公开(公告)号：US06177095B1

公开(公告)日：2001-01-23

申请号：US09479520

申请日：2000-01-07

申请人： Amarpreet S. Sawhney ,  Peter K. Jarrett ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Michelle D. Powell ,  Luis Z. Avila ,  David J. Enscore ,  Stephen D. Goodrich ,  William C. Nason ,  Fei Yao ,  Douglas Weaver ,  Shikha P. Barman

发明人： Amarpreet S. Sawhney ,  Peter K. Jarrett ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Michelle D. Powell ,  Luis Z. Avila ,  David J. Enscore ,  Stephen D. Goodrich ,  William C. Nason ,  Fei Yao ,  Douglas Weaver ,  Shikha P. Barman

IPC分类号： A61F202

CPC分类号： C08G63/64 ,  A61K9/1635 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L31/06 ,  A61L31/148 ,  C08L67/04

摘要： Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.

摘要翻译： 描述了包括由碳酸酯或二恶烷酮基团形成的至少一种可水解键，至少一种水溶性聚合物嵌段和至少一种可聚合基团的水溶性大分子单体及其制备方法和用途。 大分子单体优选在长波长紫外光或可见光激发的影响下使用自由基引发剂进行聚合。 生物降解发生在延伸低聚物内的连接处，并导致无毒且容易从体内去除的碎片。 大分子单体可用于包封细胞，以受控的方式递送预防性，治疗性或诊断性药物，堵塞组织中的渗漏，防止外科手术后的粘连形成，暂时保护或分离组织表面，以及将组织粘附或密封在一起。

公开(公告)号：US6083524A

公开(公告)日：2000-07-04

申请号：US944739

申请日：1997-10-06

申请人： Amarpreet S. Sawhney ,  David J. Enscore ,  Stephen D. Goodrich ,  William C. Nason ,  Fei Yao ,  Douglas Weaver ,  Peter K. Jarrett ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Michelle D. Powell ,  Luis Z. Avila ,  Shikha P. Barman

发明人： Amarpreet S. Sawhney ,  David J. Enscore ,  Stephen D. Goodrich ,  William C. Nason ,  Fei Yao ,  Douglas Weaver ,  Peter K. Jarrett ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Michelle D. Powell ,  Luis Z. Avila ,  Shikha P. Barman

IPC分类号： A61K9/16 ,  A61L24/00 ,  A61L24/04 ,  A61L26/00 ,  A61L31/06 ,  A61L31/14 ,  C08G63/64 ,  A61R2/02 ,  A61K31/74

CPC分类号： C08G63/64 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L31/06 ,  A61L31/148 ,  A61K9/1635

摘要： Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.

摘要翻译： 描述了包括由碳酸酯或二恶烷酮基团形成的至少一种可水解键，至少一种水溶性聚合物嵌段和至少一种可聚合基团的水溶性大分子单体及其制备方法和用途。 大分子单体优选在长波长紫外光或可见光激发的影响下使用自由基引发剂进行聚合。 生物降解发生在延伸低聚物内的连接处，并导致无毒且容易从体内去除的碎片。 大分子单体可用于包封细胞，以受控的方式递送预防性，治疗性或诊断性药物，堵塞组织中的渗漏，防止外科手术后的粘连形成，暂时保护或分离组织表面，以及将组织粘附或密封在一起。

公开(公告)号：USRE39713E1

公开(公告)日：2007-07-03

申请号：US10351930

申请日：2003-01-23

申请人： Amarpreet S. Sawhney ,  Peter K. Jarrett ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Michelle D. Lyman ,  Luis Z. Avila ,  David J. Enscore ,  Stephen D. Goodrich ,  William C. Nason ,  Fei Yao ,  Douglas Weaver ,  Shikha P. Barman

发明人： Amarpreet S. Sawhney ,  Peter K. Jarrett ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Michelle D. Lyman ,  Luis Z. Avila ,  David J. Enscore ,  Stephen D. Goodrich ,  William C. Nason ,  Fei Yao ,  Douglas Weaver ,  Shikha P. Barman

IPC分类号： A61F2/02

CPC分类号： C08G63/64 ,  A61K9/1635 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L31/06 ,  A61L31/148 ,  C08L67/04

摘要： Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.

