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公开(公告)号：US09114832B2
公开(公告)日：2015-08-25
申请号：US12625238
申请日：2009-11-24
Applicant: Guoping Wang , Keith Wendte , Charles Johnson , John Posselius , Marvin Prickel
Inventor： Guoping Wang , Keith Wendte , Charles Johnson , John Posselius , Marvin Prickel
CPC classification number: B62D13/00 , A01B69/003 , A01B69/006 , B62D13/025
Abstract: A steering system for a towable implement includes a steering sensor, an implement steering controller, a steering control valve, a steering cylinder, and an implement steering mechanism that steers the implement. The steering sensor measures, directly or indirectly, the angular position of the steerable wheels of the implement. The implement steering controller processes feedback from the steering sensor and with a desired steering angle, outputs a steering control signal that is input to the steering control valve. The steering control valve controls the flow of hydraulic fluid to the steering cylinder, which, in turn, powers the implement steering mechanism to turn the wheels of the implement. The steering system may be operated in various control modes, such as, a transportation steering mode, a corner and 180 turn steering mode, a swath tracking steering mode, crab steering mode, and a manual steering mode, which allows manual control of the steering system.
Abstract translation: 用于拖曳工具的转向系统包括转向传感器，工具转向控制器，转向控制阀，转向缸和转向工具的工具转向机构。 转向传感器直接或间接地测量工具的可转向轮的角位置。 工具转向控制器处理来自转向传感器的反馈并具有期望的转向角，输出输入到转向控制阀的转向控制信号。 转向控制阀控制到转向缸的液压流体的流动，转向缸又向车把转向机构供电以转动车把的转轮。 转向系统可以在各种控制模式下操作，例如运输转向模式，转角和180转向转向模式，条跟踪转向模式，螃蟹转向模式和手动转向模式，这允许手动控制转向 系统。
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公开(公告)号：US08901117B2
公开(公告)日：2014-12-02
申请号：US13336047
申请日：2011-12-23
Applicant: Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
Inventor： Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
IPC: A61K31/5377 , A61K31/407 , A61K31/437 , A61K31/4985 , C07D209/54 , C07D491/10 , C07D487/10
CPC classification number: C07D209/54 , C07D487/10 , C07D491/10
Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。
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3.发明申请PROCESS FOR THE PREPARATION OF SMALL MOLECULE INHIBITORS OF MDM2 AND INTERMEDIATES USED THEREIN 失效制备MDM2小分子抑制剂及其使用的中间体的方法公开(公告)号：US20130030173A1
公开(公告)日：2013-01-31
申请号：US13614751
申请日：2012-09-13
Applicant: Shaomeng Wang , Ke Ding , Guoping Wang
Inventor： Shaomeng Wang , Ke Ding , Guoping Wang
IPC: C07D487/10
CPC classification number: C07D209/54 , C07D487/10 , C07D491/10
Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对另外的药剂敏化的用途。
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公开(公告)号：US08258176B2
公开(公告)日：2012-09-04
申请号：US12676470
申请日：2008-08-29
Applicant: Guoping Wang , Quanhai Liu , Haiyan Sun , Wei Wu , Jian Hou , Lin Yao , Chungang Li , Minyu Liu , Fei Li , Xuejun Wu , Shuai Zhao
Inventor： Guoping Wang , Quanhai Liu , Haiyan Sun , Wei Wu , Jian Hou , Lin Yao , Chungang Li , Minyu Liu , Fei Li , Xuejun Wu , Shuai Zhao
IPC: A61K31/407 , C07D487/04 , C07D487/02
CPC classification number: C07D495/04
Abstract: The invention discloses a dithiolopyrrolone compound represented by formula I or its pharmaceutically acceptable salts, wherein X1, R1, R2, R3, R4 are defined as in the description. The invention also discloses the preparation of such compounds, and the use of such compounds in preparation of medicaments for increasing peripheral white blood cells and in preparation of ancillary medicaments for inhibiting the decrease of peripheral white blood cells in radiotherapy or chemotherapy.
Abstract translation: 本发明公开了由式I表示的二硫代环吡咯酮化合物或其药学上可接受的盐，其中X1，R1，R2，R3，R4如描述中所定义。 本发明还公开了这样的化合物的制备，以及这些化合物在制备用于增加外周白细胞的药物中的用途以及用于抑制放射治疗或化学疗法中外周白细胞减少的辅助药物。
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5.发明授权公开(公告)号：US07962263B2
公开(公告)日：2011-06-14
申请号：US12080489
申请日：2008-04-03
Applicant: Guoping Wang
Inventor： Guoping Wang
CPC classification number: B62D6/002 , A01B69/008
Abstract: A steering control system and method for automated steering of work vehicles that adapts to nonlinearities and uncertainties of steering mechanisms including a tolerance control law, a dynamic control law, and a saturation control law selected and executed in real time based on the magnitude of steering angle error, steering mode command, and manual override signal in real time. The dynamic control law includes a dynamic compensator having a double compensation zero, an integral, and a compensation gain, and further includes a deadband compensator and a control signal limiter.
