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公开(公告)号:US20160144077A1
公开(公告)日:2016-05-26
申请号:US15008873
申请日:2016-01-28
发明人: Michael Tittelbach , Raimund Moehl , Alwin Schwitzer , Matthias Wesselmann , Bodo Quint , Patrice Bachmann
CPC分类号: A61L29/16 , A61L2/085 , A61L29/085 , A61L2300/606 , A61L2420/02 , A61L2420/06 , C08L77/00 , C08L75/04
摘要: The invention relates to a drug-coated balloon catheter and to a method for producing the same. The balloon of the catheter includes (i) a main membrane, and (ii) an asymmetrical polymer membrane which is applied to an outside of the main membrane and into which at least one pharmaceutical active ingredient is introduced.
摘要翻译: 本发明涉及药物包衣球囊导管及其制造方法。 导管的气囊包括(i)主膜,和(ii)施加到主膜外部并且引入至少一种药物活性成分的不对称聚合物膜。
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公开(公告)号:US20150064054A1
公开(公告)日:2015-03-05
申请号:US14535826
申请日:2014-11-07
发明人: Bodo Gerold
CPC分类号: A61L31/022 , A61L31/148 , C22C23/06 , C22F1/06
摘要: An implant made in total or in parts of a biodegradable magnesium alloy consisting of Y: 2.0-6.0% by weight, Nd: 1.5-4.5% by weight, Gd: 0-4.0% by weight, Dy: 0-4.0% by weight, Er: 0-4.0% by weight, Zr: 0.1-1.0% by weight, Li: 0-0.2% by weight, Al: 0-0.3% by weight, under the condition that a) a total content of Er, Gd and Dy is in the range of 0.5-4.0% by weight and b) a total content of Nd, Er, Gd and Dy is in the range of 2.0-5.5% by weight, the balance being magnesium and incidental impurities up to a total of 0.3% by weight.
摘要翻译: 由Y:2.0-6.0重量%,Nd:1.5-4.5重量%,Gd:0-4.0重量%,Dy:0-4.0重量%组成的可生物降解镁合金的全部或部分制造的植入物 ,Er:0-4.0重量%,Zr:0.1-1.0重量%,Li:0-0.2重量%,Al:0-0.3重量%,条件是:a)Er,Gd的总含量 Dy为0.5-4.0重量%,b)Nd,Er,Gd和Dy的总含量在2.0-5.5重量%的范围内,其余为镁和附带杂质直到总量 为0.3重量%。
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公开(公告)号:US20130218265A1
公开(公告)日:2013-08-22
申请号:US13758639
申请日:2013-02-04
发明人: Baerbel Becher , Carsten Momma , Daniel Lootz , Antje Quade , Andreas Ohl , Karsten Schroeder
IPC分类号: A61F2/06
CPC分类号: A61F2/06 , A61F2/82 , A61F2210/0009 , A61L31/022 , A61L31/082 , A61L31/148 , B05D1/62 , B05D5/083 , B05D2202/20 , C23C16/22 , C23C16/511
摘要: An implant having a base body, comprised either entirely or in part of a biocorrodible metallic material wherein at least the parts of the base body having the biocorrodible metallic material are at least partially covered with a coating of a crosslinked CFx layer that is nonpolymerized and has an F/C ratio in the range of 0.5 to 1.5.
摘要翻译: 具有基体的植入体,其全部或部分由生物可腐蚀的金属材料组成,其中至少部分具有生物可腐蚀金属材料的基体至少部分被不聚合的交联CFx层的涂层覆盖并具有 F / C比在0.5至1.5的范围内。
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公开(公告)号:US09468704B2
公开(公告)日:2016-10-18
申请号:US13665307
申请日:2012-10-31
发明人: Bodo Gerold
CPC分类号: A61L31/022 , A61L31/148 , C22C23/06 , C22F1/06
摘要: An implant made in total or in parts of a biodegradable magnesium alloy consisting of Y: 2.0-6.0% by weight, Nd: 1.5-4.5% by weight, Gd: 0-4.0% by weight, Dy: 0-4.0% by weight, Er: 0-4.0% by weight, Zr: 0.1-1.0% by weight, Li: 0-0.2% by weight, Al: 0-0.3% by weight, under the condition that a) a total content of Er, Gd and Dy is in the range of 0.5-4.0% by weight and b) a total content of Nd, Er, Gd and Dy is in the range of 2.0-5.5% by weight, the balance being magnesium and incidental impurities up to a total of 0.3% by weight.
