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公开(公告)号：US20200181255A1
公开(公告)日：2020-06-11
申请号：US16793610
申请日：2020-02-18
Applicant: AMGEN INC.
Inventor： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC: C07K16/24 , A61K39/395 , A61K47/68
Abstract: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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公开(公告)号：US20190071498A1
公开(公告)日：2019-03-07
申请号：US16194896
申请日：2018-11-19
Applicant: AMGEN INC.
Inventor： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC: C07K16/24 , A61K39/395 , A61K47/68 , A61K39/00
Abstract: Antigen binding proteins that bind to human IL-23 protein arc provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes arc also provided.
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公开(公告)号：US20210163601A1
公开(公告)日：2021-06-03
申请号：US16987237
申请日：2020-08-06
Applicant: Amgen Inc.
Inventor： Paul Nioi , Peter Coward , Christopher Murawsky , Derek E. Piper , Fernando Garces , Jun Zhang , Yang Li , Brian Mingtung Chan
IPC: C07K16/28 , A61P9/10 , A61P9/04 , C12N15/113 , C07H21/02 , A61P3/06 , A61K39/395 , A61K45/06
Abstract: Antigen binding proteins that interact with ASGR, ASGR-1 and/or ASGR-2 are described as well as methods of making and using such antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of ASGR, ASGR-1 and/or ASGR-2 antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of interfering RNA compositions that reduce expression of ASGR, ASGR-1 and/or ASGR-2 are described.
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公开(公告)号：US20210024626A1
公开(公告)日：2021-01-28
申请号：US17060905
申请日：2020-10-01
Applicant: AMGEN INC.
Inventor： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC: C07K16/24 , A61K47/68 , A61K39/395
Abstract: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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公开(公告)号：US20190248902A1
公开(公告)日：2019-08-15
申请号：US16230356
申请日：2018-12-21
Applicant: Amgen Inc.
Inventor： Paul Nioi , Peter Coward , Christopher Murawsky , Derek E. Piper , Fernando Garces , Jun Zhang , Yang Li , Brian Mingtung Chan
IPC: C07K16/28 , C07H21/02 , A61K39/395 , A61P9/10 , A61P9/04 , A61K45/06 , C12N15/113
CPC classification number: C07K16/2851 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61P9/04 , A61P9/10 , C07H21/02 , C07K14/705 , C07K16/28 , C07K2317/30 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , C12N15/1138
Abstract: Antigen binding proteins that interact with ASGR, ASGR-1 and/or ASGR-2 are described as well as methods of making and using such antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of ASGR, ASGR-1 and/or ASGR-2 antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of interfering RNA compositions that reduce expression of ASGR, ASGR-1 and/or ASGR-2 are described.
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Patent Agency Ranking
公开(公告)号：US20250051457A1
公开(公告)日：2025-02-13
申请号：US18770259
申请日：2024-07-11
Applicant: Amgen Inc.
Inventor： Paul Nioi , Peter Coward , Christopher Murawsky , Derek E. Piper , Fernando Garces , Jun Zhang , Yang Li , Brian Mingtung Chan
IPC: C07K16/28 , A61K39/00 , A61K39/395 , A61K45/06 , A61P3/06 , A61P9/04 , A61P9/10 , C07H21/02 , C07K14/705 , C12N15/113
Abstract: Antigen binding proteins that interact with ASGR, ASGR-1 and/or ASGR-2 are described as well as methods of making and using such antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of ASGR, ASGR-1 and/or ASGR-2 antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of interfering RNA compositions that reduce expression of ASGR, ASGR-1 and/or ASGR-2 are described.
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公开(公告)号：US20170088620A1
公开(公告)日：2017-03-30
申请号：US15279162
申请日：2016-09-28
Applicant: Amgen Inc.
Inventor： Paul Nioi , Peter Coward , Christopher Murawsky , Derek E. Piper , Fernando Garces , Jun Zhang , Yang Li , Brian Mintung Chang
IPC: C07K16/28 , A61K45/06 , A61K39/395
CPC classification number: C07K16/2851 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61P9/04 , A61P9/10 , C07H21/02 , C07K14/705 , C07K16/28 , C07K2317/30 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , C12N15/1138
Abstract: Antigen binding proteins that interact with ASGR, ASGR-1 and/or ASGR-2 are described as well as methods of making and using such antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of ASGR, ASGR-1 and/or ASGR-2 antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of interfering RNA compositions that reduce expression of ASGR, ASGR-1 and/or ASGR-2 are described.
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公开(公告)号：US12012449B2
公开(公告)日：2024-06-18
申请号：US17525421
申请日：2021-11-12
Applicant: AMGEN INC.
Inventor： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC: A61K39/395 , A61K47/68 , C07K16/24 , A61K39/00
CPC classification number: C07K16/244 , A61K39/395 , A61K47/6845 , C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
Abstract: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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公开(公告)号：US11891435B2
公开(公告)日：2024-02-06
申请号：US17558032
申请日：2021-12-21
Applicant: AMGEN INC.
Inventor： Neeraj Jagdish Agrawal , Kevin Graham , Agnes Eva Hamburger , Christopher Mohr , Derek E. Piper , Kenneth William Walker , Zhulun Wang , Cen Xu
IPC: C07K16/00 , A61K39/395 , A61K39/00 , A61K49/00 , A61K49/16 , C12P21/08 , G01N33/53 , C07K16/18 , C07K16/28 , A61P25/06 , A61K38/22 , A61K47/68 , A61K38/17 , A61K51/10 , C07K14/575 , C07K16/26 , C07K14/72 , C07K14/47 , G01N33/74 , G01N33/68
CPC classification number: C07K16/18 , A61K38/2278 , A61P25/06 , C07K16/2869 , A61K38/1796 , A61K38/22 , A61K47/6843 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/545 , A61K2300/00 , C07K14/47 , C07K14/575 , C07K14/57563 , C07K14/72 , C07K16/00 , C07K16/26 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/70 , C07K2317/72 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C12N2501/30 , G01N33/6854 , G01N33/6896 , G01N33/74 , G01N2333/575 , G01N2333/5757 , Y02A50/30
Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.
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公开(公告)号：US20210230267A1
公开(公告)日：2021-07-29
申请号：US17229607
申请日：2021-04-13
Applicant: AMGEN INC.
Inventor： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC: C07K16/24 , A61K47/68 , A61K39/395
Abstract: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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