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    Carotid physiological parameter monitoring system
    1.
    发明授权
    Carotid physiological parameter monitoring system 有权

    公开(公告)号：US11375911B2

    公开(公告)日：2022-07-05

    申请号：US16630355

    申请日：2018-07-10

    Applicant: Shiming Lin ,  BIV MEDICAL, LTD.

    Inventor： Shiming Lin

    IPC: A61B5/0245 ,  A61B5/021 ,  A61B5/024 ,  A61B5/00 ,  A61B5/0507 ,  A61B8/04 ,  A61B5/02 ,  A61B7/04

    Abstract: The present invention provides a carotid physiological parameter monitoring system, comprising: an electrocardiographic (ECG) monitoring device, a carotid pulse wave detector, and at least one controller. The ECG monitoring device is disposed on a user's left and right wrists or on the user's chest to obtain ECG waveforms. The carotid pulse wave detector is disposed on the user's neck at a position corresponding to the user's carotid arteries for obtaining carotid pulse waveforms. The controller is provided in at least one of the ECG monitoring device, the carotid pulse wave detector, and a mobile device, wherein the controller is configured to obtain the user's carotid physiological parameter(s) (which may include carotid pulse wave velocity or carotid blood pressure) by calculating with the ECG waveforms and/or the carotid pulse waveforms.

    WEARABLE DEVICE CAPABLE OF BLOOD PRESSURE MEASUREMENT
    2.
    发明申请
    WEARABLE DEVICE CAPABLE OF BLOOD PRESSURE MEASUREMENT 审中-公开

    公开(公告)号：US20200085319A1

    公开(公告)日：2020-03-19

    申请号：US16465504

    申请日：2017-11-29

    Applicant: Shiming LIN ,  BIV MEDICAL, LTD.

    Inventor： Shiming LIN

    IPC: A61B5/0225 ,  A61B5/021 ,  A61B5/00 ,  F04B43/02 ,  F04B53/10

    Abstract: The present invention provides a wearable device capable of blood pressure measurement, comprising a wrist band assembly, a display unit provided on the wrist band assembly, and a detachable bladder provided on a backside of the wrist band assembly, wherein the wrist band assembly is provided with a micro air pump connected to the detachable bladder, an air pressure sensor provided on a side of the detachable bladder, and a processor connected to the micro air pump and the air pressure sensor, and the processor activates the micro air pump according to a trigger signal in order for the micro air pump to inflate the detachable bladder and for a user's blood pressure parameters to be derived from data sent by the air pressure sensor to the processor.

    DYNAMIC MEASUREMENT DEVICE WITH A BLOOD PRESSURE DETERMINATION FUNCTION
    3.
    发明申请
    DYNAMIC MEASUREMENT DEVICE WITH A BLOOD PRESSURE DETERMINATION FUNCTION 审中-公开

    公开(公告)号：US20200000350A1

    公开(公告)日：2020-01-02

    申请号：US16465379

    申请日：2017-11-30

    Applicant: Shiming LIN ,  BIV MEDICAL, LTD.

    Inventor： Shiming LIN ,  Shih-Wei CHIANG ,  Cheng-Yan GUO ,  Tai-Cun LIN ,  Wei-Chih HUANG ,  Chun-Nan CHEN ,  Ya-Ting CHANG

    IPC: A61B5/022 ,  A61B5/021 ,  A61B7/04 ,  A61B5/00 ,  A61B5/024

    Abstract: The present invention provides a dynamic measurement device with a blood pressure determination function, comprising: a heartbeat sensing module disposed on the chest area of a user wherein the heartbeat sensing module comprising a heart sound sensor for obtaining heartbeat signals; a pulse sensing module disposed on a limb area of the user, the pulse sensing module comprising a pulse wave sensor for obtaining pulse signals; and a data calculating module for calculating a mean arterial pressure and a value of systolic blood pressure and diastolic blood pressure based on the heartbeat signals and pulse signals. In addition to dynamically monitoring the blood pressure of a user for 24 hours, the present invention can dynamically monitor the heart sounds of the user for 24 hours individually in order to monitor user's physical condition. Therefore, the present invention has important medical meanings.

