007-03-13
申请号：US09687281
申请日：2000-10-13
申请人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
发明人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
IPC分类号： A61K38/43
CPC分类号： A61K9/0024 , A61K9/0019 , A61K38/1875 , A61K47/26 , A61K47/36 , A61L27/20 , A61L27/227 , A61L27/46 , A61L2300/414 , A61L2400/06 , A61K2300/00 , C08L5/08
摘要： An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
摘要翻译： 公开了用于递送成骨蛋白质的可注射制剂。 该制剂包含成骨蛋白的药学上可接受的混合物; 并且还公开了包含成骨蛋白，透明质酸衍生物和磷酸三钙的制剂。 还公开了从透明质酸配制多孔可注射凝胶和糊剂的方法。
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