摘要翻译： 描述了包括由碳酸酯或二恶烷酮基团形成的至少一种可水解键，至少一种水溶性聚合物嵌段和至少一种可聚合基团的水溶性大分子单体及其制备和使用方法。 大分子单体优选在长波长紫外光或可见光激发的影响下使用自由基引发剂进行聚合。 生物降解发生在延伸低聚物内的连接处，并导致无毒且容易从体内去除的碎片。 大分子单体可用于包封细胞，以受控的方式递送预防性，治疗性或诊断性药物，堵塞组织中的渗漏，防止外科手术后的粘连形成，暂时保护或分离组织表面，以及将组织粘附或密封在一起。

公开(公告)号：US06387977B1

公开(公告)日：2002-05-14

申请号：US09616256

申请日：2000-07-14

申请人： Amarpreet S. Sawhney ,  David A. Melanson ,  Chandrashekar P. Pathak ,  Jeffrey A. Hubbell ,  Luis Z. Avila ,  Mark T. Kieras ,  Stephen D. Goodrich ,  Shikha P. Barman ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Douglas J. K. Weaver ,  Marc A. Levine ,  John C. Spiridigliozzi ,  Thomas S. Bromander ,  Dean M. Pichon ,  George Selecman ,  David J. Nedder ,  Bradley C. Poff ,  Donald L. Elbert

发明人： Amarpreet S. Sawhney ,  David A. Melanson ,  Chandrashekar P. Pathak ,  Jeffrey A. Hubbell ,  Luis Z. Avila ,  Mark T. Kieras ,  Stephen D. Goodrich ,  Shikha P. Barman ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Douglas J. K. Weaver ,  Marc A. Levine ,  John C. Spiridigliozzi ,  Thomas S. Bromander ,  Dean M. Pichon ,  George Selecman ,  David J. Nedder ,  Bradley C. Poff ,  Donald L. Elbert

IPC分类号： C09D400

CPC分类号： C09D4/00 ,  A61B17/00491 ,  A61B17/085 ,  A61B2017/00495 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L24/06 ,  A61L2300/00 ,  C08F2/48 ,  C08F265/04 ,  C08F271/00 ,  C08F283/00 ,  C08F289/00 ,  C08F290/06 ,  C08F290/062 ,  C08F290/14 ,  C08F291/00 ,  C08L2666/02 ,  C09J151/00 ,  Y10S602/904 ,  C08L71/02 ,  C08L33/04 ,  C08F220/00

摘要： An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as “priming”. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, “priming” can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.

摘要翻译： 公开了一种与其所施加的表面高粘附性的经阻挡或药物递送系统，以及用于制备屏障的方法。 在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。 在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。 因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。 该方法在本文中称为“起动”。 可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。 在另一个实施例中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其它表面，或者将组织表面彼此附着。 第一表面和屏障或另一个表面用引发剂预处理，并且在它们之间放置一层含有起泡剂的可凝胶单体。 在单体凝胶化时，在两个表面之间获得强粘合性。 以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。 描述了使用非光化学体系和组合化学/光化学体系的方法。

公开(公告)号：US5844016A

公开(公告)日：1998-12-01

申请号：US478104

申请日：1995-06-07

申请人： Amarpreet S. Sawhney ,  David A. Melanson ,  Chandrashekar P. Pathak ,  Jeffrey A. Hubbell ,  Luis Z. Avila ,  Mark T. Kieras ,  Stephen D. Goodrich ,  Shikha P. Barman ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Douglas J. K. Weaver

发明人： Amarpreet S. Sawhney ,  David A. Melanson ,  Chandrashekar P. Pathak ,  Jeffrey A. Hubbell ,  Luis Z. Avila ,  Mark T. Kieras ,  Stephen D. Goodrich ,  Shikha P. Barman ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Douglas J. K. Weaver

IPC分类号： A61B17/00 ,  A61B17/08 ,  A61L24/00 ,  A61L24/04 ,  A61L24/06 ,  A61L29/00 ,  A61L31/00 ,  C08F2/48 ,  C08F2/50 ,  C08F4/00 ,  C08F4/40 ,  C08F265/04 ,  C08F271/00 ,  C08F283/00 ,  C08F289/00 ,  C08F290/06 ,  C08F290/14 ,  C08F291/00 ,  C09D4/00 ,  C09D7/00 ,  C09D171/00 ,  C09J151/00 ,  C08F4/42