Abstract translation: 一种用于工作车辆的自动转向的转向控制系统和方法，其适应于转向机构的非线性和不确定性，其包括基于转向角的大小实时选择和执行的公差控制律，动态控制律和饱和度控制律 错误，转向模式命令和手动超控信号。 动态控制规律包括具有双补偿零点，积分和补偿增益的动态补偿器，并且还包括死区补偿器和控制信号限制器。
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Patent Agency Ranking
公开(公告)号：US20110125371A1
公开(公告)日：2011-05-26
申请号：US12625238
申请日：2009-11-24
Applicant: Guoping Wang , Keith Wendte , Charles Johnson , John Posselius , Marvin Prickel
Inventor： Guoping Wang , Keith Wendte , Charles Johnson , John Posselius , Marvin Prickel
IPC: B62D6/00
CPC classification number: B62D13/00 , A01B69/003 , A01B69/006 , B62D13/025
Abstract: A steering system for a towable implement includes a steering sensor, an implement steering controller, a steering control valve, a steering cylinder, and an implement steering mechanism that steers the implement. The steering sensor measures, directly or indirectly, the angular position of the steerable wheels of the implement. The implement steering controller processes feedback from the steering sensor and with a desired steering angle, outputs a steering control signal that is input to the steering control valve. The steering control valve controls the flow of hydraulic fluid to the steering cylinder, which, in turn, powers the implement steering mechanism to turn the wheels of the implement. The steering system may be operated in various control modes, such as, a transportation steering mode, a corner and 180 turn steering mode, a swath tracking steering mode, crab steering mode, and a manual steering mode, which allows manual control of the steering system.
Abstract translation: 用于拖曳工具的转向系统包括转向传感器，工具转向控制器，转向控制阀，转向缸和转向工具的工具转向机构。 转向传感器直接或间接地测量工具的可转向轮的角位置。 工具转向控制器处理来自转向传感器的反馈并具有期望的转向角，输出输入到转向控制阀的转向控制信号。 转向控制阀控制到转向缸的液压流体的流动，转向缸又向车把转向机构供电以转动车把的转轮。 转向系统可以在各种控制模式下操作，例如运输转向模式，转角和180转向转向模式，条跟踪转向模式，螃蟹转向模式和手动转向模式，这允许手动控制转向 系统。
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公开(公告)号：US20100210856A1
公开(公告)日：2010-08-19
申请号：US12676470
申请日：2008-08-29
Applicant: Guoping Wang , Quanhai Liu , Haiyan Sun , Wei Wu , Jian Hou , Lin Yao , Chungang Li , Minyu Liu , Fei Li , Xuejun Wu , Shuai Zhao
Inventor： Guoping Wang , Quanhai Liu , Haiyan Sun , Wei Wu , Jian Hou , Lin Yao , Chungang Li , Minyu Liu , Fei Li , Xuejun Wu , Shuai Zhao
IPC: C07D495/04
CPC classification number: C07D495/04
Abstract: The invention discloses a dithiolopyrrolone compound represented by formula I or its pharmaceutically acceptable salts, wherein X1, R1, R2, R3, R4 are defined as in the description. The invention also discloses the preparation of such compounds, and the use of such compounds in preparation of medicaments for increasing peripheral white blood cells and in preparation of ancillary medicaments for inhibiting the decrease of peripheral white blood cells in radiotherapy or chemotherapy.
Abstract translation: 本发明公开了由式I表示的二硫代环吡咯酮化合物或其药学上可接受的盐，其中X1，R1，R2，R3，R4如描述中所定义。 本发明还公开了这样的化合物的制备，以及这些化合物在制备用于增加外周白细胞的药物中的用途以及用于抑制放射治疗或化学疗法中外周白细胞减少的辅助药物。
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公开(公告)号：US20060084647A1
公开(公告)日：2006-04-20
申请号：US11209998
申请日：2005-08-22
Applicant: Shaomeng Wang , Guoping Wang , Guozhi Tang , Renxiao Wang , Zaneta Nikolovska-Coleska , Dajun Yang , Liang Xu
Inventor： Shaomeng Wang , Guoping Wang , Guozhi Tang , Renxiao Wang , Zaneta Nikolovska-Coleska , Dajun Yang , Liang Xu
IPC: A61K31/5377 , A61K31/506 , A61K31/4709 , A61K31/47 , A61K31/445 , A61K31/165 , C07D413/02 , C07D401/02 , C07C317/32
CPC classification number: C07C205/38 , C07C39/10 , C07C39/15 , C07C39/17 , C07C39/367 , C07C43/23 , C07C43/295 , C07C49/747 , C07C49/82 , C07C49/83 , C07C49/84 , C07C65/105 , C07C235/60 , C07C235/64 , C07C311/29 , C07C311/46 , C07C317/22 , C07C317/40 , C07C317/44 , C07C2601/14 , C07C2603/74 , C07D211/16 , C07D213/70 , C07D215/227 , C07D215/233 , C07D217/06 , C07D263/56 , C07D277/64 , C07D307/84 , C07D321/12 , C07D333/60 , C07D333/76 , C07D401/12 , C07D405/12
Abstract: The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.
