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公开(公告)号：US09834635B2
公开(公告)日：2017-12-05
申请号：US13258857
申请日：2010-03-20
申请人： Peter Klug , Dirk Fischer , Thomas Lindner , Matthias Kunze , Wiebke Moeller , Carina Mildner , Sebastiano Lo Vasco
发明人： Peter Klug , Dirk Fischer , Thomas Lindner , Matthias Kunze , Wiebke Moeller , Carina Mildner , Sebastiano Lo Vasco
IPC分类号： A61K31/045 , A61K31/19 , A61K31/192 , A61K31/375 , A61K31/60 , C08F230/02 , A61K8/36 , A61K8/81 , A61Q5/02 , A61Q17/04 , A61Q19/10 , C08F220/26
CPC分类号： C08F230/02 , A61K8/36 , A61K8/8158 , A61Q5/02 , A61Q17/04 , A61Q19/10 , C08F220/26
摘要： Water-soluble or water-swellable polymers are described, containing a) 20.0 to 98.99 mole percent of one or more independently recurring structural units of the formula (1) and b) 1.0 to 79.99 mole percent of one or more independently recurring structural units of the formula (2), and c) 0.01 to 8.0 mole percent of one or more independently recurring cross-linking structural units, which are obtained from one or more monomers having at least two olefinic double bonds. The polymers are suitable, for example, as thickeners or yield point formers, in particular in cosmetic, dermatological or pharmaceutical compositions.
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公开(公告)号：US09012464B2
公开(公告)日：2015-04-21
申请号：US13989603
申请日：2011-11-23
申请人： Ramesh Matioram Gidwani , Channaveerayya Hiremath , Manoj Dalsingar Yadav , Wolfgang Albrecht , Dirk Fischer
发明人： Ramesh Matioram Gidwani , Channaveerayya Hiremath , Manoj Dalsingar Yadav , Wolfgang Albrecht , Dirk Fischer
IPC分类号： C07D405/12
CPC分类号： C07D405/12
摘要： Afatinib salts and crystalline forms thereof are described in the present application and processes for their preparation. Crystalline forms of Afatinib are also described in the present application and processes for their preparation. The present invention also includes pharmaceutical compositions of such Afatinib salts and crystalline forms thereof or crystalline forms of Afatinib, methods of their preparation and the use thereof in the treatment of a patient in need thereof.
摘要翻译： 在本申请中描述了阿片碱及其结晶形式及其制备方法。 在本申请中还描述了阿片碱的结晶形式及其制备方法。 本发明还包括这样的阿拉非尼碱盐及其结晶形式或结晶形式的阿拉金滨的药物组合物，其制备方法及其在治疗有需要的患者中的用途。
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公开(公告)号：US20140127147A1
公开(公告)日：2014-05-08
申请号：US14003340
申请日：2012-03-03
申请人： Peter Klug , Dirk Fischer , Thomas Lindner , Wiebke Mueckenheim , Bianca Brasch , Michael Hornung
发明人： Peter Klug , Dirk Fischer , Thomas Lindner , Wiebke Mueckenheim , Bianca Brasch , Michael Hornung
IPC分类号： A61K8/81 , A61K47/32 , A61Q5/06 , A61Q5/08 , A61Q5/04 , A61Q1/02 , A61Q1/14 , A61Q5/02 , A61Q15/00 , A61Q19/02 , A61Q19/08 , A61Q17/04 , C08F220/58 , A61Q19/00
CPC分类号： A61K8/8158 , A61K31/02 , A61K31/19 , A61K31/192 , A61K31/375 , A61K31/60 , A61K31/795 , A61K45/06 , A61K47/32 , A61K2800/48 , A61Q1/02 , A61Q1/14 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/065 , A61Q5/08 , A61Q5/10 , A61Q15/00 , A61Q17/005 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04 , A61Q19/08 , A61Q19/10 , C08F220/56 , C08F220/58 , C09J4/00 , A61K2300/00
摘要： The invention relates to water-soluble or water-swellable polymers the repeating structural units of which consist of a) 90.0 to 99.99 mole-% of one or more repeating structural units originating from special monomers with sulfonic acid groups or the salts thereof such as for example 2-acrylamido-2-methyl-propanesulfonic acid or the salts thereof and b) 0.01 to 10.0 mole-% of one or more repeating structural units originating from special cross-linking agents with at least three polymerizable double bonds. The polymers for example have an advantageous sensory property profile and are highly suitable as thickening agents even in salt-containing compositions. They are furthermore advantageously suitable for producing cosmetic, dermatological or pharmaceutical compositions.
