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    Methods and compositions for treating tissue using silk proteins
    3.
    发明授权
    Methods and compositions for treating tissue using silk proteins 有权
    使用丝蛋白处理组织的方法和组合物

    公开(公告)号：US08828436B2

    公开(公告)日：2014-09-09

    申请号：US13888143

    申请日：2013-05-06

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Syed Hossainy ,  Michael Ngo ,  Mikael Trollsas ,  John Stankus ,  Gene Michal

    IPC: A61K35/28 ,  C07K17/08 ,  A61F2/00 ,  A61K47/48 ,  C08L89/00 ,  A61K47/42 ,  A61L27/38 ,  A61K9/00 ,  A61L27/52 ,  A61K47/34 ,  A61L27/48

    CPC classification number: A61K47/42 ,  A61K9/0024 ,  A61K47/34 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3895 ,  A61L27/48 ,  A61L27/52 ,  Y10S530/812 ,  Y10S530/815 ,  C08L89/00 ,  C08L71/02

    Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.

    Abstract translation: 本文公开了用于形成自增强复合生物基质的组合物，因此制造和使用方法。 还公开了包括适合递送组合物的递送装置的试剂盒。 在一些实施方案中，组合物可以包括至少三种组分。 在一个实施方案中，第一组分可以包括第一官能化聚合物，第二组分可以包括第二官能化聚合物，第三组分可以包括丝蛋白或其组分。 在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。 在一些实施方案中，组合物可以包括生物封装的，悬浮的，置于生物降解载体内或加载到可生物降解的载体中。 在一些实施方案中，本发明的组合物可以通过双腔注射装置原位，体内和离体应用递送至治疗区域。

    METHODS AND COMPOSITIONS FOR TREATING TISSUE USING SILK PROTEINS
    4.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING TISSUE USING SILK PROTEINS 有权
    用丝素蛋白处理组织的方法和组合物

    公开(公告)号：US20130251764A1

    公开(公告)日：2013-09-26

    申请号：US13888143

    申请日：2013-05-06

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Syed Hossainy ,  Michael Ngo ,  Mikael Trollsas ,  John Stankus ,  Gene Michal

    IPC: A61K47/42 ,  A61K47/34

    CPC classification number: A61K47/42 ,  A61K9/0024 ,  A61K47/34 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3895 ,  A61L27/48 ,  A61L27/52 ,  Y10S530/812 ,  Y10S530/815 ,  C08L89/00 ,  C08L71/02

    Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.

    Abstract translation: 本文公开了用于形成自增强复合生物基质的组合物，因此制造和使用方法。 还公开了包括适合递送组合物的递送装置的试剂盒。 在一些实施方案中，组合物可以包括至少三种组分。 在一个实施方案中，第一组分可以包括第一官能化聚合物，第二组分可以包括第二官能化聚合物，第三组分可以包括丝蛋白或其组分。 在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。 在一些实施方案中，组合物可以包括生物封装的，悬浮的，置于生物降解载体内或加载到可生物降解的载体中。 在一些实施方案中，本发明的组合物可以通过双腔注射装置原位，体内和离体应用递送至治疗区域。

    System and method for a catheter
    9.
    发明授权
    System and method for a catheter 有权

    公开(公告)号：US09737361B2

    公开(公告)日：2017-08-22

    申请号：US14574664

    申请日：2014-12-18

    Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

    Inventor： Jesus Magana ,  John Stankus ,  Benny Serna ,  Michael Ngo

    IPC: A61B18/14 ,  A61B18/00 ,  A61M25/04 ,  A61B17/00

    CPC classification number: A61B18/1492 ,  A61B2017/00526 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/1435 ,  A61M25/04

    Abstract: A catheter apparatus defining a first lumen with a first internal diameter, the catheter apparatus further comprising a shaping structure having a distal end and a proximal end and a length therebetween, the shaping structure being moveable between a delivery state having a first helical shape, and a deployed state having a second helical shape. A deployment member having a second lumen with a second internal diameter, a first portion of the deployment member being positioned within the first lumen and having a third outside diameter sized to enable the deployment member to slide within the first lumen, the deployment member being operably coupled to the distal end of the shaping structure and being configured such that distal axial movement of the deployment member places the shaping structure in the delivery state, and proximal axial movement of the deployment member places the shaping structure in the deployed state.

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