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9.发明授权公开(公告)号：US08280595B2
公开(公告)日：2012-10-02
申请号：US12228370
申请日：2008-08-12
Applicant: Christopher A. Foster , Riccardo Morselli , Olivier Arnel Vanhercke , Guoping Wang , Bart M. A. Missotten , Bert Juul Frans Paquet , John H. Posselius
Inventor： Christopher A. Foster , Riccardo Morselli , Olivier Arnel Vanhercke , Guoping Wang , Bart M. A. Missotten , Bert Juul Frans Paquet , John H. Posselius
IPC: G06F19/00 , A01D41/127 , A01D43/06 , A01D91/00
CPC classification number: A01B79/005 , G06Q10/08 , G06Q50/02 , H04L63/08 , H04L67/12 , H04L67/125 , H04L67/18 , H04W4/02 , H04W4/023 , H04W4/08 , H04W4/70 , H04W4/80 , H04W84/18
Abstract: A system, and method of use thereof, for enabling short range intercommunication and the exchange of logistical information between and among a plurality of authorized agricultural machines that are designed to be operable in conjunction with one another to effect, as a specific identified group, a given agricultural operation, including a plurality of individual agricultural machines each of which has a communications control portion operable to transmit and receive short distance communications signals and each of which also has authentication credentials associated therewith establishing such machine's entitlement to share in the logistical information and to be considered and treated as a member of the specific identified group involved in the performance of the given agricultural operation, with such individual agricultural machines, when positioned in range of the short distance communications signals of the individual agricultural machines, forming a peer-to-peer network in which such individual agricultural machines are joined as group members and are operable to effect the distribution over a wireless bus of the peer-to-peer network of logistical information of a group member of such network.
Abstract translation: 一种系统及其使用方法，用于实现多个被授权的农业机器之间和之间的短距离互通和物流信息的交换，所述多个授权的农业机器被设计成可以彼此结合操作以实现作为特定的识别组， 给予农业操作，包括多个单独的农业机械，每个农机具有可操作以发送和接收短距离通信信号的通信控制部分，并且每个农机还具有与其相关联的认证证书，其建立该机器的权利以分享后勤信息，以及 被视为具体确定的集团参与执行给定农业经营的成员，与这些单独的农业机械相比，当位于各农业机械的短距离通信信号的范围内时，形成对等 - 对等网络在whic h这样的单个农业机器作为组成员加入，并且可操作以通过该对等网络的无线总线分发这样的网络的组成员的后勤信息。
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公开(公告)号：US20120215409A1
公开(公告)日：2012-08-23
申请号：US13171645
申请日：2011-06-29
Applicant: Guoping WANG , John H. Posselius , Keith W. Wendte
Inventor： Guoping WANG , John H. Posselius , Keith W. Wendte
IPC: G06F7/00
CPC classification number: A01D41/1278 , A01B69/008 , A01D43/085 , G05D1/0278 , G05D1/0293 , G05D2201/0201
Abstract: A control system and method is provided for controlling the operational configuration of a spout of a harvester being used to perform unload on the go operations with an associated transport vehicle. The velocities of the harvester and transport vehicle and the lateral and longitudinal distances between the harvester and transport vehicle are used to predict future lateral and longitudinal distances between the harvester and transport vehicle. A control signal is issued to a harvester spout control system if either of the predicted lateral distance or longitudinal distance is outside of an associated acceptable range. The harvester spout control system then either shuts off the spout or changes the orientation of the spout in response to the control signal.
Abstract translation: 提供了一种控制系统和方法，用于控制用于通过相关联的运输车辆在行驶中执行卸载的收割机的喷口的操作配置。 收割机和运输车辆的速度以及收割机和运输车辆之间的横向和纵向距离用于预测收割机和运输车辆之间的未来横向和纵向距离。 如果预测的横向距离或纵向距离之一超出相关联的可接受范围，则控制信号被发送到收割机喷口控制系统。 收割机喷口控制系统然后关闭喷嘴或响应于控制信号改变喷口的方向。
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