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10 条记录 (耗时 0.046 秒)

    Fused cyclic modulators of nuclear hormone receptor function
    10.
    发明授权
    Fused cyclic modulators of nuclear hormone receptor function 有权
    核激素受体功能的融合循环调节剂

    公开(公告)号：US07001911B2

    公开(公告)日：2006-02-21

    申请号：US10322306

    申请日：2002-12-18

    申请人： Mark E. Salvati ,  James Aaron Balog ,  Weifang Shan ,  Sören Giese ,  Lalgudi S. Harikrishnan

    发明人： Mark E. Salvati ,  James Aaron Balog ,  Weifang Shan ,  Sören Giese ,  Lalgudi S. Harikrishnan

    IPC分类号： C07D471/08 ,  C07D471/18 ,  C07D487/08 ,  A61K31/439 ,  A61P35/00

    CPC分类号： C07D487/08 ,  A61K31/00 ,  A61K31/407 ,  A61K31/655 ,  A61K31/675 ,  C07D487/14 ,  A61K2300/00

    摘要： The invention pertains to fused cyclic compounds having the formula, wherein G is an optionally substituted aryl or heterocyclo, L is an optional linker, M is a bond, O, CR7R7′ or NR10, and M′ is a bond or NR10, with the proviso that at least one of M or M′ must be a bond; E is C═Z2, CR7CR7′, SO2, P═OR2, or P═OOR2; Z1 is O, S, NH, or NR6; Z2 is O, S, NH, or NR6; A1 is CR7 or N; A2 is CR7 or N; Y is J—J′—J″ where J is (CR7R7′)n and n=0-3, J′ is a bond or O, S, S═O, SO2, NH, NR6, C═O, OC═O, NR1C═O, CR7R7′, C═CR8R8′, R2P═O, OPOOR2, OPO2, OSO2, C═N, NHNH, NHNR6, NR6NH, N═N, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo or aryl or substituted aryl, and J″ is (CR7R7′)n and n=0-3; W is CR7R7′—CR7R7′, CR8═CR8′, CR7R7′—C═O, NR9—CR7R7′, N═CR8, N═N, NR9—NR9′, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, or aryl or substituted aryl; and O, R2, R6, R7, R7′, R8, R8′, R9, R9′, and R10 are as defined in the specification, to methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and to pharmaceutical compositions containing such compounds.

    摘要翻译： 本发明涉及具有甲醛的稠合环状化合物