公开(公告)号：US12233061B2

公开(公告)日：2025-02-25

申请号：US17430453

申请日：2020-02-12

Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW ,  CAMBRIDGE ENTERPRISE LIMITED

Inventor： Colin Berry ,  Thomas J. Ford ,  Anthony P. Davenport

IPC: A61K31/497 ,  A61P9/10

Abstract: The invention provides means of diagnosing and treating microvascular angina (MVA). Diagnostic applications of intra-coronary guidewires are provided. Treatment of MVA patients with zibotentan is disclosed. The MVA patient can be identified and selected for treatment via the diagnostic applications provided.

公开(公告)号：US20250027165A1

公开(公告)日：2025-01-23

申请号：US18714695

申请日：2022-12-02

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Richard GILBERTSON ,  Eric RAHRMANN ,  David SHORTHOUSE

IPC: C12Q1/6886 ,  G01N33/574 ,  G16B5/00 ,  G16H50/30

Abstract: A method for the detection or prognosis of cancer and/or metastasis is provided. Tumour samples may be used to determine the presence of a mutation within the sodium leak channel (NALCN). A risk score of cancer and/or metastasis can be determined based on if the mutation causes a reduction in the pore size of NALCN. A computational model, a composition, and a kit are also provided.

公开(公告)号：US12195753B2

公开(公告)日：2025-01-14

申请号：US17941835

申请日：2022-09-09

Applicant: The Board of Trustees of the University of Illinois ,  Cambridge Enterprise Limited

Inventor： Aleksei Aksimentiev ,  Ulrich F. Keyser

IPC: C12N5/00 ,  A61K9/51 ,  A61K31/711 ,  A61K31/713 ,  C12N15/11

Abstract: The present invention provides compositions and methods for transferring phospholipids and other molecules between the leaflets of a cell membrane. The compositions comprise at least one nucleic acid or compound having a hydrophilic region, where the composition is able to form a nanostructure that forms a toroidal pore in a lipid membrane. The nucleic acid or hydrophilic region-containing compound further contains an attached molecule capable of inserting the nanostructure into the lipid membrane. The invention also provides methods for scrambling lipids and other molecules in a cell membrane, which can be used to alter the function of a selected cell or to facilitate the death of the cell. The scrambling activity of synthetic scramblases described herein outperforms previously known enzymatically active DNA nanostructures and naturally occurring scramblases, in some cases by several orders of magnitude.

公开(公告)号：US12163883B2

公开(公告)日：2024-12-10

申请号：US17792017

申请日：2021-01-13

Applicant: Cambridge Enterprise Limited

Inventor： Gita Khalili Moghaddam ,  Christopher Robin Lowe ,  Jeffrey Blyth

IPC: G01N21/45 ,  G01N21/77

Abstract: The present invention relates to sensors for detecting the presence or measuring the concentration of a target analyte, the sensor comprising: (i) a first phase comprising a first crosslinked polymer; (ii) a second phase comprising a second crosslinked polymer; and (ill) a target analyte recognition agent; the first phase and second phase arranged to form an optical grating. The first crosslinked polymer comprises low amounts of a crosslinking agent. The present invention also relates to methods of making a sensor for detecting the presence or measuring the concentration of a target analyte.

公开(公告)号：US12128155B2

公开(公告)日：2024-10-29

申请号：US17602237

申请日：2020-04-08

Applicant: Cambridge Enterprise Limited

Inventor： Alexander W. Justin ,  Athina E. Markaki

IPC: A61L27/24 ,  A61L27/38 ,  A61L27/52 ,  A61L27/56 ,  B29C39/10 ,  B29C39/26 ,  B29K105/00 ,  B29L31/00

CPC classification number: A61L27/24 ,  A61L27/38 ,  A61L27/52 ,  A61L27/56 ,  B29C39/10 ,  B29C39/26 ,  B29K2089/00 ,  B29K2105/0061 ,  B29L2031/753

Abstract: The present invention provides tissue equivalent scaffold structures and methods of production thereof. Such methods include providing a casting chamber comprising an elongate mould portion, axially disposing a lumen template within the elongate mould portion, and at least partly filling the casting chamber with a gel casting material comprising a matrix of fibrils or fibres and an interstitial fluid phase, such that a portion of the lumen template extends above the casting material. The fluid phase of the gel is allow to flow axially out of the elongate mould portion, in a restricted manner, thereby resulting in axial densification of the gel casting material to form a tissue equivalent tubular scaffold. Tissue equivalent scaffold structures according to the present invention are able to support cell populations both within the walls and on the surface of the construct. They have enhanced mechanical strength due to increased collagen density, and are customisable in terms of luminal diameter and wall thickness. They may find application in tubular tissue engineering.

