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1.发明授权Method of making induced pluripotent stem cell from adipose stem cells using minicircle DNA vectors 有权使用小环DNA载体从脂肪干细胞诱导多能干细胞的方法公开(公告)号：US08962331B2
公开(公告)日：2015-02-24
申请号：US12931476
申请日：2011-02-01
申请人： Joseph Wu , Michael T. Longaker , Mark A. Kay , Ning Sung , FangJun Jia , Zhi-Ying Chen , Nicholas Panetta , Deepak Gupta
发明人： Joseph Wu , Michael T. Longaker , Mark A. Kay , Ning Sung , FangJun Jia , Zhi-Ying Chen , Nicholas Panetta , Deepak Gupta
CPC分类号： C12N5/0696 , C12N15/85 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2506/1384 , C12N2510/00 , C12N2800/00 , C12N2800/108 , C12N2800/24
摘要： Human somatic cells are reprogrammed to become induced pluripotent stem cells (iPS cells) by the introduction of a minicircle DNA vector. Cells of interest include adipose stem cells.
摘要翻译： 通过引入小环DNA载体，将人体细胞重新编程成诱导多能干细胞（iPS细胞）。 感兴趣的细胞包括脂肪干细胞。
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公开(公告)号：US08608760B2
公开(公告)日：2013-12-17
申请号：US11962077
申请日：2007-12-20
申请人： Geoffrey C. Gurtner , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon Saul , C. Travis Rappleye , Evgenia Mandrusov
发明人： Geoffrey C. Gurtner , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon Saul , C. Travis Rappleye , Evgenia Mandrusov
IPC分类号： A61B17/08
CPC分类号： A61B17/00491 , A61B17/04 , A61B17/11 , A61B17/12022 , A61B17/1204 , A61B17/12109 , A61B17/12186 , A61B17/1219 , A61B17/122 , A61B17/1227 , A61B2017/1103 , A61B2017/1107
摘要： Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient's body including vascular lumens. More particularly, in various aspects, this invention provides compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique.
摘要翻译： 公开了用于将非结合腔内连接在患者体内（包括血管内腔）的组合物，方法和试剂盒。 更具体地，在各个方面，本发明提供了用于连接这种非结合腔的组合物，方法和试剂盒，包括通常需要显微外科技术的小腔。
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3.发明申请CARDIOMYOCYTES FROM INDUCED PLURIPOTENT STEM CELLS FROM PATIENTS AND METHODS OF USE THEREOF 有权来自患者的诱导性肺源性干细胞的心脏细胞及其使用方法公开(公告)号：US20130029866A1
公开(公告)日：2013-01-31
申请号：US13554946
申请日：2012-07-20
申请人： Ning Sun , Michael T. Longaker , Robert C. Robbins , Joseph Wu , Feng Lan , Andrew Stephen Lee , Paul W. Burridge
发明人： Ning Sun , Michael T. Longaker , Robert C. Robbins , Joseph Wu , Feng Lan , Andrew Stephen Lee , Paul W. Burridge
CPC分类号： C12N5/0657 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/1307 , C12N2506/45 , C12N2510/00 , G01N33/5061 , G01N33/5073 , G01N2800/324 , G01N2800/325
摘要： Human somatic cells obtained from individuals with a genetic heart condition are reprogrammed to become induced pluripotent stem cells (iPS cells), and differentiated into cardiomyocytes for use in analysis, screening programs, and the like.
摘要翻译： 从具有遗传性心脏病的个体获得的人体细胞细胞被重新编程成诱导多能干细胞（iPS细胞），并分化成心肌细胞用于分析，筛选程序等。
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公开(公告)号：US08115048B2
公开(公告)日：2012-02-14
申请号：US12358164
申请日：2009-01-22
摘要： Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.
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公开(公告)号：US20090280182A1
公开(公告)日：2009-11-12
申请号：US12387318
申请日：2009-04-29
申请人： Stayce Beck , David Myung , Curtis W. Frank , Jennifer R. Cochran , Michael T. Longaker , George P. Yang , Daphne P. Ly , Shira G. Mandel
发明人： Stayce Beck , David Myung , Curtis W. Frank , Jennifer R. Cochran , Michael T. Longaker , George P. Yang , Daphne P. Ly , Shira G. Mandel
CPC分类号： A61L15/60 , A61L15/225 , C08L71/02
摘要： Interpenetrating network hydrogels are described that may be incorporated into wound dressings and/or in implants. The properties of the interpenetrating network hydrogel may be tuned to control an amount of moisture in a wound environment. The devices, methods, and kits described herein may be adapted to treat a variety of wound types at a variety of healing stages over a range of time scales. Some hydrogels may be configured to deliver one or more vulnerary agents to a wound. The interpenetrating network hydrogels may also be adapted to control a rate and/or amount of moisture uptake so that the hydrogels may be used as expandable implants to expand tissue.