摘要翻译： 本发明涉及水溶性或水溶胀性聚合物，其重复结构单元由以下组成：a）90.0至99.99摩尔％的一种或多种源自具有磺酸基的特殊单体的重复结构单元或其盐，例如 例如2-丙烯酰氨基-2-甲基 - 丙磺酸或其盐，以及b）0.01至10.0摩尔％的源自具有至少三个可聚合双键的特殊交联剂的一种或多种重复结构单元。 聚合物例如具有有利的感官特性分布，并且甚至在含盐组合物中也非常适合作为增稠剂。 它们还有利地适用于生产化妆品，皮肤病学或药物组合物。
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公开(公告)号：US07368217B2
公开(公告)日：2008-05-06
申请号：US10513615
申请日：2002-05-08
CPC分类号： B42D25/435 , B41M3/14 , B41M5/26 , B41M5/28 , B41M5/34 , B42D25/00 , B42D25/333 , B42D25/405 , B42D25/45 , G03C5/08 , Y10S430/145 , Y10S430/146 , Y10S430/163 , Y10T428/25
摘要： The invention relates to a process for the production of a multi-layer image, preferably a multi-color image. A transfer film which is applied to a paper ubstrate and which is treated with laser irradiation is used. The transfer film has a laser-sensitive layer and a background layer arranged therebeneath. The laser-sensitive layer comprises laser-sensitive material, for example laser-sensitive pigments or other laser-sensitive coloring agents. The laser-sensitive material in the layer is region-wise bleached by laser irradiation. That results in a so-called laser-induced image component. As it is transparent or partly transparent, the background layer which is arranged therebeneath and which can have a printed image then becomes visible from above in that region. That therefore gives a multi-layer image which is formed by the laser-induced image component and by the background layer jointly.
摘要翻译： 本发明涉及用于制造多层图像的方法，优选地是多色图像。 使用施加到纸基底并用激光照射处理的转印膜。 转印膜具有激光敏感层和布置在其上的背景层。 激光敏感层包括激光敏感材料，例如激光敏感颜料或其它激光敏感着色剂。 层中的激光敏感材料通过激光照射被区域漂白。 这导致所谓的激光诱导图像分量。 由于其是透明的或部分透明的，所以布置在其下方并且可以具有打印图像的背景层然后在该区域中从上方可见。 因此，由激光引起的图像分量和背景层共同形成的多层图像。
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5.发明授权公开(公告)号：US07220479B2
公开(公告)日：2007-05-22
申请号：US10513623
申请日：2002-05-08
IPC分类号： B32B5/16
CPC分类号： B42D25/435 , B41M3/14 , B42D25/00 , B42D25/29 , B42D25/333 , B42D25/45 , Y10T428/1467 , Y10T428/25 , Y10T428/253 , Y10T428/254 , Y10T428/256
摘要： The present invention relates to a multi-layer body which is a paper document with a hot stamping film embossed thereon. The hot stamping film has a laser-sensitive layer in which a laser-induced color image is produced by laser treatment. Arranged on the document are further security identifications such as a security print, which is in the form of guilloche patterns, fluorescent threads, and a security strip. Water marks are also provided in the paper document.
摘要翻译： 本发明涉及一种多层体，其是在其上压印有热冲压膜的纸质文件。 热冲压膜具有通过激光处理产生激光诱导彩色图像的激光敏感层。 在文档上安排的是进一步的安全标识，例如安全打印，其为伪装图案，荧光丝和安全带的形式。 纸张文件中也提供了水痕。
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公开(公告)号：US07198302B1
公开(公告)日：2007-04-03
申请号：US10069786
申请日：2000-08-25
IPC分类号： B42D15/00
CPC分类号： B42D25/305 , B41M5/28 , B41M5/34 , B42D25/00 , B42D25/41 , B42D25/435 , B42D25/45 , G06K1/126 , Y10T428/21
摘要： The invention relates to a card-shaped data carrier consisting of at least one layer (1, 2, 3). Visually readable information in the form of a changed optical characteristic is introduced into the layer. Said characteristic is changed by irreversibly changing the material by means of a laser beam. The absorption capacity of said layer (1, 2, 3) for at least one wavelength (λ±λ) is at least partially reduced due to the laser radiation.
