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公开(公告)号：US11635431B2
公开(公告)日：2023-04-25
申请号：US16613745
申请日：2018-05-18
Inventor： Nongjian Tao
IPC: G01N33/557 , G01N33/84 , G01N33/552 , G01N33/553 , G01N33/543 , G01B11/14 , G01N21/17 , C12Q1/6825
Abstract: An apparatus for label-free analysis of molecules, including interactions and reactions of the molecules, is disclosed. The apparatus is based on detecting molecule movement under the influence of an external electric field. The apparatus is able to achieve sensitive detection of molecular binding to proteins or other molecules, and conformational changes of proteins or other molecules and biochemical reactions of the proteins or other molecules. Applications of the apparatus include screening of drug molecules, kinetic analysis of posttranslational modification of proteins, and small molecule-protein interactions.
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公开(公告)号：US20210172944A1
公开(公告)日：2021-06-10
申请号：US16613745
申请日：2018-05-18
Inventor： Nongjian Tao
IPC: G01N33/557 , G01N33/84
Abstract: An apparatus for label-free analysis of molecules, including interactions and reactions of the molecules, is disclosed. The apparatus is based on detecting molecule movement under the influence of an external electric field. The apparatus is able to achieve sensitive detection of molecular binding to proteins or other molecules, and conformational changes of proteins or other molecules and biochemical reactions of the proteins or other molecules. Applications of the apparatus include screening of drug molecules, kinetic analysis of posttranslational modification of proteins, and small molecule-protein interactions.
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公开(公告)号：US10947576B2
公开(公告)日：2021-03-16
申请号：US16633812
申请日：2018-07-25
Inventor： Nongjian Tao , Karan Syal
IPC: G06K9/00 , C12Q1/18 , G01N15/14 , G01N33/543 , G01N15/00
Abstract: A method for rapid antibiotic susceptibility testing by tracking sub-micron scale motion of single bacterial cells including obtaining a biological sample from a subject including live bacteria. Different doses of antibiotic are added to a multi-well glass slide and adding portions of the biological sample to the wells. Bacterial cells are tethered onto the surface. The tethered bacterial cells are imaged and tracked. Bacterial sub-micron motion of tethered cells is measured at the different doses. A processor performs statistical analysis on a population of cells for each antibiotic dose to generate an antibiotic dose curve proportional to the motion changes, where the antibiotic dose curve plots data including a decrease in movement over time indicating a proportional effectiveness of an antibiotic applied to a well.
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4.发明申请公开(公告)号：US20200172951A1
公开(公告)日：2020-06-04
申请号：US16633812
申请日：2018-07-25
Inventor： Nongjian Tao , Karan Syal
IPC: C12Q1/18 , G01N33/543 , G01N15/14 , G06K9/00
Abstract: A method for rapid antibiotic susceptibility testing by tracking sub-micron scale motion of single bacterial cells including obtaining a biological sample from a subject including live bacteria. Different doses of antibiotic are added to a multi-well glass slide and adding portions of the biological sample to the wells. Bacterial cells are tethered onto the surface. The tethered bacterial cells are imaged and tracked. Bacterial sub-micron motion of tethered cells is measured at the different doses. A processor performs statistical analysis on a population of cells for each antibiotic dose to generate an antibiotic dose curve proportional to the motion changes, where the antibiotic dose curve plots data including a decrease in movement over time indicating a proportional effectiveness of an antibiotic applied to a well.
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公开(公告)号：US10408757B2
公开(公告)日：2019-09-10
申请号：US15038629
申请日：2015-01-02
Inventor： Nongjian Tao , Hui Yu , Xiaonan Shan , Shaopeng Wang
IPC: G01N21/552 , C12M1/34
Abstract: Method and system to remove background noise with a differential approach in optical imaging is disclosed. The differential approach moves the sample position laterally over a small distance, and a differential image is generated from the images recorded before and after the lateral translation. This approach can significantly improve the image quality of objects, including single DNA molecules, for label-free optical imaging techniques, such as surface plasmon resonance imaging. Disclosed imaging technique provides high-resolution genome-wide restriction maps of single DNA molecules.
