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公开(公告)号：US20180148753A1
公开(公告)日：2018-05-31
申请号：US15509993
申请日：2015-06-30
Applicant: BASF SE
Inventor： Vaidotas NAVICKAS , Kai-Uwe BALDENIUS , Michael BREUER , Patricia WILDBERGER , Martin PFEIFFER , Bernd NIDETZKY
IPC: C12P19/02
CPC classification number: C12P19/02 , C07H1/02 , C07H11/04 , C12N9/1051 , C12N9/16 , C12P19/26 , C12Y204/01 , C12Y204/01007 , C12Y301/0301
Abstract: The present invention relates to methods of producing sugar phosphates by enzymatic transphosphorylation, wherein the phosphoryl transfer from phosphate donor substrates to sugar substrates is catalyzed by an enzyme having alpha-glucose-1-phosphatase activity. Furthermore, the present invention relates to a biocatalyst having sucrose phosphorylase as well as alpha-glucose-1-phosphatase activity and its use. The production of an enzyme having alpha-glucose-1-phosphatase activity and its use in the transphosphorylation of sugar substrates is also presented herein.
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公开(公告)号：US20240301453A1
公开(公告)日：2024-09-12
申请号：US18268177
申请日：2021-12-20
Applicant: BASF SE
Inventor： Sophie MAITRO-VOGEL , Michael BREUER , Dan-Tam Daniel TANG , Thomas SCHMIDT
IPC: C12P13/06 , C07C227/12 , C12N9/90
CPC classification number: C12P13/06 , C07C227/12 , C12N9/90 , C12Y501/01001
Abstract: The present invention relates to the field of chemical manufacture. In particular, it relates to a method for manufacturing racemic methylglycinediacetic acid (MGDA) comprising the steps of contacting a solution comprising or being enriched in D-alanine or L-alanine to an alanine racemase at a temperature of at least 50° C. and alkaline conditions for a time sufficient to allow conversion of said solution into a racemic alanine solution, obtaining a racemic alanine solution, and chemically converting the racemic alanine into racemic MGDA. The invention further contemplates an alanine racemase which is capable of converting a solution comprising or being enriched in D-alanine or L-alanine into racemic alanine solution at a temperature of at least 50° C. and under alkaline conditions as well as the use of said alanine racemase for converting a solution comprising or being enriched in D-alanine or L-alanine into racemic alanine solution at a temperature of at least 50° C. and under alkaline conditions.
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3.发明申请公开(公告)号：US20190119665A1
公开(公告)日：2019-04-25
申请号：US16212287
申请日：2018-12-06
Applicant: BASF SE
Inventor： Michael BREUER , Bernhard HAUER , Dieter JENDROSSEK , Gabriele SIEDENBURG , Juergen PLEISS , Demet SIRIM , Silvia FADENRECHT
CPC classification number: C12N9/88 , C12N9/90 , C12P5/007 , C12P7/02 , C12P7/22 , C12Y406/01 , C12Y504/99017 , Y02P20/52
Abstract: The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.
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公开(公告)号：US20180073047A1
公开(公告)日：2018-03-15
申请号：US15559962
申请日：2016-02-19
Applicant: BASF SE
Inventor： Vaidotas NAVICKAS , Michael BREUER , Michael PUHL , Melanie WEINGARTEN , Kai-Uwe BALDENIUS , Wofgang SIEGEL
CPC classification number: C12P19/02 , C12N9/0006 , C12N9/0065 , C12Y101/03009 , C12Y111/01006 , C12Y111/01007
Abstract: The present invention relates to biocatalytic methods, comprising purely enzymatic, mixed enzymatic-fermentative and purely fermentative methods, for the direct single-step conversion of L-fucitol to L-fucose, in order to easily obtain L-fucose at high amounts and levels of purity. Suitable recombinant microorganisms and fungi are further disclosed and also the use thereof in said method for the single-step conversion to L-fucose.
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5.发明申请公开(公告)号：US20230041211A1
公开(公告)日：2023-02-09
申请号：US17786127
申请日：2020-12-15
Applicant: BASF SE
Inventor： Michael BREUER , Julia Ena HARTIG , Robert THUMMER , Heike BRUESER , Stephanie RENZ , Michael Guenter BRAUN , Oliver OSWALD , Roland MINGES , Jens O. KROEMER , Heiko BABEL
Abstract: The invention pertains to novel methods to increase the tolerance of microbial host cells to toxic substance, for example terpenes and alcohols and other membrane disrupting substances, as well as modified organism with such an increased tolerance a compared to the unmodified organism.
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Patent Agency Ranking
公开(公告)号：US20190144899A1
公开(公告)日：2019-05-16
申请号：US15999299
申请日：2017-02-20
Applicant: BASF SE
Inventor： Michael BREUER , Wolfgang SIEGEL , Stefan RUEDENAUER , Ralf PELZER
IPC: C12P17/04
Abstract: The present invention relates to processes for the preparation of sclareolide and related compounds by the biocatalytic cyclization of polyunsaturated carboxylic acid compounds, in particular of homofarnesylic acid and related compounds; and to a process for the preparation of ambroxide via the biocatalytic cyclization of homofarnesylic acid to sclareolide.
