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    High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds
    2.
    发明授权
    High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds 有权

    公开(公告)号：US09969751B2

    公开(公告)日：2018-05-15

    申请号：US13323556

    申请日：2011-12-12

    申请人： Chongxi Yu ,  Lina Xu ,  Yuhua Chen ,  Binbing Yan ,  Shiqian Tu

    发明人： Chongxi Yu ,  Lina Xu ,  Yuhua Chen ,  Binbing Yan ,  Shiqian Tu

    IPC分类号： C07D499/21

    CPC分类号： C07D499/21

    摘要： The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of antimicrobials and antimicrobial-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPCs/HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPCs/HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

    HIGH PENETRATION PRODRUG COMPOSITIONS OF PEPTIDES AND PEPTIDE-RELATED COMPOUNDS
    4.
    发明申请
    HIGH PENETRATION PRODRUG COMPOSITIONS OF PEPTIDES AND PEPTIDE-RELATED COMPOUNDS 有权
    肽和肽相关化合物的高渗透性原料组合物

    公开(公告)号：US20120156279A1

    公开(公告)日：2012-06-21

    申请号：US13291904

    申请日：2011-11-08

    申请人： Chongxi Yu ,  Lina Xu ,  Yuhua Chen ,  Binbing Yan ,  Shiqian Tu

    发明人： Chongxi Yu ,  Lina Xu ,  Yuhua Chen ,  Binbing Yan ,  Shiqian Tu

    IPC分类号： A61K9/70

    CPC分类号： A61K31/145 ,  A61K9/0014 ,  A61K31/222 ,  A61K31/40 ,  A61K31/4184 ,  A61K38/00 ,  A61K47/42 ,  A61K47/54 ,  A61K47/64 ,  A61K47/645 ,  C07D403/12 ,  C07D403/14 ,  C07K1/04 ,  C07K5/06026 ,  C07K5/06078 ,  C07K5/1013 ,  C07K5/1016 ,  C07K5/1019 ,  C07K7/06 ,  C07K7/56

    摘要： The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of peptides and peptide-related compounds, which are capable of crossing biological barriers with higher penetration efficiency comparing to their parent drugs. The HPPs are capable of being converted to parent drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs/HPCs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs/HPCs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

    摘要翻译： 本发明提供了肽和肽相关化合物的新型高渗透组合物（HPC）或高渗透前药（HPP）的组合物，其能够与其母体药物相比具有更高穿透效率的生物屏障。 HPP在穿过生物屏障后能够转化为母体药物或药物代谢物，因此可以对母体药物或代谢物可以进行的处理。 此外，HPP / HPC能够达到母体药物可能无法进入或在目标区域提供足够浓度的区域，从而进行新的治疗。 HPP / HPC可以通过各种施用途径施用于受试者，例如局部递送至具有高浓度或系统地施用于生物学受试者的病症的作用部位并以更快的速率进入总体循环。