CPC分类号： A61L24/0031 ,  A61L24/0015 ,  A61L24/0042 ,  A61L24/046 ,  A61L24/06 ,  C08F2/48 ,  C08F265/04 ,  C08F271/00 ,  C08F283/00 ,  C08F289/00 ,  C08F290/06 ,  C08F290/062 ,  C08F290/14 ,  C08F291/00 ,  C09D4/00 ,  C09J151/00 ,  A61B17/00491 ,  A61B17/085 ,  A61B2017/00495 ,  A61L2300/00 ,  Y10S602/90 ,  Y10S602/904

摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. The barrier can be prepared by staining tissue with a photoinitiator, applying a solution containing a polymerizable barrier material solution and a photoinitiator to the tissue, and polymerizing the polymer solution on exposure to light. The resulting polymer adheres strongly to the tissue surface, and also forms a gel in the rest of the applied volume. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. The method can be used to adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. Tissue surfaces can be adhered to each other to repair wounds. In addition to photochemical initiators, non-photochemical initiators and combinations of chemical initiators and photochemical initiators can be used.

摘要翻译： 公开了与施加的表面高度附着的改进的屏障或药物递送系统，以及用于制造屏障的方法。 屏障可以通过用光引发剂染色组织，将含有可聚合阻挡材料溶液和光引发剂的溶液施加到组织上，以及在暴露于光下聚合聚合物溶液来制备。 所得聚合物强烈地粘附到组织表面，并且在其余施用体积中形成凝胶。 可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。 该方法可用于将预先形成的障碍物粘附到组织或其它表面，或将组织表面彼此粘附。 组织表面可以彼此粘附以修复伤口。 除了光化学引发剂之外，还可以使用非光化学引发剂以及化学引发剂和光化学引发剂的组合。

公开(公告)号：US6121341A

公开(公告)日：2000-09-19

申请号：US973077

申请日：1997-10-10

申请人： Amarpreet S. Sawhney ,  David A. Melanson ,  Chandrashekar P. Pathak ,  Jeffrey A. Hubbell ,  Luis Z. Avila ,  Mark T. Kieras ,  Stephen D. Goodrich ,  Shikha P. Barman ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Douglas J. K. Weaver ,  Marc A. Levine ,  John C. Spiridigliozzi ,  Thomas S. Bromander ,  Dean M. Pichon ,  George Selecman ,  David J. Nedder ,  Bradley C. Poff ,  Donald L. Elbert

发明人： Amarpreet S. Sawhney ,  David A. Melanson ,  Chandrashekar P. Pathak ,  Jeffrey A. Hubbell ,  Luis Z. Avila ,  Mark T. Kieras ,  Stephen D. Goodrich ,  Shikha P. Barman ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Douglas J. K. Weaver ,  Marc A. Levine ,  John C. Spiridigliozzi ,  Thomas S. Bromander ,  Dean M. Pichon ,  George Selecman ,  David J. Nedder ,  Bradley C. Poff ,  Donald L. Elbert

IPC分类号： A61B17/00 ,  A61B17/08 ,  A61L24/00 ,  A61L24/04 ,  A61L24/06 ,  A61L29/00 ,  A61L31/00 ,  C08F2/48 ,  C08F4/40 ,  C08F265/04 ,  C08F271/00 ,  C08F283/00 ,  C08F289/00 ,  C08F290/06 ,  C08F290/14 ,  C08F291/00 ,  C09D4/00 ,  C09D7/00 ,  C09D171/00 ,  C09J151/00 ,  C08K1/00 ,  A61F2/00

CPC分类号： C09D4/00 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L24/06 ,  C08F2/48 ,  C08F265/04 ,  C08F271/00 ,  C08F283/00 ,  C08F289/00 ,  C08F290/06 ,  C08F290/062 ,  C08F290/14 ,  C08F291/00 ,  C09J151/00 ,  A61B17/00491 ,  A61B17/085 ,  A61B2017/00495 ,  A61L2300/00 ,  Y10S602/904

摘要： An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". the polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.