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Patent Agency Ranking
公开(公告)号：US11576590B2
公开(公告)日：2023-02-14
申请号：US16490749
申请日：2018-03-13
Inventor： Nongjian Tao , Chenbin Liu
Abstract: A spirometry system includes an imaging device configured to capture upper body movement images of a subject during inhalation and exhalation of the subject. The system further includes at least one controller configured to receive the captured images from the imaging device and, based upon the received images, determine at least one of an image-based spirometry flow-volume curve for the subject or an image-based spirometry parameter for the subject.
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公开(公告)号：US11566801B2
公开(公告)日：2023-01-31
申请号：US16959646
申请日：2019-01-02
Inventor： Erica Forzani , Nongjian Tao , Francis Tsow
IPC: F24F11/00 , F24F11/63 , F24F11/77 , F24F110/10 , F24F110/70 , F24F120/10 , F24F11/30 , F24F11/74
Abstract: An integrated method for assessing metabolic rate and maintaining indoor air quality and efficient ventilation energy use. A physical sensor assesses room occupancy. An actuated ventilation system is set to a constant CO2 level in a predetermined healthy range, where the actuated ventilation system includes a CO2 sensor. The actuated ventilation system sets a first air ventilation rate and the sensor measures a first CO2 level. The system determines whether CO2 level is in a healthy range, if not then the CO2 level is adjusted by setting a subsequent air ventilation rate. A subsequent CO2 level is measured. If the CO2 level is determined to meet a predetermined healthy range, then an assessment of change of air ventilation rate (Δ ACH) is determined. The determination of air change rate can be further augmented by a physical pressure based measurement. The overall metabolic rate is generated.
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8.发明授权公开(公告)号：US11416991B2
公开(公告)日：2022-08-16
申请号：US16644453
申请日：2018-09-04
Inventor： Nongjian Tao , Yunze Yang
IPC: G06T7/00 , C12Q1/18 , G06K9/00 , H04N5/00 , G06T7/246 , G06T7/73 , G06K9/62 , H04N5/225 , H04N5/247 , G06V10/60 , G06V10/145
Abstract: A system for identification of bacterial cells in free solution in a sample. A sample handler is adapted to position the sample. A light source illuminates a large volume of the sample. An imager is located to receive light scattered from the sample. A computer it is coupled to receive data transmitted from the imager. A controller is coupled to send control signals to the sample handler and the computer. The imager processes the scattered light to form images of the bacteria and transmits bacteria image information to the computer, wherein the bacteria image information includes intensity values and position data for the bacteria images from which the computer determines the presence of bacteria.
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9.发明授权公开(公告)号：US10401298B2
公开(公告)日：2019-09-03
申请号：US15878277
申请日：2018-01-23
Inventor： Nongjian Tao , Yan Guan
Abstract: A system for quantitative detection and analysis of the interactions of molecules with molecular receptors on the surfaces of biological cells based on detecting a mechanical deformation in the membrane of a cell associated with the molecular interactions, which works for both large and small molecules. The mechanical deformation can be detected with high precision in real time from an optical image of the cell with a differential detection method. The system can be also used to detect the electrical activities, such as ion channel opening and closing, as well as action potential propagation in neuronal cells.
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10.发明申请公开(公告)号：US20190239761A1
公开(公告)日：2019-08-08
申请号：US16335480
申请日：2017-09-21
Inventor： Nongjian Tao , Yuting Yang
CPC classification number: A61B5/02416 , A61B5/0077 , A61B5/0806 , A61B2576/00 , G06T5/40 , G06T5/50 , G06T7/00 , G06T7/0012 , G06T7/0016 , G06T7/20 , G06T7/33 , G06T2207/10016 , G06T2207/10024 , G06T2207/30076 , H04N9/735
Abstract: Provided herein are systems and methods for computer monitoring of remote photoplethysmography (rPPG) from camera images based on chromaticity in a converted color space, which reduces motion-induced artifacts in camera images for improved rPPG computer monitoring of physiological parameters. In particular, a rPPG system for monitoring at least one physiological parameter from image data is disclosed herein. A processor subsystem electronically receives a first image data set representative of a series of consecutive images of at least a portion of a living body. The processor subsystem converts the first image data set from a first color space to a second color space to generate a second image data set including first channel data comprising a luminance component and second channel data comprising a chromatic component. The processor subsystem processes the second channel data to monitor the at least one physiological parameter of the living body.
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