    ELECTROSENSING ANTIBODY-PROBE DETECTION AND MEASUREMENT SENSOR HAVING CONDUCTIVITY PROMOTION MOLECULES
    4.
    发明申请
    ELECTROSENSING ANTIBODY-PROBE DETECTION AND MEASUREMENT SENSOR HAVING CONDUCTIVITY PROMOTION MOLECULES 审中-公开
    具有电导率促销分子的静电抗体检测和测量传感器

    公开(公告)号：US20100172800A1

    公开(公告)日：2010-07-08

    申请号：US12652419

    申请日：2010-01-05

    Applicant: Shiming Lin ,  Shih-Yuan Lee ,  Bor-ching Sheu ,  Chih-chen Lin ,  Panchien Lin

    Inventor： Shiming Lin ,  Shih-Yuan Lee ,  Bor-ching Sheu ,  Chih-chen Lin ,  Panchien Lin

    IPC: G01N30/00

    CPC classification number: G01N33/5438

    Abstract: A sensor for electrosensing an antigen in a test sample is disclosed. The sensor has two electrodes electrically disconnected and physically separated from each other, a layer of antibody immobilized on the surface of at least one of said electrodes. The antibody has specific binding reactivity with the antigen. Conductivity promotion molecules are conjugated with the antibody to improve electrical conductivity characteristics across the two electrodes. The antibody captures the antigen present in the test sample mixed in a buffer solution that comes into contact with the antibody-populated electrodes. This alters the electrical conductivity characteristic across the two electrodes in which an amount representative of the altering provides an indication for electrosensing of the antigen.

    Abstract translation: 公开了一种用于在测试样品中电敏感抗原的传感器。 该传感器具有彼此电隔离并物理分离的两个电极，一层抗体固定在至少一个所述电极的表面上。 抗体与抗原具有特异性结合活性。 电导率促进分子与抗体缀合以改善两个电极之间的导电特性。 抗体捕获与在与抗体填充的电极接触的缓冲溶液中混合的测试样品中存在的抗原。 这改变了跨越两个电极的电导率特征，其中代表改变的量提供了抗原电感应的指示。

    Biomolecular sensor system utilizing a transverse propagation wave of surface plasmon Resonance (SPR)
    8.
    发明申请
    Biomolecular sensor system utilizing a transverse propagation wave of surface plasmon Resonance (SPR) 有权
    利用表面等离振子共振（SPR）的横向传播波的生物分子传感器系统

    公开(公告)号：US20060170925A1

    公开(公告)日：2006-08-03

    申请号：US11049085

    申请日：2005-02-02

    Applicant: Chii-Wann Lin ,  Chih Kung Lee ,  Zhi-Hsiang Sung ,  Shiming Lin

    Inventor： Chii-Wann Lin ,  Chih Kung Lee ,  Zhi-Hsiang Sung ,  Shiming Lin

    IPC: G01N21/55

    CPC classification number: G01N21/553

    Abstract: A biomolecular sensor system utilizing a transverse propagation wave of surface plasmon resonance (SPR) is described. The system comprises: a substrate; a dielectric layer, having a groove therein and standing on top of the substrate; a sensing film layer, sitting at the groove; a pair of prism devices, each resting on one side of the groove and both separating a tunable distance. Besides, the sensor system further comprises a light source, a light detector (a frontend of which connecting to a spectrometer and a backend connecting to a differential amplifier) and a channel with a cover forming inside the groove for the acquisition of the reflected light from the prism devices. Since the sensor system is constructed by exploiting the SPR technique on the transverse propagation, a whole contact surface is under detection (parallel detection) which differentiates it from the traditional method of single-area SPR detection. The sensor system is applicable not only for the far-infrared remote sensing with a transverse distance of several centimeters, but further for the biomedical sensing applications in the miniature sizing and high throughput.

    Abstract translation: 描述了利用表面等离子体共振（SPR）的横向传播波的生物分子传感器系统。 该系统包括：基板; 介电层，其中具有凹槽并站立在所述基板的顶部上; 位于凹槽处的感测膜层; 一对棱镜装置，每个棱镜装置分别搁置在凹槽的一侧并且两者分离可调距离。 此外，传感器系统还包括光源，光检测器（其前端连接到光谱仪和连接到差分放大器的后端）以及形成在凹槽内的盖的通道，用于获取反射光的反射光 棱镜装置。 由于传感器系统是通过利用SPR技术在横向传播中构建的，因此整个接触面被检测（并行检测），与传统的单区域SPR检测方法相区分。 传感器系统不仅适用于横向距离为几厘米的远红外遥感，而且适用于微型尺寸和高通量的生物医学传感应用。

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