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公开(公告)号：US20210381013A1
公开(公告)日：2021-12-09
申请号：US17131930
申请日：2020-12-23
Applicant: BASF SE
Inventor： Michael BREUER , Wolfgang SIEGEL , Stefan RÜDENAUER , Ralf PELZER
IPC: C12P17/04
Abstract: The present invention relates to processes for the preparation of sclareolide and related compounds by the biocatalytic cyclization of polyunsaturated carboxylic acid compounds, in particular of homofarnesylic acid and related compounds; and to a process for the preparation of ambroxide via the biocatalytic cyclization of homofarnesylic acid to sclareolide.
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公开(公告)号：US20180273458A1
公开(公告)日：2018-09-27
申请号：US15743153
申请日：2016-07-08
Applicant: BASF SE
Inventor： JULIA STRAUTMANN , Stefan RÜDENAUER , Christian REIN , Melanie WEINGARTEN , Rocco PACIELLO , Wolfgang SIEGEL , Michael BREUER , Peter HOFMANN , Sebastian SCHMIDT
IPC: C07C45/50 , C07C47/21 , C07C29/141 , C07C29/56 , C07C33/025 , B01J31/18
CPC classification number: C07C45/50 , B01J31/186 , B01J31/1865 , B01J2231/321 , C07C29/141 , C07C29/56 , C07C33/025 , C07C47/21 , C07C2531/18 , C07D307/92
Abstract: The present invention relates to a method for the regioselective hydroformylation of polyunsaturated acyclic hydrocarbons, which are 1, 3 butadienes, which, in the 2 position, bear a saturated or monounsaturated or polyunsaturated acyclic hydrocarbon radical. The present invention also relates to the production of secondary products of these hydroformylation products, especially of ambrox.
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9.发明申请公开(公告)号：US20170233780A1
公开(公告)日：2017-08-17
申请号：US15514706
申请日：2015-09-28
Applicant: BASF SE
Inventor： Michael BREUER , Ralf PELZER
IPC: C12P17/06 , C07D311/92
CPC classification number: C12P17/06 , C07D311/92 , C12N9/90 , C12Y504/99017
Abstract: The present invention relates to a novel process for cyclizing geranyllinalool using the squalene-hopene cyclase from Zymomonas mobilis (Zm-SHC) or a cyclase with at least 80% sequence identity to the Zm-SHC, and cyclization products obtained in this process.
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公开(公告)号：US20240352490A1
公开(公告)日：2024-10-24
申请号：US18294327
申请日：2022-08-01
Applicant: BASF SE
Inventor： Michael BREUER , Melanie WEINGARTEN
CPC classification number: C12P5/005 , C12N9/88 , C12Y402/03
Abstract: The present invention relates to the use of alpha-ionylideneethane as an aroma compound, and to the use of an alpha-ionylideneethane synthase in the production of one or more aroma compounds. The inventive method for preparing one or more aroma compounds comprises a) providing farnesyl diphosphate and an alpha-ionylideneethane synthase as defined herein, under conditions suitable for the alpha-ionylideneethane synthase to produce alpha-ionylideneethane, b) converting farnesyl diphosphate to alpha-ionylideneethane, in vitro or in a host cell, c) optionally, converting alpha-ionylideneethane to one or more further aroma compounds, d) isolating alpha-ionylideneethane and the optionally one or more further aroma compounds and, e) optionally, purifying alpha-ionylideneethane and the optionally one or more further aroma compounds. The invention pertains also to method for scenting a product, particularly for imparting and/or enhancing an odor or flavor, in which at least one alpha-ionylideneethane synthase is used. In addition, the invention provides an aroma compound or composition and/or fragrance composition and/or perfumed or fragranced product, comprising i) at least an alpha-ionylideneethane. Further encompassed by the invention is a perfumed or fragranced product comprising at least an alpha-ionylideneethane. The invention further relates to a method for producing alpha-ionone (4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one), comprising the steps in the following order: a) contacting farnesyl diphosphate with at least one alpha-ionylideneethane synthase, under conditions suitable to produce at least one alpha-ionylideneethane; b) producing the at least alpha-ionylideneethane; c) exposing the at least one alpha-ionylideneethane produced in step b) to conditions suitable for oxidative cleavage of alpha-ionylideneethane to produce alpha-ionone; and d) optionally, isolating the alpha-ionone produced in step c). The invention also relates to a host cell for producing alpha-ionone (4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one), wherein the host cell comprises farnesyl diphosphate and a heterologous nucleic acid encoding an alpha-ionylideneethane synthase, wherein the host cell is capable of oxidatively cleaving alpha-ionylideneethane to produce alpha-ionone. Finally, the invention relates to the use of a host cell comprising farnesyl diphosphate and a heterologous nucleic acid encoding an alpha-ionylideneethane synthase, for (i) producing alpha-ionylideneethane; (ii) producing alpha-ionone; (iii) producing vitamin A; (iv) converting alpha-ionylideneethane to alpha-ionone; (v) converting alpha-ionylideneethane to vitamin A; (vi) for heterologous reconstitution of a terpene or terpenoid; (vii) for producing an industrial product; (viii) a fermentative production system for producing a sesquiterpene.
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