摘要翻译: 由Y:2.0-6.0重量%,Nd:1.5-4.5重量%,Gd:0-4.0重量%,Dy:0-4.0重量%组成的可生物降解镁合金的全部或部分制造的植入物 ,Er:0-4.0重量%,Zr:0.1-1.0重量%,Li:0-0.2重量%,Al:0-0.3重量%,条件是:a)Er,Gd的总含量 Dy为0.5-4.0重量%,b)Nd,Er,Gd和Dy的总含量在2.0-5.5重量%的范围内,其余为镁和附带杂质直到总量 为0.3重量%。
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公开(公告)号:US09381100B2
公开(公告)日:2016-07-05
申请号:US13937113
申请日:2013-07-08
发明人: Ullrich Bayer , Bodo Gerold
IPC分类号: C23C8/20 , C23C8/22 , C23C8/24 , C23C8/26 , C23C8/30 , C23C8/32 , A61F2/82 , A61L31/02 , A61L31/08 , A61L31/14
CPC分类号: A61F2/82 , A61L31/022 , A61L31/084 , A61L31/148 , C23C8/20 , C23C8/22 , C23C8/24 , C23C8/26 , C23C8/30 , C23C8/32
摘要: Implant in the form of an intraluminal endoprosthesis, having a tubular body containing metallic material, optionally iron, whereby in at least a portion of the implant body the following are present in the structure of a near-surface boundary layer in comparison to the respective concentration in the remaining structure: an increased carbon content in a concentration of approximately 0.5% by weight to approximately 2% by weight; or an increased carbon and nitrogen content, wherein a concentration of carbon is approximately 0.5% by weight to approximately 7% by weight, and a concentration of nitrogen is approximately 0.5% by weight to approximately 17% by weight.
摘要翻译: 以管腔内置假体形式的植入物,其具有包含金属材料的管状体,任选地铁,由此在植入物主体的至少一部分中,与各自的浓度相比,以下存在于近表面边界层的结构中 在剩余结构中:增加的碳含量为约0.5重量%至约2重量%; 或增加的碳和氮含量,其中碳的浓度为约0.5重量%至约7重量%,氮的浓度为约0.5重量%至约17重量%。
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公开(公告)号:US20130304178A1
公开(公告)日:2013-11-14
申请号:US13937097
申请日:2013-07-08
发明人: Ullrich Bayer , Bodo Gerold
IPC分类号: A61F2/82
CPC分类号: A61F2/82 , A61L31/022 , A61L31/084 , A61L31/148 , C23C8/20 , C23C8/22 , C23C8/24 , C23C8/26 , C23C8/30 , C23C8/32
摘要: The present invention relates to a method for manufacturing an implant, in particular an intraluminal endoprosthesis, having a body containing metallic material, preferably iron. For controlling the degradation of the implant the method includes the following steps: (a) providing a first part of the implant body; and (b) performing heat treatment which alters the carbon content and/or the boron content and/or the nitrogen content in the structure of a near-surface boundary layer in the first part of the implant body in such a way that strain on the lattice or a lattice transformation, optionally following a subsequent mechanical load, is achieved in the near-surface boundary layer. Such an implant is also described.
摘要翻译: 本发明涉及用于制造植入物的方法,特别是管腔内假体,其具有包含金属材料,优选铁的主体。 为了控制植入物的降解,该方法包括以下步骤:(a)提供植入体的第一部分; 和(b)进行热处理,其改变植入物体的第一部分中的近表面边界层的结构中的碳含量和/或硼含量和/或氮含量,使得在 在近表面边界层中实现晶格或晶格转变,任选地遵循随后的机械负载。 还描述了这种植入物。
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公开(公告)号:US09833547B2
公开(公告)日:2017-12-05
申请号:US15008873
申请日:2016-01-28
发明人: Michael Tittelbach , Raimund Moehl , Alwin Schwitzer , Matthias Wesselmann , Bodo Quint , Patrice Bachmann
CPC分类号: A61L29/16 , A61L2/085 , A61L29/085 , A61L2300/606 , A61L2420/02 , A61L2420/06 , C08L77/00 , C08L75/04
摘要: The invention relates to a drug-coated balloon catheter and to a method for producing the same. The balloon of the catheter includes (i) a main membrane, and (ii) an asymmetrical polymer membrane which is applied to an outside of the main membrane and into which at least one pharmaceutical active ingredient is introduced.
