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1.发明授权Redox and photoinitiator systems for priming and improved adherence of gels to substrates 失效氧化还原和光引发剂体系，用于引发和改善凝胶对底物的粘附
公开(公告)号：US6121341A
公开(公告)日：2000-09-19
申请号：US973077
申请日：1997-10-10
申请人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
发明人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
IPC分类号： A61B17/00 , A61B17/08 , A61L24/00 , A61L24/04 , A61L24/06 , A61L29/00 , A61L31/00 , C08F2/48 , C08F4/40 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/14 , C08F291/00 , C09D4/00 , C09D7/00 , C09D171/00 , C09J151/00 , C08K1/00 , A61F2/00
CPC分类号： C09D4/00 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C09J151/00 , A61B17/00491 , A61B17/085 , A61B2017/00495 , A61L2300/00 , Y10S602/904
摘要： An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". the polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.
摘要翻译： PCT No.PCT / US96 / 03834 Sec。 371日期：1997年10月10日 102（e）日期1997年10月10日PCT提交1996年3月22日PCT公布。 出版物WO96 / 29370 日期1996年9月26日披露了与施加的表面高粘附性的阻挡或药物递送系统，以及制造屏障的方法。 在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。 在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。 因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。 该方法在本文中称为“起动”。 可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。 在另一个实施例中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其它表面，或者将组织表面彼此附着。 第一表面和屏障或另一个表面用引发剂预处理，并且在它们之间放置一层含有起泡剂的可凝胶单体。 在单体凝胶化时，在两个表面之间获得强粘合性。 以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。 描述了使用非光化学体系和组合化学/光化学体系的方法。
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2.发明授权Redox and photoinitiator systems for priming for improved adherence of gels to substrates 有权氧化还原和光引发剂体系，用于引发凝胶以增强凝胶对底物的粘附性公开(公告)号：US06387977B1
公开(公告)日：2002-05-14
申请号：US09616256
申请日：2000-07-14
申请人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
发明人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
IPC分类号： C09D400
CPC分类号： C09D4/00 , A61B17/00491 , A61B17/085 , A61B2017/00495 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L2300/00 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C08L2666/02 , C09J151/00 , Y10S602/904 , C08L71/02 , C08L33/04 , C08F220/00
摘要： An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as “priming”. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, “priming” can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.
摘要翻译： 公开了一种与其所施加的表面高粘附性的经阻挡或药物递送系统，以及用于制备屏障的方法。 在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。 在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。 因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。 该方法在本文中称为“起动”。 可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。 在另一个实施例中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其它表面，或者将组织表面彼此附着。 第一表面和屏障或另一个表面用引发剂预处理，并且在它们之间放置一层含有起泡剂的可凝胶单体。 在单体凝胶化时，在两个表面之间获得强粘合性。 以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。 描述了使用非光化学体系和组合化学/光化学体系的方法。
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3.发明授权Redox and photoinitiator priming for improved adherence of gels to substrates 失效氧化还原和光引发剂引发，以提高凝胶对底物的粘附性
公开(公告)号：US5844016A
公开(公告)日：1998-12-01
申请号：US478104
申请日：1995-06-07
申请人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver
发明人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver
IPC分类号： A61B17/00 , A61B17/08 , A61L24/00 , A61L24/04 , A61L24/06 , A61L29/00 , A61L31/00 , C08F2/48 , C08F2/50 , C08F4/00 , C08F4/40 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/14 , C08F291/00 , C09D4/00 , C09D7/00 , C09D171/00 , C09J151/00 , C08F4/42
CPC分类号： A61L24/0031 , A61L24/0015 , A61L24/0042 , A61L24/046 , A61L24/06 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C09D4/00 , C09J151/00 , A61B17/00491 , A61B17/085 , A61B2017/00495 , A61L2300/00 , Y10S602/90 , Y10S602/904
摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. The barrier can be prepared by staining tissue with a photoinitiator, applying a solution containing a polymerizable barrier material solution and a photoinitiator to the tissue, and polymerizing the polymer solution on exposure to light. The resulting polymer adheres strongly to the tissue surface, and also forms a gel in the rest of the applied volume. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. The method can be used to adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. Tissue surfaces can be adhered to each other to repair wounds. In addition to photochemical initiators, non-photochemical initiators and combinations of chemical initiators and photochemical initiators can be used.
