公开(公告)号：US20160136622A1

公开(公告)日：2016-05-19

申请号：US15003804

申请日：2016-01-22

Applicant: Xinbin Ma ,  Yujun Zhao ,  Baowei Wang ,  Shengping Wang ,  Jing Lv ,  Zhenghua Li

Inventor： Xinbin Ma ,  Yujun Zhao ,  Baowei Wang ,  Shengping Wang ,  Jing Lv ,  Zhenghua Li

IPC: B01J23/89 ,  B01J37/04 ,  B01J37/00 ,  B01J35/04 ,  B01J37/02

CPC classification number: B01J23/8906 ,  B01J23/892 ,  B01J23/8946 ,  B01J23/8986 ,  B01J35/002 ,  B01J35/04 ,  B01J37/0036 ,  B01J37/0225 ,  B01J37/0228 ,  B01J37/0242 ,  B01J37/06 ,  B01J37/16 ,  B01J37/18 ,  B01J37/346 ,  B01J2523/00 ,  C07C67/36 ,  B01J2523/22 ,  B01J2523/31 ,  B01J2523/824 ,  B01J2523/842 ,  B01J2523/72 ,  C07C69/36

Abstract: Provided was a monolithic catalyst for synthesizing an oxalate by carbon monoxide (CO) gaseous-phase coupling, a preparation method and the use thereof. In the catalyst, a ceramic honeycomb or a metal honeycomb was used as skeletal carrier, metal oxides were used as a carrier coating, precious metals Pt, Pd, Ir, Rh were used as active ingredients, as well as Fe, Co, Ni were used as additives, wherein the carrier coating accounts for 5 to 50 wt. % of the honeycomb carrier; the active ingredients of the catalyst account for 0.1 to 5 wt. % of the carrier coating; the additives of the catalyst account for 0.3 to 10 wt. % of the carrier coating; and the atomic ratio of the active ingredients to the additives was 0.1 to 3. the reaction for synthesizing the oxalate was carried out in a fixed bed reactor, wherein, N2 was used as a carrier gas. The volume ratio of N2:CO:Alkyl nitrite was 20-80:5-60:10-40, and the retention time was 0.5-10 s.

Abstract translation: 提供了一种用于通过一氧化碳（CO）气相偶联合成草酸盐的整体式催化剂，其制备方法及其用途。 在催化剂中，使用陶瓷蜂窝体或金属蜂窝体作为骨架载体，使用金属氧化物作为载体涂层，使用贵金属Pt，Pd，Ir，Rh作为活性成分，以及Fe，Co，Ni分别为 用作添加剂，其中载体涂料占5至50wt。 ％的蜂窝载体; 催化剂的活性成分占0.1〜5wt。 载体涂层的％; 催化剂的添加剂占0.3〜10wt。 载体涂层的％; 并且活性成分与添加剂的原子比为0.1〜3。用于合成草酸盐的反应在固定床反应器中进行，其中使用N 2作为载气。 N2：CO：亚硝酸烷基酯的体积比为20-80：5-60：10-40，保留时间为0.5-10秒。

公开(公告)号：US08518984B2

公开(公告)日：2013-08-27

申请号：US12945511

申请日：2010-11-12

Applicant: Shaomeng Wang ,  Shanghai Yu ,  Wei Sun ,  Sanjeev Kumar ,  Duxin Sun ,  Peng Zou ,  Donna McEachern ,  Yujun Zhao

Inventor： Shaomeng Wang ,  Shanghai Yu ,  Wei Sun ,  Sanjeev Kumar ,  Duxin Sun ,  Peng Zou ,  Donna McEachern ,  Yujun Zhao

IPC: C07D487/10 ,  A61K31/4015

CPC classification number: C07D487/10 ,  A61K31/407 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/675 ,  A61K45/06 ,  C07D471/20 ,  C07D491/107 ,  C07D495/10 ,  C07F9/6561 ,  A61K2300/00

Abstract: Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

公开(公告)号：US20130150617A1

公开(公告)日：2013-06-13

申请号：US13701508

申请日：2011-05-31

Applicant: Xinbin Ma ,  Yujun Zhao ,  Baowei Wang ,  Shengping Wang ,  Jing Lv ,  Zhenghua Li

Inventor： Xinbin Ma ,  Yujun Zhao ,  Baowei Wang ,  Shengping Wang ,  Jing Lv ,  Zhenghua Li