摘要翻译： 描述了可以并入伤口敷料和/或植入物中的互穿网络水凝胶。 可以调节互穿网络水凝胶的性质以控制伤口环境中的水分量。 本文描述的装置，方法和试剂盒可适用于在多个时间范围内的各种愈合阶段处理各种伤口类型。 一些水凝胶可以被配置成将一种或多种弱毒剂递送到伤口。 互穿网络水凝胶还可以适于控制吸湿的速率和/或量，使得水凝胶可以用作可膨胀植入物以膨胀组织。
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公开(公告)号：US20080262519A1
公开(公告)日：2008-10-23
申请号：US11962077
申请日：2007-12-20
申请人： Geoffrey C. GURTNER , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon M. Saul , C. Travis Rappleye , Evgenia Mandrusov
发明人： Geoffrey C. GURTNER , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon M. Saul , C. Travis Rappleye , Evgenia Mandrusov
IPC分类号： A61B17/11
CPC分类号： A61B17/00491 , A61B17/04 , A61B17/11 , A61B17/12022 , A61B17/1204 , A61B17/12109 , A61B17/12186 , A61B17/1219 , A61B17/122 , A61B17/1227 , A61B2017/1103 , A61B2017/1107
摘要： Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient's body including vascular lumens. More particularly, in various aspects, this invention provides compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique
摘要翻译： 公开了用于将非结合腔内连接在患者体内（包括血管内腔）的组合物，方法和试剂盒。 更具体地，在各个方面，本发明提供了用于连接这种非结合腔的组合物，方法和试剂盒，包括通常需要显微手术技术的小腔
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7.发明授权Cardiomyocytes from induced pluripotent stem cells from patients and methods of use thereof 有权来自患者的诱导性多能干细胞的心肌细胞及其使用方法公开(公告)号：US09395354B2
公开(公告)日：2016-07-19
申请号：US13554946
申请日：2012-07-20
申请人： Ning Sun , Michael T. Longaker , Robert C. Robbins , Joseph Wu , Feng Lan , Andrew Stephen Lee , Paul W. Burridge
发明人： Ning Sun , Michael T. Longaker , Robert C. Robbins , Joseph Wu , Feng Lan , Andrew Stephen Lee , Paul W. Burridge
CPC分类号： C12N5/0657 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/1307 , C12N2506/45 , C12N2510/00 , G01N33/5061 , G01N33/5073 , G01N2800/324 , G01N2800/325
摘要： Human somatic cells obtained from individuals with a genetic heart condition are reprogrammed to become induced pluripotent stem cells (iPS cells), and differentiated into cardiomyocytes for use in analysis, screening programs, and the like.
摘要翻译： 从具有遗传性心脏病的个体获得的人体细胞细胞被重新编程成诱导多能干细胞（iPS细胞），并分化成心肌细胞用于分析，筛选程序等。
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公开(公告)号：US08183428B2
公开(公告)日：2012-05-22
申请号：US12358164
申请日：2009-01-22
CPC分类号： A61L15/42 , A61L15/44 , A61L15/58 , A61L2300/412 , A61L2300/428
摘要： Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.
摘要翻译： 描述了可以控制或调节伤口的机械环境以改善瘢痕和/或瘢痕疙瘩形成的装置，绷带，试剂盒和方法。 伤口的机械环境包括应力，应变和应力和应变的任何组合。 创伤的机械环境的控制可以是主动的，被动的，动态的或静态的。 这些装置被构造成可移除地固定到靠近伤口部位的皮肤表面，并且将伤口屏蔽内源性和/或外源性应激。
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公开(公告)号：US08063263B2
公开(公告)日：2011-11-22
申请号：US12358159
申请日：2009-01-22
CPC分类号： A61F13/0243 , A61F13/00051 , A61F13/00059 , A61F13/0233 , A61F2013/00123 , A61F2013/00127 , A61F2013/00153 , A61F2013/00182 , A61F2013/0028 , A61K38/00 , A61K47/64 , A61K47/67 , B82Y5/00 , C07K5/0606 , C07K5/06113 , C07K5/0806 , C07K5/081 , C07K5/1008 , C07K7/02 , C07K9/005 , G01N33/57407 , G01N33/57419 , G01N2333/95 , G01N2500/00
摘要： Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.
摘要翻译： 描述了可以控制或调节伤口的机械环境以改善瘢痕和/或瘢痕疙瘩形成的装置，绷带，试剂盒和方法。 伤口的机械环境包括应力，应变和应力和应变的任何组合。 创伤的机械环境的控制可以是主动的，被动的，动态的或静态的。 这些装置被构造成可移除地固定到靠近伤口部位的皮肤表面，并且将伤口屏蔽内源性和/或外源性应激。
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10.发明授权Devices and bandages for the treatment or prevention of scars and/or keloids and methods and kits therefor 有权用于治疗或预防疤痕和/或瘢痕疙瘩的装置和绷带及其方法和试剂盒公开(公告)号：US07683234B2
公开(公告)日：2010-03-23
申请号：US11888978
申请日：2007-08-03
CPC分类号： A61L15/42 , A61L15/44 , A61L15/58 , A61L2300/412 , A61L2300/428
摘要： Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.
摘要翻译： 描述了可以控制或调节伤口的机械环境以改善瘢痕和/或瘢痕疙瘩形成的装置，绷带，试剂盒和方法。 伤口的机械环境包括应力，应变和应力和应变的任何组合。 创伤的机械环境的控制可以是主动的，被动的，动态的或静态的。 这些装置被构造成可移除地固定到靠近伤口部位的皮肤表面，并且将伤口屏蔽内源性和/或外源性应激。
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