摘要翻译： 本发明涉及由至少一层（1,2,3）组成的卡形数据载体。 在该层中引入以改变的光学特性的形式的可视化信息。 通过激光束不可逆地改变材料来改变所述特性。 对于至少一个波长（λ±λ），所述层（1,2,3）的吸收能力由于激光辐射至少部分地减小。
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7.发明申请公开(公告)号：US20060127932A1
公开(公告)日：2006-06-15
申请号：US11293048
申请日：2005-12-02
申请人： Dirk Fischer , Jorg Geistlinger
发明人： Dirk Fischer , Jorg Geistlinger
CPC分类号： C12Q1/6837 , C12Q2535/125
摘要： The invention relates to a method for the multiparallel detection of nucleotide polymorphisms on a polydimensional array. The invention also relates to a method for detecting many individual nucleotide polymorphisms, during which the nucleotide polymorphisms of multiple individuals can be multiparallelly detected on the array. According to the invention, the hybridization of a probe molecule with a sample molecule ensues in a hybridization field on the array that is separated from surrounding hybridization fields.
摘要翻译： 本发明涉及多维平行检测多维阵列上核苷酸多态性的方法。 本发明还涉及一种用于检测许多个体核苷酸多态性的方法，其中多个个体的核苷酸多态性可以在阵列上多次平行检测。 根据本发明，探针分子与样品分子的杂交在与周围杂交领域分离的阵列上的杂交领域中发生。
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8.发明授权Method for the recording of data on/in data supports by means of laser radiation and data supports produced thus 有权通过激光辐射记录数据支持的数据支持方法和由此产生的数据支持公开(公告)号：US06986926B2
公开(公告)日：2006-01-17
申请号：US10399956
申请日：2001-10-11
IPC分类号： B32B3/02
CPC分类号： B41M5/286 , B41M3/14 , G06K1/126 , Y10T428/21
摘要： The invention relates to a method for the recording of data, in particular, personal data on and/or in a data support, by means of electromagnetic radiation. A corresponding data support is made ready, on and/or in which a dye is at least locally provided and said dye is irradiated by means of said electromagnetic radiation of at least one wavelength range, such that a change in the color of the dye by bleaching occurs in the region of the irradiation. Said color change may be determined by machine and/or by the human eye. An improved counterfeiting and manipulation security for the data support is thus achieved.
摘要翻译： 本发明涉及一种用于通过电磁辐射记录数据，特别是在数据支持上和/或数据支持中的个人数据的方法。 准备好相应的数据支持，在和/或其中至少局部提供染料并且所述染料通过至少一个波长范围的所述电磁辐射照射，使得染料的颜色变化通过 在照射区域发生漂白。 所述颜色变化可由机器和/或人眼来确定。 因此实现了数据支持的改进的伪造和操纵安全性。
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9.发明申请Method for the recording of data on/in data supports by means of laser radiation and data supports produced thus 有权通过激光辐射记录数据支持的数据支持方法和由此产生的数据支持公开(公告)号：US20050102464A1
公开(公告)日：2005-05-12
申请号：US10399956
申请日：2001-10-11
CPC分类号： B41M5/286 , B41M3/14 , G06K1/126 , Y10T428/21
摘要： The invention relates to a method for the recording of data, in particular, personal data on and/or in a data support, by means of electromagnetic radiation. A corresponding data support is made ready, on and/or in which a dye is at least locally provided and said dye is irradiated by means of said electromagnetic radiation of at least one wavelength range, such that a change in the colour of the dye by bleaching occurs in the region of the irradiation. Said colour change may be determined by machine and/or by the human eye. An improved counterfeiting and manipulation security for the data support is thus achieved.
摘要翻译： 本发明涉及一种用于通过电磁辐射记录数据，特别是在数据支持上和/或数据支持中的个人数据的方法。 准备好相应的数据支持，在和/或其中至少局部提供染料并且所述染料通过至少一个波长范围的所述电磁辐射照射，使得染料的颜色变化通过 在照射区域发生漂白。 所述颜色变化可由机器和/或人眼来确定。 因此实现了数据支持的改进的伪造和操纵安全性。
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10.发明申请公开(公告)号：US20050098636A1
公开(公告)日：2005-05-12
申请号：US10381462
申请日：2001-08-01
申请人： Mattias Schumacher , Dirk Fischer
发明人： Mattias Schumacher , Dirk Fischer
摘要： A method and device for personalizing the luminescent authenticity features on data carrier, in particular plastic cards. The luminescent authenticity feature being applied to or incorporated in a composite card and the authenticity feature is personalized with a high-energy beam in that the intensity and/or wavelength of the beam is chosen such that local bleaching of the structure of the authenticity feature takes place.
摘要翻译： 一种用于在数据载体，特别是塑料卡上个性化发光真实性特征的方法和装置。 将发光真伪特征应用于或并入复合卡中，并且使用高能束对真实性特征进行个性化，因为选择光束的强度和/或波长，使得真实性特征的结构的局部漂白 地点。
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