摘要翻译： PCT No.PCT / US96 / 03834 Sec。 371日期：1997年10月10日 102（e）日期1997年10月10日PCT提交1996年3月22日PCT公布。 出版物WO96 / 29370 日期1996年9月26日披露了与施加的表面高粘附性的阻挡或药物递送系统，以及制造屏障的方法。 在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。 在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。 因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。 该方法在本文中称为“起动”。 可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。 在另一个实施例中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其它表面，或者将组织表面彼此附着。 第一表面和屏障或另一个表面用引发剂预处理，并且在它们之间放置一层含有起泡剂的可凝胶单体。 在单体凝胶化时，在两个表面之间获得强粘合性。 以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。 描述了使用非光化学体系和组合化学/光化学体系的方法。

公开(公告)号：US07238364B2

公开(公告)日：2007-07-03

申请号：US10338933

申请日：2003-01-07

申请人： Amarpreet S. Sawhney ,  Michelle D. Lyman ,  Peter K. Jarrett ,  Ronald S. Rudowsky

发明人： Amarpreet S. Sawhney ,  Michelle D. Lyman ,  Peter K. Jarrett ,  Ronald S. Rudowsky

IPC分类号： A61F2/00 ,  A61K47/48 ,  C08G63/48 ,  C08G63/91 ,  C08G65/32 ,  A61K9/14 ,  A61K9/50 ,  C08G63/08

CPC分类号： A61L31/06 ,  A61K9/1635 ,  A61K9/1647 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L31/10 ,  A61L31/148 ,  C08G63/64 ,  C08G63/676 ,  C08L67/04

摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.

摘要翻译： 公开了与施加的表面高度附着的改进的屏障或药物递送系统，以及用于制造屏障的方法。 在优选实施例中，该系统是符合的，因为当组织在愈合过程中弯曲并变形时，其能够符合组织表面的三维结构。 通过将可聚合单体施加到表面上，然后聚合单体，将屏障或药物递送系统形成为组织表面上的聚合物涂层。 聚合的柔顺涂层优选是可生物降解和生物相容的，并且可以设计成具有选择的适应性和弹性性质，用于不同的手术和治疗应用。

公开(公告)号：US06531147B2

公开(公告)日：2003-03-11

申请号：US10053356

申请日：2001-11-07

申请人： Amapreet S. Sawhney ,  Michelle D. Lyman ,  Peter K. Jarrett ,  Ronald S. Rudowsky

发明人： Amapreet S. Sawhney ,  Michelle D. Lyman ,  Peter K. Jarrett ,  Ronald S. Rudowsky

IPC分类号： C09D400

CPC分类号： A61L31/06 ,  A61K9/1635 ,  A61K9/1647 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L31/10 ,  A61L31/148 ,  C08G63/64 ,  C08G63/676 ,  C08L67/04

摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.

公开(公告)号：US6051248A

公开(公告)日：2000-04-18

申请号：US288207

申请日：1999-04-08

申请人： Amapreet S. Sawhney ,  Michelle D. Lyman ,  Peter K. Jarrett ,  Ronald S. Rudowsky

发明人： Amapreet S. Sawhney ,  Michelle D. Lyman ,  Peter K. Jarrett ,  Ronald S. Rudowsky

IPC分类号： A61K9/16 ,  A61L24/00 ,  A61L24/04 ,  A61L26/00 ,  A61L31/06 ,  A61L31/10 ,  A61L31/14 ,  C08G63/64 ,  C08G63/676 ,  C09D4/00 ,  A61L27/00 ,  A61L29/00 ,  A61L25/00

CPC分类号： A61L31/06 ,  A61K9/1647 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L31/10 ,  A61L31/148 ,  C08G63/64 ,  C08G63/676 ,  A61K9/1635

摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.

公开(公告)号：US5900245A

公开(公告)日：1999-05-04

申请号：US710689

申请日：1996-09-23

申请人： Amapreet S. Sawhney ,  Michelle D. Lyman ,  Peter K. Jarrett ,  Ronald S. Rudowsky

发明人： Amapreet S. Sawhney ,  Michelle D. Lyman ,  Peter K. Jarrett ,  Ronald S. Rudowsky

IPC分类号： A61K9/16 ,  A61L24/00 ,  A61L24/04 ,  A61L26/00 ,  A61L31/06 ,  A61L31/10 ,  A61L31/14 ,  C08G63/64 ,  C08G63/676 ,  C09D4/00 ,  A61L25/00 ,  A61L27/00 ,  A61L29/00

CPC分类号： A61L31/06 ,  A61K9/1647 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L31/10 ,  A61L31/148 ,  C08G63/64 ,  C08G63/676 ,  A61K9/1635

摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.