摘要翻译： 公开了与施加的表面高度附着的改进的屏障或药物递送系统，以及用于制造屏障的方法。 屏障可以通过用光引发剂染色组织，将含有可聚合阻挡材料溶液和光引发剂的溶液施加到组织上，以及在暴露于光下聚合聚合物溶液来制备。 所得聚合物强烈地粘附到组织表面，并且在其余施用体积中形成凝胶。 可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。 该方法可用于将预先形成的障碍物粘附到组织或其它表面，或将组织表面彼此粘附。 组织表面可以彼此粘附以修复伤口。 除了光化学引发剂之外，还可以使用非光化学引发剂以及化学引发剂和光化学引发剂的组合。
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公开(公告)号：US06176871B1
公开(公告)日：2001-01-23
申请号：US09172537
申请日：1998-10-14
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
IPC分类号： A61F206
CPC分类号： A61F2/82 , A61B2017/22001 , A61F2/945 , A61F2/95 , A61F2210/0047 , A61F2220/0008 , A61F2250/0098 , A61L31/14 , B29C35/08 , B29C49/00 , B29C49/0042 , B29C55/24 , B29C70/74 , B29C2035/0822 , B29C2035/0827 , B29C2035/0833 , B29K2995/006 , B29L2023/00 , B29L2031/7542 , Y10S623/901
摘要： A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
摘要翻译： 公开了一种用于在体内模制聚合物结构的方法和装置。 该结构包括可以通过吸收可见光或近似可见波长的光而被加热到它们的模制温度的聚合物。 通过提供产生由聚合物材料吸收的波长的辐射的光源，该材料可以在体内被选择性地加热和成形，而相邻组织或液体的相应加热不能接受。 该装置包括具有定位在其远端附近的成形元件的导管。 设置有来自至少一个光纤的光的发射器被定位在成形元件内。 发射器用于提供具有基本上均匀的光场的位于成形元件上的可成型的聚合物制品，从而允许制品在体腔内的期望的治疗部位被加热和模制。
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公开(公告)号：US5741323A
公开(公告)日：1998-04-21
申请号：US477370
申请日：1995-06-07
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
IPC分类号： A61L27/00 , A61B17/22 , A61F2/00 , A61F2/02 , A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61F2/06
CPC分类号： A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61B2017/22001 , A61F2210/0047 , A61F2220/0008 , A61F2250/0098 , B29C2035/0822 , B29C2035/0827 , B29C2035/0833 , B29C49/0042 , B29K2995/006 , B29L2023/00 , B29L2031/7542 , Y10S623/901
摘要： A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
摘要翻译： 公开了一种用于在体内模制聚合物结构的方法和装置。 该结构包括可以通过吸收可见光或近似可见波长的光而被加热到它们的模制温度的聚合物。 通过提供产生由聚合物材料吸收的波长的辐射的光源，该材料可以在体内被选择性地加热和成形，而相邻组织或液体的相应加热不能接受。 该装置包括具有定位在其远端附近的成形元件的导管。 设置有来自至少一个光纤的光的发射器被定位在成形元件内。 发射器用于提供具有基本上均匀的光场的位于成形元件上的可成型的聚合物制品，从而允许制品在体腔内的期望的治疗部位被加热和模制。
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公开(公告)号：US5849035A
公开(公告)日：1998-12-15
申请号：US448572
申请日：1995-10-30
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
IPC分类号： A61L27/00 , A61B17/22 , A61F2/00 , A61F2/02 , A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61F2/06
CPC分类号： A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61B2017/22001 , A61F2210/0047 , A61F2220/0008 , A61F2250/0098 , B29C2035/0822 , B29C2035/0827 , B29C2035/0833 , B29C49/0042 , B29K2995/006 , B29L2023/00 , B29L2031/7542 , Y10S623/901
摘要： A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
摘要翻译： PCT No.PCT / US94 / 04824 Sec。 371 1995年10月30日第 102（e）日期1995年10月30日PCT 1994年4月28日PCT PCT。 第WO94 / 24962号公报 日期：1994年11月10日公开了一种用于在体内模制聚合物结构的方法和装置。 该结构包括可以通过吸收可见光或近似可见波长的光而被加热到它们的模制温度的聚合物。 通过提供产生由聚合物材料吸收的波长的辐射的光源，该材料可以在体内被选择性地加热和成形，而相邻组织或液体的相应加热不能接受。 该装置包括具有定位在其远端附近的成形元件的导管。 设置有来自至少一个光纤的光的发射器被定位在成形元件内。 发射器用于提供具有基本上均匀的光场的位于成形元件上的可成型的聚合物制品，从而允许制品在体腔内的期望的治疗部位被加热和模制。