IPC: B01J29/04 ,  C07C67/36 ,  B01J23/89

CPC classification number: B01J29/04 ,  B01J21/04 ,  B01J21/063 ,  B01J21/066 ,  B01J23/89 ,  B01J23/8906 ,  B01J23/892 ,  B01J23/894 ,  B01J23/8946 ,  B01J23/8986 ,  B01J35/04 ,  B01J37/0215 ,  B01J37/0225 ,  B01J37/0242 ,  C07C67/36 ,  C07C69/36

Abstract: Provided is a monolithic catalyst for synthesizing an oxalate by carbon monoxide (CO) gaseous-phase coupling, a preparation method and the use thereof. In the catalyst, a ceramic honeycomb or a metal honeycomb was used as skeletal carrier, metal oxides were used as a carrier coating, precious metals Pt, Pd, Ir, Rh were used as active ingredients, as well as Fe, Co, Ni were used as additives, wherein the carrier coating accounts for 5 to 50 wt % of the honeycomb carrier the active ingredients of the catalyst account for 0.1 to 5 wt. % of the carrier coating; the additives of the catalyst account for 0.3 to 10 wt. % of the carrier coating; and the atomic ratio of the active ingredients to the additives was 0.1 to 3. the reaction for synthesizing the oxalate was carried out in a fixed bed reactor, wherein, N2 was used as a carrier gas. The volume ratio of N2:CO: Alkyl nitrite was 20-80:5-60:10-40, and the retention time was 0.5-10 s.

Abstract translation: 提供了一种通过一氧化碳（CO）气相偶联合成草酸盐的整体式催化剂，其制备方法及其用途。 在催化剂中，使用陶瓷蜂窝体或金属蜂窝体作为骨架载体，使用金属氧化物作为载体涂层，使用贵金属Pt，Pd，Ir，Rh作为活性成分，以及Fe，Co，Ni分别为 用作添加剂，其中载体涂料占蜂窝载体的5至50重量％，催化剂的活性成分占0.1至5重量％。 载体涂层的％; 催化剂的添加剂占0.3至10wt。 载体涂层的％; 并且活性成分与添加剂的原子比为0.1〜3。用于合成草酸盐的反应在固定床反应器中进行，其中使用N 2作为载气。 N2：CO：亚硝酸烷基酯的体积比为20-80：5-60：10-40，保留时间为0.5-10秒。

公开(公告)号：US20120122947A1

公开(公告)日：2012-05-17

申请号：US13294315

申请日：2011-11-11

Applicant: Shaomeng Wang ,  Yujun Zhao ,  Wei Sun ,  Sanjeev Kumar ,  Lance Leopold ,  Laurent Debussche ,  Cedric Barriere ,  Jean-Christophe Carry ,  Kwame Amaning

Inventor： Shaomeng Wang ,  Yujun Zhao ,  Wei Sun ,  Sanjeev Kumar ,  Lance Leopold ,  Laurent Debussche ,  Cedric Barriere ,  Jean-Christophe Carry ,  Kwame Amaning

IPC: A61K31/407 ,  A61P35/00 ,  A61P35/02 ,  C07D487/10

CPC classification number: A61N5/10 ,  A61K31/407 ,  A61K45/06 ,  C07D487/10 ,  A61K2300/00

Abstract: Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

Abstract translation: 本文提供了药物化学领域中的化合物，组合物和方法。 本文提供的化合物和组合物涉及用作p53和MDM2之间相互作用的拮抗剂的螺 - 羟基吲哚，以及它们作为治疗癌症和其它疾病的治疗剂的用途。

公开(公告)号：US20110112052A1

公开(公告)日：2011-05-12

申请号：US12945511

申请日：2010-11-12

Applicant: Shaomeng Wang ,  Shanghai Yu ,  Wei Sun ,  Sanjeev Kumar Shangary ,  Duxin Sun ,  Peng Zou ,  Donna McEachern ,  Yujun Zhao

Inventor： Shaomeng Wang ,  Shanghai Yu ,  Wei Sun ,  Sanjeev Kumar Shangary ,  Duxin Sun ,  Peng Zou ,  Donna McEachern ,  Yujun Zhao

IPC: C07D487/10 ,  A61K31/407 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/675 ,  A61P1/00 ,  A61P35/04

CPC classification number: C07D487/10 ,  A61K31/407 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/675 ,  A61K45/06 ,  C07D471/20 ,  C07D491/107 ,  C07D495/10 ,  C07F9/6561 ,  A61K2300/00

Abstract: Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

Abstract translation: 本文提供了药物化学领域中的化合物，组合物和方法。 本文提供的化合物和组合物涉及作为p53和MDM2之间的相互作用的拮抗剂的螺 - 羟吲哚，以及它们作为治疗癌症和其它疾病的治疗剂的用途。