公开(公告)号：US12168827B2

公开(公告)日：2024-12-17

申请号：US15057927

申请日：2016-03-01

Applicant: HOWARD UNIVERSITY

Inventor： Kimani A. Stancil ,  James S. Hammonds

IPC: C23C24/08 ,  B82Y30/00 ,  G02B1/00

Abstract: The present disclosure provides methods of applying a filtering coating to a substrate, comprising: depositing a solution on a surface of a substrate, wherein the solution comprises an organic solvent with nanorods dispersed within the solvent. Evaporation of the solution is allowed and/or controlled to increase a volume fraction of the nanorods in the solution as a function of the evaporation. Thus, an aligned deposit of the nanorods is provided as a function of the evaporation, wherein the aligned deposit of nanorods includes at least thousands of the nanorods with at least a majority of the nanorods aligned relative to a length of the nanorods.

公开(公告)号：US12161985B2

公开(公告)日：2024-12-10

申请号：US17307515

申请日：2021-05-04

Applicant: HOWARD UNIVERSITY

Inventor： Mohsen Mosleh ,  Mousab Ahmed ,  Preethi Chandran ,  Marjan Alaghmand

IPC: C10M105/12 ,  B01J13/00 ,  C10M115/04 ,  C10M125/02 ,  C10M125/04 ,  C10M125/20 ,  C10M125/22 ,  C10M171/02 ,  C10M171/06 ,  B82Y40/00 ,  C10N20/06 ,  C10N50/00

Abstract: An organogel including a base fluid, cetyl alcohol, and a gelling agent provided in an amount to cause the fluid to change from a liquid state to a gelled state at temperatures below at least 25° C. A nanofluid including an organogel and a nanoparticle component which permits the nanofluid to change from a liquid state to a gelled state at temperatures below at least 25° C., the gelled state helping to maintain the nanoparticle component suspended throughout the base fluid; and a method for preparing a gelled nanofluid.

公开(公告)号：US12109316B2

公开(公告)日：2024-10-08

申请号：US17076435

申请日：2020-10-21

Applicant: HOWARD UNIVERSITY

Inventor： Preethi Chandran

IPC: A61K9/51 ,  A61K9/00 ,  A61K38/00 ,  A61K47/54 ,  A61K47/59 ,  A61K47/69 ,  C08G73/02

CPC classification number: A61K9/5146 ,  A61K9/0019 ,  A61K9/513 ,  A61K9/5161 ,  A61K9/5192 ,  A61K38/00 ,  A61K47/549 ,  A61K47/59 ,  A61K47/6925 ,  C08G73/02

Abstract: Non-viral delivery platforms are provided for facilitating transport of molecules across cell membranes. In some forms, DNA nanoshells capable of transporting cargo molecules are formed, and may be formed in order to surround a variety of materials for a variety of purposes.

公开(公告)号：US12105529B2

公开(公告)日：2024-10-01

申请号：US17530926

申请日：2021-11-19

Applicant: HOWARD UNIVERSITY

Inventor： Imani R. Oakley

IPC: G05D1/00 ,  B64C39/02 ,  B64U30/10 ,  B64U30/20 ,  B64U50/19

CPC classification number: G05D1/101 ,  B64C39/024 ,  B64U30/10 ,  B64U30/20 ,  B64U50/19 ,  B64U2201/104

Abstract: An aerial device is provided. The aerial device includes a processor and a memory that includes instructions configured to cause the processor to perform certain operations when the processor executes the instructions. The operations may include receiving a first signal indicative of a first position of the aerial device. The operations may also include generating, based on the first signal and based on a randomly or pseudo-randomly generated sequence, a second signal configured to actuate flight hardware of the aerial device to a second position.

公开(公告)号：US11782084B2

公开(公告)日：2023-10-10

申请号：US17364061

申请日：2021-06-30

Applicant: Howard University

Inventor： Charles J Kim

IPC: G01R31/08 ,  G06F17/17 ,  G01R31/58 ,  G01R31/52

CPC classification number: G01R31/088 ,  G01R31/083 ,  G01R31/52 ,  G01R31/58 ,  G06F17/17

Abstract: A method, computer program, and computer system is provided for fault detection in an electrical network. An inductance between a reference point and a fault is determined at a first time based on measuring a fault current. A resistance between the reference point and the fault may be determined at a second time based on measuring a differential of the fault current as zero. A location of the fault may be identified based on the inductance and the resistance.