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公开(公告)号：US6162241A
公开(公告)日：2000-12-19
申请号：US129735
申请日：1998-08-05
IPC分类号： A61L27/00 , A61K9/16 , A61K31/137 , A61K31/404 , A61K31/717 , A61K31/722 , A61K47/34 , A61L24/00 , A61L24/04 , A61L26/00 , A61L31/06 , A61L31/14 , C08G63/64 , C08G63/676 , C08G65/00 , C08G85/00 , A61B17/08
CPC分类号： C08G63/676 , A61K9/1635 , A61K9/1647 , A61K31/137 , A61K31/404 , A61K31/717 , A61K31/722 , A61K47/34 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L31/06 , A61L31/148 , A61L2300/418 , A61L2400/04 , C08G63/64 , C08L67/04
摘要： A method of controlling hemostasis by applying a hemostatic agent in a tissue sealant composition. The tissue sealant is a biodegradable, biocompatible synthetic polymer that may not intrinsically possess strong hemostatic properties. Inclusion of a hemostatic material in the tissue sealant can control bleeding at the site and may also provide improved adherence of the sealant to tissue and provide shorter healing times.
摘要翻译： 一种通过在组织密封剂组合物中应用止血剂来控制止血的方法。 组织密封剂是可生物降解的生物相容性合成聚合物，其本身不具有强的止血性能。 将止血材料包括在组织密封剂中可以控制该部位的渗血并且还可以提供密封剂对组织的改善的粘附并提供更短的愈合时间。
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公开(公告)号：US5662712A
公开(公告)日：1997-09-02
申请号：US483194
申请日：1995-06-07
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
IPC分类号： A61L27/00 , A61B17/22 , A61F2/00 , A61F2/02 , A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61F2/06
CPC分类号： A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61B2017/22001 , A61F2210/0047 , A61F2220/0008 , A61F2250/0098 , B29C2035/0822 , B29C2035/0827 , B29C2035/0833 , B29C49/0042 , B29K2995/006 , B29L2023/00 , B29L2031/7542 , Y10S623/901
摘要： A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
摘要翻译： 公开了一种用于在体内模制聚合物结构的方法和装置。 该结构包括可以通过吸收可见光或近似可见波长的光而被加热到它们的模制温度的聚合物。 通过提供产生由聚合物材料吸收的波长的辐射的光源，该材料可以在体内被选择性地加热和成形，而相邻组织或液体的相应加热不能接受。 该装置包括具有定位在其远端附近的成形元件的导管。 设置有来自至少一个光纤的光的发射器被定位在成形元件内。 发射器用于提供具有基本上均匀的光场的位于成形元件上的可成型的聚合物制品，从而允许制品在体腔内的期望的治疗部位被加热和模制。
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公开(公告)号：US07413781B2
公开(公告)日：2008-08-19
申请号：US11644606
申请日：2006-12-22
申请人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Syed F. A. Hossainy
发明人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Syed F. A. Hossainy
CPC分类号： C12N11/04 , A61K9/1635 , A61K9/1647 , A61K9/5031 , A61K9/5073 , A61K35/30 , A61K35/39 , A61K38/42 , A61K38/44 , A61K47/645 , A61K47/6925 , A61K2035/128 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L27/34 , A61L27/38 , A61L27/52 , A61L29/085 , A61L31/10 , A61L31/145 , A61L31/148 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C09D153/00 , C12N5/0012 , C12N5/0677 , C12N2533/30 , C12N2533/32 , C12N2533/40 , C12N2533/74 , C08L71/02