公开(公告)号：US12076770B2

公开(公告)日：2024-09-03

申请号：US17271816

申请日：2019-08-29

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Julian Allwood ,  Adam Nagysochacki ,  Christopher Cleaver ,  Omer Music ,  Evripides G. Loukaides

IPC: B21D19/04 ,  B21D5/01 ,  B21D5/06 ,  B21D5/08 ,  B21D22/16 ,  B21D31/00

CPC classification number: B21D19/043 ,  B21D5/01 ,  B21D5/06 ,  B21D5/08 ,  B21D22/16 ,  B21D31/005

Abstract: The present invention relates to methods of working sheet metal, and sheet metal working apparatus for performing such methods. Such methods include steps of providing a sheet metal workpiece having first and second surfaces opposed to each other and at least one edge, bending the workpiece to form at least a first sidewall portion defined between the edge and a basal region, the first sidewall portion thereby defining a curved fold region in the sheet metal workpiece adjacent the first sidewall portion. Following this, first anvil tool and a first forming tool are provided for contact with and constraint of the first and second surfaces of the sheet metal workpiece respectively. The forming tool and/or the anvil tool are then progressively slid along the curved fold region to cause shear material transfer in the curved fold region to further deform the curved fold region. Such methods can allow for formation of components of similar shape as made at present by deep drawing methods, but with less wastage of the starting material.

公开(公告)号：US20240263238A1

公开(公告)日：2024-08-08

申请号：US18578982

申请日：2022-07-14

Applicant: Cambridge Enterprise Limited

Inventor： Sudhakaran PRABAKARAN

IPC: C12Q1/6883 ,  C07K16/00 ,  C12N15/113

CPC classification number: C12Q1/6883 ,  C07K16/00 ,  C12N15/113 ,  C07K2317/622 ,  C12N2310/11 ,  C12Q2600/158

Abstract: The present application features methods of treating schizophrenia and bipolar disorder by targeting dysregulated novel open reading frames (nORF) in which increased or reduced expression of the dysregulated nORF is associated with the schizophrenia or bipolar disorder.

公开(公告)号：US20240252457A1

公开(公告)日：2024-08-01

申请号：US18568243

申请日：2022-06-08

Applicant: Cambridge Enterprise Limited

Inventor： Thomas Krieg ,  Michael Patrick Murphy ,  Hiran A. Prag

IPC: A61K31/194 ,  A61K9/00 ,  A61K45/06 ,  A61P9/10

CPC classification number: A61K31/194 ,  A61K9/0019 ,  A61K45/06 ,  A61P9/10

Abstract: The present invention relates to compositions for use in treating or preventing ischaemia reperfusion injury. In particular, the present invention relates to a composition comprising a salt of formula (I): for use in treating or preventing ischaemia reperfusion injury in a subject; wherein said composition has a pH of from about 4.0 to about 7.0. and wherein X, Y, n, m, Z, A and B are as defined herein.

公开(公告)号：US20240200098A1

公开(公告)日：2024-06-20

申请号：US18543249

申请日：2023-12-18

Applicant: Cambridge Enterprise Limited (GB/GB)

Inventor： Ludovic Vallier ,  Mark Kotter ,  Matthias Pawlowski ,  Alessandro Bertero ,  Daniel Ortmann

IPC: C12N15/86 ,  A61K35/545 ,  C12N5/0735 ,  C12N5/074 ,  C12N5/077 ,  C12N5/079 ,  C12N9/22 ,  C12N15/11 ,  G01N33/50

CPC classification number: C12N15/86 ,  A61K35/545 ,  C12N5/0606 ,  C12N5/0607 ,  C12N5/0622 ,  C12N5/0658 ,  C12N9/22 ,  C12N15/11 ,  G01N33/5005 ,  C12N2310/20 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/03 ,  C12N2750/14143 ,  C12N2800/80 ,  C12N2830/003 ,  G01N2800/00

Abstract: The present invention relates to a stable method for introducing at least one inducible cassette into a cell, and permitting controllable transcription from within that inducible cassette. The method may be used for any cell type, from any eukaryotic organism, but has a particular application in the introduction of inducible cassettes into pluripotent stem cells, such as animal or human pluripotent stem cells (hPSCs). The inducible cassette is controllably inserted in such a way to ensure that the genetic material it contains is not silenced or subject to negative influences from the insertion site, and transcription of the genetic material is controlled.

公开(公告)号：US20240175798A1

公开(公告)日：2024-05-30

申请号：US18285010

申请日：2022-03-29

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Steven F. LEE ,  Kevin O'HOLLERAN ,  Alex COLLINS

IPC: G01N15/1434 ,  G01N15/149 ,  G02B21/00

CPC classification number: G01N15/1434 ,  G01N15/149 ,  G02B21/0032 ,  G02B21/006 ,  G01N2015/1445

Abstract: A microscopic imaging method comprising: illuminating a three-dimensional object with a light sheet generated by an illumination optical system and capturing light-field information of the illuminated object with an imaging optical system.