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公开(公告)号：US12060573B2
公开(公告)日：2024-08-13
申请号：US16069774
申请日：2017-01-17
Applicant: AMORPHICAL LTD.
Inventor： Yosef Ben , Abraham Shahar , Amir Arav
IPC: C12N5/00 , C12N5/073 , C12N5/075 , C12N5/076 , C12N5/077 , C12N5/0775 , C12N5/0793
CPC classification number: C12N5/0018 , C12N5/0604 , C12N5/0609 , C12N5/061 , C12N5/0619 , C12N5/0658 , C12N5/0663 , C12N2500/14
Abstract: Stabilized amorphous calcium carbonate (ACC) as a supplement of cell culture media and the cell culture medium supplements comprising stabilized ACC are provided. In particular the stabilized ACC is useful for enhancing the growth of cell and tissue cultures, gametes and embryos in vitro.
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公开(公告)号：US11602542B2
公开(公告)日：2023-03-14
申请号：US15329677
申请日：2015-07-30
Applicant: AMORPHICAL LTD.
Inventor： Yigal Blum , Yosef Ben , Sharon Hershkovitz
IPC: A61K33/10 , C01F11/18 , A23L33/16 , A23C9/152 , A23C9/13 , A61K9/00 , A61K9/10 , A61K47/14 , A23C19/09 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/40 , A23C13/12 , A23C11/00 , A23C19/068 , A23C19/076
Abstract: The present invention provides stabilized amorphous calcium carbonate (ACC) formulations, comprising ACC and a non-aqueous liquid carrier in which the ACC is dispersed. The present invention further provides cosmetic and pharmaceutical compositions comprising ACC.
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3.发明申请公开(公告)号：US20210260103A1
公开(公告)日：2021-08-26
申请号：US17319292
申请日：2021-05-13
Applicant: AMORPHICAL LTD.
Inventor： Yosef Ben , Yigal Dov Blum
Abstract: The present invention provides compositions comprising amorphous calcium carbonate (ACC), suitable to being administered by inhalation, and methods for their use in treating ACC-responsive diseases and conditions. Kits for preparing suspension compositions of the present invention are provided as well.
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4.发明申请公开(公告)号：US20200345763A1
公开(公告)日：2020-11-05
申请号：US16929837
申请日：2020-07-15
Applicant: AMORPHICAL LTD.
Inventor： Yosef Ben , Yigal Dov Blum
Abstract: The present invention provides compositions comprising amorphous calcium carbonate (ACC), suitable to being administered by inhalation, and methods for their use in treating ACC-responsive diseases and conditions. Further provided are ACC compositions suitable for buccal or sublingual administration.
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5.发明授权公开(公告)号：US11033576B2
公开(公告)日：2021-06-15
申请号：US16929837
申请日：2020-07-15
Applicant: AMORPHICAL LTD.
Inventor： Yosef Ben , Yigal Dov Blum
Abstract: The present invention provides compositions comprising amorphous calcium carbonate (ACC), suitable to being administered by inhalation, and methods for their use in treating ACC-responsive diseases and conditions. Further provided are ACC compositions suitable for buccal or sublingual administration.
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Patent Agency Ranking
公开(公告)号：US10758566B2
公开(公告)日：2020-09-01
申请号：US16069762
申请日：2017-01-17
Applicant: AMORPHICAL LTD.
Inventor： Yosef Ben , Abraham Shahar , Amir Arav
IPC: A61K33/10 , A61K9/00 , A61K9/06 , A61K9/10 , A61P21/00 , A61P15/08 , A61K47/02 , A61K47/12 , A61K47/24 , A61K47/26 , C12N5/073 , C12N5/076 , C12N5/071
Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.
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公开(公告)号：US20170208827A1
公开(公告)日：2017-07-27
申请号：US15329664
申请日：2015-07-30
Applicant: AMORPHICAL LTD.
Inventor： Ali Abo Riziq , Sharon Hershkovitz , Yosef Ben , Yigal Blum
CPC classification number: A61K33/10 , A23C9/1322 , A23C9/1522 , A23C11/00 , A23C13/12 , A23C19/0684 , A23C19/0765 , A23C19/0921 , A23L33/16 , A23V2002/00 , A23V2250/032 , A23V2250/1578 , A23V2250/1886 , A23V2250/192 , A23V2250/5482 , A61K9/0014 , A61K9/10 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/34 , A61K47/40 , C01F11/18 , C01F11/185 , C01P2002/02 , C01P2002/72
Abstract: The present invention provides stable amorphous calcium carbonate (ACC) compositions, and food articles comprising said compositions.
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公开(公告)号：US12115184B2
公开(公告)日：2024-10-15
申请号：US17343471
申请日：2021-06-09
Applicant: AMORPHICAL LTD.
Inventor： Yosef Ben , Yigal Dov Blum , Hagay Moshe , Ben Ashkenazi
CPC classification number: A61K33/10 , A61K9/0019 , A61K9/0056 , A61K9/0073 , A61K9/10 , A61K9/143 , A61K47/24 , A61P31/00 , A61P35/00
Abstract: The present invention provides solid compositions of amorphous calcium carbonate (ACC) and a polyphosphate, bisphosphonate or pharmaceutical salts thereof as a stabilizer. Said stabilizers stabilizes the ACC and prevent crystallization to crystalline calcium carbonate (CCC) for a long period of time, even in an aqueous suspension. The invention further provides pharmaceutical composition comprising the solid ACC compositions as well their use in treating of certain diseases and conditions.
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公开(公告)号：US20230181627A1
公开(公告)日：2023-06-15
申请号：US18106735
申请日：2023-02-07
Applicant: AMORPHICAL LTD.
Inventor： Yigal Blum , Yosef Ben , Sharon Hershkovitz
IPC: A61K33/10 , C01F11/18 , A23L33/16 , A23C9/152 , A23C19/09 , A23C9/13 , A61K9/00 , A61K9/10 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/34 , A61K47/40
CPC classification number: A61K33/10 , C01F11/185 , A23L33/16 , C01F11/18 , A23C9/1522 , A23C19/0921 , A23C9/1322 , A61K9/0014 , A61K9/10 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/34 , A61K47/40 , C01P2002/02 , A23V2002/00 , A23C13/12
Abstract: The present invention provides stabilized amorphous calcium carbonate (ACC) formulations, comprising ACC and a non-aqueous liquid carrier in which the ACC is dispersed. The present invention further provides cosmetic and pharmaceutical compositions comprising ACC.
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公开(公告)号：US11207347B2
公开(公告)日：2021-12-28
申请号：US16934689
申请日：2020-07-21
Applicant: AMORPHICAL LTD.
Inventor： Yosef Ben , Abraham Shahar , Amir Arav
IPC: A61K33/10 , A61K9/00 , A61K9/06 , A61K9/10 , A61P21/00 , A61P15/08 , A61K47/02 , A61K47/12 , A61K47/24 , A61K47/26 , C12N5/073 , C12N5/076 , C12N5/071
Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.
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