摘要： This invention provides novel methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a covering to encapsulate biological materials or biomedical devices, as a “glue” to cause more than one biological substance to adhere together, or as carriers for biologically active species. Several methods for forming these membranes are provided. Each of these methods utilizes a polymerization system containing water-soluble macromers, species, which are at once polymers and macromolecules capable of further polymerization. The macromers are polymerized using a photoinitiator (such as a dye), optionally a cocatalyst, optionally an accelerator, and radiation in the form of visible or long wavelength UV light. The reaction occurs either by suspension polymerization or by interfacial polymerization. The polymer membrane can be formed directly on the surface of the biological material, or it can be formed on material, which is already encapsulated.
摘要翻译： 本发明提供了使用水溶性分子的光聚合在生物材料周围形成生物相容性膜的新方法。 该膜可以用作包封生物材料或生物医学装置的覆盖物，作为使胶粘剂引起不止一种生物物质粘附在一起，或作为生物活性物质的载体。 提供了形成这些膜的几种方法。 这些方法中的每一种都使用含有水溶性大分子单体的聚合体系，它们是能够进一步聚合的聚合物和大分子。 大分子单体使用光引发剂（例如染料），任选的助催化剂，任选的促进剂和可见或长波长UV光的形式的辐射聚合。 该反应通过悬浮聚合或通过界面聚合进行。 聚合物膜可以直接形成在生物材料的表面上，或者可以在已被包封的材料上形成。
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10.发明授权Implantable substrate coated with a macromer having free radical polymerizable substituents 失效涂有具有自由基可聚合取代基的大分子单体的可植入基材公开(公告)号：US07153519B2
公开(公告)日：2006-12-26
申请号：US10607247
申请日：2003-06-25
申请人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Jennifer L. Hill , Syed F. A. Hossainy
发明人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Jennifer L. Hill , Syed F. A. Hossainy
CPC分类号： C12N11/04 , A61K9/1635 , A61K9/1647 , A61K9/5026 , A61K9/5031 , A61K9/5073 , A61K38/42 , A61K38/44 , A61K47/645 , A61K47/6903 , A61K47/6927 , A61K2035/128 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L27/34 , A61L27/3683 , A61L27/38 , A61L27/52 , A61L29/085 , A61L31/10 , A61L31/145 , A61L31/148 , B82Y5/00 , C08B37/003 , C08B37/0072 , C08B37/0084 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/062 , C08F290/08 , C08F290/10 , C08F291/00 , C09D153/00 , C12N5/0012 , C12N5/0677 , C12N2533/30 , C12N2533/32 , C12N2533/40 , C12N2533/74 , Y10S514/801 , Y10S530/812 , Y10S530/813 , Y10S530/815 , Y10S530/817 , Y10T428/2987 , Y10T428/2989 , C08L71/02
摘要： Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules.
摘要翻译： 通过添加可自由基聚合的基团（例如含有碳 - 碳双键或三键的那些基团）来修饰水溶性大分子单体，其可在温和条件下聚合以包封组织，细胞或生物活性材料。 聚合物材料特别可用作组织粘合剂，用于包括血管的组织腔的涂层，用于细胞的涂层，例如朗格汉斯岛，涂层，塞子，用于与生物材料例如身体接触的支撑体或基底，以及作为用于 生物活性分子。
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