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公开(公告)号:US08801778B2
公开(公告)日:2014-08-12
申请号:US13758639
申请日:2013-02-04
发明人: Baerbel Becher , Carsten Momma , Daniel Lootz , Antje Quade , Andreas Ohl , Karsten Schroeder
IPC分类号: A61F2/06
CPC分类号: A61F2/06 , A61F2/82 , A61F2210/0009 , A61L31/022 , A61L31/082 , A61L31/148 , B05D1/62 , B05D5/083 , B05D2202/20 , C23C16/22 , C23C16/511
摘要: An implant having a base body, comprised either entirely or in part of a biocorrodible metallic material wherein at least the parts of the base body having the biocorrodible metallic material are at least partially covered with a coating of a crosslinked CFx layer that is nonpolymerized and has an F/C ratio in the range of 0.5 to 1.5.
摘要翻译: 具有基体的植入体,其全部或部分由生物可腐蚀的金属材料组成,其中至少部分具有生物可腐蚀金属材料的基体至少部分被不聚合的交联CFx层的涂层覆盖并具有 F / C比在0.5至1.5的范围内。
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公开(公告)号:US20130060326A1
公开(公告)日:2013-03-07
申请号:US13665307
申请日:2012-10-31
发明人: Bodo Gerold
CPC分类号: A61L31/022 , A61L31/148 , C22C23/06 , C22F1/06
摘要: An implant made in total or in parts of a biodegradable magnesium alloy consisting of Y: 2.0-6.0% by weight, Nd: 1.5-4.5% by weight, Gd: 0-4.0% by weight, Dy: 0-4.0% by weight, Er: 0-4.0% by weight, Zr: 0.1-1.0% by weight, Li:0-0.2% by weight, Al: 0-0.3% by weight, under the condition that a) a total content of Er, Gd and Dy is in the range of 0.5-4.0% by weight and b) a total content of Nd, Er, Gd and Dy is in the range of 2.0-5.5% by weight, the balance being magnesium and incidental impurities up to a total of 0.3% by weight.
摘要翻译: 由Y:2.0-6.0重量%,Nd:1.5-4.5重量%,Gd:0-4.0重量%,Dy:0-4.0重量%组成的可生物降解镁合金的全部或部分制造的植入物 ,Er:0-4.0重量%,Zr:0.1-1.0重量%,Li:0-0.2重量%,Al:0-0.3重量%,条件是:a)Er,Gd的总含量 Dy为0.5-4.0重量%,b)Nd,Er,Gd和Dy的总含量在2.0-5.5重量%的范围内,其余为镁和附带杂质直到总量 为0.3重量%。
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公开(公告)号:US20130297006A1
公开(公告)日:2013-11-07
申请号:US13937113
申请日:2013-07-08
发明人: Ullrich Bayer , Bodo Gerold
CPC分类号: A61F2/82 , A61L31/022 , A61L31/084 , A61L31/148 , C23C8/20 , C23C8/22 , C23C8/24 , C23C8/26 , C23C8/30 , C23C8/32
摘要: Implant in the form of an intraluminal endoprosthesis, having a tubular body containing metallic material, optionally iron, whereby in at least a portion of the implant body the following are present in the structure of a near-surface boundary layer in comparison to the respective concentration in the remaining structure: an increased carbon content in a concentration of approximately 0.5% by weight to approximately 2% by weight; or an increased carbon and nitrogen content, wherein a concentration of carbon is approximately 0.5% by weight to approximately 7% by weight, and a concentration of nitrogen is approximately 0.5% by weight to approximately 17% by weight.
摘要翻译: 以管腔内置假体形式的植入物,其具有包含金属材料的管状体,任选地铁,由此在植入物主体的至少一部分中,与各自的浓度相比,以下存在于近表面边界层的结构中 在剩余结构中:增加的碳含量为约0.5重量%至约2重量%; 或增加的碳和氮含量,其中碳的浓度为约0.5重量%至约7重量%,氮的浓度为约0.5重量%至约17重量%。
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