公开(公告)号：US08742121B2

公开(公告)日：2014-06-03

申请号：US13614751

申请日：2012-09-13

Applicant: Shaomeng Wang ,  Ke Ding ,  Guoping Wang

Inventor： Shaomeng Wang ,  Ke Ding ,  Guoping Wang

IPC: C07D401/02 ,  C07D487/10 ,  C07D209/04

CPC classification number: C07D209/54 ,  C07D487/10 ,  C07D491/10

Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。

公开(公告)号：US08664212B2

公开(公告)日：2014-03-04

申请号：US13557804

申请日：2012-07-25

Applicant: Shaomeng Wang ,  Yuefeng Peng ,  Haiying Sun ,  Qian Cai ,  Zaneta Nikolovska-Coleska ,  Jianfeng Lu ,  Su Qiu

Inventor： Shaomeng Wang ,  Yuefeng Peng ,  Haiying Sun ,  Qian Cai ,  Zaneta Nikolovska-Coleska ,  Jianfeng Lu ,  Su Qiu

IPC: A61K31/33 ,  C07D245/04 ,  C07D487/02

CPC classification number: G01N33/5011 ,  C07D487/04

Abstract: The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

Abstract translation: 本发明涉及作为细胞凋亡蛋白抑制剂抑制剂的Smac的重氮二环模拟物。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。

公开(公告)号：US20120309961A1

公开(公告)日：2012-12-06

申请号：US13557804

申请日：2012-07-25

Applicant: Shaomeng Wang ,  Yuefeng Peng ,  Haiying Sun ,  Qian Cai ,  Zaneta Nikolovska-Coleska ,  Jianfeng Lu ,  Su Qiu

Inventor： Shaomeng Wang ,  Yuefeng Peng ,  Haiying Sun ,  Qian Cai ,  Zaneta Nikolovska-Coleska ,  Jianfeng Lu ,  Su Qiu

IPC: C07D487/04

CPC classification number: G01N33/5011 ,  C07D487/04

Abstract: The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

Abstract translation: 本发明涉及作为细胞凋亡蛋白抑制剂抑制剂的Smac的重氮二环模拟物。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。

公开(公告)号：US20120289494A1

公开(公告)日：2012-11-15

申请号：US13469928

申请日：2012-05-11

Applicant: Shaomeng Wang ,  Wei Sun ,  Angelo Aguilar ,  Carlos Garcia-Echeverria

Inventor： Shaomeng Wang ,  Wei Sun ,  Angelo Aguilar ,  Carlos Garcia-Echeverria

IPC: A61K31/407 ,  A61K31/5377 ,  A61P35/00 ,  A61K31/438 ,  A61K31/41 ,  C07D487/10 ,  C07D471/20

CPC classification number: C07D487/10

Abstract: Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

公开(公告)号：US08088931B2

公开(公告)日：2012-01-03

申请号：US12822829

申请日：2010-06-24

Applicant: Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

Inventor： Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

IPC: C07D207/00

CPC classification number: C07D209/54 ,  C07D487/10 ,  C07D491/10

Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。

公开(公告)号：US20110046189A1

公开(公告)日：2011-02-24

申请号：US12937114

申请日：2009-04-13

Applicant: Shaomeng Wang ,  Haiying Sun ,  Zaneta Nikolovska-Coleska

Inventor： Shaomeng Wang ,  Haiying Sun ,  Zaneta Nikolovska-Coleska

IPC: A61K31/427 ,  A61K31/4178 ,  C07D487/04 ,  A61P35/00

CPC classification number: C07D487/04

Abstract: The invention relates to heteroaryl-substituted bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

Abstract translation: 本发明涉及作为细胞凋亡蛋白抑制剂抑制剂的Smac的杂芳基取代的双环模拟物。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。

公开(公告)号：US07759383B2

公开(公告)日：2010-07-20

申请号：US11360485

申请日：2006-02-22

Applicant: Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

Inventor： Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

IPC: A61K31/40 ,  C07D487/10

CPC classification number: C07D209/54 ,  C07D487/10 ,  C07D491/10

Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。

公开(公告)号：US07737174B2

公开(公告)日：2010-06-15

申请号：US11848089

申请日：2007-08-30

Applicant: Shaomeng Wang ,  Dongguang Qin ,  Jiangyong Chen ,  Shanghai Yu

Inventor： Shaomeng Wang ,  Dongguang Qin ,  Jiangyong Chen ,  Shanghai Yu

IPC: A61K31/404 ,  C07D209/30 ,  C07D209/34

CPC classification number: C07D487/10 ,  C07D491/10

Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。

公开(公告)号：US20090092684A1

公开(公告)日：2009-04-09

申请号：US12242380

申请日：2008-09-30

Applicant: Shaomeng Wang ,  Dajun Yang ,  Liang Xu

Inventor： Shaomeng Wang ,  Dajun Yang ,  Liang Xu

IPC: A61K31/12 ,  A61P35/00 ,  A61K33/24 ,  A61K31/337

CPC classification number: A61K31/11 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of Bcl-2 family proteins. In particular, the present invention provides gossypol compounds (e.g., isomers, enantiomers, racemic compounds, metabolites, derivatives, pharmaceutically acceptable salts, in combination with acids or bases, and the like) and methods of using these compounds as antagonists of the anti-apoptotic effects of Bcl-2 family member proteins (e.g., Bcl-2, Bcl-XL, and the like). The present invention also provides compositions comprising gossypol compounds and optionally one or more additional therapeutic agents (e.g., anticancer/chemotherapeutic agents). The present invention also provides methods for treating diseases and pathologies (e.g., neoplastic diseases) comprising administering a composition comprising gossypol compounds and optionally one or more additional therapeutic agents (e.g., anticancer/chemotherapeutic agents) and/or techniques (e.g., radiation therapies, surgical interventions, and the like) to a subject or in vitro cells, tissues, and organs.

公开(公告)号：US20080089896A1

公开(公告)日：2008-04-17

申请号：US11800220

申请日：2007-05-04

Applicant: Shaomeng Wang ,  Haiying Sun ,  Dongguang Qin ,  Zaneta Nikolovska-Coleska ,  Jianfeng Lu ,  Su Qiu ,  Yuefeng Peng

Inventor： Shaomeng Wang ,  Haiying Sun ,  Dongguang Qin ,  Zaneta Nikolovska-Coleska ,  Jianfeng Lu ,  Su Qiu ,  Yuefeng Peng

IPC: A61K31/407 ,  A61K31/4192 ,  A61K31/496 ,  A61K38/19 ,  A61K39/395 ,  A61P35/00 ,  C07D487/04

CPC classification number: C07D519/00 ,  A61K38/191 ,  C07D487/04

Abstract: The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

Abstract translation: 本发明涉及Smac的二价模拟物，其作为细胞凋亡蛋白抑制剂的抑制剂。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。