公开(公告)号：US20230310646A1

公开(公告)日：2023-10-05

申请号：US18207167

申请日：2023-06-08

Applicant: HOWARD UNIVERSITY

Inventor： Preethi CHANDRAN

IPC: A61K47/69 ,  A61K9/00 ,  A61K48/00 ,  C08G73/02 ,  C08J3/24 ,  C08L79/02 ,  C08J3/12 ,  C08J3/075

CPC classification number: A61K47/6935 ,  A61K9/0004 ,  A61K9/0053 ,  A61K48/0041 ,  C08G73/0206 ,  C08J3/24 ,  C08L79/02 ,  C08J3/12 ,  C08J3/075 ,  C08J3/246 ,  C08G2210/00 ,  C08K5/0025

Abstract: Covalently linked linear polyethylenimine (PEI) clusters are provided that change conformation depending upon changes in counterion concentrations. The structures may be used for the storage, delivery, and/or transport of substances.

公开(公告)号：US11737462B2

公开(公告)日：2023-08-29

申请号：US16122712

申请日：2018-09-05

Applicant: Howard University ,  Georgetown University

Inventor： Sivanesan Dakshanamurthy ,  Hemayet Ullah

IPC: A01N43/653 ,  A01N43/38

CPC classification number: A01N43/653 ,  A01N43/38

Abstract: Compounds and methods are described herein that are effective to modulate plant response (e.g., plant susceptibility) to environmentally-induced stress. The compounds and methods described herein advantageously may be used to modulate environmental stress resistance in a wide variety of plants. Environmental stresses include, for example, high light intensity (UV exposure), temperature (e.g., high heat), high soil salinity, and low soil moisture (e.g., drought). As used herein, environmental stresses include any conditions that result in increased generation of reactive oxygen species (ROS) and accumulation of ROS in the plant cells. The compounds described herein that are effective to modulate resistance to the stress prevent, directly or indirectly, or increase phosphorylation of Tyr248 of the RACK1A protein.

公开(公告)号：US11576901B2

公开(公告)日：2023-02-14

申请号：US16088392

申请日：2017-03-27

Applicant: HOWARD UNIVERSITY ,  GEORGETOWN UNIVERSITY

Inventor： Hemayet Ullah ,  Sivanesan Dakshanamurthy

IPC: A61K31/4196 ,  A61K45/06

Abstract: A method effective in treating a viral infection involves administering a therapeutically effective amount of at least one compound capable of inhibiting expression of at least a portion of a virus genome containing an internal ribosomal entry site, or a pharmaceutically acceptable salt thereof. The compound has an azole moiety comprising a five member heterocyclic ring containing at least one nitrogen atom, a hydrophobic moiety bonded to the heterocyclic ring of the azole, and a donor/acceptor moiety bonded to the heterocyclic ring having at least one of hydrogen bond donor and a hydrogen bond acceptor.

公开(公告)号：US11338016B2

公开(公告)日：2022-05-24

申请号：US16878809

申请日：2020-05-20

Applicant: Howard University

Inventor： Yousef Tizabi

IPC: A61K38/16 ,  A61K9/00

Abstract: C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) provides therapeutic effects in motor impairments associated with Parkinson disease (PD), and provides long lasting antidepressant effects, thus useful in treating and mitigating depression, particularly PD-depression co-morbid condition. A method for treating or mitigating depression, including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof. A method for treating or mitigating motor impairments associated with Parkinson's disease (PD), including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof.

公开(公告)号：US11319273B2

公开(公告)日：2022-05-03

申请号：US14689827

申请日：2015-04-17

Applicant: Howard University

Inventor： Evaristus A. Nwulia ,  Amol Kulkarni

IPC: C07C49/255 ,  A61K31/12 ,  C07D207/36 ,  A61K31/40 ,  C07D307/60 ,  A61K31/341 ,  C07D333/32 ,  A61K31/381 ,  C07C323/22 ,  A61K45/06 ,  A61M31/00 ,  A61K31/122 ,  A61K31/4025 ,  A61K9/00 ,  C07D237/14 ,  C07D265/02 ,  C07D279/02

Abstract: Compounds having formulas (I) to (VIII), salts thereof, or combinations thereof and pharmaceutical compositions comprising one or more these compounds are described herein for the treatment of HIV and neurodegenerative effects caused by HIV. Also provided herein are methods and a kit for inhibiting HIV-1, treating latent HIV in the brain, and preventing HIV-mediated cognitive decline and HIV dementia comprising administering the compounds having the formulas (I) to (VIII) and pharmaceutical compositions comprising the compounds having these formulas. The compounds having formulas I through VIII are curcumin analogs which are advantageously characterized as having anti-retroviral, neuroprotective, anti-glucosidase, and anti-HIV integrase properties. In one aspect, the pharmaceutical composition is delivered intranasally.